ORC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ORC3_HUMAN
• UniProt AC: Q9UBD5
• Protein Name: Origin recognition complex subunit 3
• Gene Name: ORC3
• Organism: Homo sapiens (Human).
• Sequence Length: 711
• Subcellular Localization: Nucleus.
• Protein Description: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3..
• Protein Sequence: MATSSMSKGCFVFKPNSKKRKISLPIEDYFNKGKNEPEDSKLRFETYQLIWQQMKSENERLQEELNKNLFDNLIEFLQKSHSGFQKNSRDLGGQIKLREIPTAALVLGVNVTDHDLTFGSLTEALQNNVTPYVVSLQAKDCPDMKHFLQKLISQLMDCCVDIKSKEEESVHVTQRKTHYSMDSLSSWYMTVTQKTDPKMLSKKRTTSSQWQSPPVVVILKDMESFATKVLQDFIIISSQHLHEFPLILIFGIATSPIIIHRLLPHAVSSLLCIELFQSLSCKEHLTTVLDKLLLTTQFPFKINEKVLQVLTNIFLYHDFSVQNFIKGLQLSLLEHFYSQPLSVLCCNLPEAKRRINFLSNNQCENIRRLPSFRRYVEKQASEKQVALLTNERYLKEETQLLLENLHVYHMNYFLVLRCLHKFTSSLPKYPLGRQIRELYCTCLEKNIWDSEEYASVLQLLRMLAKDELMTILEKCFKVFKSYCENHLGSTAKRIEEFLAQFQSLDETKEEEDASGSQPKGLQKTDLYHLQKSLLEMKELRRSKKQTKFEVLRENVVNFIDCLVREYLLPPETQPLHEVVYFSAAHALREHLNAAPRIALHTALNNPYYYLKNEALKSEEGCIPNIAPDICIAYKLHLECSRLINLVDWSEAFATVVTAAEKMDANSATSEEMNEIIHARFIRAVSELELLGFIKPTKQKTDHVARLTWGGC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Acetylation	SKGCFVFKPNSKKRK CCCEEEECCCCCCCE	37.68	25953088
20	Ubiquitination	FKPNSKKRKISLPIE ECCCCCCCEEECCHH	45.32	22817900
21	Acetylation	KPNSKKRKISLPIED CCCCCCCEEECCHHH	45.59	7682003
22	Ubiquitination	PNSKKRKISLPIEDY CCCCCCEEECCHHHH	6.25	22817900
23	Phosphorylation	NSKKRKISLPIEDYF CCCCCEEECCHHHHC	31.00	25159151
29	Phosphorylation	ISLPIEDYFNKGKNE EECCHHHHCCCCCCC	9.03	-
32	Ubiquitination	PIEDYFNKGKNEPED CHHHHCCCCCCCCCH	62.45	21906983
32 (in isoform 1)	Ubiquitination	-	62.45	21890473
32 (in isoform 2)	Ubiquitination	-	62.45	21890473
34	Acetylation	EDYFNKGKNEPEDSK HHHCCCCCCCCCHHH	60.80	7682013
34	Ubiquitination	EDYFNKGKNEPEDSK HHHCCCCCCCCCHHH	60.80	22817900
34 (in isoform 2)	Ubiquitination	-	60.80	-
41	Acetylation	KNEPEDSKLRFETYQ CCCCCHHHHHHHHHH	56.88	7682023
41	Ubiquitination	KNEPEDSKLRFETYQ CCCCCHHHHHHHHHH	56.88	22817900
41 (in isoform 1)	Ubiquitination	-	56.88	21890473
41 (in isoform 2)	Ubiquitination	-	56.88	21890473
46	Phosphorylation	DSKLRFETYQLIWQQ HHHHHHHHHHHHHHH	17.54	24719451
47	Phosphorylation	SKLRFETYQLIWQQM HHHHHHHHHHHHHHH	8.30	24719451
55	Ubiquitination	QLIWQQMKSENERLQ HHHHHHHHHHHHHHH	50.72	21906983
55 (in isoform 1)	Ubiquitination	-	50.72	21890473
55 (in isoform 2)	Ubiquitination	-	50.72	21890473
56	Phosphorylation	LIWQQMKSENERLQE HHHHHHHHHHHHHHH	40.07	24719451
86	Ubiquitination	KSHSGFQKNSRDLGG HHCCCCCCCCCCCCC	55.41	29967540
88	Phosphorylation	HSGFQKNSRDLGGQI CCCCCCCCCCCCCCE	33.92	22985185
96	Ubiquitination	RDLGGQIKLREIPTA CCCCCCEEEEECCCC	33.34	29967540
110	Ubiquitination	AALVLGVNVTDHDLT CEEEECCCCCCCCCC	29.22	22817900
112	Ubiquitination	LVLGVNVTDHDLTFG EEECCCCCCCCCCHH	23.55	22817900
145	Acetylation	AKDCPDMKHFLQKLI CCCCCCHHHHHHHHH	38.29	23749302
153	Phosphorylation	HFLQKLISQLMDCCV HHHHHHHHHHHHHHH	27.91	29083192
163	Ubiquitination	MDCCVDIKSKEEESV HHHHHHCCCCCCCCE	51.52	22817900
164	Phosphorylation	DCCVDIKSKEEESVH HHHHHCCCCCCCCEE	45.71	29083192
165	Ubiquitination	CCVDIKSKEEESVHV HHHHCCCCCCCCEEC	65.23	22817900
165 (in isoform 1)	Ubiquitination	-	65.23	21890473
165 (in isoform 2)	Ubiquitination	-	65.23	21890473
183	Phosphorylation	KTHYSMDSLSSWYMT CCEECHHHHHHCEEE	22.85	24275569
185	Phosphorylation	HYSMDSLSSWYMTVT EECHHHHHHCEEEEC	23.83	24275569
188	Phosphorylation	MDSLSSWYMTVTQKT HHHHHHCEEEECCCC	5.71	24275569
198	Ubiquitination	VTQKTDPKMLSKKRT ECCCCCHHHHCCCCC	56.11	29967540
205	Phosphorylation	KMLSKKRTTSSQWQS HHHCCCCCCCCCCCC	39.65	22199227
206	Phosphorylation	MLSKKRTTSSQWQSP HHCCCCCCCCCCCCC	30.34	22199227
207	Phosphorylation	LSKKRTTSSQWQSPP HCCCCCCCCCCCCCC	21.66	22199227
208	Phosphorylation	SKKRTTSSQWQSPPV CCCCCCCCCCCCCCE	33.09	17525332
212	Phosphorylation	TTSSQWQSPPVVVIL CCCCCCCCCCEEEEE	28.36	20068231
235	Ubiquitination	KVLQDFIIISSQHLH HHHHHHHHHCCCCHH	2.23	22817900
240	Ubiquitination	FIIISSQHLHEFPLI HHHHCCCCHHCCCEE	30.97	22817900
285	Ubiquitination	SLSCKEHLTTVLDKL CCCCHHHHHHHHHHH	4.50	21890473
287	Ubiquitination	SCKEHLTTVLDKLLL CCHHHHHHHHHHHHH	25.98	22817900
292	Ubiquitination	LTTVLDKLLLTTQFP HHHHHHHHHHHCCCC	4.77	22817900
325	Ubiquitination	DFSVQNFIKGLQLSL CCCHHHHHHHHHHHH	4.54	22817900
330	Ubiquitination	NFIKGLQLSLLEHFY HHHHHHHHHHHHHHH	4.72	22817900
337	Ubiquitination	LSLLEHFYSQPLSVL HHHHHHHHCCCCCHH	14.33	21890473
340	Ubiquitination	LEHFYSQPLSVLCCN HHHHHCCCCCHHHCC	22.21	22817900
345	Ubiquitination	SQPLSVLCCNLPEAK CCCCCHHHCCCHHHH	1.04	22817900
365	Ubiquitination	LSNNQCENIRRLPSF CCCCCCCHHHCCHHH	40.47	29967540
375	Phosphorylation	RLPSFRRYVEKQASE CCHHHHHHHHHHCCH	14.54	-
375	Ubiquitination	RLPSFRRYVEKQASE CCHHHHHHHHHHCCH	14.54	21890473
376	Ubiquitination	LPSFRRYVEKQASEK CHHHHHHHHHHCCHH	7.60	22817900
378	Ubiquitination	SFRRYVEKQASEKQV HHHHHHHHHCCHHHH	40.91	22817900
380	Ubiquitination	RRYVEKQASEKQVAL HHHHHHHCCHHHHHH	30.63	21890473
383	Acetylation	VEKQASEKQVALLTN HHHHCCHHHHHHHHC	47.80	25953088
383	Ubiquitination	VEKQASEKQVALLTN HHHHCCHHHHHHHHC	47.80	21906983
383 (in isoform 1)	Ubiquitination	-	47.80	21890473
383 (in isoform 2)	Ubiquitination	-	47.80	21890473
388	Ubiquitination	SEKQVALLTNERYLK CHHHHHHHHCHHHHH	3.31	29967540
390	Ubiquitination	KQVALLTNERYLKEE HHHHHHHCHHHHHHH	31.55	21890473
394	Ubiquitination	LLTNERYLKEETQLL HHHCHHHHHHHHHHH	7.63	29967540
404	Ubiquitination	ETQLLLENLHVYHMN HHHHHHHHHCHHHHH	35.10	27667366
421	Acetylation	LVLRCLHKFTSSLPK HHHHHHHHHHHCCCC	37.07	25953088
423	Phosphorylation	LRCLHKFTSSLPKYP HHHHHHHHHCCCCCC	23.39	20068231
424	Phosphorylation	RCLHKFTSSLPKYPL HHHHHHHHCCCCCCC	32.77	20068231
425	Phosphorylation	CLHKFTSSLPKYPLG HHHHHHHCCCCCCCH	45.71	20068231
428	Ubiquitination	KFTSSLPKYPLGRQI HHHHCCCCCCCHHHH	65.87	21890473
428	Ubiquitination	KFTSSLPKYPLGRQI HHHHCCCCCCCHHHH	65.87	22817900
428 (in isoform 1)	Ubiquitination	-	65.87	21890473
428 (in isoform 2)	Ubiquitination	-	65.87	21890473
432	Ubiquitination	SLPKYPLGRQIRELY CCCCCCCHHHHHHHH	18.23	21890473
456	Ubiquitination	DSEEYASVLQLLRML CHHHHHHHHHHHHHH	2.76	27667366
466	Ubiquitination	LLRMLAKDELMTILE HHHHHHHHHHHHHHH	48.97	22817900
467	Ubiquitination	LRMLAKDELMTILEK HHHHHHHHHHHHHHH	39.47	22817900
468	Ubiquitination	RMLAKDELMTILEKC HHHHHHHHHHHHHHH	5.42	21963094
470	Ubiquitination	LAKDELMTILEKCFK HHHHHHHHHHHHHHH	34.73	21890473
471	Ubiquitination	AKDELMTILEKCFKV HHHHHHHHHHHHHHH	2.66	21890473
473	Ubiquitination	DELMTILEKCFKVFK HHHHHHHHHHHHHHH	43.88	22817900
480	Acetylation	EKCFKVFKSYCENHL HHHHHHHHHHHHHCC	43.43	26051181
480	Ubiquitination	EKCFKVFKSYCENHL HHHHHHHHHHHHHCC	43.43	29967540
481	Ubiquitination	KCFKVFKSYCENHLG HHHHHHHHHHHHCCC	24.45	22817900
482	Ubiquitination	CFKVFKSYCENHLGS HHHHHHHHHHHCCCH	12.36	22817900
485	Ubiquitination	VFKSYCENHLGSTAK HHHHHHHHCCCHHHH	31.93	21890473
486	Ubiquitination	FKSYCENHLGSTAKR HHHHHHHCCCHHHHH	14.85	21890473
492	Ubiquitination	NHLGSTAKRIEEFLA HCCCHHHHHHHHHHH	54.73	-
492 (in isoform 2)	Ubiquitination	-	54.73	-
494	Ubiquitination	LGSTAKRIEEFLAQF CCHHHHHHHHHHHHH	6.15	27667366
495	Ubiquitination	GSTAKRIEEFLAQFQ CHHHHHHHHHHHHHH	46.89	27667366
503	Phosphorylation	EFLAQFQSLDETKEE HHHHHHHCCCCCCCC	38.79	23401153
503 (in isoform 2)	Phosphorylation	-	38.79	-
507	Phosphorylation	QFQSLDETKEEEDAS HHHCCCCCCCCCCCC	43.34	28355574
508	Ubiquitination	FQSLDETKEEEDASG HHCCCCCCCCCCCCC	62.17	29967540
508 (in isoform 2)	Phosphorylation	-	62.17	-
509	Ubiquitination	QSLDETKEEEDASGS HCCCCCCCCCCCCCC	74.22	27667366
510	Ubiquitination	SLDETKEEEDASGSQ CCCCCCCCCCCCCCC	63.83	27667366
514	Phosphorylation	TKEEEDASGSQPKGL CCCCCCCCCCCCCCC	51.83	29523821
515 (in isoform 2)	Phosphorylation	-	31.83	26714015
516	Phosphorylation	EEEDASGSQPKGLQK CCCCCCCCCCCCCCH	40.59	17525332
517 (in isoform 2)	Phosphorylation	-	47.45	26714015
519	Ubiquitination	DASGSQPKGLQKTDL CCCCCCCCCCCHHHH	65.69	22817900
520	Ubiquitination	ASGSQPKGLQKTDLY CCCCCCCCCCHHHHH	39.77	21963094
523	Ubiquitination	SQPKGLQKTDLYHLQ CCCCCCCHHHHHHHH	49.39	21890473
523	Ubiquitination	SQPKGLQKTDLYHLQ CCCCCCCHHHHHHHH	49.39	22817900
523 (in isoform 1)	Ubiquitination	-	49.39	21890473
524	Ubiquitination	QPKGLQKTDLYHLQK CCCCCCHHHHHHHHH	20.48	21890473
524 (in isoform 2)	Ubiquitination	-	20.48	21890473
525	Ubiquitination	PKGLQKTDLYHLQKS CCCCCHHHHHHHHHH	52.87	22817900
527	Phosphorylation	GLQKTDLYHLQKSLL CCCHHHHHHHHHHHH	11.86	25159151
531	Ubiquitination	TDLYHLQKSLLEMKE HHHHHHHHHHHHHHH	49.81	29967540
532	Phosphorylation	DLYHLQKSLLEMKEL HHHHHHHHHHHHHHH	25.81	29214152
532	Ubiquitination	DLYHLQKSLLEMKEL HHHHHHHHHHHHHHH	25.81	29967540
532 (in isoform 2)	Ubiquitination	-	25.81	-
537	Ubiquitination	QKSLLEMKELRRSKK HHHHHHHHHHHHCCC	44.19	29967540
538	Ubiquitination	KSLLEMKELRRSKKQ HHHHHHHHHHHCCCC	46.31	29967540
543	Acetylation	MKELRRSKKQTKFEV HHHHHHCCCCCHHHH	47.27	7265723
547	Ubiquitination	RRSKKQTKFEVLREN HHCCCCCHHHHHHHH	36.71	27667366
548	Ubiquitination	RSKKQTKFEVLRENV HCCCCCHHHHHHHHH	9.97	27667366
558	Ubiquitination	LRENVVNFIDCLVRE HHHHHHHHHHHHHHH	3.17	21963094
559	Ubiquitination	RENVVNFIDCLVREY HHHHHHHHHHHHHHH	2.85	21963094
561	Glutathionylation	NVVNFIDCLVREYLL HHHHHHHHHHHHHCC	3.02	22555962
563	Ubiquitination	VNFIDCLVREYLLPP HHHHHHHHHHHCCCC	5.70	22817900
564	Ubiquitination	NFIDCLVREYLLPPE HHHHHHHHHHCCCCC	17.56	22817900
573	Ubiquitination	YLLPPETQPLHEVVY HCCCCCCCCHHHHHH	36.57	21963094
574	Ubiquitination	LLPPETQPLHEVVYF CCCCCCCCHHHHHHH	43.00	21963094
578	Ubiquitination	ETQPLHEVVYFSAAH CCCCHHHHHHHHHHH	2.70	22817900
579	Ubiquitination	TQPLHEVVYFSAAHA CCCHHHHHHHHHHHH	3.48	22817900
607	Phosphorylation	HTALNNPYYYLKNEA HHHHCCHHHHHCHHH	13.58	17360941
611	Ubiquitination	NNPYYYLKNEALKSE CCHHHHHCHHHHHCC	36.30	21906983
611 (in isoform 1)	Ubiquitination	-	36.30	21890473
612	Ubiquitination	NPYYYLKNEALKSEE CHHHHHCHHHHHCCC	36.86	21963094
612 (in isoform 2)	Ubiquitination	-	36.86	21890473
616	Ubiquitination	YLKNEALKSEEGCIP HHCHHHHHCCCCCCC	63.97	22817900
617	Ubiquitination	LKNEALKSEEGCIPN HCHHHHHCCCCCCCC	41.55	22817900
617 (in isoform 2)	Ubiquitination	-	41.55	-
685	Phosphorylation	ARFIRAVSELELLGF HHHHHHHHHHHHHCC	35.16	-
694	Ubiquitination	LELLGFIKPTKQKTD HHHHCCCCCCCCCCC	44.36	2190698
694 (in isoform 1)	Ubiquitination	-	44.36	21890473
695 (in isoform 2)	Ubiquitination	-	39.76	21890473
699	Ubiquitination	FIKPTKQKTDHVARL CCCCCCCCCCCCCCC	58.43	-
700 (in isoform 2)	Ubiquitination	-	28.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ORC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ORC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ORC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ORC2_HUMAN	ORC2	physical	12614612
ORC5_HUMAN	ORC5	physical	12614612
ORC6_HUMAN	ORC6	physical	12614612
MCM4_HUMAN	MCM4	physical	12614612
MCM7_HUMAN	MCM7	physical	12614612
ORC4_HUMAN	ORC4	physical	11395502
ORC5_HUMAN	ORC5	physical	11395502
BRCA1_HUMAN	BRCA1	physical	17525332
ORC2_HUMAN	ORC2	physical	10402192
ORC4_HUMAN	ORC4	physical	11323433
ORC6_HUMAN	ORC6	physical	11323433
ORC5_HUMAN	ORC5	physical	11323433
XRCC5_HUMAN	XRCC5	physical	15910003
XRCC6_HUMAN	XRCC6	physical	15910003
ORC2_HUMAN	ORC2	physical	15910003
ORC6_HUMAN	ORC6	physical	15910003
A4_HUMAN	APP	physical	21832049
ORC5_HUMAN	ORC5	physical	22939629
ORC6_HUMAN	ORC6	physical	15232106
MCM7_HUMAN	MCM7	physical	15232106
ORC1_HUMAN	ORC1	physical	15232106
ORC4_HUMAN	ORC4	physical	15232106
ORC2_HUMAN	ORC2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND MASSSPECTROMETRY.
PubMed: 18669648

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-208 AND SER-516, ANDMASS SPECTROMETRY.
PubMed: 17525332