ORC5_HUMAN - dbPTM
ORC5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID ORC5_HUMAN
UniProt AC O43913
Protein Name Origin recognition complex subunit 5
Gene Name ORC5
Organism Homo sapiens (Human).
Sequence Length 435
Subcellular Localization Nucleus.
Protein Description Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication..
Protein Sequence MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYDFL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44PhosphorylationGHTASGKTYVTQTLL
EECCCCCCHHHHHHH		27.1029759185
45PhosphorylationHTASGKTYVTQTLLK
ECCCCCCHHHHHHHH		12.6529759185
49PhosphorylationGKTYVTQTLLKTLEL
CCCHHHHHHHHHCCC		25.3729759185
68PhosphorylationVNCVECFTLRLLLEQ
HCHHHHHHHHHHHHH		23.7224719451
86PhosphorylationKLNHLSSSEDGCSTE
HHHHCCCCCCCCCCE		36.01-
107UbiquitinationNDFVRLFKQVTTAEN
HHHHHHHHHHHCCCC		48.7421890473
107UbiquitinationNDFVRLFKQVTTAEN
HHHHHHHHHHHCCCC		48.7421890473
107UbiquitinationNDFVRLFKQVTTAEN
HHHHHHHHHHHCCCC		48.7421890473
116UbiquitinationVTTAENLKDQTVYIV
HHCCCCCCCCEEEEE		60.4121906983
119PhosphorylationAENLKDQTVYIVLDK
CCCCCCCEEEEEEEH		25.9728450419
126UbiquitinationTVYIVLDKAEYLRDM
EEEEEEEHHHHHHHH		38.6721906983
235UbiquitinationLAVLNFPKYCEPVVK
HHHCCCCCCCCCCCC		59.40-
236PhosphorylationAVLNFPKYCEPVVKG
HHCCCCCCCCCCCCC		11.41-
242UbiquitinationKYCEPVVKGEASERD
CCCCCCCCCCCCHHH		51.79-
262UbiquitinationRNIEPHLKKAMQTVY
HHCHHHHHHHHHHHH		35.14-
263UbiquitinationNIEPHLKKAMQTVYL
HCHHHHHHHHHHHHH		56.29-
274PhosphorylationTVYLREISSSQWEKL
HHHHHCCCHHHHHHH		21.1325954137
275PhosphorylationVYLREISSSQWEKLQ
HHHHCCCHHHHHHHC		32.0125954137
276PhosphorylationYLREISSSQWEKLQK
HHHCCCHHHHHHHCC		32.3025954137
280UbiquitinationISSSQWEKLQKDDTD
CCHHHHHHHCCCCCC		53.9421890473
283UbiquitinationSQWEKLQKDDTDPGQ
HHHHHHCCCCCCHHH		68.9221906983
292UbiquitinationDTDPGQLKGLSAHTH
CCCHHHCCCCCCCCC		50.3321890473
306 (in isoform 2)Phosphorylation-18.4226657352
330AcetylationTDKRFFLKHHGKIKK
CCCHHHHHHCCCCCC		28.537987633
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of ORC5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of ORC5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of ORC5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
MCM2_HUMANMCM2physical
12614612
ORC1_HUMANORC1physical
12614612
ORC2_HUMANORC2physical
12614612
ORC3_HUMANORC3physical
12614612
ORC4_HUMANORC4physical
12614612
ORC5_HUMANORC5physical
12614612
ORC6_HUMANORC6physical
12614612
MCM3_HUMANMCM3physical
12614612
MCM4_HUMANMCM4physical
12614612
MCM7_HUMANMCM7physical
12614612
ORC4_HUMANORC4physical
9765232
ORC2_HUMANORC2physical
9765232
ORC2_HUMANORC2physical
11395502
ORC3_HUMANORC3physical
11395502
ORC3_HUMANORC3physical
10402192
ORC3_HUMANORC3physical
15232106
ORC1_HUMANORC1physical
15232106
MCM3_HUMANMCM3physical
15232106
MCM2_HUMANMCM2physical
15232106
ORC2_HUMANORC2physical
15232106
CDC6_HUMANCDC6physical
15232106
CDC5L_HUMANCDC5Lphysical
15232106
CDC7_HUMANCDC7physical
15232106
UBQL4_HUMANUBQLN4physical
21988832
TAXB1_HUMANTAX1BP1physical
21988832
STAB1_HUMANSTAB1physical
21988832
TXD11_HUMANTXNDC11physical
21988832
SI1L2_HUMANSIPA1L2physical
21988832
NIF3L_HUMANNIF3L1physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of ORC5_HUMAN

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Related Literatures of Post-Translational Modification

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