UniProt ID | STK40_HUMAN | |
---|---|---|
UniProt AC | Q8N2I9 | |
Protein Name | Serine/threonine-protein kinase 40 | |
Gene Name | STK40 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 435 | |
Subcellular Localization | Nucleus . Cytoplasm . | |
Protein Description | May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.. | |
Protein Sequence | MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSNADSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHDARSWVPKRQFGSAPPVRRLGHDAQPMTSLDTAILAQRYLRK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
14 | Phosphorylation | DRGAGETSARAKALG CCCCCCHHHHHHHHC | 16.08 | 23879269 | |
30 | Acetylation | GISGNNAKRAGPFIL CCCCCCHHCCCCEEC | 44.92 | 7926095 | |
66 | Ubiquitination | TDDFYQLKILTLEER CCCEEEEEEEEHHHH | 21.83 | 29967540 | |
71 | Ubiquitination | QLKILTLEERGDQGI EEEEEEHHHHCCCCC | 40.17 | 29967540 | |
95 | Phosphorylation | MLLHTEYSLLSLLHT CHHHHHHHHHHHHHC | 19.32 | - | |
191 | Ubiquitination | VVEALHQKNIVHRDL HHHHHHHCCCCCCCH | 37.58 | - | |
196 (in isoform 4) | Ubiquitination | - | 39.81 | - | |
199 | Acetylation | NIVHRDLKLGNMVLN CCCCCCHHHHCEECC | 59.65 | 7494203 | |
231 | Ubiquitination | VSEGDLLKDQRGSPA CCCCCCCCCCCCCCC | 60.14 | - | |
236 (in isoform 4) | Ubiquitination | - | 14.46 | - | |
246 | Phosphorylation | YISPDVLSGRPYRGK CCCCCHHCCCCCCCC | 32.38 | 24719451 | |
255 | Phosphorylation | RPYRGKPSDMWALGV CCCCCCHHHHHHHHH | 43.51 | 28634298 | |
266 | Phosphorylation | ALGVVLFTMLYGQFP HHHHHHHHHHHCCCC | 11.34 | 28634298 | |
269 | Phosphorylation | VVLFTMLYGQFPFYD HHHHHHHHCCCCCCC | 9.69 | 28634298 | |
275 | Phosphorylation | LYGQFPFYDSIPQEL HHCCCCCCCCCCHHH | 14.71 | 28634298 | |
277 | Phosphorylation | GQFPFYDSIPQELFR CCCCCCCCCCHHHHH | 25.45 | 28634298 | |
389 | Ubiquitination | QLLLAEEKSSIHDAR HHHHHHHHHCHHHHH | 40.80 | 29967540 | |
394 | Ubiquitination | EEKSSIHDARSWVPK HHHHCHHHHHHHCCH | 41.84 | 29967540 | |
421 | Phosphorylation | GHDAQPMTSLDTAIL CCCCCCCCHHHHHHH | 32.59 | 30257219 | |
422 | Phosphorylation | HDAQPMTSLDTAILA CCCCCCCHHHHHHHH | 20.28 | 30257219 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STK40_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STK40_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STK40_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
DPOA2_HUMAN | POLA2 | physical | 16169070 | |
CSN6_HUMAN | COPS6 | physical | 16169070 | |
A4_HUMAN | APP | physical | 21832049 | |
RFWD2_HUMAN | RFWD2 | physical | 26186194 | |
TRIB1_HUMAN | TRIB1 | physical | 26186194 | |
TRIB1_HUMAN | TRIB1 | physical | 28514442 | |
RFWD2_HUMAN | RFWD2 | physical | 28514442 |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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