STK40_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: STK40_HUMAN
• UniProt AC: Q8N2I9
• Protein Name: Serine/threonine-protein kinase 40
• Gene Name: STK40
• Organism: Homo sapiens (Human).
• Sequence Length: 435
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: May be a negative regulator of NF-kappa-B and p53-mediated gene transcription..
• Protein Sequence: MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSNADSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHDARSWVPKRQFGSAPPVRRLGHDAQPMTSLDTAILAQRYLRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	DRGAGETSARAKALG CCCCCCHHHHHHHHC	16.08	23879269
30	Acetylation	GISGNNAKRAGPFIL CCCCCCHHCCCCEEC	44.92	7926095
66	Ubiquitination	TDDFYQLKILTLEER CCCEEEEEEEEHHHH	21.83	29967540
71	Ubiquitination	QLKILTLEERGDQGI EEEEEEHHHHCCCCC	40.17	29967540
95	Phosphorylation	MLLHTEYSLLSLLHT CHHHHHHHHHHHHHC	19.32	-
191	Ubiquitination	VVEALHQKNIVHRDL HHHHHHHCCCCCCCH	37.58	-
196 (in isoform 4)	Ubiquitination	-	39.81	-
199	Acetylation	NIVHRDLKLGNMVLN CCCCCCHHHHCEECC	59.65	7494203
231	Ubiquitination	VSEGDLLKDQRGSPA CCCCCCCCCCCCCCC	60.14	-
236 (in isoform 4)	Ubiquitination	-	14.46	-
246	Phosphorylation	YISPDVLSGRPYRGK CCCCCHHCCCCCCCC	32.38	24719451
255	Phosphorylation	RPYRGKPSDMWALGV CCCCCCHHHHHHHHH	43.51	28634298
266	Phosphorylation	ALGVVLFTMLYGQFP HHHHHHHHHHHCCCC	11.34	28634298
269	Phosphorylation	VVLFTMLYGQFPFYD HHHHHHHHCCCCCCC	9.69	28634298
275	Phosphorylation	LYGQFPFYDSIPQEL HHCCCCCCCCCCHHH	14.71	28634298
277	Phosphorylation	GQFPFYDSIPQELFR CCCCCCCCCCHHHHH	25.45	28634298
389	Ubiquitination	QLLLAEEKSSIHDAR HHHHHHHHHCHHHHH	40.80	29967540
394	Ubiquitination	EEKSSIHDARSWVPK HHHHCHHHHHHHCCH	41.84	29967540
421	Phosphorylation	GHDAQPMTSLDTAIL CCCCCCCCHHHHHHH	32.59	30257219
422	Phosphorylation	HDAQPMTSLDTAILA CCCCCCCHHHHHHHH	20.28	30257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of STK40_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of STK40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of STK40_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DPOA2_HUMAN	POLA2	physical	16169070
CSN6_HUMAN	COPS6	physical	16169070
A4_HUMAN	APP	physical	21832049
RFWD2_HUMAN	RFWD2	physical	26186194
TRIB1_HUMAN	TRIB1	physical	26186194
TRIB1_HUMAN	TRIB1	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.