STK40_HUMAN - dbPTM
STK40_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID STK40_HUMAN
UniProt AC Q8N2I9
Protein Name Serine/threonine-protein kinase 40
Gene Name STK40
Organism Homo sapiens (Human).
Sequence Length 435
Subcellular Localization Nucleus . Cytoplasm .
Protein Description May be a negative regulator of NF-kappa-B and p53-mediated gene transcription..
Protein Sequence MKRRASDRGAGETSARAKALGSGISGNNAKRAGPFILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSAIIASWQSLSSLSGPLQVVPDIDDQMSNADSSQEAKVTEECSQYEFENYMRQQLLLAEEKSSIHDARSWVPKRQFGSAPPVRRLGHDAQPMTSLDTAILAQRYLRK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
14PhosphorylationDRGAGETSARAKALG
CCCCCCHHHHHHHHC
16.0823879269
30AcetylationGISGNNAKRAGPFIL
CCCCCCHHCCCCEEC
44.927926095
66UbiquitinationTDDFYQLKILTLEER
CCCEEEEEEEEHHHH
21.8329967540
71UbiquitinationQLKILTLEERGDQGI
EEEEEEHHHHCCCCC
40.1729967540
95PhosphorylationMLLHTEYSLLSLLHT
CHHHHHHHHHHHHHC
19.32-
191UbiquitinationVVEALHQKNIVHRDL
HHHHHHHCCCCCCCH
37.58-
196 (in isoform 4)Ubiquitination-39.81-
199AcetylationNIVHRDLKLGNMVLN
CCCCCCHHHHCEECC
59.657494203
231UbiquitinationVSEGDLLKDQRGSPA
CCCCCCCCCCCCCCC
60.14-
236 (in isoform 4)Ubiquitination-14.46-
246PhosphorylationYISPDVLSGRPYRGK
CCCCCHHCCCCCCCC
32.3824719451
255PhosphorylationRPYRGKPSDMWALGV
CCCCCCHHHHHHHHH
43.5128634298
266PhosphorylationALGVVLFTMLYGQFP
HHHHHHHHHHHCCCC
11.3428634298
269PhosphorylationVVLFTMLYGQFPFYD
HHHHHHHHCCCCCCC
9.6928634298
275PhosphorylationLYGQFPFYDSIPQEL
HHCCCCCCCCCCHHH
14.7128634298
277PhosphorylationGQFPFYDSIPQELFR
CCCCCCCCCCHHHHH
25.4528634298
389UbiquitinationQLLLAEEKSSIHDAR
HHHHHHHHHCHHHHH
40.8029967540
394UbiquitinationEEKSSIHDARSWVPK
HHHHCHHHHHHHCCH
41.8429967540
421PhosphorylationGHDAQPMTSLDTAIL
CCCCCCCCHHHHHHH
32.5930257219
422PhosphorylationHDAQPMTSLDTAILA
CCCCCCCHHHHHHHH
20.2830257219

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of STK40_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of STK40_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of STK40_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
DPOA2_HUMANPOLA2physical
16169070
CSN6_HUMANCOPS6physical
16169070
A4_HUMANAPPphysical
21832049
RFWD2_HUMANRFWD2physical
26186194
TRIB1_HUMANTRIB1physical
26186194
TRIB1_HUMANTRIB1physical
28514442
RFWD2_HUMANRFWD2physical
28514442

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of STK40_HUMAN

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Related Literatures of Post-Translational Modification

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