TRIB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRIB1_HUMAN
• UniProt AC: Q96RU8
• Protein Name: Tribbles homolog 1
• Gene Name: TRIB1 {ECO:0000312|HGNC:HGNC:16891}
• Organism: Homo sapiens (Human).
• Sequence Length: 372
• Protein Description: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. [PubMed: 27041596 The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain]
• Protein Sequence: MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MRVGPVRSAMSGASQ CCCCCCCHHCCCCCC	28.67	-
26	Phosphorylation	PALLFPATRGVPAKR CCCCCCCCCCCCHHH	28.35	-
46	Ubiquitination	DAAAVAAKCPRLSEC HHHHHHHHCCCHHHC	34.73	29967540
67	Ubiquitination	LSPPGSPCSPQPPPA CCCCCCCCCCCCCCC	11.25	22817900
67	Ubiquitination	LSPPGSPCSPQPPPA CCCCCCCCCCCCCCC	11.25	-
68	Phosphorylation	SPPGSPCSPQPPPAA CCCCCCCCCCCCCCC	29.92	28985074
84	Phosphorylation	GAGGGSGSAPGPSRI CCCCCCCCCCCCHHH	32.75	22210691
89	Phosphorylation	SGSAPGPSRIADYLL CCCCCCCHHHHHHHH	42.08	22210691
125	Ubiquitination	RCKVFPIKHYQDKIR EEEEEECCCCHHCCC	36.18	29967540
229	Phosphorylation	RLESLEDTHIMKGED HHHHHHHCCCCCCCC	12.15	-
233	Ubiquitination	LEDTHIMKGEDDALS HHHCCCCCCCCCHHH	59.55	22817900
248	Phosphorylation	DKHGCPAYVSPEILN CCCCCCCCCCHHHHC	6.13	-
257	Phosphorylation	SPEILNTTGTYSGKA CHHHHCCCCCCCCHH	26.84	25627689
294	Phosphorylation	SDPSALFSKIRRGQF CCHHHHHHHHHCCCC	28.20	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRIB1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRIB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRIB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK40_HUMAN	STK40	physical	25852190
RFWD2_HUMAN	RFWD2	physical	27041596
MALT1_HUMAN	MALT1	physical	28514442
PECR_HUMAN	PECR	physical	28514442
DET1_HUMAN	DET1	physical	28514442
RFWD2_HUMAN	RFWD2	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
UB2E1_HUMAN	UBE2E1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.