PECR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PECR_HUMAN
• UniProt AC: Q9BY49
• Protein Name: Peroxisomal trans-2-enoyl-CoA reductase
• Gene Name: PECR
• Organism: Homo sapiens (Human).
• Sequence Length: 303
• Subcellular Localization: Peroxisome .
• Protein Description: Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity..
• Protein Sequence: MASWAKGRSYLAPGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVIPIQCNIRNEEEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETNLTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSPAASFITGQSVDVDGGRSLYTHSYEVPDHDNWPKGAGDLSVVKKMKETFKEKAKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Succinylation	GGATGIGKAIVKELL CCCCHHHHHHHHHHH	32.78	-
32	Succinylation	GGATGIGKAIVKELL CCCCHHHHHHHHHHH	32.78	-
43	Phosphorylation	KELLELGSNVVIASR HHHHHCCCCEEEEHH	38.79	27251275
49	Phosphorylation	GSNVVIASRKLERLK CCCEEEEHHHHHHHH	20.87	24275569
57	Phosphorylation	RKLERLKSAADELQA HHHHHHHHHHHHHHH	33.03	29083192
69	Phosphorylation	LQANLPPTKQARVIP HHHCCCCCCCCEEEE	33.57	29083192
92	Ubiquitination	EEVNNLVKSTLDTFG HHHHHHHHHHHHHCC	40.67	29967540
179	Phosphorylation	GAARAGVYNLTKSLA CCHHHCCCHHHHHHH	11.97	21082442
182	Phosphorylation	RAGVYNLTKSLALEW HHCCCHHHHHHHHHH	18.23	28152594
184	O-linked_Glycosylation	GVYNLTKSLALEWAC CCCHHHHHHHHHHHH	17.40	30379171
288	Phosphorylation	PKGAGDLSVVKKMKE CCCCCCHHHHHHHHH	29.60	24702127
291	Acetylation	AGDLSVVKKMKETFK CCCHHHHHHHHHHHH	45.02	25953088
296	Phosphorylation	VVKKMKETFKEKAKL HHHHHHHHHHHHHCC	34.19	29457462

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PECR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PECR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PECR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ACTA_HUMAN	ACTA2	physical	26186194
ACY1_HUMAN	ACY1	physical	26186194
LCN1_HUMAN	LCN1	physical	26186194
UBA5_HUMAN	UBA5	physical	26186194
HNRPF_HUMAN	HNRNPF	physical	28514442
LCN1_HUMAN	LCN1	physical	28514442
UBA5_HUMAN	UBA5	physical	28514442
ACY1_HUMAN	ACY1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00173: Adenine

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-179, AND MASSSPECTROMETRY.
PubMed: 18083107