dbPTM

ISCA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ISCA1_HUMAN
UniProt AC	Q9BUE6
Protein Name	Iron-sulfur cluster assembly 1 homolog, mitochondrial
Gene Name	ISCA1
Organism	Homo sapiens (Human).
Sequence Length	129
Subcellular Localization	Mitochondrion .
Protein Description	Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly..
Protein Sequence	MSASLVRATVRAVSKRKLQPTRAALTLTPSAVNKIKQLLKDKPEHVGVKVGVRTRGCNGLSYTLEYTKTKGDSDEEVIQDGVRVFIEKKAQLTLLGTEMDYVEDKLSSEFVFNNPNIKGTCGCGESFNI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	RATVRAVSKRKLQPT HHHHHHHHHCCCCCC	26.26	26074081
61	Phosphorylation	TRGCNGLSYTLEYTK ECCCCCEEEEEEEEE	19.92	28270605
62	Phosphorylation	RGCNGLSYTLEYTKT CCCCCEEEEEEEEEC	22.01	28270605
63	Phosphorylation	GCNGLSYTLEYTKTK CCCCEEEEEEEEECC	15.11	28270605
66	Phosphorylation	GLSYTLEYTKTKGDS CEEEEEEEEECCCCC	19.35	28270605
67	Phosphorylation	LSYTLEYTKTKGDSD EEEEEEEEECCCCCC	23.90	28270605
69	Phosphorylation	YTLEYTKTKGDSDEE EEEEEEECCCCCCHH	32.24	29449344
73	Phosphorylation	YTKTKGDSDEEVIQD EEECCCCCCHHHHHC	56.44	25849741
89	Ubiquitination	VRVFIEKKAQLTLLG EEEEEEECEEEEEEC	28.68	-
101	Phosphorylation	LLGTEMDYVEDKLSS EECCCCHHHHHHCCC	12.39	-
136	Ubiquitination	I-------------- C--------------		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ISCA1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ISCA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ISCA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ISCA1_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ISCA1_HUMAN

Related Literatures of Post-Translational Modification