MFSD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFSD8_HUMAN
• UniProt AC: Q8NHS3
• Protein Name: Major facilitator superfamily domain-containing protein 8
• Gene Name: MFSD8
• Organism: Homo sapiens (Human).
• Sequence Length: 518
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein . Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs.
• Protein Description: May be a carrier that transport small solutes by using chemiosmotic ion gradients..
• Protein Sequence: MAGLRNESEQEPLLGDTPGSREWDILETEEHYKSRWRSIRILYLTMFLSSVGFSVVMMSIWPYLQKIDPTADTSFLGWVIASYSLGQMVASPIFGLWSNYRPRKEPLIVSILISVAANCLYAYLHIPASHNKYYMLVARGLLGIGAGNVAVVRSYTAGATSLQERTSSMANISMCQALGFILGPVFQTCFTFLGEKGVTWDVIKLQINMYTTPVLLSAFLGILNIILILAILREHRVDDSGRQCKSINFEEASTDEAQVPQGNIDQVAVVAINVLFFVTLFIFALFETIITPLTMDMYAWTQEQAVLYNGIILAALGVEAVVIFLGVKLLSKKIGERAILLGGLIVVWVGFFILLPWGNQFPKIQWEDLHNNSIPNTTFGEIIIGLWKSPMEDDNERPTGCSIEQAWCLYTPVIHLAQFLTSAVLIGLGYPVCNLMSYTLYSKILGPKPQGVYMGWLTASGSGARILGPMFISQVYAHWGPRWAFSLVCGIIVLTITLLGVVYKRLIALSVRYGRIQE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	QEPLLGDTPGSREWD CCCCCCCCCCCCCCC	27.96	25627689
20	Phosphorylation	LLGDTPGSREWDILE CCCCCCCCCCCCCCC	28.38	26471730
49	Phosphorylation	LYLTMFLSSVGFSVV HHHHHHHHHHCHHHH	16.23	25072903
50	Phosphorylation	YLTMFLSSVGFSVVM HHHHHHHHHCHHHHH	28.54	25072903
54	Phosphorylation	FLSSVGFSVVMMSIW HHHHHCHHHHHHHHH	14.10	25850435
59	Phosphorylation	GFSVVMMSIWPYLQK CHHHHHHHHHHHHHC	11.91	25072903
63	Phosphorylation	VMMSIWPYLQKIDPT HHHHHHHHHHCCCCC	13.53	25072903
134	Phosphorylation	PASHNKYYMLVARGL CCCCCHHHHHHHHHC	5.88	-
210	Phosphorylation	IKLQINMYTTPVLLS EEEEEHHCCHHHHHH	11.72	22210691
211	Phosphorylation	KLQINMYTTPVLLSA EEEEHHCCHHHHHHH	17.54	22210691
212	Phosphorylation	LQINMYTTPVLLSAF EEEHHCCHHHHHHHH	8.23	22210691
371	N-linked_Glycosylation	IQWEDLHNNSIPNTT CCHHHCCCCCCCCCC	51.76	20406422
376	N-linked_Glycosylation	LHNNSIPNTTFGEII CCCCCCCCCCCHHHH	50.51	20406422

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MFSD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFSD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFSD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NB5R1_HUMAN	CYB5R1	physical	28514442
EBP_HUMAN	EBP	physical	28514442
TIM14_HUMAN	DNAJC19	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.