NB5R1_HUMAN - dbPTM
NB5R1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NB5R1_HUMAN
UniProt AC Q9UHQ9
Protein Name NADH-cytochrome b5 reductase 1
Gene Name CYB5R1
Organism Homo sapiens (Human).
Sequence Length 305
Subcellular Localization Membrane
Single-pass membrane protein .
Protein Description NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction..
Protein Sequence MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHNTKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKGVHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLGMIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLWFTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQKMRFTY
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Phosphorylation---MGIQTSPVLLAS
---CCCCCHHHHHHH		32.8322210691
6Phosphorylation--MGIQTSPVLLASL
--CCCCCHHHHHHHH		9.1722210691
12PhosphorylationTSPVLLASLGVGLVT
CHHHHHHHHCHHHHH		26.1424043423
19PhosphorylationSLGVGLVTLLGLAVG
HHCHHHHHHHHHHHH		22.7024043423
27PhosphorylationLLGLAVGSYLVRRSR
HHHHHHHHHHHHCCC		14.5424043423
28PhosphorylationLGLAVGSYLVRRSRR
HHHHHHHHHHHCCCC		11.8624043423
46AcetylationTLLDPNEKYLLRLLD
EEECCCHHHHHHHHH		48.0826051181
46MalonylationTLLDPNEKYLLRLLD
EEECCCHHHHHHHHH		48.0826320211
54UbiquitinationYLLRLLDKTTVSHNT
HHHHHHHHCCCCCCC		46.1729967540
55PhosphorylationLLRLLDKTTVSHNTK
HHHHHHHCCCCCCCC		31.9024641631
56PhosphorylationLRLLDKTTVSHNTKR
HHHHHHCCCCCCCCE		26.2520833797
58PhosphorylationLLDKTTVSHNTKRFR
HHHHCCCCCCCCEEE		14.6624641631
61PhosphorylationKTTVSHNTKRFRFAL
HCCCCCCCCEEEEEC		20.4124641631
62UbiquitinationTTVSHNTKRFRFALP
CCCCCCCCEEEEECC		55.6529967540
81UbiquitinationTLGLPVGKHIYLSTR
CCCCCCCCEEEEEEE		27.3623000965
84PhosphorylationLPVGKHIYLSTRIDG
CCCCCEEEEEEEECC		8.3621082442
86PhosphorylationVGKHIYLSTRIDGSL
CCCEEEEEEEECCCE		9.9227251275
92PhosphorylationLSTRIDGSLVIRPYT
EEEEECCCEEEECCC		18.7322673903
98PhosphorylationGSLVIRPYTPVTSDE
CCEEEECCCCCCCCC		17.5222673903
99PhosphorylationSLVIRPYTPVTSDED
CEEEECCCCCCCCCC		17.6122673903
102PhosphorylationIRPYTPVTSDEDQGY
EECCCCCCCCCCCCC		31.5022673903
103PhosphorylationRPYTPVTSDEDQGYV
ECCCCCCCCCCCCCE		38.9622673903
109PhosphorylationTSDEDQGYVDLVIKV
CCCCCCCCEEEEEEE		5.7822673903
119UbiquitinationLVIKVYLKGVHPKFP
EEEEEEECCCCCCCC		41.0022817900
124UbiquitinationYLKGVHPKFPEGGKM
EECCCCCCCCCCCCH		59.6921906983
130MethylationPKFPEGGKMSQYLDS
CCCCCCCCHHHHHHH		46.35-
130"N6,N6-dimethyllysine"PKFPEGGKMSQYLDS
CCCCCCCCHHHHHHH		46.35-
130UbiquitinationPKFPEGGKMSQYLDS
CCCCCCCCHHHHHHH		46.3532142685
132O-linked_GlycosylationFPEGGKMSQYLDSLK
CCCCCCHHHHHHHCC		21.1130620550
137O-linked_GlycosylationKMSQYLDSLKVGDVV
CHHHHHHHCCCCCEE		27.7430620550
139MethylationSQYLDSLKVGDVVEF
HHHHHHCCCCCEEEE		48.39-
139"N6,N6-dimethyllysine"SQYLDSLKVGDVVEF
HHHHHHCCCCCEEEE		48.39-
139UbiquitinationSQYLDSLKVGDVVEF
HHHHHHCCCCCEEEE		48.3921906983
150PhosphorylationVVEFRGPSGLLTYTG
EEEEECCCCEEEEEC		44.9221406692
154PhosphorylationRGPSGLLTYTGKGHF
ECCCCEEEEECCCCC		24.8721406692
155PhosphorylationGPSGLLTYTGKGHFN
CCCCEEEEECCCCCC		17.2927251275
156PhosphorylationPSGLLTYTGKGHFNI
CCCEEEEECCCCCCC		27.4727251275
167UbiquitinationHFNIQPNKKSPPEPR
CCCCCCCCCCCCCHH		62.4032142685
167AcetylationHFNIQPNKKSPPEPR
CCCCCCCCCCCCCHH		62.4024889843
169PhosphorylationNIQPNKKSPPEPRVA
CCCCCCCCCCCHHHH		47.5020860994
177UbiquitinationPPEPRVAKKLGMIAG
CCCHHHHHHHCCCCC		45.7522817900
178UbiquitinationPEPRVAKKLGMIAGG
CCHHHHHHHCCCCCC		40.3021906983
186PhosphorylationLGMIAGGTGITPMLQ
HCCCCCCCCHHHHHH		25.2120068231
189PhosphorylationIAGGTGITPMLQLIR
CCCCCCHHHHHHHHH		12.1820068231
200UbiquitinationQLIRAILKVPEDPTQ
HHHHHHHCCCCCCCC		50.02-
218UbiquitinationLFANQTEKDIILRED
EECCCCCCCEECHHH		58.5822817900
238UbiquitinationARYPNRFKLWFTLDH
HHCCCCEEEEEECCC		41.3921890473
242PhosphorylationNRFKLWFTLDHPPKD
CCEEEEEECCCCCCC		21.5029083192
248UbiquitinationFTLDHPPKDWAYSKG
EECCCCCCCHHHCCC		71.0623000965
254UbiquitinationPKDWAYSKGFVTADM
CCCHHHCCCCCCHHH		43.6323000965
258PhosphorylationAYSKGFVTADMIREH
HHCCCCCCHHHHHHH		18.0621406692
300UbiquitinationDKLGYSQKMRFTY--
HHCCCCCCCCCCC--		26.55-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NB5R1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NB5R1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NB5R1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NB5R1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB03147Flavin adenine dinucleotide
Regulatory Network of NB5R1_HUMAN

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Related Literatures of Post-Translational Modification

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