EBP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EBP_HUMAN
• UniProt AC: Q15125
• Protein Name: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase
• Gene Name: EBP
• Organism: Homo sapiens (Human).
• Sequence Length: 230
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein . Nucleus envelope . Cytoplasmic vesicle . During interphase, detected on the endoplasmic reticulum and the nuclear envelope. During mitosis, detected on cytoplasmic vesicles.
• Protein Description: Catalyzes the conversion of Delta(8)-sterols to their corresponding Delta(7)-isomers..
• Protein Sequence: MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGTWRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVCMETITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELGHPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTTNAGPLH ------CCCCCCCCC	28.85	25944712
2	O-linked_Glycosylation	------MTTNAGPLH ------CCCCCCCCC	28.85	51587899
3	O-linked_Glycosylation	-----MTTNAGPLHP -----CCCCCCCCCC	23.05	55821487
60	Phosphorylation	AAVVPLGTWRRLSLC CEEEECCHHHHHHHH	24.39	20068231
212	Phosphorylation	LDAVKHLTHAQSTLD HHHHHHHHHHHHHHH	18.19	23312004
216	Phosphorylation	KHLTHAQSTLDAKAT HHHHHHHHHHHHHHH	31.55	23312004
217	Phosphorylation	HLTHAQSTLDAKATK HHHHHHHHHHHHHHH	19.31	23312004
221	2-Hydroxyisobutyrylation	AQSTLDAKATKAKSK HHHHHHHHHHHHHHC	57.14	-
221	Acetylation	AQSTLDAKATKAKSK HHHHHHHHHHHHHHC	57.14	23954790
221	Ubiquitination	AQSTLDAKATKAKSK HHHHHHHHHHHHHHC	57.14	21906983
223	Phosphorylation	STLDAKATKAKSKKN HHHHHHHHHHHHCCC	30.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EBP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EBP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EBP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
MITF_HUMAN	MITF	physical	21988832
GNAI2_HUMAN	GNAI2	physical	28514442
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H01194: X-linked chondrodysplasia punctata, including: X-linked recessive chondrodysplasia punctata (CDPX1);
• OMIM Disease
• 302960: Chondrodysplasia punctata 2, X-linked dominant (CDPX2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00675: Tamoxifen