dbPTM

CHAC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CHAC2_HUMAN
UniProt AC	Q8WUX2
Protein Name	Glutathione-specific gamma-glutamylcyclotransferase 2 {ECO:0000303\|PubMed:27913623}
Gene Name	CHAC2 {ECO:0000312\|HGNC:HGNC:32363}
Organism	Homo sapiens (Human).
Sequence Length	184
Subcellular Localization	Cytoplasm, cytosol .
Protein Description	Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides..
Protein Sequence	MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPAGCVWGVAYRLPVGKEEEVKAYLDFREKGGYRTTTVIFYPKDPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFNAAGPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKERLEGKQNLNCI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MWVFGYGSLIWKV --CEEEECCCEEEEE	7.65	26503514
71	Ubiquitination	AYRLPVGKEEEVKAY EEEECCCCHHHHHHE	63.29	-
78	Phosphorylation	KEEEVKAYLDFREKG CHHHHHHEEECHHHC	10.90	-
122	Ubiquitination	NPDYLGPAPLEDIAE CCCCCCCCCHHHHHH	21.36	24816145
142	Phosphorylation	AGPSGRNTEYLFELA CCCCCCCHHHHHHHH	25.33	20068231
144	Phosphorylation	PSGRNTEYLFELANS CCCCCHHHHHHHHHH	18.04	-
172	Ubiquitination	FALEKLVKERLEGKQ HHHHHHHHHHHCCCC	47.77	-
178	Ubiquitination	VKERLEGKQNLNCI- HHHHHCCCCCCCCC-	27.00	24816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CHAC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CHAC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CHAC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
A4_HUMAN	APP	physical	21832049
DPYD_HUMAN	DPYD	physical	22939629

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CHAC2_HUMAN

Related Literatures of Post-Translational Modification