CHAC2_HUMAN - dbPTM
CHAC2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CHAC2_HUMAN
UniProt AC Q8WUX2
Protein Name Glutathione-specific gamma-glutamylcyclotransferase 2 {ECO:0000303|PubMed:27913623}
Gene Name CHAC2 {ECO:0000312|HGNC:HGNC:32363}
Organism Homo sapiens (Human).
Sequence Length 184
Subcellular Localization Cytoplasm, cytosol .
Protein Description Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides..
Protein Sequence MWVFGYGSLIWKVDFPYQDKLVGYITNYSRRFWQGSTDHRGVPGKPGRVVTLVEDPAGCVWGVAYRLPVGKEEEVKAYLDFREKGGYRTTTVIFYPKDPTTKPFSVLLYIGTCDNPDYLGPAPLEDIAEQIFNAAGPSGRNTEYLFELANSIRNLVPEEADEHLFALEKLVKERLEGKQNLNCI
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
6Phosphorylation--MWVFGYGSLIWKV
--CEEEECCCEEEEE
7.6526503514
71UbiquitinationAYRLPVGKEEEVKAY
EEEECCCCHHHHHHE
63.29-
78PhosphorylationKEEEVKAYLDFREKG
CHHHHHHEEECHHHC
10.90-
122UbiquitinationNPDYLGPAPLEDIAE
CCCCCCCCCHHHHHH
21.3624816145
142PhosphorylationAGPSGRNTEYLFELA
CCCCCCCHHHHHHHH
25.3320068231
144PhosphorylationPSGRNTEYLFELANS
CCCCCHHHHHHHHHH
18.04-
172UbiquitinationFALEKLVKERLEGKQ
HHHHHHHHHHHCCCC
47.77-
178UbiquitinationVKERLEGKQNLNCI-
HHHHHCCCCCCCCC-
27.0024816145

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CHAC2_HUMAN !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CHAC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CHAC2_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
DPYD_HUMANDPYDphysical
22939629

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CHAC2_HUMAN

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Related Literatures of Post-Translational Modification

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