CO1A2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CO1A2_HUMAN
• UniProt AC: P08123
• Protein Name: Collagen alpha-2(I) chain
• Gene Name: COL1A2
• Organism: Homo sapiens (Human).
• Sequence Length: 1366
• Subcellular Localization: Secreted, extracellular space, extracellular matrix .
• Protein Description: Type I collagen is a member of group I collagen (fibrillar forming collagen)..
• Protein Sequence: MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGPGPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIRGHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAVGNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNKGEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPRGLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQGGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAVGTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPAGPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPPGPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIAGPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKGERGYPGNIGPVGAAGAPGPHGPVGPAGKHGNRGETGPSGPVGPAGAVGPRGPSGPQGIRGDKGEPGEKGPRGLPGLKGHNGLQGLPGIAGHHGDQGAPGSVGPAGPRGPAGPSGPAGKDGRTGHPGTVGPAGIRGPQGHQGPAGPPGPPGPPGPPGVSGGGYDFGYDGDFYRADQPRSAPSLRPKDYEVDATLKSLNNQIETLLTPEGSRKNPARTCRDLRLSHPEWSSGYYWIDPNQGCTMDAIKVYCDFSTGETCIRAQPENIPAKNWYRSSKDKKHVWLGETINAGSQFEYNVEGVTSKEMATQLAFMRLLANYASQNITYHCKNSIAYMDEETGNLKKAVILQGSNDVELVAEGNSRFTYTVLVDGCSKKTNEWGKTIIEYKTNKPSRLPFLDIAPLDIGGADQEFFVDIGPVCFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Pyrrolidone_carboxylic_acid	TLCLATCQSLQEETV HHHHHHHHHHHHHHH	42.70	2394758
23	Pyrrolidone_carboxylic_acid	TLCLATCQSLQEETV HHHHHHHHHHHHHHH	42.70	2394758
47	Hydroxylation	PRGERGPPGPPGRDG CCCCCCCCCCCCCCC	71.41	3680255
50	Hydroxylation	ERGPPGPPGRDGEDG CCCCCCCCCCCCCCC	57.26	3680255
62	Hydroxylation	EDGPTGPPGPPGPPG CCCCCCCCCCCCCCC	70.08	3680255
65	Hydroxylation	PTGPPGPPGPPGPPG CCCCCCCCCCCCCCC	74.06	3680255
68	Hydroxylation	PPGPPGPPGPPGLGG CCCCCCCCCCCCCCC	74.06	3680255
71	Hydroxylation	PPGPPGPPGLGGNFA CCCCCCCCCCCCCCE	57.46	3680255
80	Pyrrolidone_carboxylic_acid	LGGNFAAQYDGKGVG CCCCCEEEECCCCCC	33.16	-
80	Pyrrolidone_carboxylic_acid	LGGNFAAQYDGKGVG CCCCCEEEECCCCCC	33.16	5529814
80	Pyrrolidone_carboxylic_acid	LGGNFAAQYDGKGVG CCCCCEEEECCCCCC	33.16	5529814
84	Allysine	FAAQYDGKGVGLGPG CEEEECCCCCCCCCC	47.74	-
84	Deamination	FAAQYDGKGVGLGPG CEEEECCCCCCCCCC	47.74	5529814
93	Sulfoxidation	VGLGPGPMGLMGPRG CCCCCCCCCCCCCCC	8.79	30846556
96	Sulfoxidation	GPGPMGLMGPRGPPG CCCCCCCCCCCCCCC	6.02	30846556
102	Hydroxylation	LMGPRGPPGAAGAPG CCCCCCCCCCCCCCC	48.13	3680255
108	Hydroxylation	PPGAAGAPGPQGFQG CCCCCCCCCCCCCCC	54.82	3680255
177	Hydroxylation	TPGLPGFKGIRGHNG CCCCCCCCCCCCCCC	60.38	4319110
177	O-linked_Glycosylation	TPGLPGFKGIRGHNG CCCCCCCCCCCCCCC	60.38	4319110
198	Acetylation	QPGAPGVKGEPGAPG CCCCCCCCCCCCCCC	64.57	20167786
209	Phosphorylation	GAPGENGTPGQTGAR CCCCCCCCCCCCCCC	35.51	24719451
251	Phosphorylation	GPAGPIGSAGPPGFP CCCCCCCCCCCCCCC	30.67	-
353	Phosphorylation	GEPGPAGSKGESGNK CCCCCCCCCCCCCCC	39.32	28787133
357	Phosphorylation	PAGSKGESGNKGEPG CCCCCCCCCCCCCCC	57.23	28787133
389	Phosphorylation	GPNGEAGSAGPPGPP CCCCCCCCCCCCCCC	36.78	-
401	Phosphorylation	GPPGLRGSPGSRGLP CCCCCCCCCCCCCCC	21.47	-
404	Phosphorylation	GLRGSPGSRGLPGAD CCCCCCCCCCCCCCC	26.93	-
420	Hydroxylation	RAGVMGPPGSRGASG CCCCCCCCCCCCCCC	47.89	4412529
426	Phosphorylation	PPGSRGASGPAGVRG CCCCCCCCCCCCCCC	48.40	28857561
441	Hydroxylation	PNGDAGRPGEPGLMG CCCCCCCCCCCCCCC	51.05	4412529
444	Hydroxylation	DAGRPGEPGLMGPRG CCCCCCCCCCCCCCC	47.32	4412529
632	O-linked_Glycosylation	GVVGAVGTAGPSGPS CCEEEEECCCCCCCC	23.11	OGP
632	Phosphorylation	GVVGAVGTAGPSGPS CCEEEEECCCCCCCC	23.11	28857561
636	Phosphorylation	AVGTAGPSGPSGLPG EEECCCCCCCCCCCC	63.52	28857561
639	Phosphorylation	TAGPSGPSGLPGERG CCCCCCCCCCCCCCC	57.39	28857561
710	Phosphorylation	GPAGPRGSPGERGEV CCCCCCCCCCCCCCC	30.89	-
756	Phosphorylation	ENGVVGPTGPVGAAG CCCCCCCCCCCCCCC	48.46	27690223
776	Phosphorylation	GPPGPAGSRGDGGPP CCCCCCCCCCCCCCC	34.89	27690223
786	Phosphorylation	DGGPPGMTGFPGAAG CCCCCCCCCCCCCCC	41.40	27690223
801	Phosphorylation	RTGPPGPSGISGPPG CCCCCCCCCCCCCCC	55.46	28857561
860	O-linked_Glycosylation	GTAGPPGTPGPQGLL CCCCCCCCCCCCCCC	30.74	OGP
981	Phosphorylation	KHGNRGETGPSGPVG CCCCCCCCCCCCCCC	58.16	30087585
984	Phosphorylation	NRGETGPSGPVGPAG CCCCCCCCCCCCCCC	58.01	30087585
999	Phosphorylation	AVGPRGPSGPQGIRG CCCCCCCCCCCCCCC	66.96	30087585
1059	Phosphorylation	PRGPAGPSGPAGKDG CCCCCCCCCCCCCCC	57.39	26437602
1064	Acetylation	GPSGPAGKDGRTGHP CCCCCCCCCCCCCCC	60.15	19815447
1073	Phosphorylation	GRTGHPGTVGPAGIR CCCCCCCCCCCCCCC	27.09	-
1104	Phosphorylation	PPGPPGVSGGGYDFG CCCCCCCCCCCCCCC	37.32	-
1124	Phosphorylation	YRADQPRSAPSLRPK EECCCCCCCCCCCCC	51.74	27251275
1138	O-linked_Glycosylation	KDYEVDATLKSLNNQ CCHHHHHHHHHHHHH	30.20	68709277
1138	Phosphorylation	KDYEVDATLKSLNNQ CCHHHHHHHHHHHHH	30.20	-
1141	Phosphorylation	EVDATLKSLNNQIET HHHHHHHHHHHHHHH	39.17	24719451
1148	Phosphorylation	SLNNQIETLLTPEGS HHHHHHHHHCCCCCC	28.79	-
1155	Phosphorylation	TLLTPEGSRKNPART HHCCCCCCCCCCCCC	38.12	-
1267	N-linked_Glycosylation	LANYASQNITYHCKN HHHHHHCCCEEEECC	26.52	UniProtKB CARBOHYD
1295	Phosphorylation	KAVILQGSNDVELVA EEEEEECCCCEEEEE	19.52	-
1309	Phosphorylation	AEGNSRFTYTVLVDG EECCCCEEEEEEEEC	19.71	22798277
1318	Phosphorylation	TVLVDGCSKKTNEWG EEEEECCCCCCCCCC	42.59	22798277

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CO1A2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CO1A2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CO1A2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDGFA_HUMAN	PDGFA	physical	8900172
PDGFB_HUMAN	PDGFB	physical	8900172
SGTA_HUMAN	SGTA	physical	25416956
UBQL1_HUMAN	UBQLN1	physical	25416956
SPB5_HUMAN	SERPINB5	physical	11788595

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 130060: Ehlers-Danlos syndrome 7B (EDS7B)
• 166200: Osteogenesis imperfecta 1 (OI1)
• 166210: Osteogenesis imperfecta 2 (OI2)
• 225320: Ehlers-Danlos syndrome, autosomal recessive, cardiac valvular form (EDSCV)
• 259420: Osteogenesis imperfecta 3 (OI3)
• 166220: Osteogenesis imperfecta 4 (OI4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.