| UniProt ID | SPB5_HUMAN | |
|---|---|---|
| UniProt AC | P36952 | |
| Protein Name | Serpin B5 | |
| Gene Name | SERPINB5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 375 | |
| Subcellular Localization | Secreted, extracellular space. | |
| Protein Description | Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.. | |
| Protein Sequence | MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLSTEFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKILVVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIELPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKFKVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSIEVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Sulfoxidation | -------MDALQLAN -------CCHHHHHH | 6.49 | 28465586 | |
| 9 | Phosphorylation | DALQLANSAFAVDLF CHHHHHHHHHHHHHH | 21.11 | 20068231 | |
| 50 | Phosphorylation | QVGAKGDTANEIGQV HHCCCCCCHHHHHCE | 39.80 | 21365746 | |
| 64 | Ubiquitination | VLHFENVKDVPFGFQ EEEEECCCCCCCCEE | 65.67 | - | |
| 72 | Phosphorylation | DVPFGFQTVTSDVNK CCCCCEEEECCCHHH | 24.40 | 29083192 | |
| 74 | Phosphorylation | PFGFQTVTSDVNKLS CCCEEEECCCHHHHH | 23.69 | 28348404 | |
| 75 | Phosphorylation | FGFQTVTSDVNKLSS CCEEEECCCHHHHHC | 34.91 | 25056879 | |
| 79 | Ubiquitination | TVTSDVNKLSSFYSL EECCCHHHHHCHHHH | 49.98 | - | |
| 81 | Phosphorylation | TSDVNKLSSFYSLKL CCCHHHHHCHHHHHH | 21.73 | 23186163 | |
| 82 | Phosphorylation | SDVNKLSSFYSLKLI CCHHHHHCHHHHHHH | 38.34 | 23186163 | |
| 84 | Phosphorylation | VNKLSSFYSLKLIKR HHHHHCHHHHHHHHH | 18.29 | 23186163 | |
| 85 | Phosphorylation | NKLSSFYSLKLIKRL HHHHCHHHHHHHHHH | 19.60 | 25056879 | |
| 93 | Phosphorylation | LKLIKRLYVDKSLNL HHHHHHHCCCCCCCC | 15.61 | 24719451 | |
| 97 | Phosphorylation | KRLYVDKSLNLSTEF HHHCCCCCCCCCHHH | 20.30 | 20068231 | |
| 99 | N-linked_Glycosylation | LYVDKSLNLSTEFIS HCCCCCCCCCHHHHH | 38.75 | UniProtKB CARBOHYD | |
| 101 | Phosphorylation | VDKSLNLSTEFISST CCCCCCCCHHHHHCC | 25.47 | 24719451 | |
| 102 | Phosphorylation | DKSLNLSTEFISSTK CCCCCCCHHHHHCCC | 37.77 | 20068231 | |
| 106 | Phosphorylation | NLSTEFISSTKRPYA CCCHHHHHCCCCCCC | 36.96 | 20068231 | |
| 107 | Phosphorylation | LSTEFISSTKRPYAK CCHHHHHCCCCCCCC | 32.88 | 20068231 | |
| 108 | Phosphorylation | STEFISSTKRPYAKE CHHHHHCCCCCCCCC | 25.04 | 20068231 | |
| 109 | Ubiquitination | TEFISSTKRPYAKEL HHHHHCCCCCCCCCC | 54.01 | - | |
| 114 | Ubiquitination | STKRPYAKELETVDF CCCCCCCCCCCCCCH | 57.92 | - | |
| 114 | Acetylation | STKRPYAKELETVDF CCCCCCCCCCCCCCH | 57.92 | 23954790 | |
| 118 | Phosphorylation | PYAKELETVDFKDKL CCCCCCCCCCHHHHH | 37.69 | 21365746 | |
| 129 | Ubiquitination | KDKLEETKGQINNSI HHHHHHHHCCCCHHH | 52.69 | - | |
| 133 | N-linked_Glycosylation | EETKGQINNSIKDLT HHHHCCCCHHHHHCC | 28.45 | UniProtKB CARBOHYD | |
| 135 | Phosphorylation | TKGQINNSIKDLTDG HHCCCCHHHHHCCCC | 26.91 | 29743597 | |
| 137 | Ubiquitination | GQINNSIKDLTDGHF CCCCHHHHHCCCCCH | 46.64 | - | |
| 157 | Phosphorylation | DNSVNDQTKILVVNA CCCCCCCCEEEEEEH | 23.94 | 21365746 | |
| 188 | N-linked_Glycosylation | KECPFRVNKTDTKPV CCCCCCCCCCCCCCE | 36.93 | UniProtKB CARBOHYD | |
| 240 | Phosphorylation | PKDVEDESTGLEKIE ECCCCCCCHHHHHHH | 39.85 | 21365746 | |
| 241 | Phosphorylation | KDVEDESTGLEKIEK CCCCCCCHHHHHHHH | 43.68 | - | |
| 245 | Ubiquitination | DESTGLEKIEKQLNS CCCHHHHHHHHHHCC | 62.30 | - | |
| 248 | Ubiquitination | TGLEKIEKQLNSESL HHHHHHHHHHCCCCH | 64.65 | - | |
| 272 | Phosphorylation | ANAKVKLSIPKFKVE HCCEEEECCCCCEEE | 31.00 | 24719451 | |
| 275 | Ubiquitination | KVKLSIPKFKVEKMI EEEECCCCCEEEECC | 57.03 | - | |
| 277 | Acetylation | KLSIPKFKVEKMIDP EECCCCCEEEECCCH | 56.46 | 20167786 | |
| 280 | Acetylation | IPKFKVEKMIDPKAC CCCCEEEECCCHHHH | 44.11 | 20167786 | |
| 285 | Ubiquitination | VEKMIDPKACLENLG EEECCCHHHHHHHCC | 48.24 | - | |
| 298 | Phosphorylation | LGLKHIFSEDTSDFS CCCCHHCCCCCCCCC | 33.68 | 21365746 | |
| 302 | Phosphorylation | HIFSEDTSDFSGMSE HHCCCCCCCCCCCCC | 49.32 | - | |
| 310 | Phosphorylation | DFSGMSETKGVALSN CCCCCCCCCCHHHHH | 26.28 | 21365746 | |
| 311 | Ubiquitination | FSGMSETKGVALSNV CCCCCCCCCHHHHHH | 47.54 | - | |
| 316 | Phosphorylation | ETKGVALSNVIHKVC CCCCHHHHHHHHHHH | 21.22 | 21365746 | |
| 345 | Ubiquitination | GARILQHKDELNADH CCEEEEEHHHHCCCC | 39.68 | - | |
| 356 | Phosphorylation | NADHPFIYIIRHNKT CCCCCEEEEEECCCC | 7.23 | 20068231 | |
| 361 | N-linked_Glycosylation | FIYIIRHNKTRNIIF EEEEEECCCCCCEEE | 37.23 | UniProtKB CARBOHYD | |
| 363 | Phosphorylation | YIIRHNKTRNIIFFG EEEECCCCCCEEEEE | 33.98 | 29802988 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPB5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPB5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPB5_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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