dbPTM

TKT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TKT_HUMAN
UniProt AC	P29401
Protein Name	Transketolase
Gene Name	TKT
Organism	Homo sapiens (Human).
Sequence Length	623
Subcellular Localization
Protein Description	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate..
Protein Sequence	MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKSQDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVAILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIAKTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIANIRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFIECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVSIGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAIIYNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPLDRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAELLKMFGIDRDAIAQAVRGLITKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESYHKPD -------CCCCCCCC	7.52	22814378
1	Sulfoxidation	-------MESYHKPD -------CCCCCCCC	7.52	28183972
3	Phosphorylation	-----MESYHKPDQQ -----CCCCCCCCHH	31.10	23401153
3 (in isoform 2)	Phosphorylation	-	31.10	27251275
4	Phosphorylation	----MESYHKPDQQK ----CCCCCCCCHHH	10.68	23186163
4 (in isoform 2)	Phosphorylation	-	10.68	27642862
6	2-Hydroxyisobutyrylation	--MESYHKPDQQKLQ --CCCCCCCCHHHHH	41.90	-
6	Acetylation	--MESYHKPDQQKLQ --CCCCCCCCHHHHH	41.90	19608861
6	Malonylation	--MESYHKPDQQKLQ --CCCCCCCCHHHHH	41.90	26320211
6	Ubiquitination	--MESYHKPDQQKLQ --CCCCCCCCHHHHH	41.90	19608861
11	Ubiquitination	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	21890473
11	Ubiquitination	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	21890473
11	2-Hydroxyisobutyrylation	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	-
11	Acetylation	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	19608861
11	Malonylation	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	26320211
11	Ubiquitination	YHKPDQQKLQALKDT CCCCCHHHHHHHHHH	36.61	19608861
16	Ubiquitination	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	21890473
16	Ubiquitination	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	21890473
16	2-Hydroxyisobutyrylation	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	-
16	Acetylation	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	25953088
16	Malonylation	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	26320211
16	Ubiquitination	QQKLQALKDTANRLR HHHHHHHHHHHHHHH	56.92	-
39	Phosphorylation	AAGSGHPTSCCSAAE CCCCCCCCCCCCHHH	28.81	21082442
40	Phosphorylation	AGSGHPTSCCSAAEI CCCCCCCCCCCHHHH	19.99	21082442
55	Phosphorylation	MAVLFFHTMRYKSQD HHHHHHHHCCCCCCC	9.74	22210691
59	2-Hydroxyisobutyrylation	FFHTMRYKSQDPRNP HHHHCCCCCCCCCCC	31.13	-
59	Acetylation	FFHTMRYKSQDPRNP HHHHCCCCCCCCCCC	31.13	26210075
70	Methylation	PRNPHNDRFVLSKGH CCCCCCCCEEEECCC	28.96	115918541
102	2-Hydroxyisobutyrylation	AELLNLRKISSDLDG HHHHCHHHCCCCCCC	50.54	-
102	Ubiquitination	AELLNLRKISSDLDG HHHHCHHHCCCCCCC	50.54	-
104	Phosphorylation	LLNLRKISSDLDGHP HHCHHHCCCCCCCCC	22.34	28355574
104 (in isoform 2)	Phosphorylation	-	22.34	27251275
105	Phosphorylation	LNLRKISSDLDGHPV HCHHHCCCCCCCCCC	45.74	23927012
114	Ubiquitination	LDGHPVPKQAFTDVA CCCCCCCCHHHCCCC	55.26	-
122	Phosphorylation	QAFTDVATGSLGQGL HHHCCCCCCCCCCHH	27.44	21712546
124	Phosphorylation	FTDVATGSLGQGLGA HCCCCCCCCCCHHHH	25.60	21712546
133	Glutathionylation	GQGLGAACGMAYTGK CCHHHHHCCHHHCCC	3.67	22555962
135	Sulfoxidation	GLGAACGMAYTGKYF HHHHHCCHHHCCCCC	2.31	30846556
140	Acetylation	CGMAYTGKYFDKASY CCHHHCCCCCCCCCE	34.64	26051181
140	Ubiquitination	CGMAYTGKYFDKASY CCHHHCCCCCCCCCE	34.64	-
144	2-Hydroxyisobutyrylation	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	-
144	Acetylation	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	19608861
144	Succinylation	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	23954790
144	Ubiquitination	YTGKYFDKASYRVYC HCCCCCCCCCEEEEE	29.36	19608861
174	Ubiquitination	MAFASIYKLDNLVAI HHHHHHHCHHCEEEE	47.93	-
190	Phosphorylation	DINRLGQSDPAPLQH EHHHCCCCCCCCCHH	43.70	23911959
199	Sulfoxidation	PAPLQHQMDIYQKRC CCCCHHHHHHHHHHH	2.95	30846556
202	Phosphorylation	LQHQMDIYQKRCEAF CHHHHHHHHHHHHHH	12.06	28152594
204	Ubiquitination	HQMDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	21890473
204	2-Hydroxyisobutyrylation	HQMDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	-
204	Acetylation	HQMDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	19608861
204	Methylation	HQMDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	19608861
204	Ubiquitination	HQMDIYQKRCEAFGW HHHHHHHHHHHHHCC	41.88	21890473
212	Ubiquitination	RCEAFGWHAIIVDGH HHHHHCCEEEEECCC	13.87	21890473
212	Acetylation	RCEAFGWHAIIVDGH HHHHHCCEEEEECCC	13.87	19608861
212	Ubiquitination	RCEAFGWHAIIVDGH HHHHHCCEEEEECCC	13.87	19608861
232	Ubiquitination	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	21890473
232	2-Hydroxyisobutyrylation	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	-
232	Acetylation	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	16916647
232	Malonylation	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	26320211
232	Ubiquitination	CKAFGQAKHQPTAII HHHHCCCCCCCCEEE	34.58	-
240	Ubiquitination	HQPTAIIAKTFKGRG CCCCEEEEEECCCCC	9.95	21890473
241	2-Hydroxyisobutyrylation	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	-
241	Acetylation	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	19608861
241	Ubiquitination	QPTAIIAKTFKGRGI CCCEEEEEECCCCCC	44.05	21906983
244	Ubiquitination	AIIAKTFKGRGITGV EEEEEECCCCCCCCC	53.59	-
246	Methylation	IAKTFKGRGITGVED EEEECCCCCCCCCCC	33.65	115918529
249	Acetylation	TFKGRGITGVEDKES ECCCCCCCCCCCCCC	37.69	19608861
249	Phosphorylation	TFKGRGITGVEDKES ECCCCCCCCCCCCCC	37.69	20873877
249	Ubiquitination	TFKGRGITGVEDKES ECCCCCCCCCCCCCC	37.69	19608861
254	Ubiquitination	GITGVEDKESWHGKP CCCCCCCCCCCCCCC	39.89	21890473
254	2-Hydroxyisobutyrylation	GITGVEDKESWHGKP CCCCCCCCCCCCCCC	39.89	-
254	Acetylation	GITGVEDKESWHGKP CCCCCCCCCCCCCCC	39.89	23954790
254	Malonylation	GITGVEDKESWHGKP CCCCCCCCCCCCCCC	39.89	26320211
254	Ubiquitination	GITGVEDKESWHGKP CCCCCCCCCCCCCCC	39.89	19608861
256	Phosphorylation	TGVEDKESWHGKPLP CCCCCCCCCCCCCCC	30.07	20873877
260	Ubiquitination	DKESWHGKPLPKNMA CCCCCCCCCCCHHHH	30.41	21890473
260	2-Hydroxyisobutyrylation	DKESWHGKPLPKNMA CCCCCCCCCCCHHHH	30.41	-
260	Acetylation	DKESWHGKPLPKNMA CCCCCCCCCCCHHHH	30.41	19608861
260	Malonylation	DKESWHGKPLPKNMA CCCCCCCCCCCHHHH	30.41	26320211
260	Ubiquitination	DKESWHGKPLPKNMA CCCCCCCCCCCHHHH	30.41	19608861
262	Ubiquitination	ESWHGKPLPKNMAEQ CCCCCCCCCHHHHHH	12.28	21890473
262	Acetylation	ESWHGKPLPKNMAEQ CCCCCCCCCHHHHHH	12.28	19608861
262	Ubiquitination	ESWHGKPLPKNMAEQ CCCCCCCCCHHHHHH	12.28	19608861
264	Ubiquitination	WHGKPLPKNMAEQII CCCCCCCHHHHHHHH	68.02	-
264 (in isoform 2)	Phosphorylation	-	68.02	27251275
266	Sulfoxidation	GKPLPKNMAEQIIQE CCCCCHHHHHHHHHH	5.61	28183972
268	Ubiquitination	PLPKNMAEQIIQEIY CCCHHHHHHHHHHHH	31.38	21890473
268	Acetylation	PLPKNMAEQIIQEIY CCCHHHHHHHHHHHH	31.38	19608861
268	Ubiquitination	PLPKNMAEQIIQEIY CCCHHHHHHHHHHHH	31.38	19608861
275	Phosphorylation	EQIIQEIYSQIQSKK HHHHHHHHHHHHHCC	8.18	27273156
276	Phosphorylation	QIIQEIYSQIQSKKK HHHHHHHHHHHHCCC	26.86	25159151
280	Phosphorylation	EIYSQIQSKKKILAT HHHHHHHHCCCCCCC	48.33	23663014
281	2-Hydroxyisobutyrylation	IYSQIQSKKKILATP HHHHHHHCCCCCCCC	41.53	-
281	Acetylation	IYSQIQSKKKILATP HHHHHHHCCCCCCCC	41.53	23954790
281	Ubiquitination	IYSQIQSKKKILATP HHHHHHHCCCCCCCC	41.53	21906983
282	Ubiquitination	YSQIQSKKKILATPP HHHHHHCCCCCCCCC	50.74	-
283	Ubiquitination	SQIQSKKKILATPPQ HHHHHCCCCCCCCCC	46.84	21890473
283	2-Hydroxyisobutyrylation	SQIQSKKKILATPPQ HHHHHCCCCCCCCCC	46.84	-
283	Ubiquitination	SQIQSKKKILATPPQ HHHHHCCCCCCCCCC	46.84	21906983
283 (in isoform 2)	Phosphorylation	-	46.84	27642862
287	Phosphorylation	SKKKILATPPQEDAP HCCCCCCCCCCCCCC	31.86	29255136
288 (in isoform 2)	Phosphorylation	-	23.99	27251275
291	Ubiquitination	ILATPPQEDAPSVDI CCCCCCCCCCCCCCC	63.01	21890473
295	Phosphorylation	PPQEDAPSVDIANIR CCCCCCCCCCCCCCC	33.86	29255136
295 (in isoform 2)	Phosphorylation	-	33.86	27251275
303	Sulfoxidation	VDIANIRMPSLPSYK CCCCCCCCCCCCCCC	2.04	28183972
303 (in isoform 2)	Phosphorylation	-	2.04	27251275
305	Phosphorylation	IANIRMPSLPSYKVG CCCCCCCCCCCCCCC	43.50	21406692
308	Phosphorylation	IRMPSLPSYKVGDKI CCCCCCCCCCCCCCH	42.76	25307156
309	Phosphorylation	RMPSLPSYKVGDKIA CCCCCCCCCCCCCHH	14.04	21406692
310	Ubiquitination	MPSLPSYKVGDKIAT CCCCCCCCCCCCHHH	44.04	21890473
310	Acetylation	MPSLPSYKVGDKIAT CCCCCCCCCCCCHHH	44.04	25953088
310	Ubiquitination	MPSLPSYKVGDKIAT CCCCCCCCCCCCHHH	44.04	21890473
313 (in isoform 2)	Phosphorylation	-	42.02	27251275
314	2-Hydroxyisobutyrylation	PSYKVGDKIATRKAY CCCCCCCCHHHHHHH	28.45	-
314	Acetylation	PSYKVGDKIATRKAY CCCCCCCCHHHHHHH	28.45	23749302
314	Ubiquitination	PSYKVGDKIATRKAY CCCCCCCCHHHHHHH	28.45	19608861
318	Ubiquitination	VGDKIATRKAYGQAL CCCCHHHHHHHHHHH	16.76	21890473
319	Ubiquitination	GDKIATRKAYGQALA CCCHHHHHHHHHHHH	41.42	21890473
319	2-Hydroxyisobutyrylation	GDKIATRKAYGQALA CCCHHHHHHHHHHHH	41.42	-
319	Ubiquitination	GDKIATRKAYGQALA CCCHHHHHHHHHHHH	41.42	21906983
321	Phosphorylation	KIATRKAYGQALAKL CHHHHHHHHHHHHHH	16.89	28152594
322	Acetylation	IATRKAYGQALAKLG HHHHHHHHHHHHHHC	15.90	19608861
327	Ubiquitination	AYGQALAKLGHASDR HHHHHHHHHCCCCCC	56.71	21890473
327	2-Hydroxyisobutyrylation	AYGQALAKLGHASDR HHHHHHHHHCCCCCC	56.71	-
327	Acetylation	AYGQALAKLGHASDR HHHHHHHHHCCCCCC	56.71	23954790
327	Ubiquitination	AYGQALAKLGHASDR HHHHHHHHHCCCCCC	56.71	21906983
334	Methylation	KLGHASDRIIALDGD HHCCCCCCEEEEECC	21.51	115918533
342	Phosphorylation	IIALDGDTKNSTFSE EEEEECCCCCCCHHH	37.34	21815630
343	2-Hydroxyisobutyrylation	IALDGDTKNSTFSEI EEEECCCCCCCHHHH	54.35	-
343	Acetylation	IALDGDTKNSTFSEI EEEECCCCCCCHHHH	54.35	23954790
343	Sumoylation	IALDGDTKNSTFSEI EEEECCCCCCCHHHH	54.35	-
343	Ubiquitination	IALDGDTKNSTFSEI EEEECCCCCCCHHHH	54.35	21906983
345	Phosphorylation	LDGDTKNSTFSEIFK EECCCCCCCHHHHHH	32.17	25159151
346	Phosphorylation	DGDTKNSTFSEIFKK ECCCCCCCHHHHHHH	40.34	21712546
348	Phosphorylation	DTKNSTFSEIFKKEH CCCCCCHHHHHHHHC	29.85	25159151
350 (in isoform 2)	Phosphorylation	-	6.25	27251275
352	2-Hydroxyisobutyrylation	STFSEIFKKEHPDRF CCHHHHHHHHCCCCE	64.01	-
352	Acetylation	STFSEIFKKEHPDRF CCHHHHHHHHCCCCE	64.01	23954790
352	Succinylation	STFSEIFKKEHPDRF CCHHHHHHHHCCCCE	64.01	23954790
352	Sumoylation	STFSEIFKKEHPDRF CCHHHHHHHHCCCCE	64.01	28112733
352	Ubiquitination	STFSEIFKKEHPDRF CCHHHHHHHHCCCCE	64.01	-
353	Acetylation	TFSEIFKKEHPDRFI CHHHHHHHHCCCCEE	50.97	25953088
353	Ubiquitination	TFSEIFKKEHPDRFI CHHHHHHHHCCCCEE	50.97	-
382	Phosphorylation	GCATRNRTVPFCSTF CCCCCCCCCCCHHHH	35.76	-
386	S-nitrosylation	RNRTVPFCSTFAAFF CCCCCCCHHHHHHHH	2.83	25040305
386	S-palmitoylation	RNRTVPFCSTFAAFF CCCCCCCHHHHHHHH	2.83	29575903
387	Phosphorylation	NRTVPFCSTFAAFFT CCCCCCHHHHHHHHH	27.26	-
406	Phosphorylation	QIRMAAISESNINLC HHHHHHHCCCCCCCC	30.19	28176443
408	Phosphorylation	RMAAISESNINLCGS HHHHHCCCCCCCCCC	35.90	28176443
415	Phosphorylation	SNINLCGSHCGVSIG CCCCCCCCCCCCCCC	18.01	28176443
420	Phosphorylation	CGSHCGVSIGEDGPS CCCCCCCCCCCCCCC	15.34	28176443
427	Phosphorylation	SIGEDGPSQMALEDL CCCCCCCCHHHHHHH	37.81	28176443
439	Phosphorylation	EDLAMFRSVPTSTVF HHHHHHHCCCCCEEE	22.60	21712546
442	Phosphorylation	AMFRSVPTSTVFYPS HHHHCCCCCEEECCC	34.57	21712546
444	Phosphorylation	FRSVPTSTVFYPSDG HHCCCCCEEECCCCC	19.67	28152594
447	Phosphorylation	VPTSTVFYPSDGVAT CCCCEEECCCCCCCC	9.48	28152594
449	Phosphorylation	TSTVFYPSDGVATEK CCEEECCCCCCCCHH	35.30	28152594
454	Phosphorylation	YPSDGVATEKAVELA CCCCCCCCHHHHHHH	35.30	28152594
456	2-Hydroxyisobutyrylation	SDGVATEKAVELAAN CCCCCCHHHHHHHHC	54.07	-
456	Acetylation	SDGVATEKAVELAAN CCCCCCHHHHHHHHC	54.07	26051181
456	Ubiquitination	SDGVATEKAVELAAN CCCCCCHHHHHHHHC	54.07	21906983
465	Ubiquitination	VELAANTKGICFIRT HHHHHCCCCEEEEEC	46.19	21890473
465	2-Hydroxyisobutyrylation	VELAANTKGICFIRT HHHHHCCCCEEEEEC	46.19	-
465	Acetylation	VELAANTKGICFIRT HHHHHCCCCEEEEEC	46.19	26051181
465	Ubiquitination	VELAANTKGICFIRT HHHHHCCCCEEEEEC	46.19	21890473
468	S-palmitoylation	AANTKGICFIRTSRP HHCCCCEEEEECCCC	2.94	29575903
472	Phosphorylation	KGICFIRTSRPENAI CCEEEEECCCCCCEE	25.03	21712546
473	Ubiquitination	GICFIRTSRPENAII CEEEEECCCCCCEEE	35.67	21890473
481	Phosphorylation	RPENAIIYNNNEDFQ CCCCEEEECCCCCCC	13.01	28152594
489 (in isoform 2)	Phosphorylation	-	6.57	27642862
493	2-Hydroxyisobutyrylation	DFQVGQAKVVLKSKD CCCCCEEEEEEECCC	25.62	-
493	Acetylation	DFQVGQAKVVLKSKD CCCCCEEEEEEECCC	25.62	27452117
493	Ubiquitination	DFQVGQAKVVLKSKD CCCCCEEEEEEECCC	25.62	-
497	Acetylation	GQAKVVLKSKDDQVT CEEEEEEECCCCCEE	43.80	25953088
497	Ubiquitination	GQAKVVLKSKDDQVT CEEEEEEECCCCCEE	43.80	-
499	2-Hydroxyisobutyrylation	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	-
499	Acetylation	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	23749302
499	Ubiquitination	AKVVLKSKDDQVTVI EEEEEECCCCCEEEE	64.83	-
523	2-Hydroxyisobutyrylation	LAAAELLKKEKINIR HHHHHHHHHCCCCEE	72.08	-
523	Acetylation	LAAAELLKKEKINIR HHHHHHHHHCCCCEE	72.08	25953088
523	Ubiquitination	LAAAELLKKEKINIR HHHHHHHHHCCCCEE	72.08	-
526	2-Hydroxyisobutyrylation	AELLKKEKINIRVLD HHHHHHCCCCEEEEC	50.35	-
538	Ubiquitination	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	21890473
538	2-Hydroxyisobutyrylation	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	-
538	Acetylation	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	25953088
538	Succinylation	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	23954790
538	Ubiquitination	VLDPFTIKPLDRKLI EECCCCCCCCCCEEH	36.15	-
543	Malonylation	TIKPLDRKLILDSAR CCCCCCCEEHHHHCC	39.28	26320211
543	Ubiquitination	TIKPLDRKLILDSAR CCCCCCCEEHHHHCC	39.28	-
546	Ubiquitination	PLDRKLILDSARATK CCCCEEHHHHCCCCC	6.53	21890473
548	Phosphorylation	DRKLILDSARATKGR CCEEHHHHCCCCCCC	19.06	-
563	Phosphorylation	ILTVEDHYYEGGIGE EEEEECCEECCCHHH	18.61	-
564	Phosphorylation	LTVEDHYYEGGIGEA EEEECCEECCCHHHH	12.51	-
574	Phosphorylation	GIGEAVSSAVVGEPG CHHHHHHHHCCCCCC	20.63	-
595	Phosphorylation	AVNRVPRSGKPAELL EECCCCCCCCHHHHH	45.13	23911959
597	2-Hydroxyisobutyrylation	NRVPRSGKPAELLKM CCCCCCCCHHHHHHH	42.15	-
597	Acetylation	NRVPRSGKPAELLKM CCCCCCCCHHHHHHH	42.15	19608861
597	Malonylation	NRVPRSGKPAELLKM CCCCCCCCHHHHHHH	42.15	26320211
597	Ubiquitination	NRVPRSGKPAELLKM CCCCCCCCHHHHHHH	42.15	19608861
603	2-Hydroxyisobutyrylation	GKPAELLKMFGIDRD CCHHHHHHHHCCCHH	44.82	-
603	Acetylation	GKPAELLKMFGIDRD CCHHHHHHHHCCCHH	44.82	19608861
603	Succinylation	GKPAELLKMFGIDRD CCHHHHHHHHCCCHH	44.82	23954790
604	Sulfoxidation	KPAELLKMFGIDRDA CHHHHHHHHCCCHHH	3.62	21406390
605	Acetylation	PAELLKMFGIDRDAI HHHHHHHHCCCHHHH	8.09	19608861
605	Ubiquitination	PAELLKMFGIDRDAI HHHHHHHHCCCHHHH	8.09	19608861
609	Methylation	LKMFGIDRDAIAQAV HHHHCCCHHHHHHHH	33.08	66701869
611	Acetylation	MFGIDRDAIAQAVRG HHCCCHHHHHHHHHH	10.42	19608861

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
382	T	Phosphorylation	Kinase	AKT1	P31749	PSP
387	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TKT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TKT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TKT_HUMAN	TKT	physical	9357955
TPIS_HUMAN	TPI1	physical	22939629
UBC9_HUMAN	UBE2I	physical	22939629
UFC1_HUMAN	UFC1	physical	22939629
VDAC3_HUMAN	VDAC3	physical	22939629
UGDH_HUMAN	UGDH	physical	22939629
UFM1_HUMAN	UFM1	physical	22939629
UB2D1_HUMAN	UBE2D1	physical	22939629
THIM_HUMAN	ACAA2	physical	26344197
PPAC_HUMAN	ACP1	physical	26344197
AK1A1_HUMAN	AKR1A1	physical	26344197
ALDR_HUMAN	AKR1B1	physical	26344197
AK1BF_HUMAN	AKR1B15	physical	26344197
AK1C2_HUMAN	AKR1C2	physical	26344197
AL4A1_HUMAN	ALDH4A1	physical	26344197
ALDOA_HUMAN	ALDOA	physical	26344197
CALR_HUMAN	CALR	physical	26344197
COX17_HUMAN	COX17	physical	26344197
DUT_HUMAN	DUT	physical	26344197
ENOA_HUMAN	ENO1	physical	26344197
ENOG_HUMAN	ENO2	physical	26344197
ENOB_HUMAN	ENO3	physical	26344197
ESTD_HUMAN	ESD	physical	26344197
FABP5_HUMAN	FABP5	physical	26344197
FABP7_HUMAN	FABP7	physical	26344197
FUMH_HUMAN	FH	physical	26344197
G3P_HUMAN	GAPDH	physical	26344197
GLRX1_HUMAN	GLRX	physical	26344197
G6PI_HUMAN	GPI	physical	26344197
GPX4_HUMAN	GPX4	physical	26344197
HINT1_HUMAN	HINT1	physical	26344197
HS74L_HUMAN	HSPA4L	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
IDHC_HUMAN	IDH1	physical	26344197
ITPA_HUMAN	ITPA	physical	26344197
LDHA_HUMAN	LDHA	physical	26344197
LDH6B_HUMAN	LDHAL6B	physical	26344197
LDHB_HUMAN	LDHB	physical	26344197
LYPA2_HUMAN	LYPLA2	physical	26344197
MIF_HUMAN	MIF	physical	26344197
SIAS_HUMAN	NANS	physical	26344197
NEDD8_HUMAN	NEDD8	physical	26344197
NDKB_HUMAN	NME2	physical	26344197
PDIA1_HUMAN	P4HB	physical	26344197
PCBP1_HUMAN	PCBP1	physical	26344197
PIMT_HUMAN	PCMT1	physical	26344197
PDCD6_HUMAN	PDCD6	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26344197
PGK1_HUMAN	PGK1	physical	26344197
PGM2_HUMAN	PGM2	physical	26344197
PIPNB_HUMAN	PITPNB	physical	26344197
PLST_HUMAN	PLS3	physical	26344197
MYP2_HUMAN	PMP2	physical	26344197
RAB10_HUMAN	RAB10	physical	26344197
RPE_HUMAN	RPE	physical	26344197
SCYL2_HUMAN	SCYL2	physical	26344197
SF01_HUMAN	SF1	physical	26344197
SODM_HUMAN	SOD2	physical	26344197
STAT4_HUMAN	STAT4	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
UFM1_HUMAN	UFM1	physical	26344197
TERA_HUMAN	VCP	physical	26344197
XRCC6_HUMAN	XRCC6	physical	26344197
KHNYN_HUMAN	KHNYN	physical	28514442
GREB1_HUMAN	GREB1	physical	28514442
SMG8_HUMAN	SMG8	physical	28514442
FIGL1_HUMAN	FIGNL1	physical	28514442
DPOA2_HUMAN	POLA2	physical	28514442
WDR54_HUMAN	WDR54	physical	28514442
CE034_HUMAN	C5orf34	physical	28514442
WDR19_HUMAN	WDR19	physical	28514442
MOCOS_HUMAN	MOCOS	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
WDR41_HUMAN	WDR41	physical	28514442
STIL_HUMAN	STIL	physical	28514442
MED20_HUMAN	MED20	physical	28514442
E2AK4_HUMAN	EIF2AK4	physical	28514442
TBL1X_HUMAN	TBL1X	physical	28514442
KCC2B_HUMAN	CAMK2B	physical	28514442
TRI32_HUMAN	TRIM32	physical	28514442
KDM5C_HUMAN	KDM5C	physical	28514442
SPC25_HUMAN	SPC25	physical	28514442
MED17_HUMAN	MED17	physical	28514442
TYW4_HUMAN	LCMT2	physical	28514442
PLEC_HUMAN	PLEC	physical	28514442
DPP9_HUMAN	DPP9	physical	28514442
EMAL4_HUMAN	EML4	physical	28514442
HD_HUMAN	HTT	physical	28514442
TPPC8_HUMAN	TRAPPC8	physical	28514442
ACSF4_HUMAN	AASDH	physical	28514442
TBCD4_HUMAN	TBC1D4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TKT_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1; LYS-6; LYS-11; LYS-144;LYS-204; LYS-241; LYS-260; LYS-314; LYS-597 AND LYS-603, AND MASSSPECTROMETRY.	19608861 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-232, AND MASS SPECTROMETRY.	16916647 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275 AND THR-287, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-287, AND MASSSPECTROMETRY.	15302935 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275, AND MASSSPECTROMETRY.	19534553 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275, AND MASSSPECTROMETRY.	18083107 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-275, AND MASSSPECTROMETRY.	15592455 [Abstract]