MYP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MYP2_HUMAN
• UniProt AC: P02689
• Protein Name: Myelin P2 protein
• Gene Name: PMP2
• Organism: Homo sapiens (Human).
• Sequence Length: 132
• Subcellular Localization: Cytoplasm.
• Protein Description: May play a role in lipid transport protein in Schwann cells. May bind cholesterol..
• Protein Sequence: MSNKFLGTWKLVSSENFDDYMKALGVGLATRKLGNLAKPTVIISKKGDIITIRTESTFKNTEISFKLGQEFEETTADNRKTKSIVTLQRGSLNQVQRWDGKETTIKRKLVNGKMVAECKMKGVVCTRIYEKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSNKFLGTW ------CCCCCCCEE	49.04	6183401
13	Phosphorylation	LGTWKLVSSENFDDY CCEEEECCCCCHHHH	42.23	27251275
14	Phosphorylation	GTWKLVSSENFDDYM CEEEECCCCCHHHHH	29.13	27251275
20	Phosphorylation	SSENFDDYMKALGVG CCCCHHHHHHHHCHH	11.45	19060867
40	Phosphorylation	LGNLAKPTVIISKKG CCCCCCCEEEEECCC	24.51	19690332
61	Phosphorylation	TESTFKNTEISFKLG ECCCCCCCEEEEEEC	34.97	24719451
64	Phosphorylation	TFKNTEISFKLGQEF CCCCCEEEEEECCCE	15.31	24719451
69	Glutamine amide	EISFKLGQEFEETTA EEEEEECCCEEEECC	63.74	-
69	Amidation	EISFKLGQEFEETTA EEEEEECCCEEEECC	63.74	6172423
73	Glutamic acid 1-amide	KLGQEFEETTADNRK EECCCEEEECCCCCC	57.70	-
73	Amidation	KLGQEFEETTADNRK EECCCEEEECCCCCC	57.70	6172423
91	Phosphorylation	IVTLQRGSLNQVQRW EEEEECCCCCEEECC	26.74	21712546
126	Phosphorylation	KMKGVVCTRIYEKV- EECCEEEEEEEECC-	14.43	24719451
129	Phosphorylation	GVVCTRIYEKV---- CEEEEEEEECC----	13.35	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MYP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MYP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MYP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCDB1_HUMAN	CCNDBP1	physical	25416956
ALDR_HUMAN	AKR1B1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"The complete amino acid sequence of human P2 protein.";
Suzuki M., Kitamura K., Sakamoto Y., Uyemura K.;
J. Neurochem. 39:1759-1762(1982).
Cited for: PROTEIN SEQUENCE OF 2-132, AND ACETYLATION AT SER-2.
PubMed: 6183401