| UniProt ID | CCDB1_HUMAN | |
|---|---|---|
| UniProt AC | O95273 | |
| Protein Name | Cyclin-D1-binding protein 1 | |
| Gene Name | CCNDBP1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 360 | |
| Subcellular Localization | Cytoplasm. Nucleus. | |
| Protein Description | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.. | |
| Protein Sequence | MASATAPAAAVPTLASPLEQLRHLAEELRLLLPRVRVGEAQETTEEFNREMFWRRLNEAAVTVSREATTLTIVFSQLPLPSPQETQKFCEQVHAAIKAFIAVYYLLPKDQGITLRKLVRGATLDIVDGMAQLMEVLSVTPTQSPENNDLISYNSVWVACQQMPQIPRDNKAAALLMLTKNVDFVKDAHEEMEQAVEECDPYSGLLNDTEENNSDNHNHEDDVLGFPSNQDLYWSEDDQELIIPCLALVRASKACLKKIRMLVAENGKKDQVAQLDDIVDISDEISPSVDDLALSIYPPMCHLTVRINSAKLVSVLKKALEITKASHVTPQPEDSWIPLLINAIDHCMNRIKELTQSELEL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MASATAPAA ------CCCCCCCCC | 14.10 | 22814378 | |
| 3 | Phosphorylation | -----MASATAPAAA -----CCCCCCCCCC | 25.50 | 24043423 | |
| 5 | Phosphorylation | ---MASATAPAAAVP ---CCCCCCCCCCCC | 30.58 | 24043423 | |
| 13 | Phosphorylation | APAAAVPTLASPLEQ CCCCCCCCCCCHHHH | 28.49 | 24043423 | |
| 16 | Phosphorylation | AAVPTLASPLEQLRH CCCCCCCCHHHHHHH | 32.88 | 24043423 | |
| 51 (in isoform 4) | Ubiquitination | - | 3.35 | 21906983 | |
| 64 | Phosphorylation | NEAAVTVSREATTLT HHHCCEEECCCCEEE | 18.29 | 24719451 | |
| 69 | Phosphorylation | TVSREATTLTIVFSQ EEECCCCEEEEEEEC | 29.02 | 24719451 | |
| 87 | Ubiquitination | PSPQETQKFCEQVHA CCHHHHHHHHHHHHH | 60.44 | - | |
| 122 | Phosphorylation | RKLVRGATLDIVDGM HHHHCCCCHHHHHHH | 27.99 | - | |
| 170 | Ubiquitination | PQIPRDNKAAALLML CCCCCCCHHHHHHHH | 43.63 | - | |
| 176 | Sulfoxidation | NKAAALLMLTKNVDF CHHHHHHHHHCCCCH | 4.67 | 21406390 | |
| 178 (in isoform 3) | Ubiquitination | - | 13.45 | 21906983 | |
| 179 | Ubiquitination | AALLMLTKNVDFVKD HHHHHHHCCCCHHHH | 51.52 | 21963094 | |
| 179 (in isoform 1) | Ubiquitination | - | 51.52 | 21906983 | |
| 179 (in isoform 2) | Ubiquitination | - | 51.52 | 21906983 | |
| 223 | Ubiquitination | HNHEDDVLGFPSNQD CCCCCCCCCCCCCCC | 8.23 | 21963094 | |
| 252 | Ubiquitination | LALVRASKACLKKIR HHHHHHHHHHHHHHH | 41.98 | 24816145 | |
| 296 | Ubiquitination | DDLALSIYPPMCHLT HHHHHHHCCCCCEEE | 9.63 | 24816145 | |
| 317 | Ubiquitination | KLVSVLKKALEITKA HHHHHHHHHHHHHHH | 54.78 | 29967540 | |
| 351 | Ubiquitination | DHCMNRIKELTQSEL HHHHHHHHHHHHHHH | 43.35 | 24816145 | |
| 395 | Ubiquitination | ------------------------------------------ ------------------------------------------ | 24816145 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CCDB1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CCDB1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CCDB1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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