| UniProt ID | CERK1_HUMAN | |
|---|---|---|
| UniProt AC | Q8TCT0 | |
| Protein Name | Ceramide kinase | |
| Gene Name | CERK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 537 | |
| Subcellular Localization |
Cytoplasm . Membrane Peripheral membrane protein . |
|
| Protein Description | Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.. | |
| Protein Sequence | MGATGAAEPLQSVLWVKQQRCAVSLEPARALLRWWRSPGPGAGAPGADACSVPVSEIIAVEETDVHGKHQGSGKWQKMEKPYAFTVHCVKRARRHRWKWAQVTFWCPEEQLCHLWLQTLREMLEKLTSRPKHLLVFINPFGGKGQGKRIYERKVAPLFTLASITTDIIVTEHANQAKETLYEINIDKYDGIVCVGGDGMFSEVLHGLIGRTQRSAGVDQNHPRAVLVPSSLRIGIIPAGSTDCVCYSTVGTSDAETSALHIVVGDSLAMDVSSVHHNSTLLRYSVSLLGYGFYGDIIKDSEKKRWLGLARYDFSGLKTFLSHHCYEGTVSFLPAQHTVGSPRDRKPCRAGCFVCRQSKQQLEEEQKKALYGLEAAEDVEEWQVVCGKFLAINATNMSCACRRSPRGLSPAAHLGDGSSDLILIRKCSRFNFLRFLIRHTNQQDQFDFTFVEVYRVKKFQFTSKHMEDEDSDLKEGGKKRFGHICSSHPSCCCTVSNSSWNCDGEVLHSPAIEVRVHCQLVRLFARGIEENPKPDSHS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 275 | Ubiquitination | AMDVSSVHHNSTLLR EECHHHCCCCCHHHH | 19.16 | - | |
| 279 | Ubiquitination | SSVHHNSTLLRYSVS HHCCCCCHHHHHHHH | 34.82 | - | |
| 280 | Ubiquitination | SVHHNSTLLRYSVSL HCCCCCHHHHHHHHH | 2.29 | - | |
| 340 | Phosphorylation | PAQHTVGSPRDRKPC CCCCCCCCCCCCCCC | 16.66 | 19899769 | |
| 357 | Phosphorylation | GCFVCRQSKQQLEEE CCEEECCHHHHHHHH | 17.06 | - | |
| 403 | Phosphorylation | MSCACRRSPRGLSPA CCCHHCCCCCCCCCC | 10.29 | 17081983 | |
| 408 | Phosphorylation | RRSPRGLSPAAHLGD CCCCCCCCCCCCCCC | 18.47 | 19899769 | |
| 427 | Phosphorylation | LILIRKCSRFNFLRF EEEEECCCCCCHHHH | 42.83 | 19899769 | |
| 457 | Ubiquitination | VEVYRVKKFQFTSKH EEEEEEEEEEEECCC | 41.35 | - | |
| 470 | Phosphorylation | KHMEDEDSDLKEGGK CCCCCCCCCCCCCCC | 42.68 | 29514088 | |
| 473 | Ubiquitination | EDEDSDLKEGGKKRF CCCCCCCCCCCCHHC | 60.34 | 21906983 | |
| 477 | Ubiquitination | SDLKEGGKKRFGHIC CCCCCCCCHHCCCCC | 52.19 | 21906983 | |
| 478 | Ubiquitination | DLKEGGKKRFGHICS CCCCCCCHHCCCCCC | 57.12 | 21906983 | |
| 493 | Phosphorylation | SHPSCCCTVSNSSWN CCCCCEEEECCCCCC | 17.04 | 30576142 | |
| 497 | Phosphorylation | CCCTVSNSSWNCDGE CEEEECCCCCCCCCC | 29.26 | 30576142 | |
| 498 | Phosphorylation | CCTVSNSSWNCDGEV EEEECCCCCCCCCCE | 26.93 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of CERK1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of CERK1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of CERK1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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