| UniProt ID | BUB1B_HUMAN | |
|---|---|---|
| UniProt AC | O60566 | |
| Protein Name | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta | |
| Gene Name | BUB1B | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1050 | |
| Subcellular Localization | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic in interphase cells. Associates with the kinetochores in early prophase. Kinetochore localization requires BUB1, | |
| Protein Description | Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.. | |
| Protein Sequence | MAAVKKEGGALSEAMSLEGDEWELSKENVQPLRQGRIMSTLQGALAQESACNNTLQQQKRAFEYEIRFYTGNDPLDVWDRYISWTEQNYPQGGKESNMSTLLERAVEALQGEKRYYSDPRFLNLWLKLGRLCNEPLDMYSYLHNQGIGVSLAQFYISWAEEYEARENFRKADAIFQEGIQQKAEPLERLQSQHRQFQARVSRQTLLALEKEEEEEVFESSVPQRSTLAELKSKGKKTARAPIIRVGGALKAPSQNRGLQNPFPQQMQNNSRITVFDENADEASTAELSKPTVQPWIAPPMPRAKENELQAGPWNTGRSLEHRPRGNTASLIAVPAVLPSFTPYVEETARQPVMTPCKIEPSINHILSTRKPGKEEGDPLQRVQSHQQASEEKKEKMMYCKEKIYAGVGEFSFEEIRAEVFRKKLKEQREAELLTSAEKRAEMQKQIEEMEKKLKEIQTTQQERTGDQQEETMPTKETTKLQIASESQKIPGMTLSSSVCQVNCCARETSLAENIWQEQPHSKGPSVPFSIFDEFLLSEKKNKSPPADPPRVLAQRRPLAVLKTSESITSNEDVSPDVCDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFDTTFQSHLNKALWKVGKLTSPGALLFQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 12 | Phosphorylation | KKEGGALSEAMSLEG CCCCCCHHHHHCCCC | 23.83 | 28555341 | |
| 16 | Phosphorylation | GALSEAMSLEGDEWE CCHHHHHCCCCCCEE | 30.25 | 30624053 | |
| 26 | Ubiquitination | GDEWELSKENVQPLR CCCEEHHHHCCHHHH | 66.97 | 29967540 | |
| 39 | Phosphorylation | LRQGRIMSTLQGALA HHHCCHHHHHHHHHH | 24.48 | - | |
| 40 | Phosphorylation | RQGRIMSTLQGALAQ HHCCHHHHHHHHHHH | 13.01 | 28555341 | |
| 49 | Phosphorylation | QGALAQESACNNTLQ HHHHHHHHHHCCHHH | 26.49 | 24043423 | |
| 54 | Phosphorylation | QESACNNTLQQQKRA HHHHHCCHHHHHHHH | 16.38 | 22817900 | |
| 59 | Ubiquitination | NNTLQQQKRAFEYEI CCHHHHHHHHHEEEE | 41.16 | - | |
| 59 (in isoform 3) | Ubiquitination | - | 41.16 | - | |
| 64 | Phosphorylation | QQKRAFEYEIRFYTG HHHHHHEEEEEEECC | 15.37 | 23898821 | |
| 83 | Phosphorylation | DVWDRYISWTEQNYP CHHHHHHHCHHHCCC | 21.00 | - | |
| 113 | Ubiquitination | VEALQGEKRYYSDPR HHHHHCCCHHCCCHH | 53.15 | 33845483 | |
| 127 (in isoform 3) | Ubiquitination | - | 37.00 | - | |
| 156 (in isoform 2) | Ubiquitination | - | 2.68 | 21890473 | |
| 170 | Ubiquitination | EARENFRKADAIFQE HHHHHHHHHHHHHHH | 46.62 | - | |
| 182 | Ubiquitination | FQEGIQQKAEPLERL HHHHHHHHHHHHHHH | 38.04 | 32015554 | |
| 196 (in isoform 3) | Ubiquitination | - | 6.55 | - | |
| 201 | Phosphorylation | RQFQARVSRQTLLAL HHHHHHHHHHHHHHH | 17.08 | 28674151 | |
| 204 | Phosphorylation | QARVSRQTLLALEKE HHHHHHHHHHHHHHH | 23.72 | 28555341 | |
| 210 | Ubiquitination | QTLLALEKEEEEEVF HHHHHHHHHHHHHHH | 71.87 | 22817900 | |
| 210 (in isoform 1) | Ubiquitination | - | 71.87 | 21890473 | |
| 220 | Phosphorylation | EEEVFESSVPQRSTL HHHHHHCCCCCCCHH | 30.53 | 28555341 | |
| 224 (in isoform 3) | Ubiquitination | - | 26.07 | 21890473 | |
| 231 | Ubiquitination | RSTLAELKSKGKKTA CCHHHHHHHCCCCCC | 41.44 | 33845483 | |
| 232 | Phosphorylation | STLAELKSKGKKTAR CHHHHHHHCCCCCCC | 60.30 | 20860994 | |
| 237 | Phosphorylation | LKSKGKKTARAPIIR HHHCCCCCCCCCEEE | 25.51 | 24719451 | |
| 250 | Sumoylation | IRVGGALKAPSQNRG EEECCEECCCCCCCC | 58.69 | - | |
| 250 | Acetylation | IRVGGALKAPSQNRG EEECCEECCCCCCCC | 58.69 | 19407811 | |
| 250 | Sumoylation | IRVGGALKAPSQNRG EEECCEECCCCCCCC | 58.69 | 19407811 | |
| 250 | Ubiquitination | IRVGGALKAPSQNRG EEECCEECCCCCCCC | 58.69 | 19407811 | |
| 264 (in isoform 3) | Ubiquitination | - | 52.32 | - | |
| 266 | Sulfoxidation | QNPFPQQMQNNSRIT CCCCCHHHHCCCCEE | 3.76 | 21406390 | |
| 270 | Phosphorylation | PQQMQNNSRITVFDE CHHHHCCCCEEEECC | 32.39 | 26425664 | |
| 304 | Ubiquitination | APPMPRAKENELQAG CCCCCCCCCCCCCCC | 63.45 | 29967540 | |
| 315 | Phosphorylation | LQAGPWNTGRSLEHR CCCCCCCCCCCCCCC | 30.06 | - | |
| 318 | Phosphorylation | GPWNTGRSLEHRPRG CCCCCCCCCCCCCCC | 39.18 | 28555341 | |
| 361 | Phosphorylation | TPCKIEPSINHILST CCCCCCCCHHHHHCC | 24.19 | 22673903 | |
| 367 | Phosphorylation | PSINHILSTRKPGKE CCHHHHHCCCCCCCC | 26.09 | 25159151 | |
| 368 | Phosphorylation | SINHILSTRKPGKEE CHHHHHCCCCCCCCC | 38.99 | 28555341 | |
| 370 | Ubiquitination | NHILSTRKPGKEEGD HHHHCCCCCCCCCCC | 59.20 | 29967540 | |
| 373 | Ubiquitination | LSTRKPGKEEGDPLQ HCCCCCCCCCCCHHH | 62.21 | 24816145 | |
| 384 | Phosphorylation | DPLQRVQSHQQASEE CHHHHHHHHHHHCHH | 22.02 | 30576142 | |
| 384 (in isoform 3) | Ubiquitination | - | 22.02 | - | |
| 404 | Phosphorylation | MYCKEKIYAGVGEFS HHHHHHHHCCCCCCC | 14.36 | 28674419 | |
| 418 (in isoform 3) | Phosphorylation | - | 32.13 | 27642862 | |
| 421 (in isoform 2) | Ubiquitination | - | 40.13 | 21890473 | |
| 434 | Phosphorylation | QREAELLTSAEKRAE HHHHHHHHHHHHHHH | 38.22 | 29255136 | |
| 435 | Phosphorylation | REAELLTSAEKRAEM HHHHHHHHHHHHHHH | 34.11 | 29255136 | |
| 438 | Ubiquitination | ELLTSAEKRAEMQKQ HHHHHHHHHHHHHHH | 57.53 | 24816145 | |
| 451 | Acetylation | KQIEEMEKKLKEIQT HHHHHHHHHHHHHHH | 63.19 | 7432055 | |
| 452 | Ubiquitination | QIEEMEKKLKEIQTT HHHHHHHHHHHHHHH | 52.03 | 29967540 | |
| 454 | Ubiquitination | EEMEKKLKEIQTTQQ HHHHHHHHHHHHHHH | 62.75 | 29967540 | |
| 464 | Phosphorylation | QTTQQERTGDQQEET HHHHHHHHCCCCCCC | 44.34 | 21406692 | |
| 468 (in isoform 3) | Ubiquitination | - | 56.06 | - | |
| 471 | Phosphorylation | TGDQQEETMPTKETT HCCCCCCCCCCCHHC | 27.91 | 21406692 | |
| 474 | Phosphorylation | QQEETMPTKETTKLQ CCCCCCCCCHHCHHE | 30.59 | 21406692 | |
| 475 | Ubiquitination | QEETMPTKETTKLQI CCCCCCCCHHCHHEC | 47.39 | 21906983 | |
| 475 (in isoform 1) | Ubiquitination | - | 47.39 | 21890473 | |
| 479 | Ubiquitination | MPTKETTKLQIASES CCCCHHCHHECCCCC | 45.90 | 22817900 | |
| 488 | Ubiquitination | QIASESQKIPGMTLS ECCCCCCCCCCCEEC | 61.21 | - | |
| 489 (in isoform 3) | Ubiquitination | - | 2.50 | 21890473 | |
| 496 | Phosphorylation | IPGMTLSSSVCQVNC CCCCEECCCCHHHHC | 29.87 | 28555341 | |
| 497 | Phosphorylation | PGMTLSSSVCQVNCC CCCEECCCCHHHHCC | 24.44 | 28555341 | |
| 502 (in isoform 3) | Ubiquitination | - | 6.83 | - | |
| 508 | Phosphorylation | VNCCARETSLAENIW HHCCCCCCHHHHHHH | 24.40 | 23186163 | |
| 509 | Phosphorylation | NCCARETSLAENIWQ HCCCCCCHHHHHHHH | 22.34 | 30576142 | |
| 521 | Phosphorylation | IWQEQPHSKGPSVPF HHHCCCCCCCCCCCC | 46.09 | 25159151 | |
| 522 | Ubiquitination | WQEQPHSKGPSVPFS HHCCCCCCCCCCCCC | 72.33 | 29967540 | |
| 537 | Phosphorylation | IFDEFLLSEKKNKSP HHHHHHHHHCCCCCC | 49.90 | 24719451 | |
| 539 | Ubiquitination | DEFLLSEKKNKSPPA HHHHHHHCCCCCCCC | 59.27 | 32015554 | |
| 540 | Ubiquitination | EFLLSEKKNKSPPAD HHHHHHCCCCCCCCC | 66.61 | - | |
| 542 | Ubiquitination | LLSEKKNKSPPADPP HHHHCCCCCCCCCCC | 73.54 | 29967540 | |
| 543 | Phosphorylation | LSEKKNKSPPADPPR HHHCCCCCCCCCCCH | 45.57 | 30266825 | |
| 554 (in isoform 3) | Ubiquitination | - | 37.44 | - | |
| 563 | Phosphorylation | RPLAVLKTSESITSN CCEEEEECCCCCCCC | 33.30 | 29116813 | |
| 564 | Phosphorylation | PLAVLKTSESITSNE CEEEEECCCCCCCCC | 27.97 | 28464451 | |
| 566 | Phosphorylation | AVLKTSESITSNEDV EEEECCCCCCCCCCC | 30.82 | 29802988 | |
| 568 | Phosphorylation | LKTSESITSNEDVSP EECCCCCCCCCCCCH | 34.48 | 28102081 | |
| 569 | Phosphorylation | KTSESITSNEDVSPD ECCCCCCCCCCCCHH | 36.23 | 29116813 | |
| 574 | Phosphorylation | ITSNEDVSPDVCDEF CCCCCCCCHHHCCCC | 27.92 | 29496963 | |
| 582 | Phosphorylation | PDVCDEFTGIEPLSE HHHCCCCCCCCCCCC | 34.89 | 28464451 | |
| 600 | Phosphorylation | ITGFRNVTICPNPED EECCCCEEECCCHHH | 22.02 | 28555341 | |
| 608 | Phosphorylation | ICPNPEDTCDFARAA ECCCHHHCCHHHHHH | 16.59 | 28555341 | |
| 619 | Phosphorylation | ARAARFVSTPFHEIM HHHHHHHCCCHHHHC | 27.87 | 22199227 | |
| 620 | Phosphorylation | RAARFVSTPFHEIMS HHHHHHCCCHHHHCC | 25.36 | 22199227 | |
| 627 | Phosphorylation | TPFHEIMSLKDLPSD CCHHHHCCCCCCCCC | 37.62 | 28555341 | |
| 629 | Ubiquitination | FHEIMSLKDLPSDPE HHHHCCCCCCCCCHH | 50.33 | 21906983 | |
| 629 (in isoform 1) | Ubiquitination | - | 50.33 | 21890473 | |
| 633 | Phosphorylation | MSLKDLPSDPERLLP CCCCCCCCCHHHHCC | 73.43 | 30576142 | |
| 643 (in isoform 3) | Ubiquitination | - | 46.65 | 21890473 | |
| 658 | Phosphorylation | DQQTACGTIYSQTLS HHCHHCHHHHEEECC | 19.34 | 21945579 | |
| 660 | Phosphorylation | QTACGTIYSQTLSIK CHHCHHHHEEECCCC | 8.45 | 21945579 | |
| 661 | Phosphorylation | TACGTIYSQTLSIKK HHCHHHHEEECCCCC | 16.91 | 21945579 | |
| 665 | Phosphorylation | TIYSQTLSIKKLSPI HHHEEECCCCCCCCC | 35.43 | 23186163 | |
| 667 | Acetylation | YSQTLSIKKLSPIIE HEEECCCCCCCCCCC | 44.26 | 25953088 | |
| 667 | Ubiquitination | YSQTLSIKKLSPIIE HEEECCCCCCCCCCC | 44.26 | 29967540 | |
| 668 | Ubiquitination | SQTLSIKKLSPIIED EEECCCCCCCCCCCC | 53.15 | 29967540 | |
| 670 | Phosphorylation | TLSIKKLSPIIEDSR ECCCCCCCCCCCCHH | 23.96 | 29255136 | |
| 676 | Phosphorylation | LSPIIEDSREATHSS CCCCCCCHHHHHCCC | 21.16 | 23927012 | |
| 680 | Phosphorylation | IEDSREATHSSGFSG CCCHHHHHCCCCCCC | 19.96 | 30576142 | |
| 682 | Phosphorylation | DSREATHSSGFSGSS CHHHHHCCCCCCCCC | 28.00 | 23186163 | |
| 682 (in isoform 3) | Ubiquitination | - | 28.00 | - | |
| 683 | Phosphorylation | SREATHSSGFSGSSA HHHHHCCCCCCCCCC | 35.93 | 30576142 | |
| 686 | Phosphorylation | ATHSSGFSGSSASVA HHCCCCCCCCCCCCC | 41.09 | 23186163 | |
| 688 | Phosphorylation | HSSGFSGSSASVAST CCCCCCCCCCCCCCC | 22.87 | 23186163 | |
| 689 | Phosphorylation | SSGFSGSSASVASTS CCCCCCCCCCCCCCC | 28.26 | 23186163 | |
| 691 | Phosphorylation | GFSGSSASVASTSSI CCCCCCCCCCCCCCC | 21.84 | 23186163 | |
| 694 | Phosphorylation | GSSASVASTSSIKCL CCCCCCCCCCCCEEE | 27.02 | 23186163 | |
| 695 | Phosphorylation | SSASVASTSSIKCLQ CCCCCCCCCCCEEEE | 19.43 | 23186163 | |
| 696 | Phosphorylation | SASVASTSSIKCLQI CCCCCCCCCCEEEEC | 27.80 | 23186163 | |
| 697 | Phosphorylation | ASVASTSSIKCLQIP CCCCCCCCCEEEECC | 26.59 | 23312004 | |
| 699 | Ubiquitination | VASTSSIKCLQIPEK CCCCCCCEEEECCCC | 30.73 | 29967540 | |
| 706 | Ubiquitination | KCLQIPEKLELTNET EEEECCCCEECCCCC | 41.74 | 29967540 | |
| 710 | Phosphorylation | IPEKLELTNETSENP CCCCEECCCCCCCCC | 22.95 | 21815630 | |
| 713 | Phosphorylation | KLELTNETSENPTQS CEECCCCCCCCCCCC | 43.33 | 25627689 | |
| 714 | Phosphorylation | LELTNETSENPTQSP EECCCCCCCCCCCCH | 29.24 | 28555341 | |
| 718 | Phosphorylation | NETSENPTQSPWCSQ CCCCCCCCCCHHHHH | 53.94 | 21815630 | |
| 720 | Phosphorylation | TSENPTQSPWCSQYR CCCCCCCCHHHHHHH | 23.89 | 21815630 | |
| 724 | Phosphorylation | PTQSPWCSQYRRQLL CCCCHHHHHHHHHHH | 26.78 | 29396449 | |
| 726 | Phosphorylation | QSPWCSQYRRQLLKS CCHHHHHHHHHHHHH | 7.47 | 29396449 | |
| 733 | Phosphorylation | YRRQLLKSLPELSAS HHHHHHHHCHHHHHC | 49.48 | 22067460 | |
| 757 | Ubiquitination | MPKLEIEKEIELGNE CCCEEEEEEEECCCC | 70.43 | 29967540 | |
| 766 | Phosphorylation | IELGNEDYCIKREYL EECCCCCCEEEEEEE | 7.01 | 22817900 | |
| 769 | Ubiquitination | GNEDYCIKREYLICE CCCCCEEEEEEEEEC | 35.30 | 29967540 | |
| 771 (in isoform 3) | Ubiquitination | - | 39.42 | - | |
| 783 (in isoform 3) | Ubiquitination | - | 4.04 | - | |
| 792 | Phosphorylation | PRNSAELTVIKVSSQ CCCCCEEEEEEEECC | 16.22 | 17376779 | |
| 797 | Phosphorylation | ELTVIKVSSQPVPWD EEEEEEEECCCCCCE | 20.46 | - | |
| 878 (in isoform 2) | Ubiquitination | - | 3.11 | 21890473 | |
| 884 | Phosphorylation | EIVHGDLSPRCLILR CHHCCCCCCCEEEEE | 18.29 | 25159151 | |
| 902 | Ubiquitination | HDPYDCNKNNQALKI CCCCCCCCCCCEEEE | 64.70 | 29967540 | |
| 912 (in isoform 3) | Phosphorylation | - | 5.24 | 27642862 | |
| 919 | Dimethylation | FSYSVDLRVQLDVFT EECEEEEEEEEEEEE | 15.07 | - | |
| 919 | Methylation | FSYSVDLRVQLDVFT EECEEEEEEEEEEEE | 15.07 | - | |
| 988 | Ubiquitination | SQNISELKDGELWNK CCCHHHCCCCHHHHH | 60.68 | 29967540 | |
| 995 | Ubiquitination | KDGELWNKFFVRILN CCCHHHHHHHHHHHC | 28.70 | 21890473 | |
| 995 (in isoform 1) | Ubiquitination | - | 28.70 | 21890473 | |
| 1008 | Phosphorylation | LNANDEATVSVLGEL HCCCCCHHHHHHHHH | 15.97 | 17376779 | |
| 1009 (in isoform 3) | Ubiquitination | - | 4.86 | 21890473 | |
| 1037 | Ubiquitination | HLNKALWKVGKLTSP HHHHHHHHHHCCCCC | 41.79 | - | |
| 1040 | Acetylation | KALWKVGKLTSPGAL HHHHHHHCCCCCCEE | 52.13 | 25953088 | |
| 1040 | Ubiquitination | KALWKVGKLTSPGAL HHHHHHHCCCCCCEE | 52.13 | 29967540 | |
| 1042 | Phosphorylation | LWKVGKLTSPGALLF HHHHHCCCCCCEECC | 36.04 | 30266825 | |
| 1043 | Phosphorylation | WKVGKLTSPGALLFQ HHHHCCCCCCEECCC | 31.60 | 30266825 | |
| 1051 (in isoform 3) | Ubiquitination | - | - | ||
| 1054 (in isoform 3) | Ubiquitination | - | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 435 | S | Phosphorylation | Kinase | TTK | P33981 | PSP |
| 543 | S | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 543 | S | Phosphorylation | Kinase | TTK | P33981 | PSP |
| 670 | S | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 670 | S | Phosphorylation | Kinase | TTK | P33981 | PSP |
| 676 | S | Phosphorylation | Kinase | PLK1 | P53350 | Uniprot |
| 680 | T | Phosphorylation | Kinase | PLK1 | P53350 | PSP |
| 792 | T | Phosphorylation | Kinase | PLK1 | P53350 | Uniprot |
| 1008 | T | Phosphorylation | Kinase | PLK1 | P53350 | Uniprot |
| 1043 | S | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 1043 | S | Phosphorylation | Kinase | TTK | P33981 | PSP |
| - | K | Ubiquitination | E3 ubiquitin ligase | FZR1 | Q9UM11 | PMID:23091007 |
| - | K | Ubiquitination | E3 ubiquitin ligase | CDC20 | Q12834 | PMID:16856867 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BUB1B_HUMAN !! | ||||||
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| Acetylation | |
| Reference | PubMed |
| "BubR1 acetylation at prometaphase is required for modulating APC/Cactivity and timing of mitosis."; Choi E., Choe H., Min J., Choi J.Y., Kim J., Lee H.; EMBO J. 28:2077-2089(2009). Cited for: INTERACTION WITH PCAF, ACETYLATION AT LYS-250, AND UBIQUITINATION. | |
| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1043, AND MASSSPECTROMETRY. | |
| "Phosphorylation sites in BubR1 that regulate kinetochore attachment,tension, and mitotic exit."; Huang H., Hittle J., Zappacosta F., Annan R.S., Hershko A., Yen T.J.; J. Cell Biol. 183:667-680(2008). Cited for: PHOSPHORYLATION AT SER-435; SER-543; SER-670 AND SER-1043. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435 AND SER-670, ANDMASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-670, AND MASSSPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-543, AND MASSSPECTROMETRY. | |
| "Tension-sensitive Plk1 phosphorylation on BubR1 regulates thestability of kinetochore microtubule interactions."; Elowe S., Huemmer S., Uldschmid A., Li X., Nigg E.A.; Genes Dev. 21:2205-2219(2007). Cited for: INTERACTION WITH PLK1, SUBCELLULAR LOCATION, PHOSPHORYLATION ATSER-676, AND MUTAGENESIS OF THR-620. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-54, AND MASSSPECTROMETRY. | |
| "Polo-like kinase 1 facilitates chromosome alignment duringprometaphase through BubR1."; Matsumura S., Toyoshima F., Nishida E.; J. Biol. Chem. 282:15217-15227(2007). Cited for: INTERACTION WITH PLK1, SUBCELLULAR LOCATION, AND PHOSPHORYLATION ATTHR-792 AND THR-1008. | |
