dbPTM

ZC3H1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZC3H1_HUMAN
UniProt AC	O60293
Protein Name	Zinc finger C3H1 domain-containing protein
Gene Name	ZFC3H1
Organism	Homo sapiens (Human).
Sequence Length	1989
Subcellular Localization	Nucleus . Excluded from the nucleolus.
Protein Description	Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters..
Protein Sequence	MATADTPAPASSGLSPKEEGELEDGEISDDDNNSQIRSRSSSSSSGGGLLPYPRRRPPHSARGGGSGGGGGSSSSSSSSQQQLRNFSRSRHASERGHLRGPSSYRPKEPFRSHPPSVRMPSSSLSESSPRPSFWERSHLALDRFRFRGRPYRGGSRWSRGRGVGERGGKPGCRPPLGGGAGSGFSSSQSWREPSPPRKSSKSFGRSPSRKQNYSSKNENCVEETFEDLLLKYKQIQLELECINKDEKLALSSKEENVQEDPKTLNFEDQTSTDNVSITKDSSKEVAPEEKTQVKTFQAFELKPLRQKLTLPGDKNRLKKVKDGAKPLSLKSDTTDSSQGLQDKEQNLTRRISTSDILSEKKLGEDEEELSELQLRLLALQSASKKWQQKEQQVMKESKEKLTKTKTVQQKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKEEDQRKQAEEEERRKREEEIRKIRDLSNQEEQYNRFMKLVGGKRRSRSKSSDPDLRRSLDKQPTDSGGGIYQYDNYEEVAMDTDSETSSPAPSPVQPPFFSECSLGYFSPAPSLSLPPPPQVSSLPPLSQPYVEGLCVSLEPLPPLPPLPPLPPEDPEQPPKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSIVSINTVSQPRIQNPKFHRGPRLPRTVISLPKHKSVVVTLNDSDDSESDGEASKSTNSVFGGLESMIKEARRTAEQASKPKVPPKSEKENDPLRTPEALPEEKKIEYRLLKEEIANREKQRLIKSDQLKTSSSSPANSDVEIDGIGRIAMVTKQVTDAESKLKKHRILLMKDESVLKNLVQQEAKKKESVRNAEAKITKLTEQLQATEKILNVNRMFLKKLQEQIHRVQQRVTIKKALTLKYGEELARAKAVASKEIGKRKLEQDRFGPNKMMRLDSSPVSSPRKHSAELIAMEKRRLQKLEYEYALKIQKLKEARALKAKEQQNISPVVEEEPEFSLPQPSLHDLTQDKLTLDTEENDVDDEILSGSSRERRRSFLESNYFTKPNLKHTDTANKECINKLNKNTVEKPELFLGLKIGELQKLYSKADSLKQLILKTTTGITEKVLHGQEISVDVDFVTAQSKTMEVKPCPFRPYHSPLLVFKSYRFSPYYRTKEKLPLSSVSYSNMIEPDQCFCRFDLTGTCNDDDCQWQHIQDYTLSRKQLFQDILSYNLSLIGCAETSTNEEITASAEKYVEKLFGVNKDRMSMDQMAVLLVSNINESKGHTPPFTTYKDKRKWKPKFWRKPISDNSFSSDEEQSTGPIKYAFQPENQINVPALDTVVTPDDVRYFTNETDDIANLEASVLENPSHVQLWLKLAYKYLNQNEGECSESLDSALNVLARALENNKDNPEIWCHYLRLFSKRGTKDEVQEMCETAVEYAPDYQSFWTFLHLESTFEEKDYVCERMLEFLMGAAKQETSNILSFQLLEALLFRVQLHIFTGRCQSALAILQNALKSANDGIVAEYLKTSDRCLAWLAYIHLIEFNILPSKFYDPSNDNPSRIVNTESFVMPWQAVQDVKTNPDMLLAVFEDAVKACTDESLAVEERIEACLPLYTNMIALHQLLERYEAAMELCKSLLESCPINCQLLEALVALYLQTNQHDKARAVWLTAFEKNPQNAEVFYHMCKFFILQNRGDNLLPFLRKFIASFFKPGFEKYNNLDLFRYLLNIPGPIDIPSRLCKGNFDDDMFNHQVPYLWLIYCLCHPLQSSIKETVEAYEAALGVAMRCDIVQKIWMDYLVFANNRAAGSRNKVQEFKFFTDLVNRCLVTVPARYPIPFSSADYWSNYEFHNRVIFFYLSCVPKTQHSKTLERFCSVMPANSGLALRLLQHEWEESNVQILKLQAKMFTYNIPTCLATWKIAIAAEIVLKGQREVHRLYQRALQKLPLCASLWKDQLLFEASEGGKTDNLRKLVSKCQEIGVSLNELLNLNSNKTESKNH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATADTPAP ------CCCCCCCCC	23.85	20068231
3	Phosphorylation	-----MATADTPAPA -----CCCCCCCCCC	36.60	30177828
6	Phosphorylation	--MATADTPAPASSG --CCCCCCCCCCCCC	20.91	19691289
11	Phosphorylation	ADTPAPASSGLSPKE CCCCCCCCCCCCCCC	24.71	25159151
12	Phosphorylation	DTPAPASSGLSPKEE CCCCCCCCCCCCCCC	45.95	29255136
15	Phosphorylation	APASSGLSPKEEGEL CCCCCCCCCCCCCCC	37.13	29255136
28	Phosphorylation	ELEDGEISDDDNNSQ CCCCCCCCCCCCCCC	30.59	23401153
34	Phosphorylation	ISDDDNNSQIRSRSS CCCCCCCCCEECCCC	32.99	17525332
40	Phosphorylation	NSQIRSRSSSSSSGG CCCEECCCCCCCCCC	35.50	20068231
41	Phosphorylation	SQIRSRSSSSSSGGG CCEECCCCCCCCCCC	32.88	20068231
42	Phosphorylation	QIRSRSSSSSSGGGL CEECCCCCCCCCCCC	35.17	22617229
43	Phosphorylation	IRSRSSSSSSGGGLL EECCCCCCCCCCCCC	30.39	21130716
44	Phosphorylation	RSRSSSSSSGGGLLP ECCCCCCCCCCCCCC	34.64	20068231
45	Phosphorylation	SRSSSSSSGGGLLPY CCCCCCCCCCCCCCC	43.32	20068231
52	Phosphorylation	SGGGLLPYPRRRPPH CCCCCCCCCCCCCCC	14.89	20068231
55	Methylation	GLLPYPRRRPPHSAR CCCCCCCCCCCCCCC	51.45	30760761
56	Methylation	LLPYPRRRPPHSARG CCCCCCCCCCCCCCC	50.83	18959123
62	Methylation	RRPPHSARGGGSGGG CCCCCCCCCCCCCCC	47.51	16289047
84	Methylation	SSSQQQLRNFSRSRH HHHHHHHHHHHHHCH	37.50	30760755
87	Phosphorylation	QQQLRNFSRSRHASE HHHHHHHHHHCHHHH	32.66	-
89	Phosphorylation	QLRNFSRSRHASERG HHHHHHHHCHHHHCC	27.50	-
95	Dimethylation	RSRHASERGHLRGPS HHCHHHHCCCCCCCC	35.02	-
95	Methylation	RSRHASERGHLRGPS HHCHHHHCCCCCCCC	35.02	30762961
99	Dimethylation	ASERGHLRGPSSYRP HHHCCCCCCCCCCCC	49.67	-
99	Methylation	ASERGHLRGPSSYRP HHHCCCCCCCCCCCC	49.67	30762967
105	Dimethylation	LRGPSSYRPKEPFRS CCCCCCCCCCCCCCC	37.45	-
105	Methylation	LRGPSSYRPKEPFRS CCCCCCCCCCCCCCC	37.45	30762973
116	Phosphorylation	PFRSHPPSVRMPSSS CCCCCCCCCCCCCCC	27.14	22210691
118	Methylation	RSHPPSVRMPSSSLS CCCCCCCCCCCCCCC	35.31	115489545
121	Phosphorylation	PPSVRMPSSSLSESS CCCCCCCCCCCCCCC	24.18	27732954
122	Phosphorylation	PSVRMPSSSLSESSP CCCCCCCCCCCCCCC	29.45	27732954
123	Phosphorylation	SVRMPSSSLSESSPR CCCCCCCCCCCCCCC	40.01	27732954
125	Phosphorylation	RMPSSSLSESSPRPS CCCCCCCCCCCCCCC	37.06	22199227
127	Phosphorylation	PSSSLSESSPRPSFW CCCCCCCCCCCCCHH	42.12	22199227
128	Phosphorylation	SSSLSESSPRPSFWE CCCCCCCCCCCCHHH	22.37	21712546
132	Phosphorylation	SESSPRPSFWERSHL CCCCCCCCHHHHHHH	44.25	23186163
143	Methylation	RSHLALDRFRFRGRP HHHHHHHHHEECCCC	26.03	115367511
185	Phosphorylation	GGAGSGFSSSQSWRE CCCCCCCCCCCCCCC	32.38	30108239
186	Phosphorylation	GAGSGFSSSQSWREP CCCCCCCCCCCCCCC	30.09	30108239
187	Phosphorylation	AGSGFSSSQSWREPS CCCCCCCCCCCCCCC	27.34	30108239
189	Phosphorylation	SGFSSSQSWREPSPP CCCCCCCCCCCCCCC	30.01	30108239
194	Phosphorylation	SQSWREPSPPRKSSK CCCCCCCCCCCCCCC	42.66	30266825
199	Phosphorylation	EPSPPRKSSKSFGRS CCCCCCCCCCCCCCC	44.25	-
200	Phosphorylation	PSPPRKSSKSFGRSP CCCCCCCCCCCCCCC	35.04	-
202	Phosphorylation	PPRKSSKSFGRSPSR CCCCCCCCCCCCCCC	34.58	23403867
206	Phosphorylation	SSKSFGRSPSRKQNY CCCCCCCCCCCCCCC	27.83	25159151
208	Phosphorylation	KSFGRSPSRKQNYSS CCCCCCCCCCCCCCC	54.05	23403867
215	Phosphorylation	SRKQNYSSKNENCVE CCCCCCCCCCCCHHH	29.19	28258704
220	Glutathionylation	YSSKNENCVEETFED CCCCCCCHHHHHHHH	3.12	22555962
224	Phosphorylation	NENCVEETFEDLLLK CCCHHHHHHHHHHHH	20.86	28258704
251	Phosphorylation	KDEKLALSSKEENVQ CCCHHHCCCCCCCCC	33.48	23312004
252	Phosphorylation	DEKLALSSKEENVQE CCHHHCCCCCCCCCC	44.96	23312004
253	Sumoylation	EKLALSSKEENVQED CHHHCCCCCCCCCCC	66.72	-
253	Sumoylation	EKLALSSKEENVQED CHHHCCCCCCCCCCC	66.72	-
270	Phosphorylation	TLNFEDQTSTDNVSI CCCCCCCCCCCCEEE	46.01	25627689
271	Phosphorylation	LNFEDQTSTDNVSIT CCCCCCCCCCCEEEC	28.29	25627689
272	Phosphorylation	NFEDQTSTDNVSITK CCCCCCCCCCEEECC	34.67	25627689
276	Phosphorylation	QTSTDNVSITKDSSK CCCCCCEEECCCCCC	30.69	30108239
278	Phosphorylation	STDNVSITKDSSKEV CCCCEEECCCCCCCC	22.69	30108239
302	Acetylation	TFQAFELKPLRQKLT EEECCCCCCHHHHCC	34.50	25953088
309	Phosphorylation	KPLRQKLTLPGDKNR CCHHHHCCCCCCHHH	37.63	23312004
319	Trimethylation	GDKNRLKKVKDGAKP CCHHHHHHCCCCCCC	60.14	-
319	Methylation	GDKNRLKKVKDGAKP CCHHHHHHCCCCCCC	60.14	-
325	Acetylation	KKVKDGAKPLSLKSD HHCCCCCCCCCCCCC	52.61	26051181
328	Phosphorylation	KDGAKPLSLKSDTTD CCCCCCCCCCCCCCC	42.13	-
331	Phosphorylation	AKPLSLKSDTTDSSQ CCCCCCCCCCCCCCC	45.54	30576142
333	Phosphorylation	PLSLKSDTTDSSQGL CCCCCCCCCCCCCCC	39.32	23312004
334	Phosphorylation	LSLKSDTTDSSQGLQ CCCCCCCCCCCCCCH	38.58	23312004
336	Phosphorylation	LKSDTTDSSQGLQDK CCCCCCCCCCCCHHH	23.59	30576142
337	Phosphorylation	KSDTTDSSQGLQDKE CCCCCCCCCCCHHHH	30.95	30576142
343	Ubiquitination	SSQGLQDKEQNLTRR CCCCCHHHHHHHHHH	48.52	29967540
348	Phosphorylation	QDKEQNLTRRISTSD HHHHHHHHHHCCHHH	26.00	23882029
352	Phosphorylation	QNLTRRISTSDILSE HHHHHHCCHHHHHCH	21.76	29255136
353	Phosphorylation	NLTRRISTSDILSEK HHHHHCCHHHHHCHH	28.22	29255136
354	Phosphorylation	LTRRISTSDILSEKK HHHHCCHHHHHCHHH	18.83	23401153
358	Phosphorylation	ISTSDILSEKKLGED CCHHHHHCHHHCCCC	47.94	23927012
361	Ubiquitination	SDILSEKKLGEDEEE HHHHCHHHCCCCHHH	58.64	29967540
381	Phosphorylation	LRLLALQSASKKWQQ HHHHHHHHHHHHHHH	35.05	25159151
383	Phosphorylation	LLALQSASKKWQQKE HHHHHHHHHHHHHHH	39.76	25159151
384	Ubiquitination	LALQSASKKWQQKEQ HHHHHHHHHHHHHHH	58.72	29967540
402	Phosphorylation	KESKEKLTKTKTVQQ HHHHHHHHHCHHHHH	47.97	28258704
406	Phosphorylation	EKLTKTKTVQQKVKT HHHHHCHHHHHHHHH	28.86	28258704
414	Phosphorylation	VQQKVKTSTKTHSAK HHHHHHHCCCCCCHH	23.37	24719451
417	Phosphorylation	KVKTSTKTHSAKKVS HHHHCCCCCCHHHHC	22.58	24719451
419	Phosphorylation	KTSTKTHSAKKVSTT HHCCCCCCHHHHCHH	47.19	24719451
424	Phosphorylation	THSAKKVSTTAKQAL CCCHHHHCHHHHHHH	28.99	20363803
426	Phosphorylation	SAKKVSTTAKQALRK CHHHHCHHHHHHHHH	25.09	-
428	Ubiquitination	KKVSTTAKQALRKQQ HHHCHHHHHHHHHHH	33.73	29967540
479	Phosphorylation	IRKIRDLSNQEEQYN HHHHHHCCCHHHHHH	40.53	28787133
500	Phosphorylation	GGKRRSRSKSSDPDL CCCCCCCCCCCCHHH	37.83	23663014
502	Phosphorylation	KRRSRSKSSDPDLRR CCCCCCCCCCHHHHH	41.02	28355574
503	Phosphorylation	RRSRSKSSDPDLRRS CCCCCCCCCHHHHHH	57.82	23663014
510	Phosphorylation	SDPDLRRSLDKQPTD CCHHHHHHHCCCCCC	34.19	25159151
561	Phosphorylation	ECSLGYFSPAPSLSL CCCCCCCCCCCCCCC	16.21	-
567	Phosphorylation	FSPAPSLSLPPPPQV CCCCCCCCCCCCCCC	43.07	22798277
647	Phosphorylation	RAFKPEETSSNSDPP CCCCCHHCCCCCCCC	35.47	30266825
648	Phosphorylation	AFKPEETSSNSDPPS CCCCHHCCCCCCCCC	30.70	30266825
649	Phosphorylation	FKPEETSSNSDPPSP CCCHHCCCCCCCCCC	48.01	30266825
651	Phosphorylation	PEETSSNSDPPSPPV CHHCCCCCCCCCCCC	54.14	30266825
655	Phosphorylation	SSNSDPPSPPVLNNS CCCCCCCCCCCCCCC	47.42	29255136
662	Phosphorylation	SPPVLNNSHPVPRSN CCCCCCCCCCCCCCC	28.26	30278072
671	Phosphorylation	PVPRSNLSIVSINTV CCCCCCCEEEEEECC	25.79	28555341
700	Phosphorylation	RLPRTVISLPKHKSV CCCCEEEECCCCCEE	33.99	24719451
706	Phosphorylation	ISLPKHKSVVVTLND EECCCCCEEEEEECC	21.62	20873877
710	Phosphorylation	KHKSVVVTLNDSDDS CCCEEEEEECCCCCC	14.29	23663014
714	Phosphorylation	VVVTLNDSDDSESDG EEEEECCCCCCCCCC	42.09	25159151
717	Phosphorylation	TLNDSDDSESDGEAS EECCCCCCCCCCCCC	43.95	25159151
719	Phosphorylation	NDSDDSESDGEASKS CCCCCCCCCCCCCHH	55.67	25159151
724	Phosphorylation	SESDGEASKSTNSVF CCCCCCCCHHHHHHH	23.88	18669648
726	Phosphorylation	SDGEASKSTNSVFGG CCCCCCHHHHHHHHH	30.26	22199227
727	Phosphorylation	DGEASKSTNSVFGGL CCCCCHHHHHHHHHH	34.94	22199227
729	Phosphorylation	EASKSTNSVFGGLES CCCHHHHHHHHHHHH	20.93	22199227
736	Phosphorylation	SVFGGLESMIKEARR HHHHHHHHHHHHHHH	30.74	28555341
744	O-linked_Glycosylation	MIKEARRTAEQASKP HHHHHHHHHHHHHCC	29.06	30379171
749	O-linked_Glycosylation	RRTAEQASKPKVPPK HHHHHHHHCCCCCCC	49.54	30379171
757	Phosphorylation	KPKVPPKSEKENDPL CCCCCCCCCCCCCCC	60.72	23186163
766	Phosphorylation	KENDPLRTPEALPEE CCCCCCCCCCCCCCH	32.91	29255136
775	Acetylation	EALPEEKKIEYRLLK CCCCCHHHHHHHHHH	44.01	30591643
778	Phosphorylation	PEEKKIEYRLLKEEI CCHHHHHHHHHHHHH	15.27	22817900
782	Ubiquitination	KIEYRLLKEEIANRE HHHHHHHHHHHHHHH	58.87	29967540
795	Ubiquitination	REKQRLIKSDQLKTS HHHHHHHHHHHCCCC	53.20	29967540
800	Ubiquitination	LIKSDQLKTSSSSPA HHHHHHCCCCCCCCC	40.50	29967540
801	Phosphorylation	IKSDQLKTSSSSPAN HHHHHCCCCCCCCCC	42.29	30266825
802	Phosphorylation	KSDQLKTSSSSPANS HHHHCCCCCCCCCCC	27.00	30266825
803	Phosphorylation	SDQLKTSSSSPANSD HHHCCCCCCCCCCCC	39.81	30266825
804	Phosphorylation	DQLKTSSSSPANSDV HHCCCCCCCCCCCCC	39.86	30266825
805	Phosphorylation	QLKTSSSSPANSDVE HCCCCCCCCCCCCCE	29.94	25159151
809	Phosphorylation	SSSSPANSDVEIDGI CCCCCCCCCCEECCC	45.18	25159151
832	Ubiquitination	QVTDAESKLKKHRIL ECCCHHHHHHHCCEE	56.69	-
848	Ubiquitination	MKDESVLKNLVQQEA ECCHHHHHHHHHHHH	46.19	29967540
872	Phosphorylation	EAKITKLTEQLQATE HHHHHHHHHHHHHHH	24.20	25022875
878	Phosphorylation	LTEQLQATEKILNVN HHHHHHHHHHHHHHH	25.50	25022875
880	Ubiquitination	EQLQATEKILNVNRM HHHHHHHHHHHHHHH	48.41	22817900
880 (in isoform 1)	Ubiquitination	-	48.41	21890473
880 (in isoform 2)	Ubiquitination	-	48.41	21890473
910	Phosphorylation	VTIKKALTLKYGEEL HHHHHHHHHHHHHHH	26.51	22210691
921	Acetylation	GEELARAKAVASKEI HHHHHHHHHHHCHHH	37.53	24848843
926	Acetylation	RAKAVASKEIGKRKL HHHHHHCHHHHHHHC	43.54	24848855
932	Acetylation	SKEIGKRKLEQDRFG CHHHHHHHCHHCCCC	60.92	24848867
948	Phosphorylation	NKMMRLDSSPVSSPR CCCCCCCCCCCCCCC	40.93	29255136
949	Phosphorylation	KMMRLDSSPVSSPRK CCCCCCCCCCCCCCH	29.05	19664994
952	Phosphorylation	RLDSSPVSSPRKHSA CCCCCCCCCCCHHHH	37.70	29255136
953	Phosphorylation	LDSSPVSSPRKHSAE CCCCCCCCCCHHHHH	29.02	29255136
958	Phosphorylation	VSSPRKHSAELIAME CCCCCHHHHHHHHHH	26.86	28634298
966	Ubiquitination	AELIAMEKRRLQKLE HHHHHHHHHHHHHCH	29.72	29967540
974	Phosphorylation	RRLQKLEYEYALKIQ HHHHHCHHHHHHHHH	25.36	22817900
976	Phosphorylation	LQKLEYEYALKIQKL HHHCHHHHHHHHHHH	19.14	22817900
998	Phosphorylation	AKEQQNISPVVEEEP HHHHCCCCCCCCCCC	21.13	30278072
1008	Phosphorylation	VEEEPEFSLPQPSLH CCCCCCCCCCCCCHH	37.16	24732914
1013	Phosphorylation	EFSLPQPSLHDLTQD CCCCCCCCHHHCCCC	32.84	27080861
1023	Phosphorylation	DLTQDKLTLDTEEND HCCCCCCCCCCCCCC	28.47	29759185
1026	Phosphorylation	QDKLTLDTEENDVDD CCCCCCCCCCCCCCH	48.59	23882029
1037	Phosphorylation	DVDDEILSGSSRERR CCCHHHHCCCCHHHH	42.14	23882029
1039	Phosphorylation	DDEILSGSSRERRRS CHHHHCCCCHHHHHH	23.89	23882029
1040	Phosphorylation	DEILSGSSRERRRSF HHHHCCCCHHHHHHH	41.51	23882029
1046	Phosphorylation	SSRERRRSFLESNYF CCHHHHHHHHHHCCC	32.16	25159151
1050	Phosphorylation	RRRSFLESNYFTKPN HHHHHHHHCCCCCCC	38.69	30266825
1052	Phosphorylation	RSFLESNYFTKPNLK HHHHHHCCCCCCCCC	23.16	23927012
1054	Phosphorylation	FLESNYFTKPNLKHT HHHHCCCCCCCCCCC	34.92	23927012
1066	Acetylation	KHTDTANKECINKLN CCCHHCCHHHHHHHC	52.04	27452117
1076	Phosphorylation	INKLNKNTVEKPELF HHHHCCCCCCCCHHH	31.48	25159151
1095	Phosphorylation	IGELQKLYSKADSLK HHHHHHHHHHHHHHH	18.37	26074081
1096	Phosphorylation	GELQKLYSKADSLKQ HHHHHHHHHHHHHHH	31.63	26074081
1100	Phosphorylation	KLYSKADSLKQLILK HHHHHHHHHHHHHHH	42.18	26074081
1102	Ubiquitination	YSKADSLKQLILKTT HHHHHHHHHHHHHHC	47.19	29967540
1108	Phosphorylation	LKQLILKTTTGITEK HHHHHHHHCCCCCHH	26.58	26074081
1109	Phosphorylation	KQLILKTTTGITEKV HHHHHHHCCCCCHHH	22.80	26074081
1110	Phosphorylation	QLILKTTTGITEKVL HHHHHHCCCCCHHHH	31.64	26074081
1113	Phosphorylation	LKTTTGITEKVLHGQ HHHCCCCCHHHHCCC	30.97	26074081
1148	Phosphorylation	CPFRPYHSPLLVFKS CCCCCCCCCEEEEEE	16.05	-
1161	Phosphorylation	KSYRFSPYYRTKEKL EEECCCCCCCCCCCC	12.37	-
1162	Phosphorylation	SYRFSPYYRTKEKLP EECCCCCCCCCCCCC	18.39	-
1244	Phosphorylation	ITASAEKYVEKLFGV HHHHHHHHHHHHHCC	12.83	21394647
1247	Ubiquitination	SAEKYVEKLFGVNKD HHHHHHHHHHCCCCC	38.79	29967540
1257	Phosphorylation	GVNKDRMSMDQMAVL CCCCCCCCHHHHHHH	21.79	30257219
1272	Phosphorylation	LVSNINESKGHTPPF HHHCCCCCCCCCCCC	39.18	30257219
1276	Phosphorylation	INESKGHTPPFTTYK CCCCCCCCCCCCCCC	41.13	25159151
1281	Phosphorylation	GHTPPFTTYKDKRKW CCCCCCCCCCCCCCC	29.02	28985074
1287	"N6,N6-dimethyllysine"	TTYKDKRKWKPKFWR CCCCCCCCCCCCCCC	66.37	-
1287	Methylation	TTYKDKRKWKPKFWR CCCCCCCCCCCCCCC	66.37	-
1295	Ubiquitination	WKPKFWRKPISDNSF CCCCCCCCCCCCCCC	36.98	29967540
1298	Phosphorylation	KFWRKPISDNSFSSD CCCCCCCCCCCCCCC	38.99	30278072
1301	Phosphorylation	RKPISDNSFSSDEEQ CCCCCCCCCCCCCHH	31.34	22167270
1303	Phosphorylation	PISDNSFSSDEEQST CCCCCCCCCCCHHCC	36.38	29255136
1304	Phosphorylation	ISDNSFSSDEEQSTG CCCCCCCCCCHHCCC	47.21	29255136
1309	Phosphorylation	FSSDEEQSTGPIKYA CCCCCHHCCCCCCEE	38.31	23927012
1310	Phosphorylation	SSDEEQSTGPIKYAF CCCCHHCCCCCCEEC	46.82	23927012
1330	Phosphorylation	INVPALDTVVTPDDV CCCCCCCEEECHHHC	20.09	28348404
1333	Phosphorylation	PALDTVVTPDDVRYF CCCCEEECHHHCHHH	19.36	30624053
1412	Phosphorylation	CHYLRLFSKRGTKDE HHHHHHHHCCCCHHH	26.49	24719451
1540	Phosphorylation	IEFNILPSKFYDPSN HHCCCCCHHCCCCCC	31.77	24719451
1849	Phosphorylation	RVIFFYLSCVPKTQH CEEEEEEECCCCCCC	11.16	25159151
1857	Phosphorylation	CVPKTQHSKTLERFC CCCCCCCCHHHHHHH	19.95	25003641
1859	Phosphorylation	PKTQHSKTLERFCSV CCCCCCHHHHHHHCC	36.54	25003641
1903 (in isoform 2)	Phosphorylation	-	19.16	20860994
1907 (in isoform 2)	Phosphorylation	-	17.84	20860994
1955	Ubiquitination	FEASEGGKTDNLRKL HHHHCCCCCHHHHHH	64.66	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZC3H1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZC3H1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZC3H1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
HD_HUMAN	HTT	physical	23275563
KHDR2_HUMAN	KHDRBS2	physical	25416956
CCD57_HUMAN	CCDC57	physical	25416956
DSRAD_HUMAN	ADAR	physical	26496610
A4_HUMAN	APP	physical	26496610
EI2BA_HUMAN	EIF2B1	physical	26496610
SRGN_HUMAN	SRGN	physical	26496610
BUB3_HUMAN	BUB3	physical	26496610
DCAF1_HUMAN	VPRBP	physical	26496610
ACTZ_HUMAN	ACTR1A	physical	26496610
MPH6_HUMAN	MPHOSPH6	physical	26496610
ZC3H3_HUMAN	ZC3H3	physical	26496610
SK2L2_HUMAN	SKIV2L2	physical	26496610
RBM27_HUMAN	RBM27	physical	26496610
PCID2_HUMAN	PCID2	physical	26496610
RT25_HUMAN	MRPS25	physical	26496610
PAPOG_HUMAN	PAPOLG	physical	26496610
U119B_HUMAN	UNC119B	physical	26496610
LENG8_HUMAN	LENG8	physical	26496610
SMYD2_HUMAN	SMYD2	physical	28514442
CARME_HUMAN	C9orf41	physical	28514442
TBCD1_HUMAN	TBC1D1	physical	28514442
SLBP_HUMAN	SLBP	physical	28514442
SUFU_HUMAN	SUFU	physical	28514442
MK09_HUMAN	MAPK9	physical	28514442
ZCH18_HUMAN	ZC3H18	physical	28514442
SRRT_HUMAN	SRRT	physical	28514442
P2R3A_HUMAN	PPP2R3A	physical	28514442
PPHLN_HUMAN	PPHLN1	physical	28514442
TBCE_HUMAN	TBCE	physical	28514442
FBXW8_HUMAN	FBXW8	physical	28514442
ANGE2_HUMAN	ANGEL2	physical	28514442
HNRC1_HUMAN	HNRNPCL1	physical	28514442
XPF_HUMAN	ERCC4	physical	28514442
RBM45_HUMAN	RBM45	physical	28514442
ERCC1_HUMAN	ERCC1	physical	28514442
DCAF1_HUMAN	VPRBP	physical	28514442
ANM6_HUMAN	PRMT6	physical	28514442
PP2AA_HUMAN	PPP2CA	physical	28514442
2ABD_HUMAN	PPP2R2D	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
MOV10_HUMAN	MOV10	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
RPAP2_HUMAN	RPAP2	physical	28514442
GPN3_HUMAN	GPN3	physical	28514442
TACC3_HUMAN	TACC3	physical	28514442
RT23_HUMAN	MRPS23	physical	28514442
RALY_HUMAN	RALY	physical	28514442
RT11_HUMAN	MRPS11	physical	28514442
RT24_HUMAN	MRPS24	physical	28514442
VP26B_HUMAN	VPS26B	physical	28514442
CUL7_HUMAN	CUL7	physical	28514442
RT14_HUMAN	MRPS14	physical	28514442
PABP4_HUMAN	PABPC4	physical	28514442
RT07_HUMAN	MRPS7	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
NOL6_HUMAN	NOL6	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
DHX30_HUMAN	DHX30	physical	28514442
MKRN2_HUMAN	MKRN2	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
RENT1_HUMAN	UPF1	physical	28514442
MTEF3_HUMAN	MTERF3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZC3H1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-809 AND SER-949, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28; SER-352; SER-714;SER-717; SER-719; THR-766; SER-809; SER-949; SER-953; SER-998;SER-1046; SER-1303 AND SER-1304, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-949 AND SER-953, ANDMASS SPECTROMETRY.	19007248 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-28 AND SER-34, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-949 AND SER-998, ANDMASS SPECTROMETRY.	16565220 [Abstract]