U119B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: U119B_HUMAN
• UniProt AC: A6NIH7
• Protein Name: Protein unc-119 homolog B
• Gene Name: UNC119B
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Cell projection, cilium . Enriched at the transition zone and extended into the proximal end of the cilium.
• Protein Description: Myristoyl-binding protein that acts as a cargo adapter: specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated NPHP3 and plays a key role in localization of NPHP3 to the primary cilium membrane. Does not bind all myristoylated proteins. Probably plays a role in trafficking proteins in photoreceptor cells..
• Protein Sequence: MSGSNPKAAAAASAAGPGGLVAGKEEKKKAGGGVLNRLKARRQAPHHAADDGVGAAVTEQELLALDTIRPEHVLRLSRVTENYLCKPEDNIYSIDFTRFKIRDLETGTVLFEIAKPCVSDQEEDEEEGGGDVDISAGRFVRYQFTPAFLRLRTVGATVEFTVGDKPVSNFRMIERHYFREHLLKNFDFDFGFCIPSSRNTCEHIYEFPQLSEDVIRLMIENPYETRSDSFYFVDNKLIMHNKADYAYNGGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGSNPKAA ------CCCCCHHHH	51.43	22814378
24	Acetylation	PGGLVAGKEEKKKAG CCCEECCHHHHHHCC	53.62	19608861
27	Acetylation	LVAGKEEKKKAGGGV EECCHHHHHHCCCHH	61.74	18585049
29	Ubiquitination	AGKEEKKKAGGGVLN CCHHHHHHCCCHHHH	64.43	-
86	Ubiquitination	VTENYLCKPEDNIYS CCCCEEECCCCCEEE	49.17	-
92	Phosphorylation	CKPEDNIYSIDFTRF ECCCCCEEEEECEEE	13.06	27642862
106	Phosphorylation	FKIRDLETGTVLFEI EEEEECCCCCEEEEE	45.51	28122231
108	Phosphorylation	IRDLETGTVLFEIAK EEECCCCCEEEEEEC	22.81	28122231
119	Phosphorylation	EIAKPCVSDQEEDEE EEECCCCCCCCHHHH	40.05	28464451
205	Phosphorylation	RNTCEHIYEFPQLSE CCCCHHHHCCCCCCH	17.27	27642862
229	Phosphorylation	PYETRSDSFYFVDNK CCCCCCCCEEEECCE	24.08	27499020
242	Ubiquitination	NKLIMHNKADYAYNG CEEEEECCCCCCCCC	28.14	-
245	Phosphorylation	IMHNKADYAYNGGQ- EEECCCCCCCCCCC-	18.82	29496907
247	Phosphorylation	HNKADYAYNGGQ--- ECCCCCCCCCCC---	14.22	29496907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of U119B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of U119B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of U119B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBAC1_HUMAN	UBAC1	physical	22939629

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-24, AND MASS SPECTROMETRY.
PubMed: 19608861