ANGE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ANGE2_HUMAN
• UniProt AC: Q5VTE6
• Protein Name: Protein angel homolog 2
• Gene Name: ANGEL2
• Organism: Homo sapiens (Human).
• Sequence Length: 544
• Protein Sequence: MEAWRCVRKGYGHCVVGRGRYPMFPHHSRSLGRDWTTPWENLQRCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPCLFESRTQFQYCNWRPDNLSQTSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKTKILGDKNVDPKCEDSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRPDISLLDRDNVGLVLLLQPKIPYAACPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFSLSSVYSHYFPDTGIPEVTTCHSRSAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Methylation	YGHCVVGRGRYPMFP CCEEEECCCCCCCCC	18.14	-
18	Dimethylation	YGHCVVGRGRYPMFP CCEEEECCCCCCCCC	18.14	-
20	Dimethylation	HCVVGRGRYPMFPHH EEEECCCCCCCCCCC	30.90	-
20	Methylation	HCVVGRGRYPMFPHH EEEECCCCCCCCCCC	30.90	-
21	Phosphorylation	CVVGRGRYPMFPHHS EEECCCCCCCCCCCC	11.24	68721877
28	Phosphorylation	YPMFPHHSRSLGRDW CCCCCCCCCCCCCCC	22.11	68721883
44	Methylation	TPWENLQRCCWNRHI CHHHHHHHHHHHHHH	22.26	-
72	Methylation	PYPYFSSRHFSLNWR CCCCCCCCCCCCCCC	33.40	-
126	Ubiquitination	EPSSKRRKHQGVIKR CCCHHHHHHHCCEEC	44.29	-
143	Ubiquitination	EYICSHDKEKTKILG EEEECCCHHHCEECC	56.54	-
152	Ubiquitination	KTKILGDKNVDPKCE HCEECCCCCCCCCCC	58.01	-
152	Acetylation	KTKILGDKNVDPKCE HCEECCCCCCCCCCC	58.01	23749302
157	Sumoylation	GDKNVDPKCEDSENK CCCCCCCCCCCCCCC	45.88	-
157	Sumoylation	GDKNVDPKCEDSENK CCCCCCCCCCCCCCC	45.88	-
184	Phosphorylation	QDLLEDNSHLYRHCR HHHHCCCCHHHHHCC	27.47	68696303
187	Phosphorylation	LEDNSHLYRHCRRPV HCCCCHHHHHCCCCE	7.90	68696309
209 (in isoform 2)	Ubiquitination	-	39.03	21906983
209	Ubiquitination	PNILKEIKHFDADVL HHHHHHHCCCCCCEE	39.03	-
259	Methylation	DGCAICFKHSKFSLL CCEEEEECCCCCEEE	42.42	-
261 (in isoform 2)	Ubiquitination	-	35.67	21906983
362	Phosphorylation	VPGSPLYSFIKEGKL CCCCCHHHHHHCCCC	28.33	24719451
368	Sumoylation	YSFIKEGKLNYEGLP HHHHHCCCCCCCCCC	34.35	-
378 (in isoform 1)	Ubiquitination	-	33.67	21906983
378	Ubiquitination	YEGLPIGKVSGQEQS CCCCCCCEECCCCCC	33.67	21906983
419	Ubiquitination	QQVPKVEKTDSDLTQ EECCCCCCCCCCCCH	61.70	-
430	Ubiquitination	DLTQTQLKQTEVLVT CCCHHHHHHCEEEEE	45.41	2190698
430 (in isoform 1)	Ubiquitination	-	45.41	21906983
483	Phosphorylation	ITVDYIFYSAEKEDV EEEEEEEEECCCHHC	9.45	154053
484	Phosphorylation	TVDYIFYSAEKEDVA EEEEEEEECCCHHCC	21.14	27762562

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ANGE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ANGE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ANGE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HNRPF_HUMAN	HNRNPF	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.