P2R3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P2R3A_HUMAN
• UniProt AC: Q06190
• Protein Name: Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
• Gene Name: PPP2R3A
• Organism: Homo sapiens (Human).
• Sequence Length: 1150
• Protein Description: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment..
• Protein Sequence: MAATYRLVVSTVNHYSSVVIDRRFEQAIHYCTGTCHTFTHGIDCIVVHHSVCADLLHIPVSQFKDADLNSMFLPHENGLSSAEGDYPQQAFTGIPRVKRGSTFQNTYNLKDIAGEAISFASGKIKEFSFEKLKNSNHAAYRKGRKVKSDSFNRRSVDLDLLCGHYNNDGNAPSFGLLRSSSVEEKPLSHRNSLDTNLTSMFLQNFSEEDLVTQILEKHKIDNFSSGTDIKMCLDILLKCSEDLKKCTDIIKQCIKKKSGSSISEGSGNDTISSSETVYMNVMTRLASYLKKLPFEFMQSGNNEALDLTELISNMPSLQLTPFSPVFGTEQPPKYEDVVQLSASDSGRFQTIELQNDKPNSRKMDTVQSIPNNSTNSLYNLEVNDPRTLKAVQVQSQSLTMNPLENVSSDDLMETLYIEEESDGKKALDKGQKTENGPSHELLKVNEHRAEFPEHATHLKKCPTPMQNEIGKIFEKSFVNLPKEDCKSKVSKFEEGDQRDFTNSSSQEEIDKLLMDLESFSQKMETSLREPLAKGKNSNFLNSHSQLTGQTLVDLEPKSKVSSPIEKVSPSCLTRIIETNGHKIEEEDRALLLRILESIEDFAQELVECKSSRGSLSQEKEMMQILQETLTTSSQANLSVCRSPVGDKAKDTTSAVLIQQTPEVIKIQNKPEKKPGTPLPPPATSPSSPRPLSPVPHVNNVVNAPLSINIPRFYFPEGLPDTCSNHEQTLSRIETAFMDIEEQKADIYEMGKIAKVCGCPLYWKAPMFRAAGGEKTGFVTAQSFIAMWRKLLNNHHDDASKFICLLAKPNCSSLEQEDFIPLLQDVVDTHPGLTFLKDAPEFHSRYITTVIQRIFYTVNRSWSGKITSTEIRKSNFLQTLALLEEEEDINQITDYFSYEHFYVIYCKFWELDTDHDLYISQADLSRYNDQASSSRIIERIFSGAVTRGKTIQKEGRMSYADFVWFLISEEDKRNPTSIEYWFRCMDVDGDGVLSMYELEYFYEEQCERMEAMGIEPLPFHDLLCQMLDLVKPAVDGKITLRDLKRCRMAHIFYDTFFNLEKYLDHEQRDPFAVQKDVENDGPEPSDWDRFAAEEYETLVAEESAQAQFQEGFEDYETDEPASPSEFGNKSNKILSASLPEKCGKLQSVDEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAATYRLVVST ----CCCEEEEEEEE	19.08	24043423
5	Phosphorylation	---MAATYRLVVSTV ---CCCEEEEEEEEC	9.38	24043423
10	Phosphorylation	ATYRLVVSTVNHYSS CEEEEEEEECCCCCC	21.11	24043423
11	Phosphorylation	TYRLVVSTVNHYSSV EEEEEEEECCCCCCE	17.45	24043423
15	Phosphorylation	VVSTVNHYSSVVIDR EEEECCCCCCEEEEH	9.46	24043423
16	Phosphorylation	VSTVNHYSSVVIDRR EEECCCCCCEEEEHH	14.76	24043423
17	Phosphorylation	STVNHYSSVVIDRRF EECCCCCCEEEEHHH	17.15	24043423
39 (in isoform 2)	Phosphorylation	-	21.98	26437602
101	Phosphorylation	IPRVKRGSTFQNTYN CCCCCCCCCCCCEEC	30.04	28857561
102	Phosphorylation	PRVKRGSTFQNTYNL CCCCCCCCCCCEECH	31.87	28348404
106	Phosphorylation	RGSTFQNTYNLKDIA CCCCCCCEECHHHHH	11.73	28857561
118	Phosphorylation	DIAGEAISFASGKIK HHHHHHHHHHCCCEE	23.08	-
148	Phosphorylation	RKGRKVKSDSFNRRS HCCCCCCCCCCCCCC	41.28	24905233
150	Phosphorylation	GRKVKSDSFNRRSVD CCCCCCCCCCCCCCC	31.35	24905233
155	Phosphorylation	SDSFNRRSVDLDLLC CCCCCCCCCCHHHHC	19.42	29507054
165	Phosphorylation	LDLLCGHYNNDGNAP HHHHCCCCCCCCCCC	10.84	27642862
179	Phosphorylation	PSFGLLRSSSVEEKP CCCCCCCCCCCCCCC	27.25	30266825
180	Phosphorylation	SFGLLRSSSVEEKPL CCCCCCCCCCCCCCC	31.78	30266825
181	Phosphorylation	FGLLRSSSVEEKPLS CCCCCCCCCCCCCCC	34.49	23401153
185	Ubiquitination	RSSSVEEKPLSHRNS CCCCCCCCCCCCCCC	37.44	29901268
188	Phosphorylation	SVEEKPLSHRNSLDT CCCCCCCCCCCCCCH	29.00	23403867
217	Ubiquitination	LVTQILEKHKIDNFS HHHHHHHHCCCCCCC	46.91	32015554
219	Ubiquitination	TQILEKHKIDNFSSG HHHHHHCCCCCCCCC	63.92	29901268
238	Acetylation	MCLDILLKCSEDLKK HHHHHHHHCCHHHHH	32.06	12429881
245	Acetylation	KCSEDLKKCTDIIKQ HCCHHHHHHHHHHHH	50.06	12429889
270	Phosphorylation	SEGSGNDTISSSETV CCCCCCCCCCCCHHH	27.10	-
273	Phosphorylation	SGNDTISSSETVYMN CCCCCCCCCHHHHHH	28.48	30576142
274	Phosphorylation	GNDTISSSETVYMNV CCCCCCCCHHHHHHH	30.42	30576142
276	Phosphorylation	DTISSSETVYMNVMT CCCCCCHHHHHHHHH	20.91	30576142
334	Phosphorylation	GTEQPPKYEDVVQLS CCCCCCCHHCEEEEE	24.12	-
341	Phosphorylation	YEDVVQLSASDSGRF HHCEEEEECCCCCCE	14.50	-
343	Phosphorylation	DVVQLSASDSGRFQT CEEEEECCCCCCEEE	29.00	-
345	Phosphorylation	VQLSASDSGRFQTIE EEEECCCCCCEEEEE	29.40	-
368	Phosphorylation	RKMDTVQSIPNNSTN CCCCCCEECCCCCCC	35.36	24114839
373	Phosphorylation	VQSIPNNSTNSLYNL CEECCCCCCCCCEEE	35.29	24114839
378	Phosphorylation	NNSTNSLYNLEVNDP CCCCCCCEEEECCCH	19.95	27642862
476	Phosphorylation	IGKIFEKSFVNLPKE HHHHHHHHHCCCCHH	27.51	28555341
501	Phosphorylation	EGDQRDFTNSSSQEE CCCCCCCCCCCCHHH	38.18	29514088
503	Phosphorylation	DQRDFTNSSSQEEID CCCCCCCCCCHHHHH	28.45	22199227
504	Phosphorylation	QRDFTNSSSQEEIDK CCCCCCCCCHHHHHH	37.80	22199227
505	Phosphorylation	RDFTNSSSQEEIDKL CCCCCCCCHHHHHHH	41.24	22617229
535	Methylation	REPLAKGKNSNFLNS HHHHHCCCCCCCCCC	57.40	-
537	Phosphorylation	PLAKGKNSNFLNSHS HHHCCCCCCCCCCCC	32.23	25394399
558	Phosphorylation	LVDLEPKSKVSSPIE EEECCCCCCCCCCCH	49.34	23403867
561	Phosphorylation	LEPKSKVSSPIEKVS CCCCCCCCCCCHHCC	33.85	30266825
562	Phosphorylation	EPKSKVSSPIEKVSP CCCCCCCCCCHHCCH	32.65	30266825
568	Phosphorylation	SSPIEKVSPSCLTRI CCCCHHCCHHHHHHH	23.36	22199227
570	Phosphorylation	PIEKVSPSCLTRIIE CCHHCCHHHHHHHHH	17.79	26074081
573	Phosphorylation	KVSPSCLTRIIETNG HCCHHHHHHHHHHCC	24.93	22199227
578	Phosphorylation	CLTRIIETNGHKIEE HHHHHHHHCCCCCCH	35.77	26074081
609	Ubiquitination	AQELVECKSSRGSLS HHHHHHHHHCCCCCH	37.65	32015554
610	Phosphorylation	QELVECKSSRGSLSQ HHHHHHHHCCCCCHH	36.61	26699800
611	Phosphorylation	ELVECKSSRGSLSQE HHHHHHHCCCCCHHH	26.59	26699800
614	Phosphorylation	ECKSSRGSLSQEKEM HHHHCCCCCHHHHHH	24.60	26699800
616	Phosphorylation	KSSRGSLSQEKEMMQ HHCCCCCHHHHHHHH	37.68	26699800
630	Phosphorylation	QILQETLTTSSQANL HHHHHHHCCCCCCCC	31.86	28348404
631	Phosphorylation	ILQETLTTSSQANLS HHHHHHCCCCCCCCE	29.50	28348404
632	Phosphorylation	LQETLTTSSQANLSV HHHHHCCCCCCCCEE	18.41	28348404
633	Phosphorylation	QETLTTSSQANLSVC HHHHCCCCCCCCEEE	31.08	28348404
638	Phosphorylation	TSSQANLSVCRSPVG CCCCCCCEEECCCCC	20.98	28348404
642	Phosphorylation	ANLSVCRSPVGDKAK CCCEEECCCCCCCCC	20.86	28348404
660	Phosphorylation	SAVLIQQTPEVIKIQ CEEEEECCCCCEEEC	12.68	28555341
676	Phosphorylation	KPEKKPGTPLPPPAT CCCCCCCCCCCCCCC	30.13	20363803
683	Phosphorylation	TPLPPPATSPSSPRP CCCCCCCCCCCCCCC	47.12	22199227
684	Phosphorylation	PLPPPATSPSSPRPL CCCCCCCCCCCCCCC	25.54	22199227
686	Phosphorylation	PPPATSPSSPRPLSP CCCCCCCCCCCCCCC	53.38	26657352
687	Phosphorylation	PPATSPSSPRPLSPV CCCCCCCCCCCCCCC	28.45	26657352
692	Phosphorylation	PSSPRPLSPVPHVNN CCCCCCCCCCCCCCC	26.91	29255136
706	Phosphorylation	NVVNAPLSINIPRFY CCCCCCCEEECCCEE	16.72	25002506
862	Phosphorylation	YTVNRSWSGKITSTE HHCCCCCCCCCCCCH	31.30	-
868	Phosphorylation	WSGKITSTEIRKSNF CCCCCCCCHHHHCCH	27.12	-
933	Phosphorylation	YNDQASSSRIIERIF HCCCCCHHHHHHHHH	25.63	-
945	Phosphorylation	RIFSGAVTRGKTIQK HHHCCCCCCCCCCCC	32.92	-
949	Phosphorylation	GAVTRGKTIQKEGRM CCCCCCCCCCCCCCC	31.31	-
1074	Acetylation	RDPFAVQKDVENDGP CCCCCCCCCCCCCCC	58.08	12655227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P2R3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P2R3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P2R3A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBL1_HUMAN	RBL1	physical	9927208
PTPA_HUMAN	PPP2R4	physical	18397887
EGFR_HUMAN	EGFR	physical	19825976
LPP_HUMAN	LPP	physical	28514442
LIMD1_HUMAN	LIMD1	physical	28514442
PP2AA_HUMAN	PPP2CA	physical	28514442
2AAB_HUMAN	PPP2R1B	physical	28514442
GTSE1_HUMAN	GTSE1	physical	28514442
TROAP_HUMAN	TROAP	physical	28514442
CE170_HUMAN	CEP170	physical	28514442
WTIP_HUMAN	WTIP	physical	28514442
ZN580_HUMAN	ZNF580	physical	28514442
2AAA_HUMAN	PPP2R1A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.