WTIP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WTIP_HUMAN
• UniProt AC: A6NIX2
• Protein Name: Wilms tumor protein 1-interacting protein
• Gene Name: WTIP
• Organism: Homo sapiens (Human).
• Sequence Length: 430
• Subcellular Localization: Cell junction, adherens junction. Nucleus. Cytoplasm, P-body. Following podocyte injury, caused by treatment with LPS, puromycin aminonucleoside, ultraviolet or hydrogen peroxide, translocates from sites of cell-cell contacts into the cytosol and nuc
• Protein Description: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture (By similarity). In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity)..
• Protein Sequence: MQRSRAGADEAALLLAGLALRELEPGCGSPGRGRRGPRPGPGDEAAPALGRRGKGSGGPEAGADGLSRGERGPRRAAVPELSAQPAGSPRASLAGSDGGGGGGSARSSGISLGYDQRHGSPRSGRSDPRPGPGPPSVGSARSSVSSLGSRGSAGAYADFLPPGACPAPARSPEPAGPAPFPLPALPLPPGREGGPSAAERRLEALTRELERALEARTARDYFGICIKCGLGIYGAQQACQAMGSLYHTDCFTCDSCGRRLRGKAFYNVGEKVYCQEDFLYSGFQQTADKCSVCGHLIMEMILQALGKSYHPGCFRCSVCNECLDGVPFTVDVENNIYCVRDYHTVFAPKCASCARPILPAQGCETTIRVVSMDRDYHVACYHCEDCGLQLSGEEGRRCYPLAGHLLCRRCHLRRLQPGPLPSPTVHVTEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	ELEPGCGSPGRGRRG HCCCCCCCCCCCCCC	28.40	24719451
56	Phosphorylation	LGRRGKGSGGPEAGA HCCCCCCCCCCCCCC	44.02	28509920
67	Phosphorylation	EAGADGLSRGERGPR CCCCCCCCCCCCCCC	43.71	28509920
88	Phosphorylation	LSAQPAGSPRASLAG CCCCCCCCCCCCCCC	17.20	30266825
92	Phosphorylation	PAGSPRASLAGSDGG CCCCCCCCCCCCCCC	21.74	29255136
96	Phosphorylation	PRASLAGSDGGGGGG CCCCCCCCCCCCCCC	27.72	29255136
104	Phosphorylation	DGGGGGGSARSSGIS CCCCCCCCCCCCCCC	24.63	29255136
114	Phosphorylation	SSGISLGYDQRHGSP CCCCCCCCCCCCCCC	17.75	-
120	Phosphorylation	GYDQRHGSPRSGRSD CCCCCCCCCCCCCCC	15.83	32645325
136	Phosphorylation	RPGPGPPSVGSARSS CCCCCCCCCCCCCHH	42.09	24719451
139	Phosphorylation	PGPPSVGSARSSVSS CCCCCCCCCCHHHHH	20.53	27251275
145	Phosphorylation	GSARSSVSSLGSRGS CCCCHHHHHCCCCCC	23.07	-
146	Phosphorylation	SARSSVSSLGSRGSA CCCHHHHHCCCCCCC	34.30	-
149	Phosphorylation	SSVSSLGSRGSAGAY HHHHHCCCCCCCCCC	38.47	-
152	Phosphorylation	SSLGSRGSAGAYADF HHCCCCCCCCCCCCC	23.55	-
156	Phosphorylation	SRGSAGAYADFLPPG CCCCCCCCCCCCCCC	13.04	-
171	Phosphorylation	ACPAPARSPEPAGPA CCCCCCCCCCCCCCC	35.40	25850435
196	Phosphorylation	PGREGGPSAAERRLE CCCCCCCCHHHHHHH	43.30	23403867
280	Phosphorylation	YCQEDFLYSGFQQTA ECCCHHHHCCHHHHH	13.52	27642862
422	Phosphorylation	LQPGPLPSPTVHVTE CCCCCCCCCCEEEEE	40.67	22199227
424	Phosphorylation	PGPLPSPTVHVTEL- CCCCCCCCEEEEEC-	27.81	29523821
428	Phosphorylation	PSPTVHVTEL----- CCCCEEEEEC-----	19.38	29523821

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WTIP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WTIP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WTIP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGLN2_HUMAN	EGLN2	physical	22286099
EGLN3_HUMAN	EGLN3	physical	22286099
VHL_HUMAN	VHL	physical	22286099

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.