dbPTM

VHL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VHL_HUMAN
UniProt AC	P40337
Protein Name	von Hippel-Lindau disease tumor suppressor
Gene Name	VHL
Organism	Homo sapiens (Human).
Sequence Length	213
Subcellular Localization	Isoform 1: Cytoplasm. Membrane Peripheral membrane protein. Nucleus. Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane. Isoform 3: Cytoplasm. Nucleus. Equally
Protein Description	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2..
Protein Sequence	MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	EEDGGEESGAEESGP CCCCCCCCCCCCCCC	38.71	22817900
38	Phosphorylation	EESGAEESGPEESGP CCCCCCCCCCCCCCC	51.67	22817900
43	Phosphorylation	EESGPEESGPEELGA CCCCCCCCCCCCCCH	58.97	22817900
65	Phosphorylation	RPRPVLRSVNSREPS CCCCCCCCCCCCCCC	22.84	28450419
68	Phosphorylation	PVLRSVNSREPSQVI CCCCCCCCCCCCEEE	35.55	28450419
72	Phosphorylation	SVNSREPSQVIFCNR CCCCCCCCEEEEECC	32.12	28450419
79	Methylation	SQVIFCNRSPRVVLP CEEEEECCCCCEEEE	49.58	80702285
80	Phosphorylation	QVIFCNRSPRVVLPV EEEEECCCCCEEEEE	11.76	27251275
100	Phosphorylation	GEPQPYPTLPPGTGR CCCCCCCCCCCCCCC	46.16	-
105	Phosphorylation	YPTLPPGTGRRIHSY CCCCCCCCCCEECEE	33.03	-
111	Phosphorylation	GTGRRIHSYRGHLWL CCCCEECEECCCEEE	17.72	22071692
112	Phosphorylation	TGRRIHSYRGHLWLF CCCEECEECCCEEEE	13.37	-
143 (in isoform 3)	Ubiquitination	-	49.27	21890473
155 (in isoform 2)	Ubiquitination	-	6.84	21890473
159	Neddylation	TLPVYTLKERCLQVV EEEEEEHHHHHHHHH	35.00	-
159	Ubiquitination	TLPVYTLKERCLQVV EEEEEEHHHHHHHHH	35.00	-
168	Phosphorylation	RCLQVVRSLVKPENY HHHHHHHHHCCHHHH	26.38	-
171	Sumoylation	QVVRSLVKPENYRRL HHHHHHCCHHHHHHH	52.48	-
171	Ubiquitination	QVVRSLVKPENYRRL HHHHHHCCHHHHHHH	52.48	-
171	Sumoylation	QVVRSLVKPENYRRL HHHHHHCCHHHHHHH	52.48	-
171	Neddylation	QVVRSLVKPENYRRL HHHHHHCCHHHHHHH	52.48	-
175	Phosphorylation	SLVKPENYRRLDIVR HHCCHHHHHHHHHHH	8.75	29496907
183	Phosphorylation	RRLDIVRSLYEDLED HHHHHHHHHHHHHHH	25.14	-
185	Phosphorylation	LDIVRSLYEDLEDHP HHHHHHHHHHHHHCC	14.51	28796482
196	Ubiquitination	EDHPNVQKDLERLTQ HHCCCHHHHHHHHHH	61.06	21890473
196	Neddylation	EDHPNVQKDLERLTQ HHCCCHHHHHHHHHH	61.06	-
196 (in isoform 1)	Ubiquitination	-	61.06	21890473
202	Phosphorylation	QKDLERLTQERIAHQ HHHHHHHHHHHHHHH	34.31	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
33	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
38	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
43	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
68	S	Phosphorylation	Kinase	GSK3B	G1T8E2	PSP
68	S	Phosphorylation	Kinase	GSK3B	P49841	PSP
72	S	Phosphorylation	Kinase	AURKA	O14965	GPS
72	S	Phosphorylation	Kinase	CSNK1A1	P48729	GPS
100	T	Phosphorylation	Kinase	NEK1	Q96PY6	PSP
105	T	Phosphorylation	Kinase	NEK1	Q96PY6	PSP
111	S	Phosphorylation	Kinase	CHEK2	O96017	GPS
112	Y	Phosphorylation	Kinase	NEK1	Q96PY6	PSP
168	S	Phosphorylation	Kinase	NEK1	Q96PY6	PSP
175	Y	Phosphorylation	Kinase	NEK1	Q96PY6	PSP
183	S	Phosphorylation	Kinase	NEK1	Q96PY6	PSP
202	T	Phosphorylation	Kinase	NEK1	Q96PY6	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VHL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VHL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLNA_HUMAN	FLNA	physical	8674032
FLNA_HUMAN	FLNA	physical	12169691
PFD3_HUMAN	VBP1	physical	8674032
JADE1_HUMAN	JADE1	physical	12169691
CUL2_HUMAN	CUL2	physical	17353931
CAB39_HUMAN	CAB39	physical	17353931
TGFI1_HUMAN	TGFB1I1	physical	17353931
STK16_HUMAN	STK16	physical	17353931
PUR4_HUMAN	PFAS	physical	17353931
ELOC_HUMAN	TCEB1	physical	17353931
PSB1_HUMAN	PSMB1	physical	17353931
ELOB_HUMAN	TCEB2	physical	17353931
RHOC_HUMAN	RHOC	physical	17353931
CNTF_HUMAN	CNTF	physical	17353931
THIO_HUMAN	TXN	physical	17353931
APT_HUMAN	APRT	physical	17353931
CDK2_HUMAN	CDK2	physical	17353931
PK1L3_HUMAN	PKD1L3	physical	17353931
FSCN1_HUMAN	FSCN1	physical	17353931
SYIC_HUMAN	IARS	physical	17353931
PSB3_HUMAN	PSMB3	physical	17353931
GRP1_HUMAN	RASGRP1	physical	17353931
RAB1B_HUMAN	RAB1B	physical	17353931
RBX1_HUMAN	RBX1	physical	17353931
NEDD8_HUMAN	NEDD8	physical	17353931
TAGL2_HUMAN	TAGLN2	physical	17353931
PHOCN_HUMAN	MOB4	physical	17353931
TAP26_HUMAN	CCDC59	physical	17353931
JHD2C_HUMAN	JMJD1C	physical	17353931
CDO1_HUMAN	CDO1	physical	17353931
PAPS2_HUMAN	PAPSS2	physical	17353931
CCD82_HUMAN	CCDC82	physical	17353931
PSD13_HUMAN	PSMD13	physical	17353931
SYTC_HUMAN	TARS	physical	17353931
TCTP_HUMAN	TPT1	physical	17353931
RFA3_HUMAN	RPA3	physical	17353931
KNTC1_HUMAN	KNTC1	physical	17353931
CRCM_HUMAN	MCC	physical	17353931
PIMT_HUMAN	PCMT1	physical	17353931
CYTB_HUMAN	CSTB	physical	17353931
CSTF3_HUMAN	CSTF3	physical	17353931
HYAS1_HUMAN	HAS1	physical	17353931
RS9_HUMAN	RPS9	physical	17353931
IMDH2_HUMAN	IMPDH2	physical	17353931
ATX2_HUMAN	ATXN2	physical	17353931
CHM2B_HUMAN	CHMP2B	physical	17353931
ML12A_HUMAN	MYL12A	physical	17353931
PPIB_HUMAN	PPIB	physical	17353931
PIN1_HUMAN	PIN1	physical	17353931
PRS6A_HUMAN	PSMC3	physical	14556007
HIF1A_HUMAN	HIF1A	physical	14556007
ZN197_HUMAN	ZNF197	physical	12682018
TIF1B_HUMAN	TRIM28	physical	12682018
HIF1N_HUMAN	HIF1AN	physical	11641274
ELOC_HUMAN	TCEB1	physical	10587522
ELOB_HUMAN	TCEB2	physical	10587522
CUL2_HUMAN	CUL2	physical	10587522
FINC_HUMAN	FN1	physical	9651579
PFD3_HUMAN	VBP1	physical	12169691
ELOC_HUMAN	TCEB1	physical	8674032
HIF1A_HUMAN	HIF1A	physical	10944113
ELOC_HUMAN	TCEB1	physical	12004076
ELOB_HUMAN	TCEB2	physical	12004076
HIF1A_HUMAN	HIF1A	physical	12004076
HIF1A_HUMAN	HIF1A	physical	11504942
UBP33_HUMAN	USP33	physical	11739384
ELOC_HUMAN	TCEB1	physical	19030229
ELOB_HUMAN	TCEB2	physical	19030229
CUL2_HUMAN	CUL2	physical	19030229
RIT1_HUMAN	RIT1	physical	19030229
HIF1A_HUMAN	HIF1A	physical	18985005
NR4A1_HUMAN	NR4A1	physical	18305400
HIF1A_HUMAN	HIF1A	physical	18305400
ELOC_HUMAN	TCEB1	physical	18305400
RPB1_HUMAN	POLR2A	physical	18285459
SP130_HUMAN	SAP130	physical	18173839
CUL2_HUMAN	CUL2	physical	18173839
ELOB_HUMAN	TCEB2	physical	18173839
EPAS1_HUMAN	EPAS1	physical	17967880
DGKZ_HUMAN	DGKZ	physical	17350623
HIF1A_HUMAN	HIF1A	physical	17558023
ELOC_HUMAN	TCEB1	physical	17558023
SAT2_HUMAN	SAT2	physical	17558023
CUL2_HUMAN	CUL2	physical	17439941
JADE1_HUMAN	JADE1	physical	14973063
HIF1A_HUMAN	HIF1A	physical	17047048
CUL2_HUMAN	CUL2	physical	16611863
RBX1_HUMAN	RBX1	physical	16325183
HIF1A_HUMAN	HIF1A	physical	16278378
DNJA3_HUMAN	DNAJA3	physical	15805242
HIF1A_HUMAN	HIF1A	physical	15805242
IREB2_HUMAN	IREB2	physical	15777842
P53_HUMAN	TP53	physical	16678111
UBP20_HUMAN	USP20	physical	12056827
HIF1A_HUMAN	HIF1A	physical	12050673
CUL2_HUMAN	CUL2	physical	12048197
RBX1_HUMAN	RBX1	physical	12048197
ELOA1_HUMAN	TCEB3	physical	12048197
ELOB_HUMAN	TCEB2	physical	12048197
HIF1A_HUMAN	HIF1A	physical	14691445
HIF1A_HUMAN	HIF1A	physical	12925778
RPB7_HUMAN	POLR2G	physical	12912922
HIF1A_HUMAN	HIF1A	physical	12808024
HIF1A_HUMAN	HIF1A	physical	12606543
RPB1_HUMAN	POLR2A	physical	12604794
EPAS1_HUMAN	EPAS1	physical	12604794
CUL2_HUMAN	CUL2	physical	12604794
ELOB_HUMAN	TCEB2	physical	12604794
ELOC_HUMAN	TCEB1	physical	12604794
RBX1_HUMAN	RBX1	physical	12604794
HIF3A_HUMAN	HIF3A	physical	12538644
HIF1A_HUMAN	HIF1A	physical	12538644
HIF1A_HUMAN	HIF1A	physical	12464182
TCPG_HUMAN	CCT3	physical	11865071
CUL2_HUMAN	CUL2	physical	11865071
HIF1A_HUMAN	HIF1A	physical	11566883
HIF1A_HUMAN	HIF1A	physical	11331613
EPAS1_HUMAN	EPAS1	physical	11331613
HIF1A_HUMAN	HIF1A	physical	11292861
HIF1A_HUMAN	HIF1A	physical	10973499
HIF1A_HUMAN	HIF1A	physical	10878807
HIF1A_HUMAN	HIF1A	physical	10823831
EPAS1_HUMAN	EPAS1	physical	10823831
CUL2_HUMAN	CUL2	physical	10823831
ELOB_HUMAN	TCEB2	physical	10823831
ELOC_HUMAN	TCEB1	physical	10823831
CUL2_HUMAN	CUL2	physical	10421634
ELOC_HUMAN	TCEB1	physical	10421634
MCM7_HUMAN	MCM7	physical	21658608
KPCI_HUMAN	PRKCI	physical	11574546
MYOG_MOUSE	Myog	physical	17344222
DVL2_HUMAN	DVL2	physical	20639871
CUL2_HUMAN	CUL2	physical	17132228
HIF1A_HUMAN	HIF1A	physical	20049704
CUL2_HUMAN	CUL2	physical	20049704
ELOB_HUMAN	TCEB2	physical	20049704
CUL2_HUMAN	CUL2	physical	15060148
HIF1A_HUMAN	HIF1A	physical	15060148
ELOC_HUMAN	TCEB1	physical	15060148
ELOB_HUMAN	TCEB2	physical	15060148
FINC_HUMAN	FN1	physical	15060148
SPY2_HUMAN	SPRY2	physical	22006925
ANR40_HUMAN	ANKRD40	physical	21942715
CDN2A_HUMAN	CDKN2A	physical	21942715
ARF_HUMAN	CDKN2A	physical	21942715
CHIP_HUMAN	STUB1	physical	21942715
COXM2_HUMAN	CMC2	physical	21942715
CUL2_HUMAN	CUL2	physical	21942715
DDX17_HUMAN	DDX17	physical	21942715
DDX3X_HUMAN	DDX3X	physical	21942715
DDX3Y_HUMAN	DDX3Y	physical	21942715
DDX5_HUMAN	DDX5	physical	21942715
DNJA1_HUMAN	DNAJA1	physical	21942715
DNJA2_HUMAN	DNAJA2	physical	21942715
DNJA3_HUMAN	DNAJA3	physical	21942715
ELOB_HUMAN	TCEB2	physical	21942715
ELOC_HUMAN	TCEB1	physical	21942715
EPHA4_HUMAN	EPHA4	physical	21942715
GRWD1_HUMAN	GRWD1	physical	21942715
GT251_HUMAN	COLGALT1	physical	21942715
HNRDL_HUMAN	HNRNPDL	physical	21942715
HNRH1_HUMAN	HNRNPH1	physical	21942715
HNRH2_HUMAN	HNRNPH2	physical	21942715
HNRLL_HUMAN	HNRNPLL	physical	21942715
HNRPC_HUMAN	HNRNPC	physical	21942715
HNRPD_HUMAN	HNRNPD	physical	21942715
HNRPL_HUMAN	HNRNPL	physical	21942715
HNRPM_HUMAN	HNRNPM	physical	21942715
HNRPR_HUMAN	HNRNPR	physical	21942715
IF5A1_HUMAN	EIF5A	physical	21942715
IF5A2_HUMAN	EIF5A2	physical	21942715
NKRF_HUMAN	NKRF	physical	21942715
P53_HUMAN	TP53	physical	21942715
RALYL_HUMAN	RALYL	physical	21942715
RBBP4_HUMAN	RBBP4	physical	21942715
RBBP7_HUMAN	RBBP7	physical	21942715
RL12_HUMAN	RPL12	physical	21942715
RL14_HUMAN	RPL14	physical	21942715
RL18A_HUMAN	RPL18A	physical	21942715
ROA2_HUMAN	HNRNPA2B1	physical	21942715
ROA3_HUMAN	HNRNPA3	physical	21942715
RS11_HUMAN	RPS11	physical	21942715
RS14_HUMAN	RPS14	physical	21942715
RS17_HUMAN	RPS17	physical	21942715
RS27L_HUMAN	RPS27L	physical	21942715
RS27_HUMAN	RPS27	physical	21942715
RS2_HUMAN	RPS2	physical	21942715
RS3A_HUMAN	RPS3A	physical	21942715
RS3_HUMAN	RPS3	physical	21942715
RSSA_HUMAN	RPSA	physical	21942715
RU17_HUMAN	SNRNP70	physical	21942715
TBA1A_HUMAN	TUBA1A	physical	21942715
TBA3C_HUMAN	TUBA3C	physical	21942715
TBA3E_HUMAN	TUBA3E	physical	21942715
TBA4A_HUMAN	TUBA4A	physical	21942715
TCPA_HUMAN	TCP1	physical	21942715
TCPB_HUMAN	CCT2	physical	21942715
TCPD_HUMAN	CCT4	physical	21942715
TCPE_HUMAN	CCT5	physical	21942715
TCPG_HUMAN	CCT3	physical	21942715
TCPH_HUMAN	CCT7	physical	21942715
TCPQ_HUMAN	CCT8	physical	21942715
TCPZ_HUMAN	CCT6A	physical	21942715
TRAD1_HUMAN	TRAFD1	physical	21942715
UBR5_HUMAN	UBR5	physical	21942715
ANM3_HUMAN	PRMT3	physical	21942715
ACTB_HUMAN	ACTB	physical	21942715
BASI_HUMAN	BSG	physical	21942715
CO4A1_HUMAN	COL4A1	physical	21942715
CO4A2_HUMAN	COL4A2	physical	21942715
CO4A3_HUMAN	COL4A3	physical	21942715
CO4A5_HUMAN	COL4A5	physical	21942715
CO4A6_HUMAN	COL4A6	physical	21942715
CO6A1_HUMAN	COL6A1	physical	21942715
CRTAP_HUMAN	CRTAP	physical	21942715
FAKD3_HUMAN	FASTKD3	physical	21942715
FINC_HUMAN	FN1	physical	21942715
GRN_HUMAN	GRN	physical	21942715
HNRPK_HUMAN	HNRNPK	physical	21942715
HNRPU_HUMAN	HNRNPU	physical	21942715
HSP7C_HUMAN	HSPA8	physical	21942715
MIF_HUMAN	MIF	physical	21942715
NS1BP_HUMAN	IVNS1ABP	physical	21942715
P3H1_HUMAN	P3H1	physical	21942715
PARP1_HUMAN	PARP1	physical	21942715
PLOD2_HUMAN	PLOD2	physical	21942715
PLOD3_HUMAN	PLOD3	physical	21942715
PPM1B_HUMAN	PPM1B	physical	21942715
RL10A_HUMAN	RPL10A	physical	21942715
RL30_HUMAN	RPL30	physical	21942715
RL7A_HUMAN	RPL7A	physical	21942715
RLA0_HUMAN	RPLP0	physical	21942715
ROA1_HUMAN	HNRNPA1	physical	21942715
ROAA_HUMAN	HNRNPAB	physical	21942715
RS15A_HUMAN	RPS15A	physical	21942715
RS5_HUMAN	RPS5	physical	21942715
STK38_HUMAN	STK38	physical	21942715
TBB4B_HUMAN	TUBB4B	physical	21942715
VHL_HUMAN	VHL	physical	21942715
XRCC5_HUMAN	XRCC5	physical	21942715
SKP2_HUMAN	SKP2	physical	21358672
HIF1A_HUMAN	HIF1A	physical	21358672
ELOC_HUMAN	TCEB1	physical	17244529
CLUS_HUMAN	CLU	physical	22532874
SIS1_YEAST	SIS1	physical	22718905
MYC_HUMAN	MYC	physical	22286234
CUL2_HUMAN	CUL2	physical	16503656
ELOB_HUMAN	TCEB2	physical	16503656
ELOC_HUMAN	TCEB1	physical	16503656
RBX1_HUMAN	RBX1	physical	16503656
PIAS4_HUMAN	PIAS4	physical	20300531
ELOC_HUMAN	TCEB1	physical	20300531
CUL2_HUMAN	CUL2	physical	16261165
RBX1_HUMAN	RBX1	physical	16261165
EPAS1_HUMAN	EPAS1	physical	11292862
HIF1A_HUMAN	HIF1A	physical	11292862
OSR1_HUMAN	OSR1	physical	12205091
CUL2_HUMAN	CUL2	physical	9447969
CBX5_HUMAN	CBX5	physical	22234250
CUL2_HUMAN	CUL2	physical	22234250
ELOB_HUMAN	TCEB2	physical	22234250
ELOC_HUMAN	TCEB1	physical	22234250
B2L11_HUMAN	BCL2L11	physical	19305426
ELOC_RAT	Tceb1	physical	9341197
ELOB_RAT	Tceb2	physical	9341197
HIF1A_HUMAN	HIF1A	physical	12086861
ELOC_HUMAN	TCEB1	physical	15611064
CUL2_HUMAN	CUL2	physical	15611064
HIF1A_HUMAN	HIF1A	physical	15611064
EPAS1_HUMAN	EPAS1	physical	15611064
CUL2_HUMAN	CUL2	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417
KPCD_HUMAN	PRKCD	physical	16669786
HIF1A_HUMAN	HIF1A	physical	17339318
EPAS1_HUMAN	EPAS1	physical	17339318
CUL2_HUMAN	CUL2	physical	17339318
ELOB_HUMAN	TCEB2	physical	17339318
TCPA_HUMAN	TCP1	physical	17339318
TCPE_HUMAN	CCT5	physical	17339318
TCPH_HUMAN	CCT7	physical	17339318
CO4A1_HUMAN	COL4A1	physical	17339318
CO4A2_HUMAN	COL4A2	physical	17339318
CO4A3_HUMAN	COL4A3	physical	17339318
ELOC_HUMAN	TCEB1	physical	21685897
CUL2_HUMAN	CUL2	physical	21685897
JAK2_HUMAN	JAK2	physical	21685897
SOCS1_HUMAN	SOCS1	physical	21685897
EPAS1_HUMAN	EPAS1	physical	21685897
LIMD1_HUMAN	LIMD1	physical	22286099
EGLN1_HUMAN	EGLN1	physical	22286099
CUL2_HUMAN	CUL2	physical	22286099
ELOB_HUMAN	TCEB2	physical	22286099
CUL2_HUMAN	CUL2	physical	11024059
FINC_HUMAN	FN1	physical	11024059
HIF1A_HUMAN	HIF1A	physical	11024059
RACK1_HUMAN	GNB2L1	physical	20871634
ELOB_HUMAN	TCEB2	physical	20871634
ELOC_HUMAN	TCEB1	physical	20871634
KPCL_HUMAN	PRKCH	physical	10491320
KPCZ_HUMAN	PRKCZ	physical	10491320
VHL_HUMAN	VHL	physical	16407835
HIF1A_HUMAN	HIF1A	physical	11358837
CUL2_HUMAN	CUL2	physical	11779168
HIF1A_HUMAN	HIF1A	physical	17986458
ELOC_HUMAN	TCEB1	physical	17986458
ELOB_HUMAN	TCEB2	physical	17986458
EPAS1_HUMAN	EPAS1	physical	17986458
DGKI_HUMAN	DGKI	physical	17986458
KIF2C_HUMAN	KIF2C	physical	17986458
SARNP_HUMAN	SARNP	physical	17986458
CAN7_HUMAN	CAPN7	physical	17986458
YYAP1_HUMAN	YY1AP1	physical	17986458
RBPS2_HUMAN	RBPMS2	physical	17986458
RBCC1_HUMAN	RB1CC1	physical	17986458
FKBP8_HUMAN	FKBP8	physical	17986458
CUL2_HUMAN	CUL2	physical	10318914
ELOB_HUMAN	TCEB2	physical	9122164
ELOC_HUMAN	TCEB1	physical	9122164
CUL2_HUMAN	CUL2	physical	9122164
CDN2A_HUMAN	CDKN2A	physical	7604013
ARF_HUMAN	CDKN2A	physical	7604013
EXOS8_HUMAN	EXOSC8	physical	7604013
ELAV1_HUMAN	ELAVL1	physical	16170373
HIF1A_HUMAN	HIF1A	physical	11986208
KIF3A_HUMAN	KIF3A	physical	17825299
KIF3B_HUMAN	KIF3B	physical	17825299
KIFA3_HUMAN	KIFAP3	physical	17825299
HIF1A_HUMAN	HIF1A	physical	10353251
EPAS1_HUMAN	EPAS1	physical	10353251
ELOC_HUMAN	TCEB1	physical	9751722
ELOB_HUMAN	TCEB2	physical	9751722
FINC_HUMAN	FN1	physical	9751722
CUL2_HUMAN	CUL2	physical	9751722
ELOC_HUMAN	TCEB1	physical	14636579
ELOB_HUMAN	TCEB2	physical	14636579
HIF1A_HUMAN	HIF1A	physical	12351678
PAR6A_HUMAN	PARD6A	physical	17101696
PARD3_HUMAN	PARD3	physical	17101696
KPCZ_HUMAN	PRKCZ	physical	17101696
KLF4_HUMAN	KLF4	physical	22284679
TBA1A_HUMAN	TUBA1A	physical	12510195
SP1_HUMAN	SP1	physical	17486080
ELAV1_HUMAN	ELAVL1	physical	17486080
ELOB_HUMAN	TCEB2	physical	7660130
ELOC_HUMAN	TCEB1	physical	7660130
CUL2_HUMAN	CUL2	physical	10449727
ELOC_HUMAN	TCEB1	physical	10449727
ELOB_HUMAN	TCEB2	physical	10449727
HNRPD_HUMAN	HNRNPD	physical	22086907
CUL2_HUMAN	CUL2	physical	22086907
ELOB_HUMAN	TCEB2	physical	7660122
ELOC_HUMAN	TCEB1	physical	7660122
CARD9_HUMAN	CARD9	physical	17936701
MKNK2_HUMAN	MKNK2	physical	16856496
UB2D1_HUMAN	UBE2D1	physical	20639871
UB2R1_HUMAN	CDC34	physical	11566883
A4_HUMAN	APP	physical	21832049
UBP33_HUMAN	USP33	physical	19706539
CUL2_HUMAN	CUL2	physical	15601820
RBX1_HUMAN	RBX1	physical	15601820
ELOB_HUMAN	TCEB2	physical	15601820
ELOC_HUMAN	TCEB1	physical	15601820
ELOB_MOUSE	Tceb2	physical	15601820
ELOC_MOUSE	Tceb1	physical	15601820
CUL2_MOUSE	Cul2	physical	15601820
RBX1_MOUSE	Rbx1	physical	15601820
CUL2_HUMAN	CUL2	physical	23401859
RBX1_HUMAN	RBX1	physical	23401859
EPAS1_HUMAN	EPAS1	physical	23401859
TGM2_HUMAN	TGM2	physical	21625219
VHL_HUMAN	VHL	physical	21625219
ELOB_HUMAN	TCEB2	physical	18323857
ELOC_HUMAN	TCEB1	physical	18323857
FINC_HUMAN	FN1	physical	18323857
HIF1A_HUMAN	HIF1A	physical	18323857
CUL2_HUMAN	CUL2	physical	18323857
FZR1_HUMAN	FZR1	physical	20802534
PCGF2_HUMAN	PCGF2	physical	21602890
HIF1A_HUMAN	HIF1A	physical	21602890
CHK2_HUMAN	CHEK2	physical	22071692
KAT5_HUMAN	KAT5	physical	22071692
EP300_HUMAN	EP300	physical	22071692
RS3_HUMAN	RPS3	physical	23612971
RS3A_HUMAN	RPS3A	physical	23612971
RS6_HUMAN	RPS6	physical	23612971
NOB1_HUMAN	NOB1	physical	23612971
RL11_HUMAN	RPL11	physical	23612971
LTV1_HUMAN	LTV1	physical	23612971
HIF1A_HUMAN	HIF1A	physical	23580587
ANM1_HUMAN	PRMT1	physical	23455924
UXT_HUMAN	UXT	physical	23961993
ANDR_HUMAN	AR	physical	23961993
NAM7_YEAST	NAM7	physical	23928302
SON_HUMAN	SON	physical	22234250
EF1B_HUMAN	EEF1B2	physical	22234250
RL21_HUMAN	RPL21	physical	22234250
RBPMS_HUMAN	RBPMS	physical	22234250
VAPB_HUMAN	VAPB	physical	22234250
NUCL_HUMAN	NCL	physical	22234250
RS15A_HUMAN	RPS15A	physical	22234250
GTR1_HUMAN	SLC2A1	physical	22234250
CD44_HUMAN	CD44	physical	22234250
4F2_HUMAN	SLC3A2	physical	22234250
ACTB_HUMAN	ACTB	physical	22234250
CBR1_HUMAN	CBR1	physical	22234250
H12_HUMAN	HIST1H1C	physical	22234250
CAPZB_HUMAN	CAPZB	physical	22234250
H2B1L_HUMAN	HIST1H2BL	physical	22234250
LANC1_HUMAN	LANCL1	physical	22234250
GRP78_HUMAN	HSPA5	physical	22234250
PRDX1_HUMAN	PRDX1	physical	22234250
RL5_HUMAN	RPL5	physical	22234250
CBX1_HUMAN	CBX1	physical	22234250
CBX3_HUMAN	CBX3	physical	22234250
HSP7C_HUMAN	HSPA8	physical	22234250
ANM8_HUMAN	PRMT8	physical	23455924
HIF1A_HUMAN	HIF1A	physical	24316222
HNRPL_HUMAN	HNRNPL	physical	23976881
ROA2_HUMAN	HNRNPA2B1	physical	23976881
ILF3_HUMAN	ILF3	physical	23976881
PIAS4_HUMAN	PIAS4	physical	24002598
CUL2_HUMAN	CUL2	physical	24469044
RBX1_HUMAN	RBX1	physical	24469044
ELOB_HUMAN	TCEB2	physical	24469044
ELOC_HUMAN	TCEB1	physical	24469044
PDCD5_HUMAN	PDCD5	physical	24469044
PARK7_HUMAN	PARK7	physical	24899725
HIF1A_HUMAN	HIF1A	physical	24899725
AURKA_HUMAN	AURKA	physical	23785518
GLI1_HUMAN	GLI1	physical	23395608
E2F1_HUMAN	E2F1	physical	24112038
SIR1_HUMAN	SIRT1	physical	24112038
HIF1A_HUMAN	HIF1A	physical	23318261
TCPA_HUMAN	TCP1	physical	23318261
HSP74_HUMAN	HSPA4	physical	23318261
HS90A_HUMAN	HSP90AA1	physical	23318261
TCTP_HUMAN	TPT1	physical	23387829
PLD1_HUMAN	PLD1	physical	25361009
HIF1A_HUMAN	HIF1A	physical	25361009
UBC_HUMAN	UBC	physical	10421634
UB2D2_HUMAN	UBE2D2	physical	22086907
RWDD3_HUMAN	RWDD3	physical	25500545
HIF1A_HUMAN	HIF1A	physical	25500545
ELOC_HUMAN	TCEB1	physical	25500545
ELOB_HUMAN	TCEB2	physical	25500545
EPAS1_HUMAN	EPAS1	physical	25500545
ELOB_HUMAN	TCEB2	physical	25661653
ELOC_HUMAN	TCEB1	physical	25661653
CUL2_HUMAN	CUL2	physical	25661653
GOGA4_HUMAN	GOLGA4	physical	26496610
TRIPC_HUMAN	TRIP12	physical	26496610
ZN350_HUMAN	ZNF350	physical	25749518
EP300_HUMAN	EP300	physical	25749518
CUL2_HUMAN	CUL2	physical	26735018
RBX1_HUMAN	RBX1	physical	26735018
ELOC_HUMAN	TCEB1	physical	26735018
ELOB_HUMAN	TCEB2	physical	26735018
ID2_HUMAN	ID2	physical	26735018
HIF1A_HUMAN	HIF1A	physical	26611735
PLD2_HUMAN	PLD2	physical	26611735
CUL2_HUMAN	CUL2	physical	26751167
TADBP_HUMAN	TARDBP	physical	26751167
ELOC_HUMAN	TCEB1	physical	26751167
ELOB_HUMAN	TCEB2	physical	26751167
PHLD_HUMAN	GPLD1	physical	26680696
CERKL_HUMAN	CERKL	physical	26296657
EPOR_HUMAN	EPOR	physical	26846855
CUL2_HUMAN	CUL2	physical	26846855
DACT1_HUMAN	DACT1	physical	25825496
HIF1A_HUMAN	HIF1A	physical	26215701
EGLN1_HUMAN	EGLN1	physical	26215701
RHBT3_HUMAN	RHOBTB3	physical	26215701
LIMD1_HUMAN	LIMD1	physical	26215701
HIF1A_HUMAN	HIF1A	physical	23413029
UBE2S_HUMAN	UBE2S	physical	27685940
ELOB_HUMAN	TCEB2	physical	27517496
ELOC_HUMAN	TCEB1	physical	27517496
HUWE1_HUMAN	HUWE1	physical	27517496
USP9X_HUMAN	USP9X	physical	27517496
CUL2_HUMAN	CUL2	physical	26743088
SQSTM_HUMAN	SQSTM1	physical	26743088
HIF1A_HUMAN	HIF1A	physical	26743088
HIF1A_HUMAN	HIF1A	physical	27281823
CUL2_HUMAN	CUL2	physical	27697924
CEP68_HUMAN	CEP68	physical	28089774
HIF1A_HUMAN	HIF1A	physical	12101228
MCAF1_HUMAN	ATF7IP	physical	28514442
SETB1_HUMAN	SETDB1	physical	28514442
AL14E_HUMAN	ARL14EP	physical	28514442
CUL2_HUMAN	CUL2	physical	28514442
ELOC_HUMAN	TCEB1	physical	28514442
ELOB_HUMAN	TCEB2	physical	28514442
UTRO_HUMAN	UTRN	physical	28514442
ACTBL_HUMAN	ACTBL2	physical	28514442
AURKA_HUMAN	AURKA	physical	28114281
AKT1_HUMAN	AKT1	physical	27563096
AKT1_MOUSE	Akt1	physical	27563096
AKT2_HUMAN	AKT2	physical	27563096
HIF1A_HUMAN	HIF1A	physical	27563096
PP2AA_HUMAN	PPP2CA	physical	27563096
FAS_HUMAN	FASN	physical	28775317
PYR1_HUMAN	CAD	physical	28775317
HIF1A_HUMAN	HIF1A	physical	28775317
CUL2_HUMAN	CUL2	physical	28775317
ELOB_HUMAN	TCEB2	physical	28775317
ELOC_HUMAN	TCEB1	physical	28775317
EPAS1_HUMAN	EPAS1	physical	28775317
RPB1_HUMAN	POLR2A	physical	28775317
IL32_HUMAN	IL32	physical	29050245
KPCD_HUMAN	PRKCD	physical	29050245

Drug and Disease Associations

Kegg Disease
H00021	Renal cell carcinoma
H00236	Congenital polycythemia; Familial erythrocytosis (ECYT)
H00559	von Hippel-Lindau syndrome
OMIM Disease
171300	Pheochromocytoma (PCC)
193300	von Hippel-Lindau disease (VHLD)
263400	Erythrocytosis, familial, 2 (ECYT2)
144700	Renal cell carcinoma (RCC)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VHL_HUMAN

Related Literatures of Post-Translational Modification