dbPTM

NR4A1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	NR4A1_HUMAN
UniProt AC	P22736
Protein Name	Nuclear receptor subfamily 4 group A member 1
Gene Name	NR4A1
Organism	Homo sapiens (Human).
Sequence Length	598
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation..
Protein Sequence	MPCIQAQYGTPAPSPGPRDHLASDPLTPEFIKPTMDLASPEAAPAAPTALPSFSTFMDGYTGEFDTFLYQLPGTVQPCSSASSSASSTSSSSATSPASASFKFEDFQVYGCYPGPLSGPVDEALSSSGSDYYGSPCSAPSPSTPSFQPPQLSPWDGSFGHFSPSQTYEGLRAWTEQLPKASGPPQPPAFFSFSPPTGPSPSLAQSPLKLFPSQATHQLGEGESYSMPTAFPGLAPTSPHLEGSGILDTPVTSTKARSGAPGGSEGRCAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKQPPDASPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYDLLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MPCIQAQYGTPAPSP CCCEECCCCCCCCCC	26.44	26270265
10	Phosphorylation	CIQAQYGTPAPSPGP CEECCCCCCCCCCCC	16.02	25159151
14	Phosphorylation	QYGTPAPSPGPRDHL CCCCCCCCCCCCCCC	44.59	25159151
23	Phosphorylation	GPRDHLASDPLTPEF CCCCCCCCCCCCHHH	46.23	25159151
27	Phosphorylation	HLASDPLTPEFIKPT CCCCCCCCHHHHCCC	26.59	25159151
48	Phosphorylation	EAAPAAPTALPSFST CCCCCCCCCCCCCCH	35.78	-
52	Phosphorylation	AAPTALPSFSTFMDG CCCCCCCCCCHHHCC	32.45	-
54	Phosphorylation	PTALPSFSTFMDGYT CCCCCCCCHHHCCCC	25.69	-
55	Phosphorylation	TALPSFSTFMDGYTG CCCCCCCHHHCCCCC	22.44	-
60	Phosphorylation	FSTFMDGYTGEFDTF CCHHHCCCCCEEEEE	13.80	-
61	Phosphorylation	STFMDGYTGEFDTFL CHHHCCCCCEEEEEE	35.45	-
95	Phosphorylation	TSSSSATSPASASFK CCCCCCCCCCEECEE	20.41	22002310
100	Phosphorylation	ATSPASASFKFEDFQ CCCCCEECEEECCEE	26.86	24719451
102	Sumoylation	SPASASFKFEDFQVY CCCEECEEECCEEEE	45.40	-
140	Phosphorylation	GSPCSAPSPSTPSFQ CCCCCCCCCCCCCCC	31.06	22002310
143	Phosphorylation	CSAPSPSTPSFQPPQ CCCCCCCCCCCCCCC	26.74	22234305
152	Phosphorylation	SFQPPQLSPWDGSFG CCCCCCCCCCCCCCC	20.78	-
174	Phosphorylation	YEGLRAWTEQLPKAS HHHHHHHHHHCCCCC	16.93	28555341
191	Phosphorylation	PQPPAFFSFSPPTGP CCCCCEEECCCCCCC	20.54	28102081
193	Phosphorylation	PPAFFSFSPPTGPSP CCCEEECCCCCCCCC	28.86	25159151
196	Phosphorylation	FFSFSPPTGPSPSLA EEECCCCCCCCCCHH	66.17	21712546
199	Phosphorylation	FSPPTGPSPSLAQSP CCCCCCCCCCHHCCC	28.59	25850435
201	Phosphorylation	PPTGPSPSLAQSPLK CCCCCCCCHHCCCCC	40.45	18691976
205	Phosphorylation	PSPSLAQSPLKLFPS CCCCHHCCCCCCCCC	26.96	25850435
214	Phosphorylation	LKLFPSQATHQLGEG CCCCCCCCCCCCCCC	16.04	24719451
218	Phosphorylation	PSQATHQLGEGESYS CCCCCCCCCCCCCCC	5.38	27251275
236	Phosphorylation	AFPGLAPTSPHLEGS CCCCCCCCCCCCCCC	49.65	26074081
237	Phosphorylation	FPGLAPTSPHLEGSG CCCCCCCCCCCCCCC	14.84	26074081
243	Phosphorylation	TSPHLEGSGILDTPV CCCCCCCCCCCCCCC	17.18	28348404
257	Phosphorylation	VTSTKARSGAPGGSE CCCCCCCCCCCCCCC	44.13	-
263	Phosphorylation	RSGAPGGSEGRCAVC CCCCCCCCCCCEEEC	42.67	21712546
279	Phosphorylation	DNASCQHYGVRTCEG CCCCCCCCCCCCCCC	7.46	-
283	Phosphorylation	CQHYGVRTCEGCKGF CCCCCCCCCCCCCCH	16.71	-
288	Acetylation	VRTCEGCKGFFKRTV CCCCCCCCCHHHHHH	70.39	26051181
300	Sumoylation	RTVQKNAKYICLANK HHHHHCCCEEEECCC	44.54	-
300	Sumoylation	RTVQKNAKYICLANK HHHHHCCCEEEECCC	44.54	-
300	Ubiquitination	RTVQKNAKYICLANK HHHHHCCCEEEECCC	44.54	-
300	Acetylation	RTVQKNAKYICLANK HHHHHCCCEEEECCC	44.54	26051181
307	Ubiquitination	KYICLANKDCPVDKR CEEEECCCCCCCCHH	55.91	-
307	Acetylation	KYICLANKDCPVDKR CEEEECCCCCCCCHH	55.91	26051181
339	Phosphorylation	MVKEVVRTDSLKGRR CEEEEEECCCCCCCC	20.52	28102081
341	Phosphorylation	KEVVRTDSLKGRRGR EEEEECCCCCCCCCC	31.22	28355574
351	Phosphorylation	GRRGRLPSKPKQPPD CCCCCCCCCCCCCCC	67.21	22322096
360	Phosphorylation	PKQPPDASPANLLTS CCCCCCCCHHHHHHH	31.74	22322096
364	Phosphorylation	PDASPANLLTSLVRA CCCCHHHHHHHHHHH	6.32	24719451
381	Sumoylation	DSGPSTAKLDYSKFQ HCCCCCCCCCHHHHH	41.81	-
381	Ubiquitination	DSGPSTAKLDYSKFQ HCCCCCCCCCHHHHH	41.81	21906983
381	Sumoylation	DSGPSTAKLDYSKFQ HCCCCCCCCCHHHHH	41.81	-
386	Ubiquitination	TAKLDYSKFQELVLP CCCCCHHHHHHHHCC	44.85	-
431	Phosphorylation	IPGFAELSPADQDLL CCCCCCCCHHHHHHH	15.00	22002310
558	Ubiquitination	CLSRLLGKLPELRTL HHHHHHCCCHHHHHH	61.92	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
95	S	Phosphorylation	Kinase	MAPK8	P45983	GPS
95	S	Phosphorylation	Kinase	JNK-SUBFAMILY	-	GPS
152	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
341	S	Phosphorylation	Kinase	PKA	-	Uniprot
351	S	Phosphorylation	Kinase	AKT1	P31749	PSP
351	S	Phosphorylation	Kinase	AKT1	P31750	PSP
351	S	Phosphorylation	Kinase	AKT-FAMILY	-	GPS
351	S	Phosphorylation	Kinase	PKB_GROUP	-	PhosphoELM
431	S	Phosphorylation	Kinase	MAPK1	P28482	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
351	S	Phosphorylation		17360704
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of NR4A1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
G45IP_HUMAN	GADD45GIP1	physical	15459248
BCL2_HUMAN	BCL2	physical	14980220
RXRA_HUMAN	RXRA	physical	14980220
NCOA3_HUMAN	NCOA3	physical	12082103
NCOA1_HUMAN	NCOA1	physical	12082103
EP300_HUMAN	EP300	physical	12082103
KAT2B_HUMAN	KAT2B	physical	12082103
RXRG_HUMAN	RXRG	physical	12082103
FXYD3_HUMAN	FXYD3	physical	16169070
PML_HUMAN	PML	physical	12032831
VHL_HUMAN	VHL	physical	18305400
HIF1A_HUMAN	HIF1A	physical	18305400
P53_HUMAN	TP53	physical	17139261
CHD4_HUMAN	CHD4	physical	19321449
TOP2A_HUMAN	TOP2A	physical	19321449
PELP1_HUMAN	PELP1	physical	19321449
SMRC1_HUMAN	SMARCC1	physical	19321449
MBB1A_HUMAN	MYBBP1A	physical	19321449
MTA2_HUMAN	MTA2	physical	19321449
TIF1B_HUMAN	TRIM28	physical	19321449
SMCE1_HUMAN	SMARCE1	physical	19321449
TMOD3_HUMAN	TMOD3	physical	19321449
EF1A1_HUMAN	EEF1A1	physical	19321449
HDAC6_HUMAN	HDAC6	physical	19321449
DPOA2_HUMAN	POLA2	physical	21900206
HES1_HUMAN	HES1	physical	21900206
ROBO2_HUMAN	ROBO2	physical	21900206
GCR_HUMAN	NR3C1	physical	21900206
ZN579_HUMAN	ZNF579	physical	21900206
HS90B_HUMAN	HSP90AB1	physical	21900206
MED31_HUMAN	MED31	physical	21900206
RL7_HUMAN	RPL7	physical	21900206
RTN4_HUMAN	RTN4	physical	21900206
BBS10_HUMAN	BBS10	physical	21900206
NACAD_HUMAN	NACAD	physical	21900206
ZN331_HUMAN	ZNF331	physical	21900206
PRDX4_HUMAN	PRDX4	physical	21900206
GLOD4_HUMAN	GLOD4	physical	21900206
ROA2_HUMAN	HNRNPA2B1	physical	21900206
ITF2_HUMAN	TCF4	physical	21900206
CHD3_HUMAN	CHD3	physical	21900206
KAIN_HUMAN	SERPINA4	physical	21900206
FAF1_HUMAN	FAF1	physical	21900206
CXCL7_HUMAN	PPBP	physical	21900206
CTNB1_HUMAN	CTNNB1	physical	21986938
RXRA_HUMAN	RXRA	physical	17761950
STAT3_HUMAN	STAT3	physical	21988832
SGT1_HUMAN	SUGT1	physical	21988832
RBL1_HUMAN	RBL1	physical	21988832
IC1_HUMAN	SERPING1	physical	21988832
SMAD3_HUMAN	SMAD3	physical	21988832
PPM1A_HUMAN	PPM1A	physical	21988832
PRDX6_HUMAN	PRDX6	physical	21988832
PRDX4_HUMAN	PRDX4	physical	21988832
SOCS4_HUMAN	SOCS4	physical	21988832
TBB4A_HUMAN	TUBB4A	physical	20195357
CUTA_HUMAN	CUTA	physical	20195357
AKIB1_HUMAN	ANKIB1	physical	20195357
VASP_HUMAN	VASP	physical	20195357
PGBD1_HUMAN	PGBD1	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
KR101_HUMAN	KRTAP10-1	physical	25416956
RXRA_HUMAN	RXRA	physical	7705655
KS6A5_HUMAN	RPS6KA5	physical	25241761
SMAD7_HUMAN	SMAD7	physical	24584437
RNF12_HUMAN	RLIM	physical	24584437
RN111_HUMAN	RNF111	physical	24584437
AXIN2_HUMAN	AXIN2	physical	24584437
MIDN_HUMAN	MIDN	physical	28514442
ACD11_HUMAN	ACAD11	physical	28514442
TMTC4_HUMAN	TMTC4	physical	28514442
GRK6_HUMAN	GRK6	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of NR4A1_HUMAN

Related Literatures of Post-Translational Modification

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