dbPTM

ZN579_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	ZN579_HUMAN
UniProt AC	Q8NAF0
Protein Name	Zinc finger protein 579
Gene Name	ZNF579
Organism	Homo sapiens (Human).
Sequence Length	562
Subcellular Localization	Nucleus .
Protein Description	May be involved in transcriptional regulation..
Protein Sequence	MDPQPPPPAQGSPPHRGRGRGRGRGRGRGRGRGRGGAGAPRAPLPCPTCGRLFRFPYYLSRHRLSHSGLRPHACPLCPKAFRRPAHLSRHLRGHGPQPPLRCAACPRTFPEPAQLRRHLAQEHAGGEVELAIERVAKETAEPSWGPQDEGSEPPTTAAAGATEEEAVAAWPETWPAGEPSTLAAPTSAAEPRESESEEAEAGAAELRAELALAAGRQEEKQVLLQADWTLLCLRCREAFATKGELKAHPCLRPEGEQEGEGGPPPRPKRHQCSICLKAFARPWSLSRHRLVHSTDRPFVCPDCGLAFRLASYLRQHRRVHGPLSLLAPLPAAGKKDDKASGARNSAKGPEGGEGAECGGASEGGEGQNGGDAAPARPPAGEPRFWCPECGKGFRRRAHLRQHGVTHSGARPFQCVRCQREFKRLADLARHAQVHAGGPAPHPCPRCPRRFSRAYSLLRHQRCHRAELERAAALQALQAQAPTSPPPPPPPLKAEQEEEGLPLPLANIKEEPPSPGTPPQSPPAPPVFLSASCFDSQDHSAFEMEEEEVDSKAHLRGLGGLAS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	PPPPAQGSPPHRGRG CCCCCCCCCCCCCCC	24.15	28188228
32	Methylation	GRGRGRGRGRGGAGA CCCCCCCCCCCCCCC	30.21	58855031
34	Methylation	GRGRGRGRGGAGAPR CCCCCCCCCCCCCCC	38.72	58855037
57	Phosphorylation	GRLFRFPYYLSRHRL CHHHCHHHHHHHHCC	17.83	27273156
58	Phosphorylation	RLFRFPYYLSRHRLS HHHCHHHHHHHHCCC	9.84	28152594
60	Phosphorylation	FRFPYYLSRHRLSHS HCHHHHHHHHCCCCC	15.21	28152594
65	Phosphorylation	YLSRHRLSHSGLRPH HHHHHCCCCCCCCCC	18.63	20068231
67	Phosphorylation	SRHRLSHSGLRPHAC HHHCCCCCCCCCCCC	35.83	20068231
92	Methylation	AHLSRHLRGHGPQPP HHHHHHHHCCCCCCC	29.01	24129315
194	Phosphorylation	SAAEPRESESEEAEA CCCCCCCCHHHHHHH	47.94	19664994
196	Phosphorylation	AEPRESESEEAEAGA CCCCCCHHHHHHHHH	50.44	29255136
242	Ubiquitination	CREAFATKGELKAHP HHHHHCCCCCCCCCC	47.13	33845483
273	Phosphorylation	RPKRHQCSICLKAFA CCCCCCCHHHHHHHC	15.12	27080861
293	Phosphorylation	SRHRLVHSTDRPFVC CCCCCCCCCCCCEEC	25.23	21857030
324	Phosphorylation	RRVHGPLSLLAPLPA CCCCCCHHHHCCCCC	25.19	-
334	Acetylation	APLPAAGKKDDKASG CCCCCCCCCCCCCCC	48.58	25953088
405	Phosphorylation	HLRQHGVTHSGARPF HHHHCCCCCCCCCCC	18.21	29214152
407	Phosphorylation	RQHGVTHSGARPFQC HHCCCCCCCCCCCEE	25.45	20068231
454	Phosphorylation	PRRFSRAYSLLRHQR CHHHHHHHHHHHHHH	9.95	23186163
455	Phosphorylation	RRFSRAYSLLRHQRC HHHHHHHHHHHHHHH	21.68	28355574
482	Phosphorylation	ALQAQAPTSPPPPPP HHHHCCCCCCCCCCC	57.81	30266825
483	Phosphorylation	LQAQAPTSPPPPPPP HHHCCCCCCCCCCCC	34.06	29255136
513	Phosphorylation	NIKEEPPSPGTPPQS CCCCCCCCCCCCCCC	46.83	27362937
516	Phosphorylation	EEPPSPGTPPQSPPA CCCCCCCCCCCCCCC	34.87	27362937
520	Phosphorylation	SPGTPPQSPPAPPVF CCCCCCCCCCCCCEE	38.33	27362937
562	Phosphorylation	RGLGGLAS------- CCCCCCCC-------	45.88	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of ZN579_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of ZN579_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of ZN579_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of ZN579_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of ZN579_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, AND MASSSPECTROMETRY.	15302935 [Abstract]