CUTA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CUTA_HUMAN
• UniProt AC: O60888
• Protein Name: Protein CutA
• Gene Name: CUTA
• Organism: Homo sapiens (Human).
• Sequence Length: 179
• Protein Description: May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE)..
• Protein Sequence: MSGGRAPAVLLGGVASLLLSFVWMPALLPVASRLLLLPRVLLTMASGSPPTQPSPASDSGSGYVPGSVSAAFVTCPNEKVAKEIARAVVEKRLAACVNLIPQITSIYEWKGKIEEDSEVLMMIKTQSSLVPALTDFVRSVHPYEVAEVIALPVEQGNFPYLQWVRQVTESVSDSITVLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGGRAPAV ------CCCCCCHHH	50.37	24043423
16	Phosphorylation	VLLGGVASLLLSFVW HHHHHHHHHHHHHHH	19.69	24043423
20	Phosphorylation	GVASLLLSFVWMPAL HHHHHHHHHHHHHHH	20.09	24043423
32	Phosphorylation	PALLPVASRLLLLPR HHHHHHHHHHHHHHH	24.56	24043423
48	Phosphorylation	LLTMASGSPPTQPSP HHHHCCCCCCCCCCC	25.80	26657352
54	Phosphorylation	GSPPTQPSPASDSGS CCCCCCCCCCCCCCC	24.23	26657352
57	O-linked_Glycosylation	PTQPSPASDSGSGYV CCCCCCCCCCCCCCC	35.38	OGP
59	O-linked_Glycosylation	QPSPASDSGSGYVPG CCCCCCCCCCCCCCC	32.15	OGP
59	Ubiquitination	QPSPASDSGSGYVPG CCCCCCCCCCCCCCC	32.15	29967540
61	Phosphorylation	SPASDSGSGYVPGSV CCCCCCCCCCCCCCE	30.79	26657352
79	Ubiquitination	FVTCPNEKVAKEIAR EEECCCHHHHHHHHH	54.88	-
82	Ubiquitination	CPNEKVAKEIARAVV CCCHHHHHHHHHHHH	53.28	29967540
87	Ubiquitination	VAKEIARAVVEKRLA HHHHHHHHHHHHHHH	10.73	21963094
89	Ubiquitination	KEIARAVVEKRLAAC HHHHHHHHHHHHHHH	7.57	32015554
101	Ubiquitination	AACVNLIPQITSIYE HHHHHHHHHCCCHHE	23.76	30230243
107	Phosphorylation	IPQITSIYEWKGKIE HHHCCCHHEECCCCC	18.59	-
110	Ubiquitination	ITSIYEWKGKIEEDS CCCHHEECCCCCCCC	38.08	21963094
112	Ubiquitination	SIYEWKGKIEEDSEV CHHEECCCCCCCCCE	43.12	32015554
124	Ubiquitination	SEVLMMIKTQSSLVP CCEEEEEECHHHHHH	23.71	30230243
125	Phosphorylation	EVLMMIKTQSSLVPA CEEEEEECHHHHHHH	23.82	21712546
127	Phosphorylation	LMMIKTQSSLVPALT EEEEECHHHHHHHHH	30.76	21712546
128	Phosphorylation	MMIKTQSSLVPALTD EEEECHHHHHHHHHH	24.46	21712546
129	Ubiquitination	MIKTQSSLVPALTDF EEECHHHHHHHHHHH	6.92	21963094
131 (in isoform 2)	Ubiquitination	-	27.18	-
139	Phosphorylation	ALTDFVRSVHPYEVA HHHHHHHHCCCHHHE	21.34	-
168	O-linked_Glycosylation	LQWVRQVTESVSDSI HHHHHHHHHHHHCCC	17.76	55835517
170	Phosphorylation	WVRQVTESVSDSITV HHHHHHHHHHCCCEE	19.97	24275569
172	Phosphorylation	RQVTESVSDSITVLP HHHHHHHHCCCEECC	34.61	27251275
174	Phosphorylation	VTESVSDSITVLP-- HHHHHHCCCEECC--	16.80	28348404
176	Phosphorylation	ESVSDSITVLP---- HHHHCCCEECC----	21.68	28348404
176	O-linked_Glycosylation	ESVSDSITVLP---- HHHHCCCEECC----	21.68	55835523
191	Phosphorylation	------------------- -------------------		27251275
193	Phosphorylation	--------------------- ---------------------		27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CUTA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CUTA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CUTA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBLI1_HUMAN	FBLIM1	physical	25416956
PXDNL_HUMAN	PXDNL	physical	26344197
UPP1_HUMAN	UPP1	physical	28514442
AAPK1_HUMAN	PRKAA1	physical	28514442
CLH2_HUMAN	CLTCL1	physical	28514442
UBB_HUMAN	UBB	physical	28514442
AAKB1_HUMAN	PRKAB1	physical	28514442
GID4_HUMAN	GID4	physical	28514442
ARMC8_HUMAN	ARMC8	physical	28514442
ZER1_HUMAN	ZER1	physical	28514442
AAKG1_HUMAN	PRKAG1	physical	28514442
PDIA5_HUMAN	PDIA5	physical	28514442
ZY11B_HUMAN	ZYG11B	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.