ZER1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZER1_HUMAN
• UniProt AC: Q7Z7L7
• Protein Name: Protein zer-1 homolog
• Gene Name: ZER1
• Organism: Homo sapiens (Human).
• Sequence Length: 766
• Protein Description: Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZER1-CUL2-Elongin BC..
• Protein Sequence: MASDTPESLMALCTDFCLRNLDGTLGYLLDKETLRLHPDIFLPSEICDRLVNEYVELVNAACNFEPHESFFSLFSDPRSTRLTRIHLREDLVQDQDLEAIRKQDLVELYLTNCEKLSAKSLQTLRSFSHTLVSLSLFGCTNIFYEEENPGGCEDEYLVNPTCQVLVKDFTFEGFSRLRFLNLGRMIDWVPVESLLRPLNSLAALDLSGIQTSDAAFLTQWKDSLVSLVLYNMDLSDDHIRVIVQLHKLRHLDISRDRLSSYYKFKLTREVLSLFVQKLGNLMSLDISGHMILENCSISKMEEEAGQTSIEPSKSSIIPFRALKRPLQFLGLFENSLCRLTHIPAYKVSGDKNEEQVLNAIEAYTEHRPEITSRAINLLFDIARIERCNQLLRALKLVITALKCHKYDRNIQVTGSAALFYLTNSEYRSEQSVKLRRQVIQVVLNGMESYQEVTVQRNCCLTLCNFSIPEELEFQYRRVNELLLSILNPTRQDESIQRIAVHLCNALVCQVDNDHKEAVGKMGFVVTMLKLIQKKLLDKTCDQVMEFSWSALWNITDETPDNCEMFLNFNGMKLFLDCLKEFPEKQELHRNMLGLLGNVAEVKELRPQLMTSQFISVFSNLLESKADGIEVSYNACGVLSHIMFDGPEAWGVCEPQREEVEERMWAAIQSWDINSRRNINYRSFEPILRLLPQGISPVSQHWATWALYNLVSVYPDKYCPLLIKEGGMPLLRDIIKMATARQETKEMARKVIEHCSNFKEENMDTSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASDTPESL ------CCCCCHHHH	19.00	22814378
24	Phosphorylation	CLRNLDGTLGYLLDK HHHCCCCCHHHHCCH	19.37	22199227
31	Ubiquitination	TLGYLLDKETLRLHP CHHHHCCHHHHHCCC	53.20	21906983
102	Ubiquitination	QDLEAIRKQDLVELY CCHHHHHHHHHHHHH	41.89	-
115	Ubiquitination	LYLTNCEKLSAKSLQ HHHHCHHHCCHHHHH	50.36	-
119	Ubiquitination	NCEKLSAKSLQTLRS CHHHCCHHHHHHHHH	48.61	-
230	Phosphorylation	SLVSLVLYNMDLSDD HHHHHEEECCCCCHH	10.85	-
254	Phosphorylation	KLRHLDISRDRLSSY HHCCCCCCHHHHHHH	28.00	26270265
260	Phosphorylation	ISRDRLSSYYKFKLT CCHHHHHHHHHHHHH	36.75	22461510
261	Phosphorylation	SRDRLSSYYKFKLTR CHHHHHHHHHHHHHH	13.80	22461510
263	Ubiquitination	DRLSSYYKFKLTREV HHHHHHHHHHHHHHH	27.99	-
307	Phosphorylation	MEEEAGQTSIEPSKS HHHHHCCCCCCCCCC	30.65	23403867
308	Phosphorylation	EEEAGQTSIEPSKSS HHHHCCCCCCCCCCC	19.64	23403867
312	Phosphorylation	GQTSIEPSKSSIIPF CCCCCCCCCCCCCCH	32.17	23403867
313	Ubiquitination	QTSIEPSKSSIIPFR CCCCCCCCCCCCCHH	59.96	21906983
323	Ubiquitination	IIPFRALKRPLQFLG CCCHHHCCCCHHHHH	51.49	-
351	Ubiquitination	AYKVSGDKNEEQVLN CEECCCCCCHHHHHH	70.55	-
448	Phosphorylation	VVLNGMESYQEVTVQ HHHHCCCHHCEEEEE	24.19	24043423
449	Phosphorylation	VLNGMESYQEVTVQR HHHCCCHHCEEEEEC	8.72	24043423
526	Phosphorylation	GKMGFVVTMLKLIQK HHHHHHHHHHHHHHH	16.10	-
584	Ubiquitination	CLKEFPEKQELHRNM HHHHCCHHHHHHHHH	49.68	-
738	Phosphorylation	RDIIKMATARQETKE HHHHHHHHHHHHHHH	20.90	19651622
744	Acetylation	ATARQETKEMARKVI HHHHHHHHHHHHHHH	44.75	7431089
749	Ubiquitination	ETKEMARKVIEHCSN HHHHHHHHHHHHHHH	37.72	-
758	Ubiquitination	IEHCSNFKEENMDTS HHHHHHCHHHHCCCC	69.26	-
764	Phosphorylation	FKEENMDTSR----- CHHHHCCCCC-----	18.68	29214152
765	Phosphorylation	KEENMDTSR------ HHHHCCCCC------	31.56	29214152

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZER1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZER1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZER1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL2_HUMAN	CUL2	physical	17304241
CUL2_HUMAN	CUL2	physical	18187417
ELOB_HUMAN	TCEB2	physical	18187417
ELOC_HUMAN	TCEB1	physical	18187417

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.