dbPTM

CLH2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CLH2_HUMAN
UniProt AC	P53675
Protein Name	Clathrin heavy chain 2
Gene Name	CLTCL1
Organism	Homo sapiens (Human).
Sequence Length	1640
Subcellular Localization	Cytoplasmic vesicle membrane Peripheral membrane protein Cytoplasmic side. Membrane, coated pit Peripheral membrane protein Cytoplasmic side. Cytoplasmic face of coated pits and vesicles..
Protein Description	Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network (By similarity)..
Protein Sequence	MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRRPISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHWSMEGDSQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIEGHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDFPVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVLSVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKGILRTRETVQKFQSIPAQSGQASPLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKEDKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLRGVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWLLEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPEWLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYFLGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCDRFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDELVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYCEKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQVVQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNEPAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYIETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHLGEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEELILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPRLDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNISLAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLEEGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEEHVTEPAPLVFDFDGHE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAQILPVRF ------CCCCCCCCH	19.20	-
16	Ubiquitination	FQEHFQLQNLGINPA HHHHHCHHCCCCCHH	32.11	21963094
31	Phosphorylation	NIGFSTLTMESDKFI HCCCEEEECCCCEEE	20.98	-
34	Ubiquitination	FSTLTMESDKFICIR CEEEECCCCEEEEEE	34.97	21963094
67	Phosphorylation	APIRRPISAESAIMN CCCCCCCCHHHHHCC	28.77	-
78	Acetylation	AIMNPASKVIALKAG HHCCCCHHEEEHHCC	39.50	26051181
78	Ubiquitination	AIMNPASKVIALKAG HHCCCCHHEEEHHCC	39.50	22817900
83	Acetylation	ASKVIALKAGKTLQI CHHEEEHHCCCEEEE	46.18	25953088
83	Ubiquitination	ASKVIALKAGKTLQI CHHEEEHHCCCEEEE	46.18	27667366
86	Ubiquitination	VIALKAGKTLQIFNI EEEHHCCCEEEEEEE	51.42	22817900
86 (in isoform 1)	Ubiquitination	-	51.42	21890473
86 (in isoform 2)	Ubiquitination	-	51.42	21890473
95	Sulfoxidation	LQIFNIEMKSKMKAH EEEEEEECCHHHCCC	5.41	21406390
96	Acetylation	QIFNIEMKSKMKAHT EEEEEECCHHHCCCC	33.85	26051181
96	Neddylation	QIFNIEMKSKMKAHT EEEEEECCHHHCCCC	33.85	32015554
96	Ubiquitination	QIFNIEMKSKMKAHT EEEEEECCHHHCCCC	33.85	22817900
96 (in isoform 1)	Ubiquitination	-	33.85	21890473
96 (in isoform 2)	Ubiquitination	-	33.85	21890473
98	Ubiquitination	FNIEMKSKMKAHTMA EEEECCHHHCCCCCH	38.61	22817900
100	Ubiquitination	IEMKSKMKAHTMAEE EECCHHHCCCCCHHH	40.53	22817900
103	Phosphorylation	KSKMKAHTMAEEVIF CHHHCCCCCHHHHHH	23.96	17081983
115	Phosphorylation	VIFWKWVSVNTVALV HHHHEECCCCCEEEE	14.45	24425749
134	Ubiquitination	VYHWSMEGDSQPMKM EHHHHCCCCCCCCCC	31.09	21963094
139	Ubiquitination	MEGDSQPMKMFDRHT CCCCCCCCCCCCCCC	3.68	22817900
161	Ubiquitination	IHYRTDEYQKWLLLV EEEECHHHHHHHHHH	20.43	27667366
171	Phosphorylation	WLLLVGISAQQNRVV HHHHHCCCCCCCCCE	17.69	-
181	Sulfoxidation	QNRVVGAMQLYSVDR CCCCEEEEEEEECCC	2.02	28183972
184	Phosphorylation	VVGAMQLYSVDRKVS CEEEEEEEECCCCCC	6.97	28152594
185	Phosphorylation	VGAMQLYSVDRKVSQ EEEEEEEECCCCCCC	26.57	28152594
189	Ubiquitination	QLYSVDRKVSQPIEG EEEECCCCCCCCCCC	41.60	22505724
191	Phosphorylation	YSVDRKVSQPIEGHA EECCCCCCCCCCCCH	33.02	-
203	Ubiquitination	GHAAAFAEFKMEGNA CCHHHHHEEECCCCC	39.07	23000965
214	Phosphorylation	EGNAKPATLFCFAVR CCCCCCEEEEEEEEE	28.97	-
224	Phosphorylation	CFAVRNPTGGKLHII EEEEECCCCCCEEEE	63.21	-
227	Ubiquitination	VRNPTGGKLHIIEVG EECCCCCCEEEEEEC	37.93	29967540
245	Ubiquitination	AGNQPFVKKAVDVFF CCCCCCCCEEEEEEC	35.08	21963094
246	Ubiquitination	GNQPFVKKAVDVFFP CCCCCCCEEEEEECC	48.63	22817900
248	Ubiquitination	QPFVKKAVDVFFPPE CCCCCEEEEEECCHH	9.90	23000965
253	Ubiquitination	KAVDVFFPPEAQNDF EEEEEECCHHHCCCC	17.85	23000965
308	Ubiquitination	DTIFVTAPHKPTSGI CEEEEECCCCCCCCE	27.03	23000965
329	Ubiquitination	GQVLSVCVEEDNIVN CCEEEEEECCCCHHH	9.40	21963094
338	Ubiquitination	EDNIVNYATNVLQNP CCCHHHHHHHHHHCC	6.36	21963094
362	Ubiquitination	SNLAGAEKLFVRKFN CCCCCHHHHHHHHHH	46.84	29967540
367	Ubiquitination	AEKLFVRKFNTLFAQ HHHHHHHHHHHHHHC	37.35	29967540
377	Phosphorylation	TLFAQGSYAEAAKVA HHHHCCCHHHHHHHH	18.45	23532336
386	Phosphorylation	EAAKVAASAPKGILR HHHHHHHCCCCCEEC	35.05	22210691
389	Ubiquitination	KVAASAPKGILRTRE HHHHCCCCCEECCHH	59.30	29967540
394	Phosphorylation	APKGILRTRETVQKF CCCCEECCHHHHHHH	29.43	20068231
394 (in isoform 2)	Phosphorylation	-	29.43	-
397	Phosphorylation	GILRTRETVQKFQSI CEECCHHHHHHHHCC	25.58	20068231
407	Ubiquitination	KFQSIPAQSGQASPL HHHCCCCCCCCCCHH	42.62	22817900
412	Ubiquitination	PAQSGQASPLLQYFG CCCCCCCCHHHHHHH	14.27	21890473
415	Ubiquitination	SGQASPLLQYFGILL CCCCCHHHHHHHHCC	4.38	21963094
418	Ubiquitination	ASPLLQYFGILLDQG CCHHHHHHHHCCCCC	2.94	22817900
431	Ubiquitination	QGQLNKLESLELCHL CCCCHHHHHHHHHHH	55.69	23000965
445	Ubiquitination	LVLQQGRKQLLEKWL HHHHHHHHHHHHHHH	52.72	22817900
450	Acetylation	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	23236377
450	Malonylation	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	26320211
450	Ubiquitination	GRKQLLEKWLKEDKL HHHHHHHHHHHHCCC	58.77	21890473
450 (in isoform 1)	Ubiquitination	-	58.77	21890473
450 (in isoform 2)	Ubiquitination	-	58.77	21890473
453	Acetylation	QLLEKWLKEDKLECS HHHHHHHHHCCCHHH	63.85	25953088
453	Malonylation	QLLEKWLKEDKLECS HHHHHHHHHCCCHHH	63.85	26320211
453	Ubiquitination	QLLEKWLKEDKLECS HHHHHHHHHCCCHHH	63.85	27667366
453 (in isoform 1)	Ubiquitination	-	63.85	21890473
453 (in isoform 2)	Ubiquitination	-	63.85	21890473
456	Acetylation	EKWLKEDKLECSEEL HHHHHHCCCHHHHHH	47.48	26822725
456	Ubiquitination	EKWLKEDKLECSEEL HHHHHHCCCHHHHHH	47.48	22817900
468	Ubiquitination	EELGDLVKTTDPMLA HHHHHHHHCCCCHHH	53.67	23000965
469	Ubiquitination	ELGDLVKTTDPMLAL HHHHHHHCCCCHHHH	29.02	23000965
477	Phosphorylation	TDPMLALSVYLRANV CCCHHHHHHHHHCCC	11.78	21406692
479	Phosphorylation	PMLALSVYLRANVPS CHHHHHHHHHCCCCH	6.26	21406692
506	Acetylation	QKIVLYAKKVGYTPD EEEEEHHHHHCCCCH	34.14	26051181
506	Malonylation	QKIVLYAKKVGYTPD EEEEEHHHHHCCCCH	34.14	26320211
506	Ubiquitination	QKIVLYAKKVGYTPD EEEEEHHHHHCCCCH	34.14	23000965
507	Acetylation	KIVLYAKKVGYTPDW EEEEHHHHHCCCCHH	32.49	23236377
507	Ubiquitination	KIVLYAKKVGYTPDW EEEEHHHHHCCCCHH	32.49	23000965
507 (in isoform 1)	Ubiquitination	-	32.49	21890473
507 (in isoform 2)	Ubiquitination	-	32.49	21890473
510	Phosphorylation	LYAKKVGYTPDWIFL EHHHHHCCCCHHHHH	20.34	-
576	Ubiquitination	ALKNNRPAEGLLQTW HHHCCCCCHHHHHHH	21.91	21963094
581	Ubiquitination	RPAEGLLQTWLLEMN CCCHHHHHHHHHHCC	35.36	21963094
599	Ubiquitination	APQVADAILGNKMFT HHHHHHHHHCCCCCC	5.35	21963094
619	Ubiquitination	HIAQLCEKAGLLQQA HHHHHHHHHCHHHHH	46.92	21963094
634	Phosphorylation	LEHYTDLYDIKRAVV HHHCCCHHHHHHHHH	20.59	-
637	Acetylation	YTDLYDIKRAVVHTH CCCHHHHHHHHHHHH	31.26	26051181
637	Ubiquitination	YTDLYDIKRAVVHTH CCCHHHHHHHHHHHH	31.26	21963094
651	Ubiquitination	HLLNPEWLVNFFGSL HCCCHHHHHHHHCCC	1.84	21963094
672	Phosphorylation	ECLHAMLSANIRQNL HHHHHHHCCHHHHHH	13.24	20068231
699	Ubiquitination	QLGTQALVELFESFK HHHHHHHHHHHHHHC	7.23	21963094
704	Ubiquitination	ALVELFESFKSYKGL HHHHHHHHHCCCCHH	30.55	22817900
726	Ubiquitination	VNFSQDPDVHLKYIQ HCCCCCCHHHHHHHH	49.08	27667366
731	Phosphorylation	DPDVHLKYIQAACKT CCHHHHHHHHHHHHC	12.48	28152594
737	Acetylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	25953088
737	Malonylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	26320211
737	Succinylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	-
737	Succinylation	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	27452117
737	Ubiquitination	KYIQAACKTGQIKEV HHHHHHHHCCCHHHH	51.46	21963094
742	Acetylation	ACKTGQIKEVERICR HHHCCCHHHHHHHHH	48.06	23749302
742	Ubiquitination	ACKTGQIKEVERICR HHHCCCHHHHHHHHH	48.06	21906983
742 (in isoform 1)	Ubiquitination	-	48.06	21890473
742 (in isoform 2)	Ubiquitination	-	48.06	21890473
744	Ubiquitination	KTGQIKEVERICRES HCCCHHHHHHHHHHC	5.21	21890473
751	Phosphorylation	VERICRESSCYNPER HHHHHHHCCCCCHHH	13.32	22617229
752	Phosphorylation	ERICRESSCYNPERV HHHHHHCCCCCHHHH	18.83	22617229
754	Phosphorylation	ICRESSCYNPERVKN HHHHCCCCCHHHHHH	35.38	30619164
760	Ubiquitination	CYNPERVKNFLKEAK CCCHHHHHHHHHHCC	48.48	-
764	Acetylation	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	25953088
764	Malonylation	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	26320211
764	Ubiquitination	ERVKNFLKEAKLTDQ HHHHHHHHHCCCCCC	52.03	27667366
768	Ubiquitination	NFLKEAKLTDQLPLI HHHHHCCCCCCCCEE	9.10	23000965
784	Ubiquitination	VCDRFGFVHDLVLYL EECCCCCHHHHHHHH	3.34	22817900
789	Ubiquitination	GFVHDLVLYLYRNNL CCHHHHHHHHHHCCH	2.95	22817900
794	Ubiquitination	LVLYLYRNNLQRYIE HHHHHHHCCHHHHHE	39.75	21963094
799	Phosphorylation	YRNNLQRYIEIYVQK HHCCHHHHHEEEEEE	7.02	-
803	Phosphorylation	LQRYIEIYVQKVNPS HHHHHEEEEEECCCC	5.52	-
806	Ubiquitination	YIEIYVQKVNPSRTP HHEEEEEECCCCCCC	33.66	30230243
806 (in isoform 1)	Ubiquitination	-	33.66	21890473
806 (in isoform 2)	Ubiquitination	-	33.66	21890473
813	Ubiquitination	KVNPSRTPAVIGGLL ECCCCCCCCEECCEE	24.34	23000965
818	Ubiquitination	RTPAVIGGLLDVDCS CCCCEECCEECCCCC	16.37	23000965
841	Phosphorylation	MAVRGQFSTDELVAE HHHHCCCCHHHHHHH	27.36	-
842	Phosphorylation	AVRGQFSTDELVAEV HHHCCCCHHHHHHHH	34.48	-
846	Ubiquitination	QFSTDELVAEVEKRN CCCHHHHHHHHHHHC	3.92	21890473
851	Acetylation	ELVAEVEKRNRLKLL HHHHHHHHHCHHHHH	61.21	23236377
851	Ubiquitination	ELVAEVEKRNRLKLL HHHHHHHHHCHHHHH	61.21	23000965
856	Acetylation	VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH	33.57	26051181
856	Ubiquitination	VEKRNRLKLLLPWLE HHHHCHHHHHHHHHH	33.57	23000965
873	Ubiquitination	IQEGCEEPATHNALA HHHCCCCCCHHCCEE	21.84	23000965
881	Acetylation	ATHNALAKIYIDSNN CHHCCEEEEEECCCC	36.57	26051181
883	Phosphorylation	HNALAKIYIDSNNSP HCCEEEEEECCCCCC	9.66	22817900
889	Phosphorylation	IYIDSNNSPECFLRE EEECCCCCCCEECCC	26.73	21815630
894	Ubiquitination	NNSPECFLRENAYYD CCCCCEECCCCCCCC	11.53	21963094
899	Phosphorylation	CFLRENAYYDSSVVG EECCCCCCCCHHHHH	21.27	27642862
900	Phosphorylation	FLRENAYYDSSVVGR ECCCCCCCCHHHHHH	13.62	27642862
903	Ubiquitination	ENAYYDSSVVGRYCE CCCCCCHHHHHHHHC	20.23	21963094
911	Ubiquitination	VVGRYCEKRDPHLAC HHHHHHCCCCCCEEE	59.55	23000965
921	Phosphorylation	PHLACVAYERGQCDL CCEEEEEECCCCCCH	5.93	28152594
932	Ubiquitination	QCDLELIKVCNENSL CCCHHHHHHCCCCCC	54.05	21963094
938	Phosphorylation	IKVCNENSLFKSEAR HHHCCCCCCCCHHHH	29.07	24719451
941	Ubiquitination	CNENSLFKSEARYLV CCCCCCCCHHHHHHE	53.32	21963094
951	Ubiquitination	ARYLVCRKDPELWAH HHHHEECCCHHHHHH	72.94	29967540
959	Ubiquitination	DPELWAHVLEETNPS CHHHHHHHHHHCCHH	5.78	21963094
963	Phosphorylation	WAHVLEETNPSRRQL HHHHHHHCCHHHHHH	42.95	27251275
966	Phosphorylation	VLEETNPSRRQLIDQ HHHHCCHHHHHHHHH	42.01	27251275
989	Phosphorylation	TRDPEEISVTVKAFM CCCHHHEEEEEEEHH	18.27	21406692
991	Phosphorylation	DPEEISVTVKAFMTA CHHHEEEEEEEHHHC	14.97	21406692
996	Sulfoxidation	SVTVKAFMTADLPNE EEEEEEHHHCCCCHH	3.45	28183972
996	Ubiquitination	SVTVKAFMTADLPNE EEEEEEHHHCCCCHH	3.45	23000965
1016	Phosphorylation	EKIVLDNSVFSEHRN HHHHCCCCCCCCCCC	24.98	20068231
1019	Phosphorylation	VLDNSVFSEHRNLQN HCCCCCCCCCCCHHH	30.27	20068231
1034	Acetylation	LLILTAIKADRTRVM HHHHHHHHCCHHHHH	41.59	25953088
1034	Ubiquitination	LLILTAIKADRTRVM HHHHHHHHCCHHHHH	41.59	23000965
1034 (in isoform 1)	Ubiquitination	-	41.59	21890473
1034 (in isoform 2)	Ubiquitination	-	41.59	21890473
1038	Phosphorylation	TAIKADRTRVMEYIS HHHHCCHHHHHHHHH	28.32	-
1043	Phosphorylation	DRTRVMEYISRLDNY CHHHHHHHHHCCCCC	6.01	23403867
1045	Phosphorylation	TRVMEYISRLDNYDA HHHHHHHHCCCCCCH	26.37	-
1096	Phosphorylation	IGNLDRAYEFAERCN HCCHHHHHHHHHHCC	16.69	28152594
1122	Ubiquitination	QLQKDLVKEAINSYI HHHHHHHHHHHHHHH	49.04	29967540
1141	Ubiquitination	PSSYLEVVQSASRSN HHHHHHHHHHHCCCC	2.44	21963094
1167	Phosphorylation	ARKKGRESYIETELI HHHCCCHHHHHHHHH	30.01	28857561
1168	Phosphorylation	RKKGRESYIETELIF HHCCCHHHHHHHHHH	9.68	20068231
1168 (in isoform 2)	Phosphorylation	-	9.68	-
1171	Phosphorylation	GRESYIETELIFALA CCHHHHHHHHHHHHH	26.91	23898821
1171 (in isoform 2)	Phosphorylation	-	26.91	-
1179	Ubiquitination	ELIFALAKTSRVSEL HHHHHHHHCCCHHHH	48.13	21963094
1181	Phosphorylation	IFALAKTSRVSELED HHHHHHCCCHHHHHH	29.94	-
1206	Phosphorylation	QQVGDRCYEEGMYEA HHHHHHHHHHCHHHH	20.22	-
1211	Phosphorylation	RCYEEGMYEAAKLLY HHHHHCHHHHHHHHH	17.17	27642862
1216	Ubiquitination	GMYEAAKLLYSNVSN CHHHHHHHHHHCHHH	4.68	21963094
1229	Phosphorylation	SNFARLASTLVHLGE HHHHHHHHHHHHHHH	27.19	-
1254	Ubiquitination	ASSTRTWKEVCFACM CCCCCCHHHHHHHCC	39.39	21963094
1275	Ubiquitination	FAQLCGLHIVIHADE HHHHHCCEEEEEHHH	9.50	21890473
1309	Ubiquitination	LLEAALGLERAHMGM HHHHHHCCCHHHHCH	4.13	21890473
1314	Sulfoxidation	LGLERAHMGMFTELA HCCCHHHHCHHHHHH	3.98	28183972
1315	Ubiquitination	GLERAHMGMFTELAI CCCHHHHCHHHHHHH	9.74	22817900
1316	Sulfoxidation	LERAHMGMFTELAIL CCHHHHCHHHHHHHH	2.67	28183972
1318	Phosphorylation	RAHMGMFTELAILYS HHHHCHHHHHHHHHH	22.61	24117733
1320	Ubiquitination	HMGMFTELAILYSKF HHCHHHHHHHHHHCC	3.05	22817900
1324	Phosphorylation	FTELAILYSKFKPQK HHHHHHHHHCCCHHH	12.05	24117733
1325	Phosphorylation	TELAILYSKFKPQKM HHHHHHHHCCCHHHH	28.33	24117733
1325	Ubiquitination	TELAILYSKFKPQKM HHHHHHHHCCCHHHH	28.33	21963094
1341	Phosphorylation	EHLELFWSRVNIPKV HHHHHHHHHCCHHHH	21.01	30108239
1347	Acetylation	WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH	50.53	26051181
1347	Malonylation	WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH	50.53	26320211
1347	Ubiquitination	WSRVNIPKVLRAAEQ HHHCCHHHHHHHHHH	50.53	27667366
1347 (in isoform 1)	Ubiquitination	-	50.53	21890473
1347 (in isoform 2)	Ubiquitination	-	50.53	21890473
1349	Ubiquitination	RVNIPKVLRAAEQAH HCCHHHHHHHHHHHH	3.73	22817900
1354	Ubiquitination	KVLRAAEQAHLWAEL HHHHHHHHHHHHHHH	29.38	22817900
1359	Ubiquitination	AEQAHLWAELVFLYD HHHHHHHHHHHHHHH	13.45	21963094
1377	Ubiquitination	EYDNAVLTMMSHPTE HHCCCHHHHCCCCHH	12.29	21890473
1387	Ubiquitination	SHPTEAWKEGQFKDI CCCHHHHHCCCHHHH	60.04	22817900
1392	Acetylation	AWKEGQFKDIITKVA HHHCCCHHHHHHHHH	39.88	25953088
1392	Succinylation	AWKEGQFKDIITKVA HHHCCCHHHHHHHHH	39.88	23954790
1392	Ubiquitination	AWKEGQFKDIITKVA HHHCCCHHHHHHHHH	39.88	27667366
1392 (in isoform 1)	Ubiquitination	-	39.88	21890473
1392 (in isoform 2)	Ubiquitination	-	39.88	21890473
1396	Phosphorylation	GQFKDIITKVANVEL CCHHHHHHHHHCHHH	21.57	-
1397	Ubiquitination	QFKDIITKVANVELC CHHHHHHHHHCHHHH	29.01	21963094
1411	Ubiquitination	CYRALQFYLDYKPLL HHHHHHHHHCCHHHH	5.91	21890473
1441	Acetylation	WTVSFFSKAGQLPLV EEEEEECCCCCCCCC	51.91	-
1441	Succinylation	WTVSFFSKAGQLPLV EEEEEECCCCCCCCC	51.91	-
1441	Succinylation	WTVSFFSKAGQLPLV EEEEEECCCCCCCCC	51.91	-
1449	Acetylation	AGQLPLVKPYLRSVQ CCCCCCCHHHHHHHH	35.31	19608861
1449	Ubiquitination	AGQLPLVKPYLRSVQ CCCCCCCHHHHHHHH	35.31	21963094
1451	Phosphorylation	QLPLVKPYLRSVQSH CCCCCHHHHHHHHHC	14.72	28152594
1461	Ubiquitination	SVQSHNNKSVNEALN HHHHCCCCCHHHHHH	62.18	29967540
1462	Phosphorylation	VQSHNNKSVNEALNH HHHCCCCCHHHHHHH	32.09	17081983
1462 (in isoform 2)	Phosphorylation	-	32.09	-
1468	Ubiquitination	KSVNEALNHLLTEEE CCHHHHHHHHCCCCC	30.70	21963094
1477	Phosphorylation	LLTEEEDYQGLRASI HCCCCCHHCHHHHHC	14.04	27642862
1487	Phosphorylation	LRASIDAYDNFDNIS HHHHCHHHCCCCCCH	13.99	-
1490	Ubiquitination	SIDAYDNFDNISLAQ HCHHHCCCCCCHHHH	7.51	21963094
1494	Phosphorylation	YDNFDNISLAQQLEK HCCCCCCHHHHHHHH	24.73	-
1501	Acetylation	SLAQQLEKHQLMEFR HHHHHHHHHCCHHHH	45.29	-
1505	Ubiquitination	QLEKHQLMEFRCIAA HHHHHCCHHHHHHHH	3.53	21963094
1524	Ubiquitination	GNNWWAQSVELCKKD CCCEEHHHHHHHHCC	15.15	21963094
1529	Acetylation	AQSVELCKKDHLYKD HHHHHHHHCCCHHHH	74.08	25953088
1529	Ubiquitination	AQSVELCKKDHLYKD HHHHHHHHCCCHHHH	74.08	32015554
1535	Ubiquitination	CKKDHLYKDAMQHAA HHCCCHHHHHHHHHH	45.42	29967540
1555	Ubiquitination	ELAQKLLQWFLEEGK HHHHHHHHHHHHHCH	39.03	29967540
1562	Ubiquitination	QWFLEEGKRECFAAC HHHHHHCHHHHHHHH	48.59	21963094
1564	Ubiquitination	FLEEGKRECFAACLF HHHHCHHHHHHHHHH	37.16	29967540
1612	Ubiquitination	EYLSKVDKLDALESL HHHHCCHHHHHHHHH	51.78	29967540
1618	Phosphorylation	DKLDALESLRKQEEH HHHHHHHHHHHHHCC	34.03	19413330
1621	Ubiquitination	DALESLRKQEEHVTE HHHHHHHHHHCCCCC	68.31	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of CLH2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CLH2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CLH2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SNX5_HUMAN	SNX5	physical	15133132
AHSA1_HUMAN	AHSA1	physical	26344197
AT1A1_HUMAN	ATP1A1	physical	26344197
TCPW_HUMAN	CCT6B	physical	26344197
SYEP_HUMAN	EPRS	physical	26344197
IDH3A_HUMAN	IDH3A	physical	26344197
2AAA_HUMAN	PPP2R1A	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CLH2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-450; LYS-764 AND LYS-1449,AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-103, AND MASSSPECTROMETRY.	17081983 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1096, AND MASSSPECTROMETRY.	19534553 [Abstract]