ARMC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARMC8_HUMAN
• UniProt AC: Q8IUR7
• Protein Name: Armadillo repeat-containing protein 8
• Gene Name: ARMC8
• Organism: Homo sapiens (Human).
• Sequence Length: 673
• Protein Sequence: MACLLETPIRMSVLSEVTASSRHYVDRLFDPDPQKVLQGVIDMKNAVIGNNKQKANLIVLGAVPRLLYLLQQETSSTELKTECAVVLGSLAMGTENNVKSLLDCHIIPALLQGLLSPDLKFIEACLRCLRTIFTSPVTPEELLYTDATVIPHLMALLSRSRYTQEYICQIFSHCCKGPDHQTILFNHGAVQNIAHLLTSLSYKVRMQALKCFSVLAFENPQVSMTLVNVLVDGELLPQIFVKMLQRDKPIEMQLTSAKCLTYMCRAGAIRTDDNCIVLKTLPCLVRMCSKERLLEERVEGAETLAYLIEPDVELQRIASITDHLIAMLADYFKYPSSVSAITDIKRLDHDLKHAHELRQAAFKLYASLGANDEDIRKKIIETENMMDRIVTGLSESSVKVRLAAVRCLHSLSRSVQQLRTSFQDHAVWKPLMKVLQNAPDEILVVASSMLCNLLLEFSPSKEPILESGAVELLCGLTQSENPALRVNGIWALMNMAFQAEQKIKADILRSLSTEQLFRLLSDSDLNVLMKTLGLLRNLLSTRPHIDKIMSTHGKQIMQAVTLILEGEHNIEVKEQTLCILANIADGTTAKDLIMTNDDILQKIKYYMGHSHVKLQLAAMFCISNLIWNEEEGSQERQDKLRDMGIVDILHKLSQSPDSNLCDKAKMALQQYLA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MACLLETPI ------CCCCCCCCC	7.83	-
7	Phosphorylation	-MACLLETPIRMSVL -CCCCCCCCCCHHHH	24.80	24719451
10	Methylation	CLLETPIRMSVLSEV CCCCCCCCHHHHHHH	16.72	-
12	Phosphorylation	LETPIRMSVLSEVTA CCCCCCHHHHHHHCC	15.28	27732954
15	Phosphorylation	PIRMSVLSEVTASSR CCCHHHHHHHCCCCC	28.06	27732954
18	Phosphorylation	MSVLSEVTASSRHYV HHHHHHHCCCCCCHH	19.44	27732954
20	Phosphorylation	VLSEVTASSRHYVDR HHHHHCCCCCCHHHH	20.66	24719451
21	Phosphorylation	LSEVTASSRHYVDRL HHHHCCCCCCHHHHH	22.17	24719451
24	Phosphorylation	VTASSRHYVDRLFDP HCCCCCCHHHHHCCC	11.70	24043423
74	Phosphorylation	LYLLQQETSSTELKT HHHHHCCCCCCCHHH	24.52	29514088
75	Phosphorylation	YLLQQETSSTELKTE HHHHCCCCCCCHHHH	34.21	29514088
76	Phosphorylation	LLQQETSSTELKTEC HHHCCCCCCCHHHHH	33.06	29514088
77	Phosphorylation	LQQETSSTELKTECA HHCCCCCCCHHHHHH	45.14	29514088
134 (in isoform 7)	Phosphorylation	-	28.42	24248375
135 (in isoform 7)	Phosphorylation	-	13.46	24248375
144 (in isoform 7)	Phosphorylation	-	18.39	24248375
168 (in isoform 7)	Phosphorylation	-	2.19	24248375
234	Ubiquitination	VNVLVDGELLPQIFV EEEHHCCCHHHHHHH	42.54	-
248	Ubiquitination	VKMLQRDKPIEMQLT HHHHCCCCCCCHHCC	50.51	-
255	Phosphorylation	KPIEMQLTSAKCLTY CCCCHHCCHHHHHHH	15.11	-
261	Phosphorylation	LTSAKCLTYMCRAGA CCHHHHHHHHHHHCC	20.76	-
262	Phosphorylation	TSAKCLTYMCRAGAI CHHHHHHHHHHHCCC	4.93	-
265	Ubiquitination	KCLTYMCRAGAIRTD HHHHHHHHHCCCCCC	21.37	-
279	Ubiquitination	DDNCIVLKTLPCLVR CCCEEEECCHHHHHH	36.80	-
323	Phosphorylation	RIASITDHLIAMLAD HHHHHHHHHHHHHHH	15.53	-
331	Ubiquitination	LIAMLADYFKYPSSV HHHHHHHHHCCCCCC	9.07	-
336	Phosphorylation	ADYFKYPSSVSAITD HHHHCCCCCCHHHHH	40.04	23186163
337	Phosphorylation	DYFKYPSSVSAITDI HHHCCCCCCHHHHHH	18.65	23917254
338	Ubiquitination	YFKYPSSVSAITDIK HHCCCCCCHHHHHHH	5.41	-
339	Phosphorylation	FKYPSSVSAITDIKR HCCCCCCHHHHHHHH	18.85	23186163
366 (in isoform 6)	Phosphorylation	-	14.55	25159151
376 (in isoform 6)	Phosphorylation	-	46.68	30622161
378 (in isoform 6)	Phosphorylation	-	38.78	30622161
382	Phosphorylation	IRKKIIETENMMDRI HHHHHHHCHHHHHHH	23.42	24114839
385	Ubiquitination	KIIETENMMDRIVTG HHHHCHHHHHHHHHC	2.11	-
399	Ubiquitination	GLSESSVKVRLAAVR CCCHHHHHHHHHHHH	24.48	-
415	Ubiquitination	LHSLSRSVQQLRTSF HHHHHHHHHHHHHHH	4.01	-
429	Ubiquitination	FQDHAVWKPLMKVLQ HHHHHHHHHHHHHHH	22.98	-
498	Phosphorylation	ALMNMAFQAEQKIKA HHHHHHHHHHHHHHH	34.16	-
504	2-Hydroxyisobutyrylation	FQAEQKIKADILRSL HHHHHHHHHHHHHHC	47.22	-
507	Phosphorylation	EQKIKADILRSLSTE HHHHHHHHHHHCCHH	4.04	-
512	Phosphorylation	ADILRSLSTEQLFRL HHHHHHCCHHHHHHH	31.01	14702039
513	Phosphorylation	DILRSLSTEQLFRLL HHHHHCCHHHHHHHH	32.80	23186163
521	Phosphorylation	EQLFRLLSDSDLNVL HHHHHHHCHHHHHHH	39.39	-
587	Phosphorylation	LANIADGTTAKDLIM EEECCCCCCHHHHHH	24.91	26546556
588	Ubiquitination	ANIADGTTAKDLIMT EECCCCCCHHHHHHC	36.92	-
665	Ubiquitination	SNLCDKAKMALQQYL CCHHHHHHHHHHHHH	30.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARMC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARMC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARMC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CTNB1_HUMAN	CTNNB1	physical	18215130
CTNA1_HUMAN	CTNNA1	physical	18215130
HGS_HUMAN	HGS	physical	20224683

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.