PDIA5_HUMAN - dbPTM
PDIA5_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDIA5_HUMAN
UniProt AC Q14554
Protein Name Protein disulfide-isomerase A5
Gene Name PDIA5
Organism Homo sapiens (Human).
Sequence Length 519
Subcellular Localization Endoplasmic reticulum lumen .
Protein Description
Protein Sequence MARAGPAWLLLAIWVVLPSWLSSAKVSSLIERISDPKDLKKLLRTRNNVLVLYSKSEVAAENHLRLLSTVAQAVKGQGTICWVDCGDAESRKLCKKMKVDLSPKDKKVELFHYQDGAFHTEYNRAVTFKSIVAFLKDPKGPPLWEEDPGAKDVVHLDSEKDFRRLLKKEEKPLLIMFYAPWCSMCKRMMPHFQKAATQLRGHAVLAGMNVYSSEFENIKEEYSVRGFPTICYFEKGRFLFQYDNYGSTAEDIVEWLKNPQPPQPQVPETPWADEGGSVYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFEKAAEALHGEADSSGVLAAVDATVNKALAERFHISEFPTLKYFKNGEKYAVPVLRTKKKFLEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNFRETLKKKKHTLVMFYAPWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQQEAVKGYPTFHYYHYGKFAEKYDSDRTELGFTNYIRALREGDHERLGKKKEEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
27PhosphorylationWLSSAKVSSLIERIS
HHHHHHHHHHHHHCC		20.7928060719
28PhosphorylationLSSAKVSSLIERISD
HHHHHHHHHHHHCCC		36.0327535140
54PhosphorylationNNVLVLYSKSEVAAE
CCEEEEEEHHHHHHH		26.0830631047
102PhosphorylationKKMKVDLSPKDKKVE
HHCCCCCCCCCCCEE		25.9928060719
1602-HydroxyisobutyrylationVVHLDSEKDFRRLLK
CEECCCHHHHHHHHH		67.15-
160UbiquitinationVVHLDSEKDFRRLLK
CEECCCHHHHHHHHH		67.1529967540
178PhosphorylationKPLLIMFYAPWCSMC
CCEEEEEEHHHHHHH		8.3822817900
197PhosphorylationPHFQKAATQLRGHAV
HHHHHHHHHHHCCHH		32.7520446291
211PhosphorylationVLAGMNVYSSEFENI
HHCCCEEECHHHCCC		11.0728270605
212PhosphorylationLAGMNVYSSEFENIK
HCCCEEECHHHCCCC		21.0728270605
213PhosphorylationAGMNVYSSEFENIKE
CCCEEECHHHCCCCH		28.7228270605
328PhosphorylationALHGEADSSGVLAAV
HHCCCCCCCCHHHHH		35.7224275569
364PhosphorylationYFKNGEKYAVPVLRT
ECCCCCCCEEEEEEC		14.4522817900
391O-linked_GlycosylationAPPPPEPTWEEQQTS
CCCCCCCCHHHHHHH		43.79OGP
439O-linked_GlycosylationVIPHFTATADAFKDD
HHCCCCCCCHHCCCC		23.24OGP
448MalonylationDAFKDDRKIACAAVD
HHCCCCCHHHHHHHH		41.4730639696
515UbiquitinationDHERLGKKKEEL---
CHHHHCCCHHCC---		64.7124816145
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDIA5_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDIA5_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDIA5_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
KR107_HUMANKRTAP10-7physical
25416956
KR103_HUMANKRTAP10-3physical
25416956
CDC5L_HUMANCDC5Lphysical
26344197
MO4L2_HUMANMORF4L2physical
26344197
RPB7_HUMANPOLR2Gphysical
26344197
IPP2_HUMANPPP1R2physical
26344197
PRP19_HUMANPRPF19physical
26344197
PSDE_HUMANPSMD14physical
26344197
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDIA5_HUMAN

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Related Literatures of Post-Translational Modification

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