PXDNL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PXDNL_HUMAN
• UniProt AC: A1KZ92
• Protein Name: Peroxidasin-like protein
• Gene Name: PXDNL
• Organism: Homo sapiens (Human).
• Sequence Length: 1463
• Subcellular Localization: Secreted .; Isoform PMR1: Cytoplasm. Associates with polysomes.
• Protein Description: Isoform PMR1: Endonuclease selectively degrading some target mRNAs while they are engaged by translating ribosomes, among which albumin and beta-globin mRNAs..
• Protein Sequence: MEPRLFCWTTLFLLAGWCLPGLPCPSRCLCFKSTVRCMHLMLDHIPQVPQQTTVLDLRFNRIREIPGSAFKKLKNLNTLLLNNNHIRKISRNAFEGLENLLYLYLYKNEIHALDKQTFKGLISLEHLYIHFNQLEMLQPETFGDLLRLERLFLHNNKLSKIPAGSFSNLDSLKRLRLDSNALVCDCDLMWLGELLQGFAQHGHTQAAATCEYPRRLHGRAVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVEGQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSVEVGKNINISCHAQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNSFGLAVTNMFLTVTAIQGRQAGDDFVESSILDAVQRVDSAINSTRRHLFSQKPHTSSDLLAQFHYPRDPLIVEMARAGEIFEHTLQLIRERVKQGLTVDLEGKEFRYNDLVSPRSLSLIANLSGCTARRPLPNCSNRCFHAKYRAHDGTCNNLQQPTWGAALTAFARLLQPAYRDGIRAPRGLGLPVGSRQPLPPPRLVATVWARAAAVTPDHSYTRMLMHWGWFLEHDLDHTVPALSTARFSDGRPCSSVCTNDPPCFPMNTRHADPRGTHAPCMLFARSSPACASGRPSATVDSVYAREQINQQTAYIDGSNVYGSSERESQALRDPSVPRGLLKTGFPWPPSGKPLLPFSTGPPTECARQEQESPCFLAGDHRANEHLALAAMHTLWFREHNRMATELSALNPHWEGNTVYQEARKIVGAELQHITYSHWLPKVLGDPGTRMLRGYRGYNPNVNAGIINSFATAAFRFGHTLINPILYRLNATLGEISEGHLPFHKALFSPSRIIKEGGIDPVLRGLFGVAAKWRAPSYLLSPELTQRLFSAAYSAAVDSAATIIQRGRDHGIPPYVDFRVFCNLTSVKNFEDLQNEIKDSEIRQKLRKLYGSPGDIDLWPALMVEDLIPGTRVGPTLMCLFVTQFQRLRDGDRFWYENPGVFTPAQLTQLKQASLSRVLCDNGDSIQQVQADVFVKAEYPQDYLNCSEIPKVDLRVWQDCCADCRSRGQFRAVTQESQKKRSAQYSYPVDKDMELSHLRSRQQDKIYVGEDARNVTVLAKTKFSQDFSTFAAEIQETITALREQINKLEARLRQAGCTDVRGVPRKAEERWMKEDCTHCICESGQVTCVVEICPPAPCPSPELVKGTCCPVCRDRGMPSDSPEKR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
303	Phosphorylation	RESDQGVYQCMARNS CHHHCCHHHHHHCCC	11.65	24043423
387	N-linked_Glycosylation	SSGLYLQNITQRDHG CCCEEECCCCCCCCC	36.36	UniProtKB CARBOHYD
424	Phosphorylation	APPQFTVTPKDQVVL CCCCEECCCHHHEEE	22.89	24719451
500	Phosphorylation	SLGVKKVSVQLTVKP CCCCCEEEEEEEECC	17.02	25159151
520	Phosphorylation	FTQLPQDTSVEVGKN EEECCCCCEEECCCC	29.44	-
554	Phosphorylation	EGVQITESGKFHVDD CCEEECCCCCEEECC	38.34	21712546
649	Phosphorylation	DLLAQFHYPRDPLIV HHHHHCCCCCCHHHH	10.97	24719451
673	Dimethylation	EHTLQLIRERVKQGL HHHHHHHHHHHHCCC	33.97	-
673	Methylation	EHTLQLIRERVKQGL HHHHHHHHHHHHCCC	33.97	24411673
675	Dimethylation	TLQLIRERVKQGLTV HHHHHHHHHHCCCEE	30.96	-
675	Methylation	TLQLIRERVKQGLTV HHHHHHHHHHCCCEE	30.96	24411679
1140	Phosphorylation	AAVDSAATIIQRGRD HHHHHHHHHHHHCHH	20.52	-
1252	Phosphorylation	LTQLKQASLSRVLCD HHHHHHHCHHEEECC	25.12	27174698
1254	Phosphorylation	QLKQASLSRVLCDNG HHHHHCHHEEECCCC	20.18	27174698
1277	Phosphorylation	DVFVKAEYPQDYLNC EEEEEECCCCCCCCC	15.85	29978859
1281	Phosphorylation	KAEYPQDYLNCSEIP EECCCCCCCCCCCCC	8.45	29978859
1285	Phosphorylation	PQDYLNCSEIPKVDL CCCCCCCCCCCCCCC	37.17	29978859
1334	Phosphorylation	VDKDMELSHLRSRQQ CCCCCHHHHHHHCCC	13.73	30576142
1338	Phosphorylation	MELSHLRSRQQDKIY CHHHHHHHCCCCCEE	40.58	30576142
1354	Phosphorylation	GEDARNVTVLAKTKF CCCCCCEEEEEEECC	17.22	-
1377	Phosphorylation	AEIQETITALREQIN HHHHHHHHHHHHHHH	27.36	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PXDNL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PXDNL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PXDNL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CARM1_HUMAN	CARM1	physical	26344197
SPTN1_HUMAN	SPTAN1	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.