NACAD_HUMAN - dbPTM
NACAD_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NACAD_HUMAN
UniProt AC O15069
Protein Name NAC-alpha domain-containing protein 1
Gene Name NACAD
Organism Homo sapiens (Human).
Sequence Length 1562
Subcellular Localization Cytoplasm. Nucleus.
Protein Description May prevent inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). May bind to nascent polypeptide chains as they emerge from the ribosome and block their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. May also reduce the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)..
Protein Sequence MPGEAARAELLLPEADRPGPRTDLSCDAAAATTILGGDRREPCALTPGPSHLALTFLPSKPGARPQPEGASWDAGPGGAPSAWADPGEGGPSPMLLPEGLSSQALSTEAPLPATLEPRIVMGEETCQALLSPRAARTALRDQEGGHASPDPPPELCSQGDLSVPSPPPDPDSFFTPPSTPTKTTYALLPACGPHGDARDSEAELRDELLDSPPASPSGSYITADGDSWASSPSCSLSLLAPAEGLDFPSGWGLSPQGSMVDERELHPAGTPEPPSSESSLSADSSSSWGQEGHFFDLDFLANDPMIPAALLPFQGSLIFQVEAVEVTPLSPEEEEEEAVADPDPGGDLAGEGEEDSTSASFLQSLSDLSITEGMDEAFAFRDDTSAASSDSDSASYAEADDERLYSGEPHAQATLLQDSVQKTEEESGGGAKGLQAQDGTVSWAVEAAPQTSDRGAYLSQRQELISEVTEEGLALGQESTATVTPHTLQVAPGLQVEVATRVTPQAGEEETDSTAGQESAAMAMPQPSQEGISEILGQESVTAEKLPTPQEETSLTLCPDSPQNLKEEGGLDLPSGRKPVAAATIVPRQAKEDLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSVMTPPLPLQDTELSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATLVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATIVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTPPLPLQDTDLSSAPKPVAAATPVSQQAEEGLTLPQDSAMTAPLPLQDTGPTSGPEPLAVATPQTLQAEAGCAPGTEPVATMAQQEVGEALGPRPAPEEKNAALPTVPEPAALDQVQQDDPQPAAEAGTPWAAQEDADSTLGMEALSLPEPASGAGEEIAEALSRPGREACLEARAHTGDGAKPDSPQKETLEVENQQEGGLKPLAQEHGPRSALGGAREVPDAPPAACPEVSQARLLSPAREERGLSGKSTPEPTLPSAVATEASLDSCPESSVGAVSSLDRGCPDAPAPTSAPTSQQPEPVLGLGSVEQPHEVPSVLGTPLLQPPENLAKGQPSTPVDRPLGPDPSAPGTLAGAALPPLEPPAPCLCQDPQEDSVEDEEPPGSLGLPPPQAGVQPAAAAVSGTTQPLGTGPRVSLSPHSPLLSPKVASMDAKDLALQILPPCQVPPPSGPQSPAGPQGLSAPEQQEDEDSLEEDSPRALGSGQHSDSHGESSAELDEQDILAPQTVQCPAQAPAGGSEETIAKAKQSRSEKKARKAMSKLGLRQIQGVTRITIQKSKNILFVIAKPDVFKSPASDTYVVFGEAKIEDLSQQVHKAAAEKFKVPSEPSALVPESAPRPRVRLECKEEEEEEEEEVDEAGLELRDIELVMAQANVSRAKAVRALRDNHSDIVNAIMELTM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
59PhosphorylationLALTFLPSKPGARPQ
EEEEECCCCCCCCCC		54.3424719451
131PhosphorylationETCQALLSPRAARTA
HHHHHHHCHHHHHHH		17.1228555341
137PhosphorylationLSPRAARTALRDQEG
HCHHHHHHHHHCCCC		25.8925921289
148PhosphorylationDQEGGHASPDPPPEL
CCCCCCCCCCCCHHH		24.9425921289
162PhosphorylationLCSQGDLSVPSPPPD
HHCCCCCCCCCCCCC		36.4026471730
165PhosphorylationQGDLSVPSPPPDPDS
CCCCCCCCCCCCCCC		48.1326471730
172PhosphorylationSPPPDPDSFFTPPST
CCCCCCCCCCCCCCC		27.8726471730
175PhosphorylationPDPDSFFTPPSTPTK
CCCCCCCCCCCCCCC		32.0725921289
178PhosphorylationDSFFTPPSTPTKTTY
CCCCCCCCCCCCCEE		48.5026471730
179PhosphorylationSFFTPPSTPTKTTYA
CCCCCCCCCCCCEEE		40.5328787133
181PhosphorylationFTPPSTPTKTTYALL
CCCCCCCCCCEEEEE		40.9028787133
405PhosphorylationEADDERLYSGEPHAQ
CCCCHHHHCCCCCHH		22.3527732954
406PhosphorylationADDERLYSGEPHAQA
CCCHHHHCCCCCHHH		41.0727732954
414PhosphorylationGEPHAQATLLQDSVQ
CCCCHHHHHHHHHHH		18.8727732954
419PhosphorylationQATLLQDSVQKTEEE
HHHHHHHHHHHCHHH		17.3128555341
548PhosphorylationVTAEKLPTPQEETSL
CCCCCCCCCCHHHCC		48.3027732954
553PhosphorylationLPTPQEETSLTLCPD
CCCCCHHHCCEECCC		28.4327732954
554PhosphorylationPTPQEETSLTLCPDS
CCCCHHHCCEECCCC		23.7227732954
556PhosphorylationPQEETSLTLCPDSPQ
CCHHHCCEECCCCCC		26.5327732954
561PhosphorylationSLTLCPDSPQNLKEE
CCEECCCCCCCHHHC		17.3327732954
575PhosphorylationEGGLDLPSGRKPVAA
CCCCCCCCCCCCCEE		59.5328555341
600PhosphorylationDLTLPQDSAMTPPLP
CCCCCCCCCCCCCCC		18.0727732954
603PhosphorylationLPQDSAMTPPLPLQD
CCCCCCCCCCCCCCC		22.8227732954
611PhosphorylationPPLPLQDTDLSSAPK
CCCCCCCCCCCCCCC		26.3627732954
614PhosphorylationPLQDTDLSSAPKPVA
CCCCCCCCCCCCCCE		27.5427732954
615PhosphorylationLQDTDLSSAPKPVAA
CCCCCCCCCCCCCEE		56.7527732954
880PhosphorylationGLTLPQDSAMTPPLP
CCCCCCCCCCCCCCC		18.0727732954
883PhosphorylationLPQDSAMTPPLPLQD
CCCCCCCCCCCCCCC		22.8227732954
891PhosphorylationPPLPLQDTDLSSAPK
CCCCCCCCCCCCCCC		26.3627732954
894PhosphorylationPLQDTDLSSAPKPVA
CCCCCCCCCCCCCCE		27.5427732954
895PhosphorylationLQDTDLSSAPKPVAA
CCCCCCCCCCCCCEE		56.7527732954
1060PhosphorylationCLEARAHTGDGAKPD
HHHHHHCCCCCCCCC		35.66-
1068PhosphorylationGDGAKPDSPQKETLE
CCCCCCCCCCCCEEE		37.4424117733
1073PhosphorylationPDSPQKETLEVENQQ
CCCCCCCEEEEECCC		34.9424117733
1121PhosphorylationVSQARLLSPAREERG
CHHHHHCCHHHHHCC		22.5529900121
1130PhosphorylationAREERGLSGKSTPEP
HHHHCCCCCCCCCCC		47.1827732954
1133PhosphorylationERGLSGKSTPEPTLP
HCCCCCCCCCCCCCC		53.3627732954
1134PhosphorylationRGLSGKSTPEPTLPS
CCCCCCCCCCCCCCC		34.8527732954
1138PhosphorylationGKSTPEPTLPSAVAT
CCCCCCCCCCCHHHC		50.0327732954
1141PhosphorylationTPEPTLPSAVATEAS
CCCCCCCCHHHCHHH		38.1927732954
1145PhosphorylationTLPSAVATEASLDSC
CCCCHHHCHHHHHCC		26.0322468782
1148PhosphorylationSAVATEASLDSCPES
CHHHCHHHHHCCCCC		26.8627732954
1151PhosphorylationATEASLDSCPESSVG
HCHHHHHCCCCCHHC		36.5427732954
1210UbiquitinationTPLLQPPENLAKGQP
CCCCCCCCHHCCCCC		72.1221890473
1255UbiquitinationPCLCQDPQEDSVEDE
CCCCCCCCCCCCCCC		75.3522817900
1298PhosphorylationLGTGPRVSLSPHSPL
CCCCCCCCCCCCCCC		25.1423403867
1300PhosphorylationTGPRVSLSPHSPLLS
CCCCCCCCCCCCCCC		17.0423403867
1303PhosphorylationRVSLSPHSPLLSPKV
CCCCCCCCCCCCCCC		22.1922617229
1307PhosphorylationSPHSPLLSPKVASMD
CCCCCCCCCCCCCCC		30.2922617229
1332PhosphorylationPCQVPPPSGPQSPAG
CCCCCCCCCCCCCCC		69.7325921289
1336PhosphorylationPPPSGPQSPAGPQGL
CCCCCCCCCCCCCCC		21.6125921289
1344PhosphorylationPAGPQGLSAPEQQED
CCCCCCCCCCCCCCC		48.9125921289
1354PhosphorylationEQQEDEDSLEEDSPR
CCCCCCCCCCCCCCC		35.3225921289
1359PhosphorylationEDSLEEDSPRALGSG
CCCCCCCCCCHHCCC		21.4025921289
1365PhosphorylationDSPRALGSGQHSDSH
CCCCHHCCCCCCCCC		35.8125921289
1369PhosphorylationALGSGQHSDSHGESS
HHCCCCCCCCCCCCC		32.6825921289
1371PhosphorylationGSGQHSDSHGESSAE
CCCCCCCCCCCCCCC		36.0825921289
1375PhosphorylationHSDSHGESSAELDEQ
CCCCCCCCCCCCCCC		39.1725921289
1409UbiquitinationEETIAKAKQSRSEKK
HHHHHHHHHHHHHHH		48.37-
1419MethylationRSEKKARKAMSKLGL
HHHHHHHHHHHHHCH		53.99-
1422PhosphorylationKKARKAMSKLGLRQI
HHHHHHHHHHCHHHH		29.5924719451
1423UbiquitinationKARKAMSKLGLRQIQ
HHHHHHHHHCHHHHC		33.2332015554
1433PhosphorylationLRQIQGVTRITIQKS
HHHHCCEEEEEEECC		24.1529978859
1436PhosphorylationIQGVTRITIQKSKNI
HCCEEEEEEECCCCE		17.6729978859
1440PhosphorylationTRITIQKSKNILFVI
EEEEEECCCCEEEEE		17.9829978859
1468UbiquitinationYVVFGEAKIEDLSQQ
EEEEEEEEHHHHHHH		42.1822817900
1538PhosphorylationVMAQANVSRAKAVRA
HHHHCCCHHHHHHHH		26.7429396449
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NACAD_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NACAD_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NACAD_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NACAD_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NACAD_HUMAN

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Related Literatures of Post-Translational Modification

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