SOCS4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SOCS4_HUMAN
• UniProt AC: Q8WXH5
• Protein Name: Suppressor of cytokine signaling 4
• Gene Name: SOCS4
• Organism: Homo sapiens (Human).
• Sequence Length: 440
• Protein Description: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR..
• Protein Sequence: MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRNMEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	VRPKTSRSRSADRKD CCCCCCCCCCCCCCC	30.29	22210691
27	Acetylation	RSRSADRKDGYVWSG CCCCCCCCCCEEECC	56.93	7707133
30	Phosphorylation	SADRKDGYVWSGKKL CCCCCCCEEECCCCC	14.63	28152594
33	Phosphorylation	RKDGYVWSGKKLSWS CCCCEEECCCCCCCC	30.59	28152594
106	Ubiquitination	VGQCFPIKNCSSRHS HHHCEECCCCCCCCC	52.73	-
109	Phosphorylation	CFPIKNCSSRHSSGL CEECCCCCCCCCCCC	39.54	29978859
110	Phosphorylation	FPIKNCSSRHSSGLP EECCCCCCCCCCCCC	35.89	29978859
113	Phosphorylation	KNCSSRHSSGLPSKR CCCCCCCCCCCCCCC	25.62	28842319
114	Phosphorylation	NCSSRHSSGLPSKRK CCCCCCCCCCCCCCE	37.92	28842319
118	Phosphorylation	RHSSGLPSKRKIHIS CCCCCCCCCCEEEHH	50.57	24719451
219	Phosphorylation	GSVMNLVSNNSIEDS CHHHHHHCCCCCCCC	33.20	-
260	Phosphorylation	DEILQLETPPKYHTQ HHHHHCCCCCCCCCC	54.18	24719451
323	Phosphorylation	EDYLFSVSFRRYSRS CCEEEEEEEHHHHHH	16.31	24719451
327	Phosphorylation	FSVSFRRYSRSLHAR EEEEEHHHHHHHHHH	12.27	-
343	Phosphorylation	EQWNHNFSFDAHDPC HHCCCCCCCCCCCCC	27.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SOCS4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SOCS4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SOCS4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EGFR_HUMAN	EGFR	physical	17997974
VWF_HUMAN	VWF	physical	21988832
SPY1_HUMAN	SPRY1	physical	21988832
ELOB_HUMAN	TCEB2	physical	23990909
ELOC_HUMAN	TCEB1	physical	23990909
CUL5_MOUSE	Cul5	physical	23990909
RBX2_MOUSE	Rnf7	physical	23990909
SHC1_MOUSE	Shc1	physical	23990909
PLPP6_HUMAN	PPAPDC2	physical	25814554
LDH6B_HUMAN	LDHAL6B	physical	25814554
CNMD_HUMAN	LECT1	physical	25814554
MPP5_HUMAN	MPP5	physical	25814554
PINK1_HUMAN	PINK1	physical	25814554
RET7_HUMAN	RBP7	physical	25814554
ACK1_HUMAN	TNK2	physical	25814554
FRS3_HUMAN	FRS3	physical	25814554
GRB2_HUMAN	GRB2	physical	25814554
P55G_HUMAN	PIK3R3	physical	25814554

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.