LDH6B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LDH6B_HUMAN
• UniProt AC: Q9BYZ2
• Protein Name: L-lactate dehydrogenase A-like 6B
• Gene Name: LDHAL6B
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Protein Sequence: MSWTVPVVRASQRVSSVGANFLCLGMALCPRQATRIPLNGTWLFTPVSKMATVKSELIERFTSEKPVHHSKVSIIGTGSVGMACAISILLKGLSDELALVDLDEDKLKGETMDLQHGSPFTKMPNIVCSKDYFVTANSNLVIITAGARQEKGETRLNLVQRNVAIFKLMISSIVQYSPHCKLIIVSNPVDILTYVAWKLSAFPKNRIIGSGCNLDTARFRFLIGQKLGIHSESCHGWILGEHGDSSVPVWSGVNIAGVPLKDLNSDIGTDKDPEQWKNVHKEVTATAYEIIKMKGYTSWAIGLSVADLTESILKNLRRIHPVSTIIKGLYGIDEEVFLSIPCILGENGITNLIKIKLTPEEEAHLKKSAKTLWEIQNKLKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	Acetylation	LVDLDEDKLKGETMD EEECCCHHHCCCEEE	50.48	25038526
108	Acetylation	DLDEDKLKGETMDLQ ECCCHHHCCCEEECC	61.51	25038526
121	Phosphorylation	LQHGSPFTKMPNIVC CCCCCCCCCCCCEEE	29.80	-
129	Phosphorylation	KMPNIVCSKDYFVTA CCCCEEECCCEEEEC	20.05	-
138	Phosphorylation	DYFVTANSNLVIITA CEEEECCCCEEEEEC	29.13	24719451
144	Phosphorylation	NSNLVIITAGARQEK CCCEEEEECCCCCCC	14.12	28857561
154	Phosphorylation	ARQEKGETRLNLVQR CCCCCCCHHHHHHHH	49.47	-
181	Ubiquitination	VQYSPHCKLIIVSNP HHHCCCCEEEEECCC	39.42	-
194	Phosphorylation	NPVDILTYVAWKLSA CCHHHHHHHHHHHCC	5.68	20090780
216	Phosphorylation	GSGCNLDTARFRFLI CCCCCCCHHHHHHHH	23.93	-
271	Acetylation	NSDIGTDKDPEQWKN CCCCCCCCCHHHHHH	75.03	25038526
277	Ubiquitination	DKDPEQWKNVHKEVT CCCHHHHHHHCHHHH	49.11	-
277	Acetylation	DKDPEQWKNVHKEVT CCCHHHHHHHCHHHH	49.11	25038526
281	Acetylation	EQWKNVHKEVTATAY HHHHHHCHHHHHHHH	49.99	25038526
288	Phosphorylation	KEVTATAYEIIKMKG HHHHHHHHHHHHHCC	11.87	22817900
311	Phosphorylation	SVADLTESILKNLRR CHHHHHHHHHHHHHH	28.17	24719451
323	Phosphorylation	LRRIHPVSTIIKGLY HHHHCCHHHHHHHCC	20.52	20068231
324	Phosphorylation	RRIHPVSTIIKGLYG HHHCCHHHHHHHCCC	27.27	20068231
358	Phosphorylation	NLIKIKLTPEEEAHL EEEEEECCHHHHHHH	24.53	23403867
370	Acetylation	AHLKKSAKTLWEIQN HHHHHHHHHHHHHHH	51.76	25038526

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LDH6B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LDH6B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LDH6B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANM5_HUMAN	PRMT5	physical	23455924
ANM6_HUMAN	PRMT6	physical	23455924
SUV91_HUMAN	SUV39H1	physical	23455924
BCCIP_HUMAN	BCCIP	physical	22863883
CAN1_HUMAN	CAPN1	physical	22863883
KYNU_HUMAN	KYNU	physical	22863883
LDHA_HUMAN	LDHA	physical	22863883
NHRF1_HUMAN	SLC9A3R1	physical	22863883
SPSY_HUMAN	SMS	physical	22863883
IF2M_HUMAN	MTIF2	physical	26186194
GRP78_HUMAN	HSPA5	physical	26186194
APBB2_HUMAN	APBB2	physical	26186194
GABT_HUMAN	ABAT	physical	26344197
AL4A1_HUMAN	ALDH4A1	physical	26344197
ARF4_HUMAN	ARF4	physical	26344197
ARF5_HUMAN	ARF5	physical	26344197
MDHC_HUMAN	MDH1	physical	26344197
DHSO_HUMAN	SORD	physical	26344197
TALDO_HUMAN	TALDO1	physical	26344197
TPIS_HUMAN	TPI1	physical	26344197
APBB2_HUMAN	APBB2	physical	28514442
IF2M_HUMAN	MTIF2	physical	28514442
DNLZ_HUMAN	DNLZ	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.