GABT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GABT_HUMAN
• UniProt AC: P80404
• Protein Name: 4-aminobutyrate aminotransferase, mitochondrial
• Gene Name: ABAT
• Organism: Homo sapiens (Human).
• Sequence Length: 500
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine..
• Protein Sequence: MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASMLLAQRL -----CHHHHHHHHH	14.52	24043423
98	Phosphorylation	NRMLDLYSQISSVPI CEEEHHHHHHHCCCC	28.47	22210691
107	Phosphorylation	ISSVPIGYSHPALLK HHCCCCCCCCHHHHH	12.43	22210691
108	Phosphorylation	SSVPIGYSHPALLKL HCCCCCCCCHHHHHH	20.13	22210691
231	Succinylation	CLATTHSKAIHKIDI EEEECCCCCEEECCC	43.70	-
231	Succinylation	CLATTHSKAIHKIDI EEEECCCCCEEECCC	43.70	-
252	Succinylation	IAPFPRLKYPLEEFV CCCCCCCCCCHHHHH	46.21	-
252	Succinylation	IAPFPRLKYPLEEFV CCCCCCCCCCHHHHH	46.21	-
252	Acetylation	IAPFPRLKYPLEEFV CCCCCCCCCCHHHHH	46.21	27178108
279	Acetylation	EVEDLIVKYRKKKKT HHHHHHHHHHHCCCE	32.13	-
286	Phosphorylation	KYRKKKKTVAGIIVE HHHHCCCEEEEEEEE	25.19	46156231
318	Acetylation	KLRDIARKHGCAFLV HHHHHHHHHCCEEEE	35.01	-
357	Other	ADVMTFSKKMMTGGF HHHHHHHHHHHCCCC	40.26	-
357	Acetylation	ADVMTFSKKMMTGGF HHHHHHHHHHHCCCC	40.26	7744091
357	N6-(pyridoxal phosphate)lysine	ADVMTFSKKMMTGGF HHHHHHHHHHHCCCC	40.26	-
358	Acetylation	DVMTFSKKMMTGGFF HHHHHHHHHHCCCCC	32.48	24888411
413	Acetylation	NNAAHAGKALLTGLL HCHHHHHHHHHHHHH	36.32	-
413	Succinylation	NNAAHAGKALLTGLL HCHHHHHHHHHHHHH	36.32	-
413	Succinylation	NNAAHAGKALLTGLL HCHHHHHHHHHHHHH	36.32	-
452	Acetylation	PDDSIRNKLILIARN CCHHHHCCEEEEECC	27.36	-
470	Acetylation	VLGGCGDKSIRFRPT EECCCCCCCCCCCCE	32.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GABT_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GABT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GABT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PUR8_HUMAN	ADSL	physical	26344197
ALDR_HUMAN	AKR1B1	physical	26344197
CBS_HUMAN	CBS	physical	26344197
ENOA_HUMAN	ENO1	physical	26344197
ESTD_HUMAN	ESD	physical	26344197
FAAA_HUMAN	FAH	physical	26344197
FAHD1_HUMAN	FAHD1	physical	26344197
G6PI_HUMAN	GPI	physical	26344197
DHB14_HUMAN	HSD17B14	physical	26344197
CH10_HUMAN	HSPE1	physical	26344197
PDC6I_HUMAN	PDCD6IP	physical	26344197
PGM1_HUMAN	PGM1	physical	26344197
PGM2_HUMAN	PGM2	physical	26344197
DHPR_HUMAN	QDPR	physical	26344197
RD23B_HUMAN	RAD23B	physical	26344197
DHSO_HUMAN	SORD	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613163: GABA transaminase deficiency (GABATD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.