FAHD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FAHD1_HUMAN
• UniProt AC: Q6P587
• Protein Name: Acylpyruvase FAHD1, mitochondrial
• Gene Name: FAHD1
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Mitochondrion . Cytoplasm, cytosol .
• Protein Description: Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. [PubMed: 15551868]
• Protein Sequence: MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPILMPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWTLAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPKGVGPVKENDEIEAGIHGLVSMTFKVEKPEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
36	Phosphorylation	DHVREMRSAVLSEPV HHHHHHHHHHHCCCE	22.78	20068231
40	Phosphorylation	EMRSAVLSEPVLFLK HHHHHHHCCCEEEEC	33.00	27050516
47	Ubiquitination	SEPVLFLKPSTAYAP CCCEEEECCCCCCCC	29.59	24816145
49	Phosphorylation	PVLFLKPSTAYAPEG CEEEECCCCCCCCCC	24.88	20068231
50	Phosphorylation	VLFLKPSTAYAPEGS EEEECCCCCCCCCCC	32.01	20068231
52	Phosphorylation	FLKPSTAYAPEGSPI EECCCCCCCCCCCCC	23.83	20068231
57	Phosphorylation	TAYAPEGSPILMPAY CCCCCCCCCCEEECE	13.70	20068231
64	Phosphorylation	SPILMPAYTRNLHHE CCCEEECEECCCCHH	10.60	20068231
65	Phosphorylation	PILMPAYTRNLHHEL CCEEECEECCCCHHH	18.39	20068231
80	2-Hydroxyisobutyrylation	ELGVVMGKRCRAVPE HHHHHCCCCCCCCCH	30.17	-
113	Acetylation	RDVQDECKKKGLPWT HHHHHHHHHCCCCCH	56.31	2380357
113	Succinylation	RDVQDECKKKGLPWT HHHHHHHHHCCCCCH	56.31	23954790
114	Acetylation	DVQDECKKKGLPWTL HHHHHHHHCCCCCHH	64.83	2402149
115 (in isoform 3)	Malonylation	-	51.69	26320211
115	Succinylation	VQDECKKKGLPWTLA HHHHHHHCCCCCHHH	51.69	-
115	Malonylation	VQDECKKKGLPWTLA HHHHHHHCCCCCHHH	51.69	26320211
115	Succinylation	VQDECKKKGLPWTLA HHHHHHHCCCCCHHH	51.69	-
190	Phosphorylation	EEGDIILTGTPKGVG CCCCEEEECCCCCCC	28.71	-
192	Phosphorylation	GDIILTGTPKGVGPV CCEEEECCCCCCCCC	19.32	18452278
194	Succinylation	IILTGTPKGVGPVKE EEEECCCCCCCCCCC	67.09	23954790
217 (in isoform 3)	Phosphorylation	-	6.63	27251275
219 (in isoform 3)	Phosphorylation	-	11.32	27251275
219	Phosphorylation	LVSMTFKVEKPEY-- EEEEEEEECCCCC--	11.32	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FAHD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FAHD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FAHD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PLPP1_HUMAN	PPAP2A	physical	21988832
UBR3_HUMAN	UBR3	physical	26186194
CPT2_HUMAN	CPT2	physical	26186194
PNPT1_HUMAN	PNPT1	physical	26186194
CLU_HUMAN	CLUH	physical	26186194
DHTK1_HUMAN	DHTKD1	physical	26186194
UBR3_HUMAN	UBR3	physical	28514442
PNPT1_HUMAN	PNPT1	physical	28514442
CPT2_HUMAN	CPT2	physical	28514442
DHTK1_HUMAN	DHTKD1	physical	28514442
CLU_HUMAN	CLUH	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.