DHTK1_HUMAN - dbPTM
DHTK1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID DHTK1_HUMAN
UniProt AC Q96HY7
Protein Name Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial
Gene Name DHTKD1
Organism Homo sapiens (Human).
Sequence Length 919
Subcellular Localization Mitochondrion .
Protein Description The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity)..
Protein Sequence MASATAAAARRGLGRALPLFWRGYQTERGVYGYRPRKPESREPQGALERPPVDHGLARLVTVYCEHGHKAAKINPLFTGQALLENVPEIQALVQTLQGPFHTAGLLNMGKEEASLEEVLVYLNQIYCGQISIETSQLQSQDEKDWFAKRFEELQKETFTTEERKHLSKLMLESQEFDHFLATKFSTVKRYGGEGAESMMGFFHELLKMSAYSGITDVIIGMPHRGRLNLLTGLLQFPPELMFRKMRGLSEFPENFSATGDVLSHLTSSVDLYFGAHHPLHVTMLPNPSHLEAVNPVAVGKTRGRQQSRQDGDYSPDNSAQPGDRVICLQVHGDASFCGQGIVPETFTLSNLPHFRIGGSVHLIVNNQLGYTTPAERGRSSLYCSDIGKLVGCAIIHVNGDSPEEVVRATRLAFEYQRQFRKDVIIDLLCYRQWGHNELDEPFYTNPIMYKIIRARKSIPDTYAEHLIAGGLMTQEEVSEIKSSYYAKLNDHLNNMAHYRPPALNLQAHWQGLAQPEAQITTWSTGVPLDLLRFVGMKSVEVPRELQMHSHLLKTHVQSRMEKMMDGIKLDWATAEALALGSLLAQGFNVRLSGQDVGRGTFSQRHAIVVCQETDDTYIPLNHMDPNQKGFLEVSNSPLSEEAVLGFEYGMSIESPKLLPLWEAQFGDFFNGAQIIFDTFISGGEAKWLLQSGIVILLPHGYDGAGPDHSSCRIERFLQMCDSAEEGVDGDTVNMFVVHPTTPAQYFHLLRRQMVRNFRKPLIVASPKMLLRLPAAVSTLQEMAPGTTFNPVIGDSSVDPKKVKTLVFCSGKHFYSLVKQRESLGAKKHDFAIIRVEELCPFPLDSLQQEMSKYKHVKDHIWSQEEPQNMGPWSFVSPRFEKQLACKLRLVGRPPLPVPAVGIGTVHLHQHEDILAKTFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
148UbiquitinationDEKDWFAKRFEELQK
CHHHHHHHHHHHHHH		48.4232015554
148AcetylationDEKDWFAKRFEELQK
CHHHHHHHHHHHHHH		48.4219608861
157PhosphorylationFEELQKETFTTEERK
HHHHHHHCCCHHHHH		33.0624275569
183SuccinylationFDHFLATKFSTVKRY
HHHHHHHHHHCCHHH		31.54-
183SuccinylationFDHFLATKFSTVKRY
HHHHHHHHHHCCHHH		31.54-
188AcetylationATKFSTVKRYGGEGA
HHHHHCCHHHCCCCH		39.742380393
188SuccinylationATKFSTVKRYGGEGA
HHHHHCCHHHCCCCH		39.74-
188SuccinylationATKFSTVKRYGGEGA
HHHHHCCHHHCCCCH		39.74-
537UbiquitinationLLRFVGMKSVEVPRE
HHHHCCCCCCCCCHH		45.48-
553UbiquitinationQMHSHLLKTHVQSRM
HHHHHHHHHHHHHHH		42.8329967540
765PhosphorylationRKPLIVASPKMLLRL
CCCEEEECHHHHHHH		17.7325247763
777PhosphorylationLRLPAAVSTLQEMAP
HHHHHHHHHHHHHCC		20.7620068231
778PhosphorylationRLPAAVSTLQEMAPG
HHHHHHHHHHHHCCC		26.3420068231
786PhosphorylationLQEMAPGTTFNPVIG
HHHHCCCCCCCCCCC		27.4420068231
787PhosphorylationQEMAPGTTFNPVIGD
HHHCCCCCCCCCCCC		27.5920068231
795PhosphorylationFNPVIGDSSVDPKKV
CCCCCCCCCCCHHHC		27.3520068231
796PhosphorylationNPVIGDSSVDPKKVK
CCCCCCCCCCHHHCC		34.9720068231
800SuccinylationGDSSVDPKKVKTLVF
CCCCCCHHHCCEEEE		66.78-
800SuccinylationGDSSVDPKKVKTLVF
CCCCCCHHHCCEEEE		66.7823954790
800AcetylationGDSSVDPKKVKTLVF
CCCCCCHHHCCEEEE		66.7823954790
809PhosphorylationVKTLVFCSGKHFYSL
CCEEEEECCHHHHHH		39.14-
818AcetylationKHFYSLVKQRESLGA
HHHHHHHHHHHHHCC		49.2623954790
818SuccinylationKHFYSLVKQRESLGA
HHHHHHHHHHHHHCC		49.2627452117
818SuccinylationKHFYSLVKQRESLGA
HHHHHHHHHHHHHCC		49.26-
839GlutathionylationIIRVEELCPFPLDSL
EEEHHHHCCCCHHHH		3.5522555962
881UbiquitinationFVSPRFEKQLACKLR
CCCHHHHHHHHHHEE		48.1529967540
886UbiquitinationFEKQLACKLRLVGRP
HHHHHHHHEEECCCC		30.91-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of DHTK1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of DHTK1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of DHTK1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of DHTK1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615025Charcot-Marie-Tooth disease 2Q (CMT2Q)
2047502-aminoadipic 2-oxoadipic aciduria (AMOXAD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of DHTK1_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory