dbPTM

DHPR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DHPR_HUMAN
UniProt AC	P09417
Protein Name	Dihydropteridine reductase
Gene Name	QDPR
Organism	Homo sapiens (Human).
Sequence Length	244
Subcellular Localization
Protein Description	The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases..
Protein Sequence	MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAAAAGE ------CHHHHHHHH	13.05	22223895
11	Methylation	AAAAGEARRVLVYGG HHHHHHCEEEEEECC	25.57	115489771
16	Phosphorylation	EARRVLVYGGRGALG HCEEEEEECCCHHHH	15.09	-
57	Phosphorylation	ASIIVKMTDSFTEQA EEEEEEECCCHHHHH	23.83	22210691
59	Phosphorylation	IIVKMTDSFTEQADQ EEEEECCCHHHHHHH	25.54	22210691
61	Phosphorylation	VKMTDSFTEQADQVT EEECCCHHHHHHHHH	31.01	22210691
68	Phosphorylation	TEQADQVTAEVGKLL HHHHHHHHHHHHHHH	16.09	22210691
73	Succinylation	QVTAEVGKLLGEEKV HHHHHHHHHHCCCCC	45.79	-
73	Succinylation	QVTAEVGKLLGEEKV HHHHHHHHHHCCCCC	45.79	-
79	Succinylation	GKLLGEEKVDAILCV HHHHCCCCCCEEEEE	40.90	-
79	Succinylation	GKLLGEEKVDAILCV HHHHCCCCCCEEEEE	40.90	-
96	Succinylation	GWAGGNAKSKSLFKN CCCCCCCCCCHHHHC	63.52	-
96	Succinylation	GWAGGNAKSKSLFKN CCCCCCCCCCHHHHC	63.52	-
97	Phosphorylation	WAGGNAKSKSLFKNC CCCCCCCCCHHHHCC	25.68	24719451
99	Phosphorylation	GGNAKSKSLFKNCDL CCCCCCCHHHHCCCE	46.24	24719451
102	Acetylation	AKSKSLFKNCDLMWK CCCCHHHHCCCEEEC	63.06	25038526
102	Succinylation	AKSKSLFKNCDLMWK CCCCHHHHCCCEEEC	63.06	-
102	Succinylation	AKSKSLFKNCDLMWK CCCCHHHHCCCEEEC	63.06	-
102	Malonylation	AKSKSLFKNCDLMWK CCCCHHHHCCCEEEC	63.06	26320211
107	Ubiquitination	LFKNCDLMWKQSIWT HHHCCCEEECCHHHH	2.41	-
109	Methylation	KNCDLMWKQSIWTST HCCCEEECCHHHHHH	21.87	115975993
123	Phosphorylation	TISSHLATKHLKEGG HHHHHHHHHHHHHCC	25.92	-
124	Acetylation	ISSHLATKHLKEGGL HHHHHHHHHHHHCCE	41.13	25953088
133	Phosphorylation	LKEGGLLTLAGAKAA HHHCCEEEHHCHHHH	21.43	20068231
138	Ubiquitination	LLTLAGAKAALDGTP EEEHHCHHHHHCCCC	33.02	-
147	Sulfoxidation	ALDGTPGMIGYGMAK HHCCCCCHHHHHHHH	1.95	30846556
152	Sulfoxidation	PGMIGYGMAKGAVHQ CCHHHHHHHHHHHHH	2.34	30846556
184	Phosphorylation	AIAVLPVTLDTPMNR EEEEEEEEECCCCCC	19.58	-
187	Phosphorylation	VLPVTLDTPMNRKSM EEEEEECCCCCCCCC	27.79	-
193	Phosphorylation	DTPMNRKSMPEADFS CCCCCCCCCCCCCCC	36.01	-
203	Phosphorylation	EADFSSWTPLEFLVE CCCCCCCCHHHHHHH	21.68	-
223	Phosphorylation	ITGKNRPSSGSLIQV HHCCCCCCCCCCEEE	44.06	8137944
224	Phosphorylation	TGKNRPSSGSLIQVV HCCCCCCCCCCEEEE	34.77	28857561
226	Phosphorylation	KNRPSSGSLIQVVTT CCCCCCCCCEEEEEC	25.01	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
223	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
223	S	Phosphorylation	Kinase	CAM-KII_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DHPR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DHPR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHPR_HUMAN	QDPR	physical	25416956
AN13A_HUMAN	ANKRD13A	physical	25416956
CH10_HUMAN	HSPE1	physical	26344197
PDCD6_HUMAN	PDCD6	physical	26344197
TNG2_HUMAN	TANGO2	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
261630	Hyperphenylalaninemia, BH4-deficient, C (HPABH4C)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DHPR_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]