AN13A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AN13A_HUMAN
• UniProt AC: Q8IZ07
• Protein Name: Ankyrin repeat domain-containing protein 13A
• Gene Name: ANKRD13A
• Organism: Homo sapiens (Human).
• Sequence Length: 590
• Subcellular Localization: Cell membrane . Late endosome . Interaction with EGFR may enhance association with the cell membrane.
• Protein Description: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane..
• Protein Sequence: MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSACDAGD ------CCCCCCCCC	27.00	28857561
3	Phosphorylation	-----MSSACDAGDH -----CCCCCCCCCC	31.45	28857561
19	Ubiquitination	PLHLLVWKNDYRQLE CEEEEEEECHHHHHH	32.25	21890473
27	Ubiquitination	NDYRQLEKELQGQNV CHHHHHHHHHCCCCC	72.77	21906983
91	Phosphorylation	TGDPEMVYTVLQHRD CCCHHHHEEEEHHCC	6.99	75317
99	Phosphorylation	TVLQHRDYHNTSMAL EEEHHCCCCCHHHHH	9.27	22199227
102	Phosphorylation	QHRDYHNTSMALEGV HHCCCCCHHHHHCCH	13.43	28857561
103	Phosphorylation	HRDYHNTSMALEGVP HCCCCCHHHHHCCHH	13.84	22199227
175	Phosphorylation	SWIRGRRSFIFKGED CEECCCCEEEEECCC	22.72	24719451
188	Sulfoxidation	EDNWAELMEVNHDDK CCCHHHHCCCCCCCC	3.98	30846556
195	Ubiquitination	MEVNHDDKVVTTERF CCCCCCCCEEEECCC	44.66	21906983
205	Phosphorylation	TTERFDLSQEMERLT EECCCCHHHHHHHHH	26.41	21082442
208	Sulfoxidation	RFDLSQEMERLTLDL CCCHHHHHHHHHHHH	2.55	21406390
217	Ubiquitination	RLTLDLMKPKSREVE HHHHHHHCCCCHHHH	57.50	21906983
217	Acetylation	RLTLDLMKPKSREVE HHHHHHHCCCCHHHH	57.50	7825331
219	Ubiquitination	TLDLMKPKSREVERR HHHHHCCCCHHHHHH	57.54	-
219	Acetylation	TLDLMKPKSREVERR HHHHHCCCCHHHHHH	57.54	7825341
228	Phosphorylation	REVERRLTSPVINTS HHHHHHHCCCCCCCC	29.22	28857561
229	Phosphorylation	EVERRLTSPVINTSL HHHHHHCCCCCCCCC	23.05	28857561
239	Ubiquitination	INTSLDTKNIAFERT CCCCCCCCCCEEEEC	46.13	21906983
247	Ubiquitination	NIAFERTKSGFWGWR CCEEEECCCCCCCEE	55.60	21906983
248	Phosphorylation	IAFERTKSGFWGWRT CEEEECCCCCCCEEC	38.31	28857561
257	Ubiquitination	FWGWRTDKAEVVNGY CCCEECCCEEEECCE	45.92	21906983
269	Phosphorylation	NGYEAKVYTVNNVNV CCEEEEEEEECCEEE	12.31	28064214
270	Phosphorylation	GYEAKVYTVNNVNVI CEEEEEEEECCEEEE	21.53	30301811
279	Ubiquitination	NNVNVITKIRTEHLT CCEEEEEEEEHHHCC	21.04	21906983
281	Methylation	VNVITKIRTEHLTEE EEEEEEEEHHHCCHH	35.30	-
290	Ubiquitination	EHLTEEEKKRYKADR HHCCHHHHHHHHCCC	45.92	-
291	Ubiquitination	HLTEEEKKRYKADRN HCCHHHHHHHHCCCC	65.33	-
351	Ubiquitination	DRDIGRPKELTIRTQ CCCCCCCCCCEEHHH	65.09	-
400	Ubiquitination	ARLRDFIKLEFPPGF HHHHHHHCCCCCCCC	41.79	21906983
410	Ubiquitination	FPPGFPVKIEIPLFH CCCCCCEEEEEEEEE	34.55	21906983
470	Phosphorylation	FEIPESYYVQDNGRN EECCCCEEEEECCEE	10.83	22817900
485	Phosphorylation	VHLQDEDYEIMQFAI EEECCCCHHHHHHHH	12.81	119633
506	Phosphorylation	SSRSQELSGPASNGG HCCCCCCCCCCCCCC	41.81	28857561
510	Phosphorylation	QELSGPASNGGISQT CCCCCCCCCCCCCCC	38.86	113326403
515	Phosphorylation	PASNGGISQTNTYDA CCCCCCCCCCCCHHH	33.94	28555341
519	Phosphorylation	GGISQTNTYDAQYER CCCCCCCCHHHHHHH	26.60	21552520
520	Phosphorylation	GISQTNTYDAQYERA CCCCCCCHHHHHHHH	16.02	22817900
524	Phosphorylation	TNTYDAQYERAIQES CCCHHHHHHHHHHHH	14.76	22817900
534	Phosphorylation	AIQESLLTSTEGLCP HHHHHHHHCCCCCCH	38.61	28857561
535	Phosphorylation	IQESLLTSTEGLCPS HHHHHHHCCCCCCHH	25.16	28857561
536	Phosphorylation	QESLLTSTEGLCPSA HHHHHHCCCCCCHHH	28.92	28857561
563	Ubiquitination	LAMELSAKELEEWEL HHHHHCHHHHHHHHH	60.50	21906983
586	Phosphorylation	LQQVLQLSLTDK--- HHHHHHHHHCCC---	19.09	22298428

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AN13A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AN13A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_HUMAN	UBC	physical	22298428
TERA_HUMAN	VCP	physical	26797118
CAV1_HUMAN	CAV1	physical	26797118
GDIR1_HUMAN	ARHGDIA	physical	27173435
STOM_HUMAN	STOM	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.