PDCD6_HUMAN - dbPTM
PDCD6_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDCD6_HUMAN
UniProt AC O75340
Protein Name Programmed cell death protein 6
Gene Name PDCD6
Organism Homo sapiens (Human).
Sequence Length 191
Subcellular Localization Endoplasmic reticulum membrane
Peripheral membrane protein . Cytoplasmic vesicle, COPII-coated vesicle membrane . Cytoplasm . Nucleus . Endosome . Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus (PubMed:17045351). Tr
Protein Description Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair. Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes. [PubMed: 20691033]
Protein Sequence MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAYSYRPG
------CCCCCCCCC		18.3322223895
4Phosphorylation----MAAYSYRPGPG
----CCCCCCCCCCC		9.1924173317
5Phosphorylation---MAAYSYRPGPGA
---CCCCCCCCCCCC		15.2225159151
34MethylationFLWNVFQRVDKDRSG
HHHHHHHHHCCCCCC		27.43115383731
40PhosphorylationQRVDKDRSGVISDTE
HHHCCCCCCCCCHHH		47.7730622161
44PhosphorylationKDRSGVISDTELQQA
CCCCCCCCHHHHHHH		35.7525332170
46PhosphorylationRSGVISDTELQQALS
CCCCCCHHHHHHHHH		31.6328787133
53PhosphorylationTELQQALSNGTWTPF
HHHHHHHHCCCCCCC		35.9121712546
56PhosphorylationQQALSNGTWTPFNPV
HHHHHCCCCCCCCCC		30.3428787133
58PhosphorylationALSNGTWTPFNPVTV
HHHCCCCCCCCCCHH		20.1728787133
64PhosphorylationWTPFNPVTVRSIISM
CCCCCCCHHHHHHHH		16.0925332170
67PhosphorylationFNPVTVRSIISMFDR
CCCCHHHHHHHHHCC		21.6720363803
70PhosphorylationVTVRSIISMFDRENK
CHHHHHHHHHCCCCC		16.2420363803
71SulfoxidationTVRSIISMFDRENKA
HHHHHHHHHCCCCCC		2.5921406390
74MethylationSIISMFDRENKAGVN
HHHHHHCCCCCCCCC		37.82115486745
77UbiquitinationSMFDRENKAGVNFSE
HHHCCCCCCCCCHHH		41.59-
83PhosphorylationNKAGVNFSEFTGVWK
CCCCCCHHHHHCCHH		26.9621712546
107PhosphorylationRTYDRDNSGMIDKNE
HHCCCCCCCCCCHHH		33.7425159151
109SulfoxidationYDRDNSGMIDKNELK
CCCCCCCCCCHHHHH		3.4321406390
112UbiquitinationDNSGMIDKNELKQAL
CCCCCCCHHHHHHHH		41.20-
112AcetylationDNSGMIDKNELKQAL
CCCCCCCHHHHHHHH		41.2026822725
116UbiquitinationMIDKNELKQALSGFG
CCCHHHHHHHHHHCC		27.6121906983
120PhosphorylationNELKQALSGFGYRLS
HHHHHHHHHCCCHHH		34.7820068231
124PhosphorylationQALSGFGYRLSDQFH
HHHHHCCCHHHHHHH		13.2020068231
127PhosphorylationSGFGYRLSDQFHDIL
HHCCCHHHHHHHHHH		21.9920873877
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PDCD6_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PDCD6_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDCD6_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
HEBP2_HUMANHEBP2physical
16189514
MISSL_HUMANMAPK1IP1Lphysical
16189514
PDCD6_HUMANPDCD6physical
16189514
M3K5_HUMANMAP3K5physical
12372597
TNR6_HUMANFASphysical
11606059
PDC6I_HUMANPDCD6IPphysical
9880530
PEF1_HUMANPEF1physical
11278427
PDC6I_HUMANPDCD6IPphysical
11883939
ANX11_HUMANANXA11physical
11883939
PDC6I_HUMANPDCD6IPphysical
18940611
PEF1_HUMANPEF1physical
21988832
PDCD6_HUMANPDCD6physical
21988832
DAPK1_HUMANDAPK1physical
16132846
PDCD6_HUMANPDCD6physical
25416956
HEBP2_HUMANHEBP2physical
25416956
VP37C_HUMANVPS37Cphysical
25416956
PEF1_HUMANPEF1physical
25416956
HNRPU_HUMANHNRNPUphysical
26344197
HNRL1_HUMANHNRNPUL1physical
26344197
HNRL2_HUMANHNRNPUL2physical
26344197
IF2B3_HUMANIGF2BP3physical
26344197
ITPA_HUMANITPAphysical
26344197
MIF_HUMANMIFphysical
26344197
PCBP1_HUMANPCBP1physical
26344197
SAR1B_HUMANSAR1Bphysical
26344197
FCL_HUMANTSTA3physical
26344197
PEF1_HUMANPEF1physical
21516116
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PDCD6_HUMAN

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Related Literatures of Post-Translational Modification

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