ITPA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ITPA_HUMAN
• UniProt AC: Q9BY32
• Protein Name: Inosine triphosphate pyrophosphatase {ECO:0000255|HAMAP-Rule:MF_03148}
• Gene Name: ITPA {ECO:0000255|HAMAP-Rule:MF_03148}
• Organism: Homo sapiens (Human).
• Sequence Length: 194
• Subcellular Localization: Cytoplasm .
• Protein Description: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions..
• Protein Sequence: MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAVRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFRALLELQEYFGSLAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAASLVGKK ------CCCHHCCCE	13.03	-
4	Phosphorylation	----MAASLVGKKIV ----CCCHHCCCEEE	17.66	27251275
8	2-Hydroxyisobutyrylation	MAASLVGKKIVFVTG CCCHHCCCEEEEECC	31.67	-
8	Ubiquitination	MAASLVGKKIVFVTG CCCHHCCCEEEEECC	31.67	-
9	Ubiquitination	AASLVGKKIVFVTGN CCHHCCCEEEEECCC	37.87	21890473
9	Ubiquitination	AASLVGKKIVFVTGN CCHHCCCEEEEECCC	37.87	21890473
14	Phosphorylation	GKKIVFVTGNAKKLE CCEEEEECCCHHHHH	17.16	21406692
18	Acetylation	VFVTGNAKKLEEVVQ EEECCCHHHHHHHHH	62.99	25953088
18	Succinylation	VFVTGNAKKLEEVVQ EEECCCHHHHHHHHH	62.99	23954790
18	Ubiquitination	VFVTGNAKKLEEVVQ EEECCCHHHHHHHHH	62.99	-
18	2-Hydroxyisobutyrylation	VFVTGNAKKLEEVVQ EEECCCHHHHHHHHH	62.99	-
19	Ubiquitination	FVTGNAKKLEEVVQI EECCCHHHHHHHHHH	59.73	-
30	Ubiquitination	VVQILGDKFPCTLVA HHHHHCCCCCCEEEE	49.78	-
30	Acetylation	VVQILGDKFPCTLVA HHHHHCCCCCCEEEE	49.78	25953088
39	Ubiquitination	PCTLVAQKIDLPEYQ CCEEEEEECCCCCCC	28.57	-
45	Phosphorylation	QKIDLPEYQGEPDEI EECCCCCCCCCCCCC	21.63	20873877
53	Phosphorylation	QGEPDEISIQKCQEA CCCCCCCCHHHHHHH	19.54	27067055
55	Ubiquitination	EPDEISIQKCQEAVR CCCCCCHHHHHHHHH	33.41	21890473
56	Ubiquitination	PDEISIQKCQEAVRQ CCCCCHHHHHHHHHH	35.89	-
73	Phosphorylation	GPVLVEDTCLCFNAL CCEEEECCEEHHHHH	8.22	24043423
79	Ubiquitination	DTCLCFNALGGLPGP CCEEHHHHHCCCCHH	6.32	21890473
87	Phosphorylation	LGGLPGPYIKWFLEK HCCCCHHHHHHHHHH	22.50	24043423
96	Ubiquitination	KWFLEKLKPEGLHQL HHHHHHHCCCCHHHH	52.68	21890473
111	Phosphorylation	LAGFEDKSAYALCTF HHCCCCHHHHHHHHH	38.54	28152594
113	Phosphorylation	GFEDKSAYALCTFAL CCCCHHHHHHHHHHH	13.75	20090780
117	Phosphorylation	KSAYALCTFALSTGD HHHHHHHHHHHHCCC	16.88	28152594
121	Phosphorylation	ALCTFALSTGDPSQP HHHHHHHHCCCCCCC	27.24	30576142
122	Phosphorylation	LCTFALSTGDPSQPV HHHHHHHCCCCCCCE	46.59	30576142
154	Glutathionylation	QDFGWDPCFQPDGYE CCCCCCCCCCCCCCH	4.60	22555962
167	Sulfoxidation	YEQTYAEMPKAEKNA CHHHHHCCCHHHHHH	2.92	30846556
169	Ubiquitination	QTYAEMPKAEKNAVS HHHHCCCHHHHHHHH	68.79	21890473
172	2-Hydroxyisobutyrylation	AEMPKAEKNAVSHRF HCCCHHHHHHHHHHH	55.88	-
172	Ubiquitination	AEMPKAEKNAVSHRF HCCCHHHHHHHHHHH	55.88	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ITPA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ITPA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ITPA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LGUL_HUMAN	GLO1	physical	22939629
ITPA_HUMAN	ITPA	physical	25416956
ECHM_HUMAN	ECHS1	physical	26344197
PDXK_HUMAN	PDXK	physical	26344197
PSMG4_HUMAN	PSMG4	physical	26344197
SSNA1_HUMAN	SSNA1	physical	26344197
STIP1_HUMAN	STIP1	physical	26344197
TES_HUMAN	TES	physical	26344197
UB2V1_HUMAN	UBE2V1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613850: Inosine triphosphate pyrophosphohydrolase deficiency (ITPAD)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.