| UniProt ID | VP37C_HUMAN | |
|---|---|---|
| UniProt AC | A5D8V6 | |
| Protein Name | Vacuolar protein sorting-associated protein 37C | |
| Gene Name | VPS37C | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 355 | |
| Subcellular Localization |
Late endosome membrane Peripheral membrane protein . Probably associates with membranes. Recruited to the plasma membrane by HIV-1. |
|
| Protein Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.. | |
| Protein Sequence | METLKDKTLQELEELQNDSEAIDQLALESPEVQDLQLEREMALATNRSLAERNLEFQGPLEISRSNLSDRYQELRKLVERCQEQKAKLEKFSSALQPGTLLDLLQVEGMKIEEESEAMAEKFLEGEVPLETFLENFSSMRMLSHLRRVRVEKLQEVVRKPRASQELAGDAPPPRPPPPVRPVPQGTPPVVEEQPQPPLAMPPYPLPYSPSPSLPVGPTAHGALPPAPFPVVSQPSFYSGPLGPTYPAAQLGPRGAAGYSWSPQRSMPPRPGYPGTPMGASGPGYPLRGGRAPSPGYPQQSPYPATGGKPPYPIQPQLPSFPGQPQPSVPLQPPYPPGPAPPYGFPPPPGPAWPGY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 29 | Phosphorylation | IDQLALESPEVQDLQ HHHHHHHCHHHHHHH | 27.49 | - | |
| 68 | Phosphorylation | EISRSNLSDRYQELR HHCCCCHHHHHHHHH | 25.05 | 29507054 | |
| 70 | Methylation | SRSNLSDRYQELRKL CCCCHHHHHHHHHHH | 31.49 | 115919857 | |
| 90 | Ubiquitination | EQKAKLEKFSSALQP HHHHHHHHHHHHCCC | 62.07 | 29967540 | |
| 92 | Phosphorylation | KAKLEKFSSALQPGT HHHHHHHHHHCCCCC | 26.26 | - | |
| 93 | Phosphorylation | AKLEKFSSALQPGTL HHHHHHHHHCCCCCH | 35.81 | - | |
| 99 | Phosphorylation | SSALQPGTLLDLLQV HHHCCCCCHHHHHHH | 30.72 | - | |
| 163 | Phosphorylation | VVRKPRASQELAGDA HHHCCCHHHHHCCCC | 26.01 | 23312004 | |
| 284 | Phosphorylation | MGASGPGYPLRGGRA CCCCCCCCCCCCCCC | 11.39 | 18491316 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VP37C_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VP37C_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VP37C_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HGS_HUMAN | HGS | physical | 15509564 | |
| VPS28_HUMAN | VPS28 | physical | 15509564 | |
| TS101_HUMAN | TSG101 | physical | 15509564 | |
| PDC6I_HUMAN | PDCD6IP | physical | 15509564 | |
| CEP55_HUMAN | CEP55 | physical | 17853893 | |
| TS101_HUMAN | TSG101 | physical | 21757351 | |
| A4_HUMAN | APP | physical | 21832049 | |
| CEP55_HUMAN | CEP55 | physical | 25416956 | |
| RINT1_HUMAN | RINT1 | physical | 25416956 | |
| CA094_HUMAN | C1orf94 | physical | 25416956 | |
| MISSL_HUMAN | MAPK1IP1L | physical | 25416956 | |
| RFX6_HUMAN | RFX6 | physical | 25416956 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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