RFX6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFX6_HUMAN
• UniProt AC: Q8HWS3
• Protein Name: DNA-binding protein RFX6
• Gene Name: RFX6
• Organism: Homo sapiens (Human).
• Sequence Length: 928
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. [PubMed: 20148032]
• Protein Sequence: MAKVPELEDTFLQAQPAPQLSPGIQEDCCVQLLGKGLLVYPEETVYLAAEGQPGGEQGGGEKGEDPELPGAVKSEMHLNNGNFSSEEEDADNHDSKTKAADQYLSQKKTITQIVKDKKKQTQLTLQWLEENYIVCEGVCLPRCILYAHYLDFCRKEKLEPACAATFGKTIRQKFPLLTTRRLGTRGHSKYHYYGIGIKESSAYYHSVYSGKGLTRFSGSKLKNEGGFTRKYSLSSKTGTLLPEFPSAQHLVYQGCISKDKVDTLIMMYKTHCQCILDNAINGNFEEIQHFLLHFWQGMPDHLLPLLENPVIIDIFCVCDSILYKVLTDVLIPATMQEMPESLLADIRNFAKNWEQWVVSSLENLPEALTDKKIPIVRRFVSSLKRQTSFLHLAQIARPALFDQHVVNSMVSDIERVDLNSIGSQALLTISGSTDTESGIYTEHDSITVFQELKDLLKKNATVEAFIEWLDTVVEQRVIKTSKQNGRSLKKRAQDFLLKWSFFGARVMHNLTLNNASSFGSFHLIRMLLDEYILLAMETQFNNDKEQELQNLLDKYMKNSDASKAAFTASPSSCFLANRNKGSMVSSDAVKNESHVETTYLPLPSSQPGGLGPALHQFPAGNTDNMPLTGQMELSQIAGHLMTPPISPAMASRGSVINQGPMAGRPPSVGPVLSAPSHCSTYPEPIYPTLPQANHDFYSTSSNYQTVFRAQPHSTSGLYPHHTEHGRCMAWTEQQLSRDFFSGSCAGSPYNSRPPSSYGPSLQAQDSHNMQFLNTGSFNFLSNTGAASCQGATLPPNSPNGYYGSNINYPESHRLGSMVNQHVSVISSIRSLPPYSDIHDPLNILDDSGRKQTSSFYTDTSSPVACRTPVLASSLQTPIPSSSSQCMYGTSNQYPAQETLDSHGTSSREMVSSLPPINTVFMGTAAGGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	AQPAPQLSPGIQEDC CCCCCCCCCCCCCCH	18.81	26657352
97	Phosphorylation	ADNHDSKTKAADQYL CCCCCHHHHHHHHHH	29.84	26074081
103	Phosphorylation	KTKAADQYLSQKKTI HHHHHHHHHHCCCCH	14.63	26074081
105	Phosphorylation	KAADQYLSQKKTITQ HHHHHHHHCCCCHHH	34.71	26074081
109	Phosphorylation	QYLSQKKTITQIVKD HHHHCCCCHHHHHCC	35.97	26074081
111	Phosphorylation	LSQKKTITQIVKDKK HHCCCCHHHHHCCCH	19.92	26074081
115	Acetylation	KTITQIVKDKKKQTQ CCHHHHHCCCHHHHH	66.51	7427389
117	Acetylation	ITQIVKDKKKQTQLT HHHHHCCCHHHHHHH	57.03	7427399
118	Acetylation	TQIVKDKKKQTQLTL HHHHCCCHHHHHHHH	61.31	7427409
178	Phosphorylation	RQKFPLLTTRRLGTR HHHCCEEEEECCCCC	26.41	24043423
179	Phosphorylation	QKFPLLTTRRLGTRG HHCCEEEEECCCCCC	17.48	24043423
184	Phosphorylation	LTTRRLGTRGHSKYH EEEECCCCCCCCCCE	37.76	24043423
200	Phosphorylation	YGIGIKESSAYYHSV EEEEECCCCCEEEEC	18.44	-
201	Phosphorylation	GIGIKESSAYYHSVY EEEECCCCCEEEECC	22.75	-
206	Phosphorylation	ESSAYYHSVYSGKGL CCCCEEEECCCCCCC	13.46	-
208	Phosphorylation	SAYYHSVYSGKGLTR CCEEEECCCCCCCEE	18.08	-
217	Phosphorylation	GKGLTRFSGSKLKNE CCCCEEECCCCCCCC	38.58	-
511	Phosphorylation	ARVMHNLTLNNASSF HHEEECCCCCCCCCC	32.53	-
531	Phosphorylation	IRMLLDEYILLAMET HHHHHHHHHHHHHHH	9.13	-
538	Phosphorylation	YILLAMETQFNNDKE HHHHHHHHCCCCCHH	25.94	-
715	Phosphorylation	RAQPHSTSGLYPHHT ECCCCCCCCCCCCCC	29.80	24719451
722	Phosphorylation	SGLYPHHTEHGRCMA CCCCCCCCCCCCCCC	27.00	24719451
826	Phosphorylation	NQHVSVISSIRSLPP HHHHHHHHHHHCCCC	19.98	24719451
827	Phosphorylation	QHVSVISSIRSLPPY HHHHHHHHHHCCCCC	15.76	25954137

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFX6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFX6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFX6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RIPK3_HUMAN	RIPK3	physical	21988832
RSMB_HUMAN	SNRPB	physical	21516116

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.