| UniProt ID | VPS28_HUMAN | |
|---|---|---|
| UniProt AC | Q9UK41 | |
| Protein Name | Vacuolar protein sorting-associated protein 28 homolog | |
| Gene Name | VPS28 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 221 | |
| Subcellular Localization |
Cell membrane . Late endosome membrane Peripheral membrane protein . |
|
| Protein Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process.. | |
| Protein Sequence | MFHGIPATPGIGAPGNKPELYEEVKLYKNAREREKYDNMAELFAVVKTMQALEKAYIKDCVSPSEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITIKDDKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWLQTLSGMSASDELDDSQVRQMLFDLESAYNAFNRFLHA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MFHGIPAT -------CCCCCCCC | 5.16 | 25944712 | |
| 8 | Phosphorylation | MFHGIPATPGIGAPG CCCCCCCCCCCCCCC | 19.38 | 25159151 | |
| 8 (in isoform 2) | Phosphorylation | - | 19.38 | 24719451 | |
| 17 (in isoform 2) | Ubiquitination | - | 45.87 | - | |
| 17 | Ubiquitination | GIGAPGNKPELYEEV CCCCCCCCHHHHHHH | 45.87 | - | |
| 21 | Phosphorylation | PGNKPELYEEVKLYK CCCCHHHHHHHHHHH | 14.37 | 25106551 | |
| 21 (in isoform 2) | Phosphorylation | - | 14.37 | 27642862 | |
| 25 (in isoform 2) | Ubiquitination | - | 49.75 | - | |
| 28 (in isoform 2) | Ubiquitination | - | 55.34 | - | |
| 35 | Acetylation | KNAREREKYDNMAEL HHHHHHHHHCCHHHH | 65.21 | 25953088 | |
| 48 | Phosphorylation | ELFAVVKTMQALEKA HHHHHHHHHHHHHHH | 11.69 | 20068231 | |
| 56 | Phosphorylation | MQALEKAYIKDCVSP HHHHHHHHHCCCCCH | 21.41 | 29496907 | |
| 58 | Ubiquitination | ALEKAYIKDCVSPSE HHHHHHHCCCCCHHH | 32.19 | - | |
| 58 (in isoform 2) | Ubiquitination | - | 32.19 | - | |
| 62 (in isoform 2) | Phosphorylation | - | 29.10 | 24719451 | |
| 62 | Phosphorylation | AYIKDCVSPSEYTAA HHHCCCCCHHHHHHH | 29.10 | 21815630 | |
| 66 | Phosphorylation | DCVSPSEYTAACSRL CCCCHHHHHHHHHHH | 13.15 | 29496907 | |
| 111 | Ubiquitination | PLAMERIKEDRPITI CHHHHHHHCCCCCEE | 60.84 | - | |
| 150 | Sulfoxidation | LRLEIRAMDEIQPDL HHHHHHHHHHHCHHH | 3.22 | 21406390 | |
| 161 | Sulfoxidation | QPDLRELMETMHRMS CHHHHHHHHHHHHHH | 3.27 | 30846556 | |
| 164 | Sulfoxidation | LRELMETMHRMSHLP HHHHHHHHHHHHCCC | 0.90 | 30846556 | |
| 168 | Phosphorylation | METMHRMSHLPPDFE HHHHHHHHCCCCCCC | 23.10 | 24275569 | |
| 204 (in isoform 2) | Phosphorylation | - | 2.56 | 24719451 | |
| 210 | Phosphorylation | QMLFDLESAYNAFNR HHHHHHHHHHHHHHH | 43.27 | 30576142 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of VPS28_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of VPS28_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of VPS28_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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