VP37D_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VP37D_HUMAN
• UniProt AC: Q86XT2
• Protein Name: Vacuolar protein sorting-associated protein 37D
• Gene Name: VPS37D {ECO:0000312|HGNC:HGNC:18287}
• Organism: Homo sapiens (Human).
• Sequence Length: 251
• Subcellular Localization: Late endosome membrane ; Peripheral membrane protein .
• Protein Description: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation..
• Protein Sequence: MYRARAARAGPEPGSPGRFGILSTGQLRDLLQDEPKLDRIVRLSRKFQGLQLEREACLASNYALAKENLALRPRLEMGRAALAIKYQELREVAENCADKLQRLEESMHRWSPHCALGWLQAELEEAEQEAEEQMEQLLLGEQSLEAFLPAFQRGRALAHLRRTQAEKLQELLRRRERSAQPAPTSAADPPKSFPAAAVLPTGAARGPPAVPRSLPPLDSRPVPPLKGSPGCPLGPAPLLSPRPSQPEPPHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RAGPEPGSPGRFGIL HCCCCCCCCCCEEEC	34.59	29759185
62	Phosphorylation	EACLASNYALAKENL HHHHHHCHHHHHHCC	10.66	-
66	Ubiquitination	ASNYALAKENLALRP HHCHHHHHHCCCHHH	48.24	29967540
99	Ubiquitination	VAENCADKLQRLEES HHHHHHHHHHHHHHH	28.17	-
178	Phosphorylation	LLRRRERSAQPAPTS HHHHHHHHCCCCCCC	26.88	29759185
228	Phosphorylation	PVPPLKGSPGCPLGP CCCCCCCCCCCCCCC	19.28	32142685
240	Phosphorylation	LGPAPLLSPRPSQPE CCCCCCCCCCCCCCC	26.92	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VP37D_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VP37D_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VP37D_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP55_HUMAN	CEP55	physical	17853893
ACAD8_HUMAN	ACAD8	physical	28514442
TS101_HUMAN	TSG101	physical	28514442
CRTAP_HUMAN	CRTAP	physical	28514442
SAV1_HUMAN	SAV1	physical	28514442
P3H1_HUMAN	P3H1	physical	28514442
AASS_HUMAN	AASS	physical	28514442
KBP_HUMAN	KIAA1279	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.