CRTAP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRTAP_HUMAN
• UniProt AC: O75718
• Protein Name: Cartilage-associated protein
• Gene Name: CRTAP
• Organism: Homo sapiens (Human).
• Sequence Length: 401
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues..
• Protein Sequence: MEPGRRGAAALLALLCVACALRAGRAQYERYSFRSFPRDELMPLESAYRHALDKYSGEHWAESVGYLEISLRLHRLLRDSEAFCHRNCSAAPQPEPAAGLASYPELRLFGGLLRRAHCLKRCKQGLPAFRQSQPSREVLADFQRREPYKFLQFAYFKANNLPKAIAAAHTFLLKHPDDEMMKRNMAYYKSLPGAEDYIKDLETKSYESLFIRAVRAYNGENWRTSITDMELALPDFFKAFYECLAACEGSREIKDFKDFYLSIADHYVEVLECKIQCEENLTPVIGGYPVEKFVATMYHYLQFAYYKLNDLKNAAPCAVSYLLFDQNDKVMQQNLVYYQYHRDTWGLSDEHFQPRPEAVQFFNVTTLQKELYDFAKENIMDDDEGEVVEYVDDLLELEETS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Phosphorylation	RAQYERYSFRSFPRD HHHHHHCCCCCCCHH	22.02	29496963
42	Sulfoxidation	SFPRDELMPLESAYR CCCHHHHCCHHHHHH	3.15	30846556
55	Phosphorylation	YRHALDKYSGEHWAE HHHHHHHCCCCHHHH	22.90	23663014
56	Phosphorylation	RHALDKYSGEHWAES HHHHHHCCCCHHHHH	43.37	23663014
63	Phosphorylation	SGEHWAESVGYLEIS CCCHHHHHHCHHHHH	17.07	23663014
66	Phosphorylation	HWAESVGYLEISLRL HHHHHHCHHHHHHHH	10.06	23663014
87	N-linked_Glycosylation	SEAFCHRNCSAAPQP CHHHHCCCCCCCCCC	10.63	UniProtKB CARBOHYD
89	O-linked_Glycosylation	AFCHRNCSAAPQPEP HHHCCCCCCCCCCCC	30.89	30059200
123	Ubiquitination	AHCLKRCKQGLPAFR HHHHHHHHCCCHHHH	51.97	29967540
149	Ubiquitination	FQRREPYKFLQFAYF HHHCCCHHHHHHHHH	50.76	21963094
157	Ubiquitination	FLQFAYFKANNLPKA HHHHHHHHHCCHHHH	37.21	21906983
163	Ubiquitination	FKANNLPKAIAAAHT HHHCCHHHHHHHHHH	56.44	21963094
174	Ubiquitination	AAHTFLLKHPDDEMM HHHHHHHHCCCHHHH	56.06	21963094
182	2-Hydroxyisobutyrylation	HPDDEMMKRNMAYYK CCCHHHHHHHHHHHH	39.03	-
182	Ubiquitination	HPDDEMMKRNMAYYK CCCHHHHHHHHHHHH	39.03	21906983
189	Ubiquitination	KRNMAYYKSLPGAED HHHHHHHHCCCCHHH	32.61	21906983
190	Phosphorylation	RNMAYYKSLPGAEDY HHHHHHHCCCCHHHH	24.55	22985185
197	Phosphorylation	SLPGAEDYIKDLETK CCCCHHHHHHHHCCC	11.02	24719451
199	Ubiquitination	PGAEDYIKDLETKSY CCHHHHHHHHCCCCH	50.46	21963094
204	Ubiquitination	YIKDLETKSYESLFI HHHHHCCCCHHHHHH	41.48	21906983
241	Phosphorylation	PDFFKAFYECLAACE HHHHHHHHHHHHHCC	15.59	28152594
307	Ubiquitination	YLQFAYYKLNDLKNA HHHHHHHHHHCHHCH	28.30	22817900
312	Ubiquitination	YYKLNDLKNAAPCAV HHHHHCHHCHHHCHH	47.61	21963094
329	Ubiquitination	LLFDQNDKVMQQNLV HEEECCCHHHHHHEE	47.35	21963094
363	N-linked_Glycosylation	PEAVQFFNVTTLQKE HHHHHEEECHHHHHH	31.36	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRTAP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRTAP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRTAP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARMC9_HUMAN	ARMC9	physical	22863883
GPN1_HUMAN	GPN1	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
SHLB2_HUMAN	SH3GLB2	physical	22863883
SURF2_HUMAN	SURF2	physical	22863883
TM1L1_HUMAN	TOM1L1	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 610682: Osteogenesis imperfecta 7 (OI7)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.