dbPTM

SURF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SURF2_HUMAN
UniProt AC	Q15527
Protein Name	Surfeit locus protein 2
Gene Name	SURF2
Organism	Homo sapiens (Human).
Sequence Length	256
Subcellular Localization
Protein Description
Protein Sequence	MSELPGDVRAFLREHPSLRLQTDARKVRCILTGHELPCRLPELQVYTRGKKYQRLVRASPAFDYAEFEPHIVPSTKNPHQLFCKLTLRHINKCPEHVLRHTQGRRYQRALCKYEECQKQGVEYVPACLVHRRRRREDQMDGDGPRPREAFWEPTSSDEGGAASDDSMTDLYPPELFTRKDLGSTEDGDGTDDFLTDKEDEKAKPPREKATDESRRETTVYRGLVQKRGKKQLGSLKKKFKSHHRKPKSFSSCKQPG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Methylation	SELPGDVRAFLREHP CCCCHHHHHHHHHCC	25.10	115918041
17	Phosphorylation	AFLREHPSLRLQTDA HHHHHCCCCCCCCCC	28.20	24719451
29	S-nitrosocysteine	TDARKVRCILTGHEL CCCCCEEEEHHCCCC	3.15	-
29	S-nitrosylation	TDARKVRCILTGHEL CCCCCEEEEHHCCCC	3.15	19483679
38	S-nitrosocysteine	LTGHELPCRLPELQV HHCCCCCCCCCCCEE	12.48	-
38	S-nitrosylation	LTGHELPCRLPELQV HHCCCCCCCCCCCEE	12.48	19483679
59	Phosphorylation	YQRLVRASPAFDYAE HHHHHHCCCCCCHHH	13.24	30576142
64	Phosphorylation	RASPAFDYAEFEPHI HCCCCCCHHHCCCCC	11.11	23312004
74	Phosphorylation	FEPHIVPSTKNPHQL CCCCCCCCCCCHHHH	40.91	28348404
75	Phosphorylation	EPHIVPSTKNPHQLF CCCCCCCCCCHHHHH	28.86	28348404
84	Acetylation	NPHQLFCKLTLRHIN CHHHHHHHHHHHHHH	36.85	23749302
112	Acetylation	RYQRALCKYEECQKQ HHHHHHHCHHHHHHC	57.45	25953088
118	Ubiquitination	CKYEECQKQGVEYVP HCHHHHHHCCCCCCC	61.76	29967540
145	Phosphorylation	QMDGDGPRPREAFWE CCCCCCCCCHHHCCC	48.73	32645325
154	Phosphorylation	REAFWEPTSSDEGGA HHHCCCCCCCCCCCC	29.37	25849741
155	Phosphorylation	EAFWEPTSSDEGGAA HHCCCCCCCCCCCCC	46.65	25849741
156	Phosphorylation	AFWEPTSSDEGGAAS HCCCCCCCCCCCCCC	42.00	22115753
163	Phosphorylation	SDEGGAASDDSMTDL CCCCCCCCCCCCCCC	41.22	22617229
166	Phosphorylation	GGAASDDSMTDLYPP CCCCCCCCCCCCCCH	28.68	23663014
168	Phosphorylation	AASDDSMTDLYPPEL CCCCCCCCCCCCHHH	27.14	23663014
171	Phosphorylation	DDSMTDLYPPELFTR CCCCCCCCCHHHCCC	21.39	23663014
177	Phosphorylation	LYPPELFTRKDLGST CCCHHHCCCCCCCCC	49.81	20068231
183	Phosphorylation	FTRKDLGSTEDGDGT CCCCCCCCCCCCCCC	35.60	30266825
184	Phosphorylation	TRKDLGSTEDGDGTD CCCCCCCCCCCCCCC	35.98	30266825
190	Phosphorylation	STEDGDGTDDFLTDK CCCCCCCCCCCCCCH	36.82	29255136
195	Phosphorylation	DGTDDFLTDKEDEKA CCCCCCCCCHHHHCC	45.05	29255136
197	Ubiquitination	TDDFLTDKEDEKAKP CCCCCCCHHHHCCCC	62.93	24816145
217	Phosphorylation	TDESRRETTVYRGLV CHHHHHHHHHHHHHH	21.54	29209046
218	Phosphorylation	DESRRETTVYRGLVQ HHHHHHHHHHHHHHH	15.70	29209046
220	Phosphorylation	SRRETTVYRGLVQKR HHHHHHHHHHHHHHH	9.25	29209046
221	Methylation	RRETTVYRGLVQKRG HHHHHHHHHHHHHHC	27.86	115918037
234	Phosphorylation	RGKKQLGSLKKKFKS HCHHHHHHHHHHHHH	45.68	28355574
248	Phosphorylation	SHHRKPKSFSSCKQP HCCCCCCCHHHCCCC	38.60	22210691
250	Phosphorylation	HRKPKSFSSCKQPG- CCCCCCHHHCCCCC-	41.75	21712546
251	Phosphorylation	RKPKSFSSCKQPG-- CCCCCHHHCCCCC--	24.27	21712546

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SURF2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SURF2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SURF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NPTN_HUMAN	NPTN	physical	21900206
RL5_HUMAN	RPL5	physical	21900206
ZN331_HUMAN	ZNF331	physical	21900206
A4_HUMAN	APP	physical	21832049
ANKY2_HUMAN	ANKMY2	physical	22863883
GPN1_HUMAN	GPN1	physical	22863883
HSF1_HUMAN	HSF1	physical	22863883
HPBP1_HUMAN	HSPBP1	physical	22863883
LPP_HUMAN	LPP	physical	22863883
NPL4_HUMAN	NPLOC4	physical	22863883
OGT1_HUMAN	OGT	physical	22863883
PPME1_HUMAN	PPME1	physical	22863883
RPR1A_HUMAN	RPRD1A	physical	22863883
RPR1B_HUMAN	RPRD1B	physical	22863883
STA5B_HUMAN	STAT5B	physical	22863883
TM1L1_HUMAN	TOM1L1	physical	22863883
WDR4_HUMAN	WDR4	physical	22863883
ZPR1_HUMAN	ZPR1	physical	22863883
POP1_HUMAN	POP1	physical	26186194
SPB1_HUMAN	FTSJ3	physical	26186194
RL11_HUMAN	RPL11	physical	26186194
LA_HUMAN	SSB	physical	26186194
RL3_HUMAN	RPL3	physical	26186194
RL5_HUMAN	RPL5	physical	26186194
PABP4_HUMAN	PABPC4	physical	26186194
HEAT3_HUMAN	HEATR3	physical	26186194
LARP1_HUMAN	LARP1	physical	26186194
IMA7_HUMAN	KPNA6	physical	26186194
RIOX2_HUMAN	MINA	physical	26186194
RRS1_HUMAN	RRS1	physical	26186194
BRX1_HUMAN	BRIX1	physical	26186194
DDX18_HUMAN	DDX18	physical	26186194
MDM2_HUMAN	MDM2	physical	26186194
HEXI1_HUMAN	HEXIM1	physical	26186194
ZCHC9_HUMAN	ZCCHC9	physical	26186194
TRI27_HUMAN	TRIM27	physical	26186194
LN28B_HUMAN	LIN28B	physical	26186194
RS13_HUMAN	RPS13	physical	26186194
CE022_HUMAN	C5orf22	physical	26186194
PURA_HUMAN	PURA	physical	26186194
H2AX_HUMAN	H2AFX	physical	26186194
KBTB7_HUMAN	KBTBD7	physical	26186194
ZCRB1_HUMAN	ZCRB1	physical	26186194
DBLOH_HUMAN	DIABLO	physical	26344197
CE022_HUMAN	C5orf22	physical	28514442
H2AX_HUMAN	H2AFX	physical	28514442
RL11_HUMAN	RPL11	physical	28514442
HEXI1_HUMAN	HEXIM1	physical	28514442
RIOX2_HUMAN	MINA	physical	28514442
RL5_HUMAN	RPL5	physical	28514442
LA_HUMAN	SSB	physical	28514442
ZCHC9_HUMAN	ZCCHC9	physical	28514442
HEAT3_HUMAN	HEATR3	physical	28514442
RRS1_HUMAN	RRS1	physical	28514442
ZCRB1_HUMAN	ZCRB1	physical	28514442
IMA7_HUMAN	KPNA6	physical	28514442
MDM2_HUMAN	MDM2	physical	28514442
KBTB7_HUMAN	KBTBD7	physical	28514442
LN28B_HUMAN	LIN28B	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442
YBOX1_HUMAN	YBX1	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SURF2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-154; SER-155; SER-156;SER-163; THR-190 AND THR-195, AND MASS SPECTROMETRY.	17081983 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-195, AND MASSSPECTROMETRY.	17287340 [Abstract]