LARP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LARP1_HUMAN
• UniProt AC: Q6PKG0
• Protein Name: La-related protein 1
• Gene Name: LARP1
• Organism: Homo sapiens (Human).
• Sequence Length: 1096
• Subcellular Localization: Cytoplasm . Cytoplasmic granule . Colocalizes with RPTOR and PABPC1 in cytoplasmic granules that resemble stress granules.
• Protein Description: RNA-binding protein that promotes translation of specific classes of mRNAs downstream of the mTORC1 complex. [PubMed: 24532714]
• Protein Sequence: MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDVRGGEPDGSARRPRPPCAKPHKEGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAGGGAAGAAGAGRRDFVEAPPPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPKQRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSKESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPPEPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGARASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGVEGPRTPKYMNNITYYFDNVSSTELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQALTTDISLIFAALKDSKVVEIVDEKVRRREEPEKWPLPPIVDYSQTDFSQLLNCPEFVPRQHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRPSPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFTAWSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKVINDGLFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPPRFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPRTPQLKDSSQTSRFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGTPTVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNTLFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFKDFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPMGEEGNHKRHSVVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVREDAKWTSQHSNTQTLGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MATQVEPLL ------CCCCCCCCC	20.31	22223895
3	Phosphorylation	-----MATQVEPLLP -----CCCCCCCCCC	45.03	28122231
28	Ubiquitination	HGGLVRKKPPPAPEG HCCCCCCCCCCCCCC	52.79	24816145
38 (in isoform 3)	Phosphorylation	-	51.04	25849741
45	Methylation	EPGPNDVRGGEPDGS CCCCCCCCCCCCCCC	50.71	115481763
52	Phosphorylation	RGGEPDGSARRPRPP CCCCCCCCCCCCCCC	26.44	25072903
55	Ubiquitination	EPDGSARRPRPPCAK CCCCCCCCCCCCCCC	31.15	32015554
68	Phosphorylation	AKPHKEGTGQQERES CCCCCCCCCCCCCCC	32.67	30278072
71 (in isoform 3)	Phosphorylation	-	53.73	25332170
75	Phosphorylation	TGQQERESPRPLQLP CCCCCCCCCCCCCCC	32.22	29255136
90	Phosphorylation	GAEGPAISDGEEGGG CCCCCCCCCCCCCCC	41.49	19664994
95	Ubiquitination	AISDGEEGGGEPGAG CCCCCCCCCCCCCCC	45.14	23000965
104	Phosphorylation	GEPGAGGGAAGAAGA CCCCCCCCCCCCCCC	16.01	32142685
129	Methylation	PKVNPWTKNALPPVL CCCCCCCCCCCCCEE	36.03	115972329
129	Ubiquitination	PKVNPWTKNALPPVL CCCCCCCCCCCCCEE	36.03	23000965
137	Phosphorylation	NALPPVLTTVNGQSP CCCCCEEEECCCCCC	29.00	23401153
138	Phosphorylation	ALPPVLTTVNGQSPP CCCCEEEECCCCCCC	14.07	30278072
143	Phosphorylation	LTTVNGQSPPEHSAP EEECCCCCCCCCCCC	43.77	29255136
148	O-linked_Glycosylation	GQSPPEHSAPAKVVR CCCCCCCCCCHHHHH	34.00	23301498
148	Phosphorylation	GQSPPEHSAPAKVVR CCCCCCCCCCHHHHH	34.00	29255136
152	Acetylation	PEHSAPAKVVRAAVP CCCCCCHHHHHHHCC	39.96	26051181
162	Ubiquitination	RAAVPKQRKGSKVGD HHHCCCCCCCCCCCC	51.97	23000965
163	Acetylation	AAVPKQRKGSKVGDF HHCCCCCCCCCCCCC	66.11	155309
165	Phosphorylation	VPKQRKGSKVGDFGD CCCCCCCCCCCCCCC	27.48	23401153
171	Phosphorylation	GSKVGDFGDAINWPT CCCCCCCCCCCCCCC	28.34	32142685
178	Phosphorylation	GDAINWPTPGEIAHK CCCCCCCCCCCCCCC	35.22	22199227
183	Ubiquitination	WPTPGEIAHKSVQPQ CCCCCCCCCCCCCCC	10.35	32015554
185	Acetylation	TPGEIAHKSVQPQSH CCCCCCCCCCCCCCC	43.21	25953088
186	Phosphorylation	PGEIAHKSVQPQSHK CCCCCCCCCCCCCCC	19.00	28555341
190	Ubiquitination	AHKSVQPQSHKPQPT CCCCCCCCCCCCCCC	40.87	22817900
191	Phosphorylation	HKSVQPQSHKPQPTR CCCCCCCCCCCCCCC	39.91	28555341
193	Ubiquitination	SVQPQSHKPQPTRKL CCCCCCCCCCCCCCC	51.07	33845483
201	Ubiquitination	PQPTRKLPPKKDMKE CCCCCCCCCCCCCCH	41.52	33845483
215	Phosphorylation	EQEKGEGSDSKESPK HHHCCCCCCCCCCCC	34.11	27794612
217	Phosphorylation	EKGEGSDSKESPKTK HCCCCCCCCCCCCCC	39.77	27794612
220	Phosphorylation	EGSDSKESPKTKSDE CCCCCCCCCCCCCCC	35.12	26055452
223	Phosphorylation	DSKESPKTKSDESGE CCCCCCCCCCCCCCC	38.88	26846344
224	Ubiquitination	SKESPKTKSDESGEE CCCCCCCCCCCCCCC	63.13	22817900
225	Phosphorylation	KESPKTKSDESGEEK CCCCCCCCCCCCCCC	52.41	26846344
226	Ubiquitination	ESPKTKSDESGEEKN CCCCCCCCCCCCCCC	56.49	23000965
227	Ubiquitination	SPKTKSDESGEEKNG CCCCCCCCCCCCCCC	68.67	33845483
228	Phosphorylation	PKTKSDESGEEKNGD CCCCCCCCCCCCCCC	57.40	23401153
232	Ubiquitination	SDESGEEKNGDEDCQ CCCCCCCCCCCHHHH	63.03	23000965
234	Ubiquitination	ESGEEKNGDEDCQRG CCCCCCCCCHHHHCC	51.24	29967540
235	Ubiquitination	SGEEKNGDEDCQRGG CCCCCCCCHHHHCCC	58.93	33845483
240	Methylation	NGDEDCQRGGQKKKG CCCHHHHCCCCCCCC	58.50	30987761
254	Phosphorylation	GNKHKWVPLQIDMKP CCCCCCEEEEEECCC	19.89	32142685
257	Ubiquitination	HKWVPLQIDMKPEVP CCCEEEEEECCCCCC	8.02	22817900
259	Ubiquitination	WVPLQIDMKPEVPRE CEEEEEECCCCCCHH	9.24	23000965
260	Sumoylation	VPLQIDMKPEVPREK EEEEEECCCCCCHHH	33.99	28112733
260	Ubiquitination	VPLQIDMKPEVPREK EEEEEECCCCCCHHH	33.99	33845483
264	Ubiquitination	IDMKPEVPREKLASR EECCCCCCHHHHCCC	36.73	32142685
267	Ubiquitination	KPEVPREKLASRPTR CCCCCHHHHCCCCCC	51.11	21890473
268	Ubiquitination	PEVPREKLASRPTRP CCCCHHHHCCCCCCC	4.48	33845483
270	Phosphorylation	VPREKLASRPTRPPE CCHHHHCCCCCCCCC	49.59	23186163
271	Methylation	PREKLASRPTRPPEP CHHHHCCCCCCCCCC	30.88	115481767
271	Ubiquitination	PREKLASRPTRPPEP CHHHHCCCCCCCCCC	30.88	22817900
273	Phosphorylation	EKLASRPTRPPEPRH HHHCCCCCCCCCCCC	55.48	23186163
274	Methylation	KLASRPTRPPEPRHI HHCCCCCCCCCCCCC	47.67	115481775
276	Phosphorylation	ASRPTRPPEPRHIPA CCCCCCCCCCCCCCC	62.02	32142685
285	Methylation	PRHIPANRGEIKGSE CCCCCCCCCCCCCCC	46.35	97778569
288	Phosphorylation	IPANRGEIKGSESAT CCCCCCCCCCCCCCC	7.34	32142685
290	Ubiquitination	ANRGEIKGSESATYV CCCCCCCCCCCCCEE	42.16	23000965
291	Phosphorylation	NRGEIKGSESATYVP CCCCCCCCCCCCEEC	24.31	21945579
293	Phosphorylation	GEIKGSESATYVPVA CCCCCCCCCCEECCC	27.84	21945579
293	Ubiquitination	GEIKGSESATYVPVA CCCCCCCCCCEECCC	27.84	33845483
295	Phosphorylation	IKGSESATYVPVAPP CCCCCCCCEECCCCC	34.04	21945579
296	Phosphorylation	KGSESATYVPVAPPT CCCCCCCEECCCCCC	11.50	21945579
299	Phosphorylation	ESATYVPVAPPTPAW CCCCEECCCCCCCCC	9.97	32142685
300	Ubiquitination	SATYVPVAPPTPAWQ CCCEECCCCCCCCCC	9.78	23000965
301	Ubiquitination	ATYVPVAPPTPAWQP CCEECCCCCCCCCCC	33.27	21890473
303	Phosphorylation	YVPVAPPTPAWQPEI EECCCCCCCCCCCCC	25.28	21945579
305	Ubiquitination	PVAPPTPAWQPEIKP CCCCCCCCCCCCCCC	21.73	22817900
310	Phosphorylation	TPAWQPEIKPEPAWH CCCCCCCCCCCCCCC	13.20	32142685
311	Sumoylation	PAWQPEIKPEPAWHD CCCCCCCCCCCCCCC	41.49	-
311	Sumoylation	PAWQPEIKPEPAWHD CCCCCCCCCCCCCCC	41.49	28112733
321	Phosphorylation	PAWHDQDETSSVKSD CCCCCCCCCCCCCCC	44.98	32142685
321	Ubiquitination	PAWHDQDETSSVKSD CCCCCCCCCCCCCCC	44.98	22817900
322	Phosphorylation	AWHDQDETSSVKSDG CCCCCCCCCCCCCCC	34.29	21945579
323	Phosphorylation	WHDQDETSSVKSDGA CCCCCCCCCCCCCCC	30.96	21945579
324	Phosphorylation	HDQDETSSVKSDGAG CCCCCCCCCCCCCCC	40.77	21945579
324	Ubiquitination	HDQDETSSVKSDGAG CCCCCCCCCCCCCCC	40.77	22817900
326	Ubiquitination	QDETSSVKSDGAGGA CCCCCCCCCCCCCCC	44.79	33845483
327	Phosphorylation	DETSSVKSDGAGGAR CCCCCCCCCCCCCCC	38.84	23927012
327	Ubiquitination	DETSSVKSDGAGGAR CCCCCCCCCCCCCCC	38.84	22817900
330	Ubiquitination	SSVKSDGAGGARASF CCCCCCCCCCCCCCC	20.45	22817900
332	Ubiquitination	VKSDGAGGARASFRG CCCCCCCCCCCCCCC	16.03	22817900
334	Ubiquitination	SDGAGGARASFRGRG CCCCCCCCCCCCCCC	33.76	23000965
338	Ubiquitination	GGARASFRGRGRGRG CCCCCCCCCCCCCCC	31.25	22817900
341	Ubiquitination	RASFRGRGRGRGRGR CCCCCCCCCCCCCCC	38.94	23000965
343	Phosphorylation	SFRGRGRGRGRGRGR CCCCCCCCCCCCCCC	38.94	32142685
354	Ubiquitination	GRGRGRGGTRTHFDY CCCCCCCCCCCCEEE	15.63	22817900
355	Phosphorylation	RGRGRGGTRTHFDYQ CCCCCCCCCCCEEEE	34.91	32142685
357	Phosphorylation	RGRGGTRTHFDYQFG CCCCCCCCCEEEECC	27.08	29978859
357	Ubiquitination	RGRGGTRTHFDYQFG CCCCCCCCCEEEECC	27.08	22817900
359	Phosphorylation	RGGTRTHFDYQFGYR CCCCCCCEEEECCCC	10.40	32142685
361	Phosphorylation	GTRTHFDYQFGYRKF CCCCCEEEECCCCCC	12.56	20007894
362	Ubiquitination	TRTHFDYQFGYRKFD CCCCEEEECCCCCCC	27.42	33845483
365	Phosphorylation	HFDYQFGYRKFDGVE CEEEECCCCCCCCCC	16.36	28152594
365	Ubiquitination	HFDYQFGYRKFDGVE CEEEECCCCCCCCCC	16.36	22817900
366	Methylation	FDYQFGYRKFDGVEG EEEECCCCCCCCCCC	33.28	115481783
367	Ubiquitination	DYQFGYRKFDGVEGP EEECCCCCCCCCCCC	39.05	23000965
370	Ubiquitination	FGYRKFDGVEGPRTP CCCCCCCCCCCCCCC	23.62	33845483
376	Phosphorylation	DGVEGPRTPKYMNNI CCCCCCCCCCCCCCE	27.54	29255136
377	Phosphorylation	GVEGPRTPKYMNNIT CCCCCCCCCCCCCEE	27.36	32142685
379	Phosphorylation	EGPRTPKYMNNITYY CCCCCCCCCCCEEEE	13.28	18669648
385	Ubiquitination	KYMNNITYYFDNVSS CCCCCEEEEECCCCC	9.80	22817900
385 (in isoform 3)	Ubiquitination	-	9.80	21890473
388	Ubiquitination	NNITYYFDNVSSTEL CCEEEEECCCCCCEE	38.20	33845483
389	Phosphorylation	NITYYFDNVSSTELY CEEEEECCCCCCEEE	26.18	32142685
392	Phosphorylation	YYFDNVSSTELYSVD EEECCCCCCEEEECC	22.94	-
393	Phosphorylation	YFDNVSSTELYSVDQ EECCCCCCEEEECCH	23.62	18669648
395	Ubiquitination	DNVSSTELYSVDQEL CCCCCCEEEECCHHH	3.80	22817900
396	Phosphorylation	NVSSTELYSVDQELL CCCCCEEEECCHHHH	10.62	-
396	Ubiquitination	NVSSTELYSVDQELL CCCCCEEEECCHHHH	10.62	33845483
396 (in isoform 3)	Ubiquitination	-	10.62	21890473
397	Phosphorylation	VSSTELYSVDQELLK CCCCEEEECCHHHHH	31.66	-
398	Ubiquitination	SSTELYSVDQELLKD CCCEEEECCHHHHHH	5.79	21890473
402	Ubiquitination	LYSVDQELLKDYIKR EEECCHHHHHHHHHH	6.31	22817900
404	Ubiquitination	SVDQELLKDYIKRQI ECCHHHHHHHHHHHH	62.20	21890473
406	Phosphorylation	DQELLKDYIKRQIEY CHHHHHHHHHHHHHE	13.52	29978859
406	Ubiquitination	DQELLKDYIKRQIEY CHHHHHHHHHHHHHE	13.52	22817900
408	Ubiquitination	ELLKDYIKRQIEYYF HHHHHHHHHHHHEEE	31.83	22817900
411	Phosphorylation	KDYIKRQIEYYFSVD HHHHHHHHHEEECCC	4.22	32142685
413	Phosphorylation	YIKRQIEYYFSVDNL HHHHHHHEEECCCCC	16.07	29978859
414	Phosphorylation	IKRQIEYYFSVDNLE HHHHHHEEECCCCCC	4.06	29978859
416	Phosphorylation	RQIEYYFSVDNLERD HHHHEEECCCCCCCC	16.67	29978859
422	Phosphorylation	FSVDNLERDFFLRRK ECCCCCCCCCHHHHC	49.56	32142685
423	Phosphorylation	SVDNLERDFFLRRKM CCCCCCCCCHHHHCC	29.31	32142685
426	Phosphorylation	NLERDFFLRRKMDAD CCCCCCHHHHCCCCC	5.38	32142685
428	Ubiquitination	ERDFFLRRKMDADGF CCCCHHHHCCCCCCC	40.58	33845483
429	Ubiquitination	RDFFLRRKMDADGFL CCCHHHHCCCCCCCH	34.40	22817900
431	Ubiquitination	FFLRRKMDADGFLPI CHHHHCCCCCCCHHH	44.54	21890473
432	Ubiquitination	FLRRKMDADGFLPIT HHHHCCCCCCCHHHH	18.48	33845483
435	Ubiquitination	RKMDADGFLPITLIA HCCCCCCCHHHHHHH	8.25	22817900
436	Ubiquitination	KMDADGFLPITLIAS CCCCCCCHHHHHHHH	3.52	33845483
439	Ubiquitination	ADGFLPITLIASFHR CCCCHHHHHHHHHHH	15.35	22817900
440	Ubiquitination	DGFLPITLIASFHRV CCCHHHHHHHHHHHH	2.97	33845483
444	Phosphorylation	PITLIASFHRVQALT HHHHHHHHHHHHHHH	2.93	32142685
445	Phosphorylation	ITLIASFHRVQALTT HHHHHHHHHHHHHHC	26.89	32142685
447	Ubiquitination	LIASFHRVQALTTDI HHHHHHHHHHHHCCH	2.68	22817900
449	Phosphorylation	ASFHRVQALTTDISL HHHHHHHHHHCCHHH	12.20	32142685
452	Phosphorylation	HRVQALTTDISLIFA HHHHHHHCCHHHHHH	31.99	32142685
454	Ubiquitination	VQALTTDISLIFAAL HHHHHCCHHHHHHHH	3.20	32015554
462	Ubiquitination	SLIFAALKDSKVVEI HHHHHHHCCCCEEEE	56.05	21906983
462 (in isoform 1)	Ubiquitination	-	56.05	21890473
462 (in isoform 3)	Ubiquitination	-	56.05	21890473
465	Ubiquitination	FAALKDSKVVEIVDE HHHHCCCCEEEEECH	61.51	22817900
466	Ubiquitination	AALKDSKVVEIVDEK HHHCCCCEEEEECHH	5.60	22817900
471	Phosphorylation	SKVVEIVDEKVRRRE CCEEEEECHHHHCCC	56.51	32142685
472	Ubiquitination	KVVEIVDEKVRRREE CEEEEECHHHHCCCC	42.42	21890473
473	2-Hydroxyisobutyrylation	VVEIVDEKVRRREEP EEEEECHHHHCCCCC	36.26	-
473	Ubiquitination	VVEIVDEKVRRREEP EEEEECHHHHCCCCC	36.26	21906983
473 (in isoform 1)	Ubiquitination	-	36.26	21890473
476	Ubiquitination	IVDEKVRRREEPEKW EECHHHHCCCCCCCC	54.04	22817900
481	Ubiquitination	VRRREEPEKWPLPPI HHCCCCCCCCCCCCC	71.66	23000965
486	Phosphorylation	EPEKWPLPPIVDYSQ CCCCCCCCCCCCCCC	16.70	32142685
491	Phosphorylation	PLPPIVDYSQTDFSQ CCCCCCCCCCCCHHH	7.56	-
492	Phosphorylation	LPPIVDYSQTDFSQL CCCCCCCCCCCHHHH	23.34	27251275
493	Phosphorylation	PPIVDYSQTDFSQLL CCCCCCCCCCHHHHH	38.57	32142685
494	Phosphorylation	PIVDYSQTDFSQLLN CCCCCCCCCHHHHHC	32.83	30576142
497	Phosphorylation	DYSQTDFSQLLNCPE CCCCCCHHHHHCCCC	23.80	27251275
498	Ubiquitination	YSQTDFSQLLNCPEF CCCCCHHHHHCCCCC	50.38	33845483
502	Phosphorylation	DFSQLLNCPEFVPRQ CHHHHHCCCCCCCHH	3.26	32142685
505	Phosphorylation	QLLNCPEFVPRQHYQ HHHCCCCCCCHHHHH	5.75	32142685
506	Ubiquitination	LLNCPEFVPRQHYQK HHCCCCCCCHHHHHH	3.49	21890473
510	Phosphorylation	PEFVPRQHYQKETES CCCCCHHHHHHCCCC	28.42	32142685
510	Ubiquitination	PEFVPRQHYQKETES CCCCCHHHHHHCCCC	28.42	22817900
511	Phosphorylation	EFVPRQHYQKETESA CCCCHHHHHHCCCCC	16.97	23927012
513	Ubiquitination	VPRQHYQKETESAPG CCHHHHHHCCCCCCC	60.48	21890473
515	Phosphorylation	RQHYQKETESAPGSP HHHHHHCCCCCCCCC	42.13	29255136
515	Ubiquitination	RQHYQKETESAPGSP HHHHHHCCCCCCCCC	42.13	23000965
516	Phosphorylation	QHYQKETESAPGSPR HHHHHCCCCCCCCCC	46.09	32645325
517	Phosphorylation	HYQKETESAPGSPRA HHHHCCCCCCCCCCC	47.38	29255136
517	Ubiquitination	HYQKETESAPGSPRA HHHHCCCCCCCCCCC	47.38	22817900
519	Phosphorylation	QKETESAPGSPRAVT HHCCCCCCCCCCCCC	53.74	32142685
520	Ubiquitination	KETESAPGSPRAVTP HCCCCCCCCCCCCCC	50.42	33845483
521	Phosphorylation	ETESAPGSPRAVTPV CCCCCCCCCCCCCCC	15.34	29255136
524	Phosphorylation	SAPGSPRAVTPVPTK CCCCCCCCCCCCCCC	16.96	32142685
526	Phosphorylation	PGSPRAVTPVPTKTE CCCCCCCCCCCCCCH	19.99	29255136
528	Phosphorylation	SPRAVTPVPTKTEEV CCCCCCCCCCCCHHC	7.40	32142685
530	Phosphorylation	RAVTPVPTKTEEVSN CCCCCCCCCCHHCCC	51.32	30266825
531	Acetylation	AVTPVPTKTEEVSNL CCCCCCCCCHHCCCC	48.12	25953088
531	Sumoylation	AVTPVPTKTEEVSNL CCCCCCCCCHHCCCC	48.12	28112733
531	Ubiquitination	AVTPVPTKTEEVSNL CCCCCCCCCHHCCCC	48.12	33845483
532	Phosphorylation	VTPVPTKTEEVSNLK CCCCCCCCHHCCCCC	39.60	23927012
533	Ubiquitination	TPVPTKTEEVSNLKT CCCCCCCHHCCCCCC	58.94	23000965
536	Phosphorylation	PTKTEEVSNLKTLPK CCCCHHCCCCCCCCC	39.46	23927012
539	Acetylation	TEEVSNLKTLPKGLS CHHCCCCCCCCCCHH	52.87	25953088
539	Phosphorylation	TEEVSNLKTLPKGLS CHHCCCCCCCCCCHH	52.87	32142685
539	Ubiquitination	TEEVSNLKTLPKGLS CHHCCCCCCCCCCHH	52.87	22817900
539 (in isoform 1)	Ubiquitination	-	52.87	21890473
540	Phosphorylation	EEVSNLKTLPKGLSA HHCCCCCCCCCCHHC	52.00	28464451
541	Ubiquitination	EVSNLKTLPKGLSAS HCCCCCCCCCCHHCC	3.84	33845483
543	Ubiquitination	SNLKTLPKGLSASLP CCCCCCCCCHHCCCC	75.49	22817900
544	Phosphorylation	NLKTLPKGLSASLPD CCCCCCCCHHCCCCC	23.95	32142685
546	Phosphorylation	KTLPKGLSASLPDLD CCCCCCHHCCCCCCC	25.20	22167270
548	Phosphorylation	LPKGLSASLPDLDSE CCCCHHCCCCCCCCC	36.74	19664994
548	Ubiquitination	LPKGLSASLPDLDSE CCCCHHCCCCCCCCC	36.74	23000965
550	Phosphorylation	KGLSASLPDLDSENW CCHHCCCCCCCCCCC	37.31	32142685
554	Phosphorylation	ASLPDLDSENWIEVK CCCCCCCCCCCEEEC	39.88	30266825
554	Ubiquitination	ASLPDLDSENWIEVK CCCCCCCCCCCEEEC	39.88	33845483
558	Phosphorylation	DLDSENWIEVKKRPR CCCCCCCEEECCCCC	7.04	32142685
561	Phosphorylation	SENWIEVKKRPRPSP CCCCEEECCCCCCCC	30.21	32142685
567	Phosphorylation	VKKRPRPSPARPKKS ECCCCCCCCCCCCCC	32.26	30576142
567	Ubiquitination	VKKRPRPSPARPKKS ECCCCCCCCCCCCCC	32.26	23000965
569	Phosphorylation	KRPRPSPARPKKSEE CCCCCCCCCCCCCHH	44.75	32142685
572	Phosphorylation	RPSPARPKKSEESRF CCCCCCCCCCHHHHH	64.48	32142685
574	Phosphorylation	SPARPKKSEESRFSH CCCCCCCCHHHHHHH	53.36	25627689
575	Ubiquitination	PARPKKSEESRFSHL CCCCCCCHHHHHHHH	69.72	33845483
577	Phosphorylation	RPKKSEESRFSHLTS CCCCCHHHHHHHHHC	34.28	25159151
580	Phosphorylation	KSEESRFSHLTSLPQ CCHHHHHHHHHCCCC	19.24	25159151
583	Phosphorylation	ESRFSHLTSLPQQLP HHHHHHHHCCCCCCC	23.85	28450419
584	O-linked_Glycosylation	SRFSHLTSLPQQLPS HHHHHHHCCCCCCCH	44.40	23301498
584	Phosphorylation	SRFSHLTSLPQQLPS HHHHHHHCCCCCCCH	44.40	21130716
587	Ubiquitination	SHLTSLPQQLPSQQL HHHHCCCCCCCHHHH	63.84	33845483
591	Phosphorylation	SLPQQLPSQQLMSKD CCCCCCCHHHHCCCC	38.87	25159151
592	Phosphorylation	LPQQLPSQQLMSKDQ CCCCCCHHHHCCCCH	38.19	32142685
594	Phosphorylation	QQLPSQQLMSKDQDE CCCCHHHHCCCCHHH	3.03	32142685
596	Phosphorylation	LPSQQLMSKDQDEQE CCHHHHCCCCHHHHH	41.49	25159151
598	Phosphorylation	SQQLMSKDQDEQEEL HHHHCCCCHHHHHHH	54.58	32142685
599	Ubiquitination	QQLMSKDQDEQEELD HHHCCCCHHHHHHHH	60.93	21890473
600	Ubiquitination	QLMSKDQDEQEELDF HHCCCCHHHHHHHHH	70.45	23000965
608	Ubiquitination	EQEELDFLFDEEMEQ HHHHHHHHCHHHHHH	5.44	33845483
609	Ubiquitination	QEELDFLFDEEMEQM HHHHHHHCHHHHHHC	12.87	21890473
611	Phosphorylation	ELDFLFDEEMEQMDG HHHHHCHHHHHHCCC	52.49	32142685
612	Ubiquitination	LDFLFDEEMEQMDGR HHHHCHHHHHHCCCC	50.27	21890473
616	Phosphorylation	FDEEMEQMDGRKNTF CHHHHHHCCCCCCCE	3.62	32142685
618	Ubiquitination	EEMEQMDGRKNTFTA HHHHHCCCCCCCEEE	36.80	21890473
621	Phosphorylation	EQMDGRKNTFTAWSD HHCCCCCCCEEECCC	38.78	32142685
622	Phosphorylation	QMDGRKNTFTAWSDE HCCCCCCCEEECCCC	25.95	23927012
624	Phosphorylation	DGRKNTFTAWSDEES CCCCCCEEECCCCCC	25.77	20201521
625	Phosphorylation	GRKNTFTAWSDEESD CCCCCEEECCCCCCC	10.28	32142685
626	Ubiquitination	RKNTFTAWSDEESDY CCCCEEECCCCCCCC	11.85	29967540
627	Phosphorylation	KNTFTAWSDEESDYE CCCEEECCCCCCCCC	32.45	19664994
631	Phosphorylation	TAWSDEESDYEIDDR EECCCCCCCCCCCCC	43.37	22167270
633	Phosphorylation	WSDEESDYEIDDRDV CCCCCCCCCCCCCCC	24.86	23927012
633	Ubiquitination	WSDEESDYEIDDRDV CCCCCCCCCCCCCCC	24.86	21890473
643	Ubiquitination	DDRDVNKILIVTQTP CCCCCCEEEEEECCC	2.40	21890473
644	Phosphorylation	DRDVNKILIVTQTPH CCCCCEEEEEECCCC	2.48	32142685
645	Ubiquitination	RDVNKILIVTQTPHY CCCCEEEEEECCCCH	3.43	21890473
647	Phosphorylation	VNKILIVTQTPHYMR CCEEEEEECCCCHHC	21.52	29255136
649	Phosphorylation	KILIVTQTPHYMRRH EEEEEECCCCHHCCC	11.58	29255136
650	Ubiquitination	ILIVTQTPHYMRRHP EEEEECCCCHHCCCC	13.54	33845483
651	Ubiquitination	LIVTQTPHYMRRHPG EEEECCCCHHCCCCC	32.20	24816145
652	Phosphorylation	IVTQTPHYMRRHPGG EEECCCCHHCCCCCC	8.10	23927012
657	Ubiquitination	PHYMRRHPGGDRTGN CCHHCCCCCCCCCCC	46.80	24816145
662	Phosphorylation	RHPGGDRTGNHTSRA CCCCCCCCCCCHHHH	47.26	22210691
663	Phosphorylation	HPGGDRTGNHTSRAK CCCCCCCCCCHHHHH	25.47	32142685
664	Ubiquitination	PGGDRTGNHTSRAKM CCCCCCCCCHHHHHH	34.35	23000965
666	Phosphorylation	GDRTGNHTSRAKMSA CCCCCCCHHHHHHHH	24.73	22210691
666	Ubiquitination	GDRTGNHTSRAKMSA CCCCCCCHHHHHHHH	24.73	21890473
667	Phosphorylation	DRTGNHTSRAKMSAE CCCCCCHHHHHHHHH	23.77	22210691
670	Acetylation	GNHTSRAKMSAELAK CCCHHHHHHHHHHHH	32.07	25953088
670	Ubiquitination	GNHTSRAKMSAELAK CCCHHHHHHHHHHHH	32.07	21890473
671	Phosphorylation	NHTSRAKMSAELAKV CCHHHHHHHHHHHHH	4.47	32142685
672	O-linked_Glycosylation	HTSRAKMSAELAKVI CHHHHHHHHHHHHHH	20.20	23301498
672	Phosphorylation	HTSRAKMSAELAKVI CHHHHHHHHHHHHHH	20.20	27251275
672	Ubiquitination	HTSRAKMSAELAKVI CHHHHHHHHHHHHHH	20.20	21890473
674	Phosphorylation	SRAKMSAELAKVIND HHHHHHHHHHHHHHC	41.79	32142685
676	Ubiquitination	AKMSAELAKVINDGL HHHHHHHHHHHHCCC	8.79	23000965
676 (in isoform 3)	Ubiquitination	-	8.79	21890473
679	Phosphorylation	SAELAKVINDGLFYY HHHHHHHHHCCCCEE	3.71	32142685
684	Ubiquitination	KVINDGLFYYEQDLW HHHHCCCCEEHHHHH	8.15	24816145
684 (in isoform 3)	Phosphorylation	-	8.15	18220336
685	Phosphorylation	VINDGLFYYEQDLWA HHHCCCCEEHHHHHH	15.90	32645325
686	Ubiquitination	INDGLFYYEQDLWAE HHCCCCEEHHHHHHH	10.36	21890473
689	Phosphorylation	GLFYYEQDLWAEKFE CCCEEHHHHHHHHHC	32.03	32142685
689	Ubiquitination	GLFYYEQDLWAEKFE CCCEEHHHHHHHHHC	32.03	33845483
691	Phosphorylation	FYYEQDLWAEKFEPE CEEHHHHHHHHHCHH	15.63	32142685
697	Phosphorylation	LWAEKFEPEYSQIKQ HHHHHHCHHHHHHHH	49.29	32142685
697	Ubiquitination	LWAEKFEPEYSQIKQ HHHHHHCHHHHHHHH	49.29	21890473
698	Ubiquitination	WAEKFEPEYSQIKQE HHHHHCHHHHHHHHH	51.09	32015554
699	Phosphorylation	AEKFEPEYSQIKQEV HHHHCHHHHHHHHHH	19.32	28796482
700	Phosphorylation	EKFEPEYSQIKQEVE HHHCHHHHHHHHHHH	24.62	28796482
700	Ubiquitination	EKFEPEYSQIKQEVE HHHCHHHHHHHHHHH	24.62	21890473
702	Ubiquitination	FEPEYSQIKQEVENF HCHHHHHHHHHHHHH	4.01	33845483
703	Sumoylation	EPEYSQIKQEVENFK CHHHHHHHHHHHHHH	32.54	28112733
705	Phosphorylation	EYSQIKQEVENFKKV HHHHHHHHHHHHHHH	46.96	32142685
706	Ubiquitination	YSQIKQEVENFKKVN HHHHHHHHHHHHHHC	7.26	21890473
710	Ubiquitination	KQEVENFKKVNMISR HHHHHHHHHHCCCCH	68.35	33845483
711	Phosphorylation	QEVENFKKVNMISRE HHHHHHHHHCCCCHH	34.40	32645325
715	Ubiquitination	NFKKVNMISREQFDT HHHHHCCCCHHHHCC	2.71	27667366
716	Phosphorylation	FKKVNMISREQFDTL HHHHCCCCHHHHCCC	20.99	20044836
720	Ubiquitination	NMISREQFDTLTPEP CCCCHHHHCCCCCCC	7.12	23000965
722	Phosphorylation	ISREQFDTLTPEPPV CCHHHHCCCCCCCCC	33.54	29255136
724	Phosphorylation	REQFDTLTPEPPVDP HHHHCCCCCCCCCCC	27.91	29255136
725	Ubiquitination	EQFDTLTPEPPVDPN HHHCCCCCCCCCCCC	56.03	24816145
727	Phosphorylation	FDTLTPEPPVDPNQE HCCCCCCCCCCCCCC	35.10	32142685
727	Ubiquitination	FDTLTPEPPVDPNQE HCCCCCCCCCCCCCC	35.10	21890473
728	Ubiquitination	DTLTPEPPVDPNQEV CCCCCCCCCCCCCCC	41.29	23000965
728 (in isoform 3)	Ubiquitination	-	41.29	21890473
730	Ubiquitination	LTPEPPVDPNQEVPP CCCCCCCCCCCCCCC	42.05	21890473
731	Ubiquitination	TPEPPVDPNQEVPPG CCCCCCCCCCCCCCC	44.64	33845483
733	Phosphorylation	EPPVDPNQEVPPGPP CCCCCCCCCCCCCCC	59.46	32142685
734	Ubiquitination	PPVDPNQEVPPGPPR CCCCCCCCCCCCCCC	64.73	21890473
736	Ubiquitination	VDPNQEVPPGPPRFQ CCCCCCCCCCCCCHH	27.64	21890473
738	Ubiquitination	PNQEVPPGPPRFQQV CCCCCCCCCCCHHCC	38.48	21890473
739	Ubiquitination	NQEVPPGPPRFQQVP CCCCCCCCCCHHCCC	23.75	21890473
740	Ubiquitination	QEVPPGPPRFQQVPT CCCCCCCCCHHCCCH	56.48	21890473
741	Phosphorylation	EVPPGPPRFQQVPTD CCCCCCCCHHCCCHH	45.18	32142685
744	Phosphorylation	PGPPRFQQVPTDALA CCCCCHHCCCHHHHH	40.21	32142685
745	Ubiquitination	GPPRFQQVPTDALAN CCCCHHCCCHHHHHH	3.71	23000965
746	Phosphorylation	PPRFQQVPTDALANK CCCHHCCCHHHHHHH	21.88	32142685
746	Ubiquitination	PPRFQQVPTDALANK CCCHHCCCHHHHHHH	21.88	21890473
747	Phosphorylation	PRFQQVPTDALANKL CCHHCCCHHHHHHHH	34.74	26074081
749	Phosphorylation	FQQVPTDALANKLFG HHCCCHHHHHHHHHC	15.85	32142685
753	Acetylation	PTDALANKLFGAPEP CHHHHHHHHHCCCCC	39.32	25953088
753	Phosphorylation	PTDALANKLFGAPEP CHHHHHHHHHCCCCC	39.32	32142685
753	Ubiquitination	PTDALANKLFGAPEP CHHHHHHHHHCCCCC	39.32	23000965
753 (in isoform 1)	Ubiquitination	-	39.32	21890473
755	Phosphorylation	DALANKLFGAPEPST HHHHHHHHCCCCCCH	9.29	32645325
759	Ubiquitination	NKLFGAPEPSTIARS HHHHCCCCCCHHHHC	51.88	33845483
761	Phosphorylation	LFGAPEPSTIARSLP HHCCCCCCHHHHCCC	30.68	26503892
762	Phosphorylation	FGAPEPSTIARSLPT HCCCCCCHHHHCCCC	29.39	25159151
763	Ubiquitination	GAPEPSTIARSLPTT CCCCCCHHHHCCCCC	3.35	21890473
765	Ubiquitination	PEPSTIARSLPTTVP CCCCHHHHCCCCCCC	34.57	33845483
766	Phosphorylation	EPSTIARSLPTTVPE CCCHHHHCCCCCCCC	29.67	29255136
766	Ubiquitination	EPSTIARSLPTTVPE CCCHHHHCCCCCCCC	29.67	24816145
767	Ubiquitination	PSTIARSLPTTVPES CCHHHHCCCCCCCCC	3.49	21890473
769	Phosphorylation	TIARSLPTTVPESPN HHHHCCCCCCCCCCC	45.80	22167270
770	O-linked_Glycosylation	IARSLPTTVPESPNY HHHCCCCCCCCCCCC	31.93	23301498
770	Phosphorylation	IARSLPTTVPESPNY HHHCCCCCCCCCCCC	31.93	22167270
772	Phosphorylation	RSLPTTVPESPNYRN HCCCCCCCCCCCCCC	33.97	32142685
772	Ubiquitination	RSLPTTVPESPNYRN HCCCCCCCCCCCCCC	33.97	23000965
773	Ubiquitination	SLPTTVPESPNYRNT CCCCCCCCCCCCCCC	74.60	21890473
774	Phosphorylation	LPTTVPESPNYRNTR CCCCCCCCCCCCCCC	16.63	19664994
777	Phosphorylation	TVPESPNYRNTRTPR CCCCCCCCCCCCCCC	14.50	26846344
779	Ubiquitination	PESPNYRNTRTPRTP CCCCCCCCCCCCCCC	24.45	23000965
780	Phosphorylation	ESPNYRNTRTPRTPR CCCCCCCCCCCCCCC	27.24	25159151
780	Ubiquitination	ESPNYRNTRTPRTPR CCCCCCCCCCCCCCC	27.24	33845483
782	Phosphorylation	PNYRNTRTPRTPRTP CCCCCCCCCCCCCCC	18.32	22167270
785	Phosphorylation	RNTRTPRTPRTPQLK CCCCCCCCCCCCCCC	20.51	22167270
788	Phosphorylation	RTPRTPRTPQLKDSS CCCCCCCCCCCCCCC	19.31	22167270
792	Methylation	TPRTPQLKDSSQTSR CCCCCCCCCCCCCCC	50.76	24604681
792	Ubiquitination	TPRTPQLKDSSQTSR CCCCCCCCCCCCCCC	50.76	27667366
794	Phosphorylation	RTPQLKDSSQTSRFY CCCCCCCCCCCCCCC	23.82	26055452
794	Ubiquitination	RTPQLKDSSQTSRFY CCCCCCCCCCCCCCC	23.82	21890473
794 (in isoform 3)	Ubiquitination	-	23.82	21890473
795	Phosphorylation	TPQLKDSSQTSRFYP CCCCCCCCCCCCCCH	47.84	25159151
797	Phosphorylation	QLKDSSQTSRFYPVV CCCCCCCCCCCCHHH	24.66	28650797
798	Phosphorylation	LKDSSQTSRFYPVVK CCCCCCCCCCCHHHC	16.86	28857561
798	Ubiquitination	LKDSSQTSRFYPVVK CCCCCCCCCCCHHHC	16.86	33845483
799	Phosphorylation	KDSSQTSRFYPVVKE CCCCCCCCCCHHHCC	38.21	32142685
799	Ubiquitination	KDSSQTSRFYPVVKE CCCCCCCCCCHHHCC	38.21	32015554
801	Phosphorylation	SSQTSRFYPVVKEGR CCCCCCCCHHHCCCC	8.26	-
803	Ubiquitination	QTSRFYPVVKEGRTL CCCCCCHHHCCCCCC	7.00	21890473
804	Ubiquitination	TSRFYPVVKEGRTLD CCCCCHHHCCCCCCC	3.95	21890473
804 (in isoform 3)	Ubiquitination	-	3.95	21890473
805	Ubiquitination	SRFYPVVKEGRTLDA CCCCHHHCCCCCCCC	55.47	23000965
805 (in isoform 1)	Ubiquitination	-	55.47	21890473
809	O-linked_Glycosylation	PVVKEGRTLDAKMPR HHHCCCCCCCCCCCC	39.59	23301498
809	Phosphorylation	PVVKEGRTLDAKMPR HHHCCCCCCCCCCCC	39.59	-
809	Ubiquitination	PVVKEGRTLDAKMPR HHHCCCCCCCCCCCC	39.59	21890473
812	Ubiquitination	KEGRTLDAKMPRKRK CCCCCCCCCCCCCCC	17.10	23000965
813	Acetylation	EGRTLDAKMPRKRKT CCCCCCCCCCCCCCC	49.45	25953088
813	Ubiquitination	EGRTLDAKMPRKRKT CCCCCCCCCCCCCCC	49.45	33845483
814	Ubiquitination	GRTLDAKMPRKRKTR CCCCCCCCCCCCCCC	4.09	21890473
815	Acetylation	RTLDAKMPRKRKTRH CCCCCCCCCCCCCCC	37.62	19608861
816	Phosphorylation	TLDAKMPRKRKTRHS CCCCCCCCCCCCCCC	48.16	32142685
820	Phosphorylation	KMPRKRKTRHSSNPP CCCCCCCCCCCCCCC	37.33	28450419
823	Phosphorylation	RKRKTRHSSNPPLES CCCCCCCCCCCCCHH	28.64	22167270
824	Phosphorylation	KRKTRHSSNPPLESH CCCCCCCCCCCCHHH	47.43	22167270
830	Phosphorylation	SSNPPLESHVGWVMD CCCCCCHHHCEECCC	31.02	26846344
831	Ubiquitination	SNPPLESHVGWVMDS CCCCCHHHCEECCCC	16.85	21890473
832	Ubiquitination	NPPLESHVGWVMDSR CCCCHHHCEECCCCC	10.07	32015554
833	Phosphorylation	PPLESHVGWVMDSRE CCCHHHCEECCCCCC	13.06	32142685
833	Ubiquitination	PPLESHVGWVMDSRE CCCHHHCEECCCCCC	13.06	32015554
836	Ubiquitination	ESHVGWVMDSREHRP HHHCEECCCCCCCCC	2.89	21890473
837	Ubiquitination	SHVGWVMDSREHRPR HHCEECCCCCCCCCC	34.62	21890473
838	Phosphorylation	HVGWVMDSREHRPRT HCEECCCCCCCCCCC	22.82	23927012
838	Ubiquitination	HVGWVMDSREHRPRT HCEECCCCCCCCCCC	22.82	21890473
841	Ubiquitination	WVMDSREHRPRTASI ECCCCCCCCCCCCCC	43.89	33845483
845	Phosphorylation	SREHRPRTASISSSP CCCCCCCCCCCCCCC	27.69	20201521
845	Ubiquitination	SREHRPRTASISSSP CCCCCCCCCCCCCCC	27.69	21890473
847	Phosphorylation	EHRPRTASISSSPSE CCCCCCCCCCCCCCC	23.53	20201521
848	Ubiquitination	HRPRTASISSSPSEG CCCCCCCCCCCCCCC	4.25	21890473
849	Phosphorylation	RPRTASISSSPSEGT CCCCCCCCCCCCCCC	23.44	23927012
850	Phosphorylation	PRTASISSSPSEGTP CCCCCCCCCCCCCCC	44.60	20201521
851	Phosphorylation	RTASISSSPSEGTPT CCCCCCCCCCCCCCC	26.17	25159151
853	Phosphorylation	ASISSSPSEGTPTVG CCCCCCCCCCCCCCC	51.08	23927012
855	Ubiquitination	ISSSPSEGTPTVGSY CCCCCCCCCCCCCCC	41.13	21890473
856	Phosphorylation	SSSPSEGTPTVGSYG CCCCCCCCCCCCCCC	16.25	23927012
858	Phosphorylation	SPSEGTPTVGSYGCT CCCCCCCCCCCCCCC	37.02	30278072
859	Ubiquitination	PSEGTPTVGSYGCTP CCCCCCCCCCCCCCC	5.16	32015554
861	Phosphorylation	EGTPTVGSYGCTPQS CCCCCCCCCCCCCCC	17.64	30278072
862	Phosphorylation	GTPTVGSYGCTPQSL CCCCCCCCCCCCCCC	15.42	23927012
864	Glutathionylation	PTVGSYGCTPQSLPK CCCCCCCCCCCCCCC	3.68	22555962
864	S-nitrosylation	PTVGSYGCTPQSLPK CCCCCCCCCCCCCCC	3.68	2212679
864	Ubiquitination	PTVGSYGCTPQSLPK CCCCCCCCCCCCCCC	3.68	21890473
865	Phosphorylation	TVGSYGCTPQSLPKF CCCCCCCCCCCCCCC	21.72	25159151
866	Phosphorylation	VGSYGCTPQSLPKFQ CCCCCCCCCCCCCCC	26.32	32142685
867	Ubiquitination	GSYGCTPQSLPKFQH CCCCCCCCCCCCCCC	39.17	21890473
867 (in isoform 3)	Ubiquitination	-	39.17	21890473
868	Phosphorylation	SYGCTPQSLPKFQHP CCCCCCCCCCCCCCC	48.09	26503892
871	Acetylation	CTPQSLPKFQHPSHE CCCCCCCCCCCCCHH	64.05	26051181
871	Ubiquitination	CTPQSLPKFQHPSHE CCCCCCCCCCCCCHH	64.05	21890473
871 (in isoform 1)	Ubiquitination	-	64.05	21890473
876	Phosphorylation	LPKFQHPSHELLKEN CCCCCCCCHHHHHHC	27.71	26074081
876	Ubiquitination	LPKFQHPSHELLKEN CCCCCCCCHHHHHHC	27.71	21890473
877	Ubiquitination	PKFQHPSHELLKENG CCCCCCCHHHHHHCC	33.89	21890473
881	Ubiquitination	HPSHELLKENGFTQH CCCHHHHHHCCCHHH	62.85	21890473
881 (in isoform 1)	Ubiquitination	-	62.85	21890473
882	Ubiquitination	PSHELLKENGFTQHV CCHHHHHHCCCHHHH	63.66	21890473
892	Acetylation	FTQHVYHKYRRRCLN CHHHHHHHHHHHHHH	23.82	19608861
895	Ubiquitination	HVYHKYRRRCLNERK HHHHHHHHHHHHHHH	30.49	21890473
895 (in isoform 3)	Ubiquitination	-	30.49	21890473
900	Ubiquitination	YRRRCLNERKRLGIG HHHHHHHHHHHHCCC	46.78	33845483
903	Ubiquitination	RCLNERKRLGIGQSQ HHHHHHHHHCCCCCH	44.35	32015554
905	Ubiquitination	LNERKRLGIGQSQEM HHHHHHHCCCCCHHH	26.47	21890473
909	Ubiquitination	KRLGIGQSQEMNTLF HHHCCCCCHHHHHHH	23.93	21890473
911	Ubiquitination	LGIGQSQEMNTLFRF HCCCCCHHHHHHHHH	39.38	21890473
914	Ubiquitination	GQSQEMNTLFRFWSF CCCHHHHHHHHHHHH	26.43	33845483
918	Ubiquitination	EMNTLFRFWSFFLRD HHHHHHHHHHHHHHH	5.12	21890473
926	Ubiquitination	WSFFLRDHFNKKMYE HHHHHHHHHHHHHHH	23.03	33845483
933	Ubiquitination	HFNKKMYEEFKQLAL HHHHHHHHHHHHHHH	54.16	29967540
934	Ubiquitination	FNKKMYEEFKQLALE HHHHHHHHHHHHHHH	40.43	32015554
936	Ubiquitination	KKMYEEFKQLALEDA HHHHHHHHHHHHHHH	47.91	32015554
939	Ubiquitination	YEEFKQLALEDAKEG HHHHHHHHHHHHHHH	13.35	21890473
940	Acetylation	EEFKQLALEDAKEGY HHHHHHHHHHHHHHH	9.23	19608861
940	Ubiquitination	EEFKQLALEDAKEGY HHHHHHHHHHHHHHH	9.23	23000965
940 (in isoform 3)	Ubiquitination	-	9.23	21890473
944	Ubiquitination	QLALEDAKEGYRYGL HHHHHHHHHHHHHHH	65.08	22817900
944 (in isoform 1)	Ubiquitination	-	65.08	21890473
946	Ubiquitination	ALEDAKEGYRYGLEC HHHHHHHHHHHHHHH	16.12	21890473
949	Phosphorylation	DAKEGYRYGLECLFR HHHHHHHHHHHHHHH	19.99	-
950	Ubiquitination	AKEGYRYGLECLFRY HHHHHHHHHHHHHHH	13.15	21890473
957	Phosphorylation	GLECLFRYYSYGLEK HHHHHHHHHHHCCCC	6.88	20860994
959	Phosphorylation	ECLFRYYSYGLEKKF HHHHHHHHHCCCCCC	12.09	20860994
960	Ubiquitination	CLFRYYSYGLEKKFR HHHHHHHHCCCCCCC	15.03	32015554
964	2-Hydroxyisobutyrylation	YYSYGLEKKFRLDIF HHHHCCCCCCCEEEC	63.35	-
964	Acetylation	YYSYGLEKKFRLDIF HHHHCCCCCCCEEEC	63.35	26051181
968	Phosphorylation	GLEKKFRLDIFKDFQ CCCCCCCEEECHHHC	7.15	32142685
970	Ubiquitination	EKKFRLDIFKDFQEE CCCCCEEECHHHCHH	5.68	33845483
972	Ubiquitination	KFRLDIFKDFQEETV CCCEEECHHHCHHHH	58.95	21890473
972 (in isoform 1)	Ubiquitination	-	58.95	21890473
984	Ubiquitination	ETVKDYEAGQLYGLE HHHHHHCHHHHHCHH	12.56	23000965
991	Ubiquitination	AGQLYGLEKFWAFLK HHHHHCHHHHHHHHH	41.67	21890473
994	Phosphorylation	LYGLEKFWAFLKYSK HHCHHHHHHHHHHHH	9.36	32142685
1003	Ubiquitination	FLKYSKAKNLDIDPK HHHHHHHCCCCCCHH	62.88	33845483
1004	Ubiquitination	LKYSKAKNLDIDPKL HHHHHHCCCCCCHHH	48.05	32015554
1010	Acetylation	KNLDIDPKLQEYLGK CCCCCCHHHHHHHHH	60.08	90195
1017	Acetylation	KLQEYLGKFRRLEDF HHHHHHHHCCCHHHC	32.86	19608861
1017	Malonylation	KLQEYLGKFRRLEDF HHHHHHHHCCCHHHC	32.86	26320211
1017	Ubiquitination	KLQEYLGKFRRLEDF HHHHHHHHCCCHHHC	32.86	23000965
1017 (in isoform 1)	Ubiquitination	-	32.86	21890473
1037	Acetylation	MGEEGNHKRHSVVAG CCCCCCCCCCCEECC	56.67	12436447
1037	Ubiquitination	MGEEGNHKRHSVVAG CCCCCCCCCCCEECC	56.67	32015554
1038	Phosphorylation	GEEGNHKRHSVVAGG CCCCCCCCCCEECCC	21.55	32142685
1040	Phosphorylation	EGNHKRHSVVAGGGG CCCCCCCCEECCCCC	23.48	23401153
1052	Acetylation	GGGGEGRKRCPSQSS CCCCCCCCCCCCCCC	70.03	12436461
1056	Phosphorylation	EGRKRCPSQSSSRPA CCCCCCCCCCCCCCC	46.44	23401153
1058	Phosphorylation	RKRCPSQSSSRPAAM CCCCCCCCCCCCCCH	34.32	23927012
1059	Phosphorylation	KRCPSQSSSRPAAMI CCCCCCCCCCCCCHH	23.80	23927012
1060	Phosphorylation	RCPSQSSSRPAAMIS CCCCCCCCCCCCHHC	47.75	23927012
1067	Phosphorylation	SRPAAMISQPPTPPT CCCCCHHCCCCCCCC	24.45	23927012
1071	Phosphorylation	AMISQPPTPPTGQPV CHHCCCCCCCCCCCC	48.89	23401153
1074	Phosphorylation	SQPPTPPTGQPVRED CCCCCCCCCCCCCCC	50.05	29255136
1083	Acetylation	QPVREDAKWTSQHSN CCCCCCCCCCCCCCC	64.42	25953088
1083	Phosphoglycerylation	QPVREDAKWTSQHSN CCCCCCCCCCCCCCC	64.42	-
1085	Phosphorylation	VREDAKWTSQHSNTQ CCCCCCCCCCCCCCC	20.15	28450419
1086	Phosphorylation	REDAKWTSQHSNTQT CCCCCCCCCCCCCCC	25.44	28450419
1089	Phosphorylation	AKWTSQHSNTQTLGK CCCCCCCCCCCCCCC	33.66	25159151
1091	Phosphorylation	WTSQHSNTQTLGK-- CCCCCCCCCCCCC--	26.41	25159151
1093	Phosphorylation	SQHSNTQTLGK---- CCCCCCCCCCC----	35.12	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
303	T	Phosphorylation	Kinase	CDK2	P24941	PSP
649	T	Phosphorylation	Kinase	CDK2	P24941	PSP
766	S	Phosphorylation	Kinase	MTOR	P42345	PSP
774	S	Phosphorylation	Kinase	CDK2	P24941	PSP
774	S	Phosphorylation	Kinase	MTOR	P42345	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LARP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LARP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KASH5_HUMAN	CCDC155	physical	25416956
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
CING_HUMAN	CGN	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-517; SER-521; THR-526; SER-548; THR-622;THR-624; SER-627; SER-631; TYR-633; THR-724; SER-766; SER-774;SER-847; SER-849; SER-850; SER-851; SER-853 AND TYR-862, AND MASSSPECTROMETRY.
PubMed: 19413330

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-892 AND LYS-1017, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-90; THR-526;SER-548; SER-627; SER-631; THR-724; SER-774 AND SER-824, AND MASSSPECTROMETRY.
PubMed: 19690332

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-517; SER-521;THR-526; SER-546; SER-548; THR-622; SER-627; SER-631; SER-766 ANDSER-774, AND MASS SPECTROMETRY.
PubMed: 19369195

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-517; SER-521; THR-526; SER-548; THR-622;THR-624; SER-627; SER-631; TYR-633; THR-724; SER-766; SER-774;SER-847; SER-849; SER-850; SER-851; SER-853 AND TYR-862, AND MASSSPECTROMETRY.
PubMed: 19413330

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-143; SER-165;SER-517; SER-521; THR-526; SER-627; SER-631; THR-649; THR-724;SER-766; SER-774; SER-824; THR-845; SER-851 AND SER-853, AND MASSSPECTROMETRY.
PubMed: 18669648

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-548, AND MASSSPECTROMETRY.
PubMed: 18691976

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75; SER-90; SER-766;SER-774; SER-823 AND SER-824, AND MASS SPECTROMETRY.
PubMed: 18220336

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, AND MASSSPECTROMETRY.
PubMed: 18088087

"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;
Anal. Sci. 24:161-166(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526 AND SER-774, ANDMASS SPECTROMETRY.
PubMed: 18187866

"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis.";
Wang B., Malik R., Nigg E.A., Korner R.;
Anal. Chem. 80:9526-9533(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526; SER-847 ANDSER-851, AND MASS SPECTROMETRY.
PubMed: 19007248

"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage.";
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.;
Science 316:1160-1166(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1056 AND THR-1071, ANDMASS SPECTROMETRY.
PubMed: 17525332

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-517; SER-521; THR-526;THR-622; THR-624; SER-627; THR-785 AND THR-788, AND MASS SPECTROMETRY.
PubMed: 17287340

"Quantitative phosphoproteome profiling of Wnt3a-mediated signalingnetwork: indicating the involvement of ribonucleoside-diphosphatereductase M2 subunit phosphorylation at residue serine 20 in canonicalWnt signal transduction.";
Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S.,Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R.;
Mol. Cell. Proteomics 6:1952-1967(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90 AND THR-526, AND MASSSPECTROMETRY.
PubMed: 17693683

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-90; SER-517; SER-521;THR-526; SER-627; SER-631; SER-766; SER-774; SER-824 AND THR-1071, ANDMASS SPECTROMETRY.
PubMed: 17081983

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526; SER-548; SER-627AND SER-774, AND MASS SPECTROMETRY.
PubMed: 15302935

"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.";
Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.;
J. Proteome Res. 6:4150-4162(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526 AND THR-649, ANDMASS SPECTROMETRY.
PubMed: 17924679

"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-526; THR-785 ANDTHR-788, AND MASS SPECTROMETRY.
PubMed: 16964243