| UniProt ID | GGYF1_HUMAN | |
|---|---|---|
| UniProt AC | O75420 | |
| Protein Name | GRB10-interacting GYF protein 1 | |
| Gene Name | GIGYF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1035 | |
| Subcellular Localization | ||
| Protein Description | May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity).. | |
| Protein Sequence | MAAETLNFGPEWLRALSGGGSVASPPPSPAMPKYKLADYRYGREEMLALYVKENKVPEELQDKEFAAVLQDEPLQPLALEPLTEEEQRNFSLSVNSVAVLRLMGKGAGPPLAGTSRGRGSTRSRGRGRGDSCFYQRSIEEGDGAFGRSPREIQRSQSWDDRGERRFEKSARRDGARCGFEEGGAGPRKEHARSDSENWRSLREEQEEEEEGSWRLGAGPRRDGDRWRSASPDGGPRSAGWREHGERRRKFEFDLRGDRGGCGEEEGRGGGGSSHLRRCRAPEGFEEDKDGLPEWCLDDEDEEMGTFDASGAFLPLKKGPKEPIPEEQELDFQGLEEEEEPSEGLEEEGPEAGGKELTPLPPQEEKSSSPSPLPTLGPLWGTNGDGDETAEKEPPAAEDDIRGIQLSPGVGSSAGPPGDLEDDEGLKHLQQEAEKLVASLQDSSLEEEQFTAAMQTQGLRHSAAATALPLSHGAARKWFYKDPQGEIQGPFTTQEMAEWFQAGYFSMSLLVKRGCDEGFQPLGEVIKMWGRVPFAPGPSPPPLLGNMDQERLKKQQELAAAALYQQLQHQQFLQLVSSRQLPQCALREKAALGDLTPPPPPPPQQQQQQLTAFLQQLQALKPPRGGDQNLLPTMSRSLSVPDSGRLWDVHTSASSQSGGEASLWDIPINSSTQGPILEQLQLQHKFQERREVELRAKREEEERKRREEKRRQQQQEEQKRRQEEEELFRRKHVRQQELLLKLLQQQQAVPVPPAPSSPPPLWAGLAKQGLSMKTLLELQLEGERQLHKQPPPREPARAQAPNHRVQLGGLGTAPLNQWVSEAGPLWGGPDKSGGGSSGLGLWEDTPKSGGSLVRGLGLKNSRSSPSLSDSYSHLSGRPIRKKTEEEEKLLKLLQGIPRPQDGFTQWCEQMLHTLSATGSLDVPMAVAILKEVESPYDVHDYIRSCLGDTLEAKEFAKQFLERRAKQKASQQRQQQQEAWLSSASLQTAFQANHSTKLGPGEGSKAKRRALMLHSDPSILGYSLHGSSGEIESVDDY | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 17 | Phosphorylation | PEWLRALSGGGSVAS HHHHHHHHCCCCCCC | 30266825 | ||
| 21 | Phosphorylation | RALSGGGSVASPPPS HHHHCCCCCCCCCCC | 30266825 | ||
| 24 | Phosphorylation | SGGGSVASPPPSPAM HCCCCCCCCCCCCCC | 29255136 | ||
| 28 | Phosphorylation | SVASPPPSPAMPKYK CCCCCCCCCCCCCCC | 30266825 | ||
| 35 | Methylation | SPAMPKYKLADYRYG CCCCCCCCCCCCCCC | - | ||
| 35 | Ubiquitination | SPAMPKYKLADYRYG CCCCCCCCCCCCCCC | - | ||
| 91 | Phosphorylation | EEEQRNFSLSVNSVA HHHHHCCCCCCCHHH | 29759185 | ||
| 93 | Phosphorylation | EQRNFSLSVNSVAVL HHHCCCCCCCHHHHH | 29759185 | ||
| 96 | Phosphorylation | NFSLSVNSVAVLRLM CCCCCCCHHHHHHHH | 29759185 | ||
| 137 | Phosphorylation | DSCFYQRSIEEGDGA CCCCEECCCCCCCCC | 23401153 | ||
| 148 | Phosphorylation | GDGAFGRSPREIQRS CCCCCCCCHHHHHHC | 25159151 | ||
| 155 | O-linked_Glycosylation | SPREIQRSQSWDDRG CHHHHHHCCCCCHHH | 23301498 | ||
| 155 | Phosphorylation | SPREIQRSQSWDDRG CHHHHHHCCCCCHHH | 22617229 | ||
| 157 | Phosphorylation | REIQRSQSWDDRGER HHHHHCCCCCHHHHH | 23401153 | ||
| 193 | Phosphorylation | PRKEHARSDSENWRS CCHHHCCCCCHHHHH | 29449344 | ||
| 195 | Phosphorylation | KEHARSDSENWRSLR HHHCCCCCHHHHHHH | 24719451 | ||
| 228 | Phosphorylation | RDGDRWRSASPDGGP CCCCCCCCCCCCCCC | 26329039 | ||
| 230 | Phosphorylation | GDRWRSASPDGGPRS CCCCCCCCCCCCCCC | 29255136 | ||
| 237 | Phosphorylation | SPDGGPRSAGWREHG CCCCCCCCCCCHHHC | 23403867 | ||
| 267 | Methylation | GCGEEEGRGGGGSSH CCCCCCCCCCCCCHH | 80701045 | ||
| 272 | Phosphorylation | EGRGGGGSSHLRRCR CCCCCCCCHHHHHCC | 28555341 | ||
| 273 | Phosphorylation | GRGGGGSSHLRRCRA CCCCCCCHHHHHCCC | - | ||
| 341 | Phosphorylation | LEEEEEPSEGLEEEG CCCCCCCCCCCCCCC | - | ||
| 357 | Phosphorylation | EAGGKELTPLPPQEE CCCCCCCCCCCCHHH | 21815630 | ||
| 366 | Phosphorylation | LPPQEEKSSSPSPLP CCCHHHCCCCCCCCC | 28450419 | ||
| 367 | Phosphorylation | PPQEEKSSSPSPLPT CCHHHCCCCCCCCCC | 28450419 | ||
| 368 | Phosphorylation | PQEEKSSSPSPLPTL CHHHCCCCCCCCCCC | 28450419 | ||
| 370 | Phosphorylation | EEKSSSPSPLPTLGP HHCCCCCCCCCCCCC | 29507054 | ||
| 374 | Phosphorylation | SSPSPLPTLGPLWGT CCCCCCCCCCCCCCC | 28450419 | ||
| 381 | Phosphorylation | TLGPLWGTNGDGDET CCCCCCCCCCCCCCC | 26074081 | ||
| 388 | Phosphorylation | TNGDGDETAEKEPPA CCCCCCCCCCCCCCC | 26074081 | ||
| 406 | Phosphorylation | DIRGIQLSPGVGSSA CCCCCEECCCCCCCC | 30266825 | ||
| 411 | Phosphorylation | QLSPGVGSSAGPPGD EECCCCCCCCCCCCC | 30266825 | ||
| 412 | Phosphorylation | LSPGVGSSAGPPGDL ECCCCCCCCCCCCCC | 30266825 | ||
| 438 | Phosphorylation | EAEKLVASLQDSSLE HHHHHHHHHHCCCCC | 22199227 | ||
| 442 | Phosphorylation | LVASLQDSSLEEEQF HHHHHHCCCCCHHHH | 22199227 | ||
| 443 | Phosphorylation | VASLQDSSLEEEQFT HHHHHCCCCCHHHHH | 22199227 | ||
| 450 | Phosphorylation | SLEEEQFTAAMQTQG CCCHHHHHHHHHHHC | 23186163 | ||
| 461 | Phosphorylation | QTQGLRHSAAATALP HHHCCCHHHHHHHHC | 28555341 | ||
| 538 | Phosphorylation | VPFAPGPSPPPLLGN CCCCCCCCCCCCCCC | 29255136 | ||
| 576 | Phosphorylation | QQFLQLVSSRQLPQC HHHHHHHHCCCCCHH | 24719451 | ||
| 595 | Phosphorylation | KAALGDLTPPPPPPP HHHHCCCCCCCCCCC | 25159151 | ||
| 620 | Ubiquitination | LQQLQALKPPRGGDQ HHHHHHHCCCCCCCC | - | ||
| 634 | O-linked_Glycosylation | QNLLPTMSRSLSVPD CCCCCCCCCCCCCCC | 23301498 | ||
| 636 | Phosphorylation | LLPTMSRSLSVPDSG CCCCCCCCCCCCCCC | 20873877 | ||
| 638 | Phosphorylation | PTMSRSLSVPDSGRL CCCCCCCCCCCCCCC | 25159151 | ||
| 642 | Phosphorylation | RSLSVPDSGRLWDVH CCCCCCCCCCCEEEE | 23927012 | ||
| 755 | Phosphorylation | VPVPPAPSSPPPLWA CCCCCCCCCCCCCHH | 28176443 | ||
| 756 | Phosphorylation | PVPPAPSSPPPLWAG CCCCCCCCCCCCHHH | 25159151 | ||
| 787 | Ubiquitination | EGERQLHKQPPPREP HHHHHHCCCCCCCCC | - | ||
| 819 | Phosphorylation | APLNQWVSEAGPLWG CCHHHHHHHCCCCCC | 28348404 | ||
| 831 | Phosphorylation | LWGGPDKSGGGSSGL CCCCCCCCCCCCCCC | 25159151 | ||
| 835 | Phosphorylation | PDKSGGGSSGLGLWE CCCCCCCCCCCCCCC | 27251275 | ||
| 836 | Phosphorylation | DKSGGGSSGLGLWED CCCCCCCCCCCCCCC | 27251275 | ||
| 844 | Phosphorylation | GLGLWEDTPKSGGSL CCCCCCCCCCCCCCE | 21815630 | ||
| 846 | Ubiquitination | GLWEDTPKSGGSLVR CCCCCCCCCCCCEEE | - | ||
| 847 | Phosphorylation | LWEDTPKSGGSLVRG CCCCCCCCCCCEEEC | 21712546 | ||
| 850 | Phosphorylation | DTPKSGGSLVRGLGL CCCCCCCCEEECCCC | 24719451 | ||
| 858 | Ubiquitination | LVRGLGLKNSRSSPS EEECCCCCCCCCCCC | - | ||
| 858 | Methylation | LVRGLGLKNSRSSPS EEECCCCCCCCCCCC | - | ||
| 860 | Phosphorylation | RGLGLKNSRSSPSLS ECCCCCCCCCCCCHH | 28464451 | ||
| 862 | Phosphorylation | LGLKNSRSSPSLSDS CCCCCCCCCCCHHHH | 23401153 | ||
| 863 | Phosphorylation | GLKNSRSSPSLSDSY CCCCCCCCCCHHHHH | 25159151 | ||
| 865 | Phosphorylation | KNSRSSPSLSDSYSH CCCCCCCCHHHHHHH | 23927012 | ||
| 867 | Phosphorylation | SRSSPSLSDSYSHLS CCCCCCHHHHHHHHC | 23663014 | ||
| 869 | Phosphorylation | SSPSLSDSYSHLSGR CCCCHHHHHHHHCCC | 23663014 | ||
| 870 | Phosphorylation | SPSLSDSYSHLSGRP CCCHHHHHHHHCCCC | 23663014 | ||
| 871 | Phosphorylation | PSLSDSYSHLSGRPI CCHHHHHHHHCCCCC | 23663014 | ||
| 874 | Phosphorylation | SDSYSHLSGRPIRKK HHHHHHHCCCCCCCC | 23663014 | ||
| 887 | Ubiquitination | KKTEEEEKLLKLLQG CCCHHHHHHHHHHCC | - | ||
| 952 | Ubiquitination | LGDTLEAKEFAKQFL HCCHHHHHHHHHHHH | - | ||
| 956 | Ubiquitination | LEAKEFAKQFLERRA HHHHHHHHHHHHHHH | - | ||
| 1003 | Acetylation | LGPGEGSKAKRRALM CCCCCCCHHHHHHHH | 23954790 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of GGYF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of GGYF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of GGYF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| IF4E2_HUMAN | EIF4E2 | physical | 22751931 | |
| GRB10_HUMAN | GRB10 | physical | 20878056 | |
| KI13B_HUMAN | KIF13B | physical | 27173435 | |
| CING_HUMAN | CGN | physical | 27173435 | |
| SI1L1_HUMAN | SIPA1L1 | physical | 27173435 | |
| MAGI1_HUMAN | MAGI1 | physical | 27173435 | |
| TESK2_HUMAN | TESK2 | physical | 27173435 | |
| HDAC4_HUMAN | HDAC4 | physical | 27173435 | |
| SYDE1_HUMAN | SYDE1 | physical | 27173435 | |
| F110B_HUMAN | FAM110B | physical | 27173435 | |
| GGYF2_HUMAN | GIGYF2 | physical | 27173435 | |
| NGAP_HUMAN | RASAL2 | physical | 27173435 | |
| F110A_HUMAN | FAM110A | physical | 27173435 | |
| KIF1C_HUMAN | KIF1C | physical | 27173435 | |
| RPTOR_HUMAN | RPTOR | physical | 27173435 | |
| NAV1_HUMAN | NAV1 | physical | 27173435 | |
| HDAC7_HUMAN | HDAC7 | physical | 27173435 | |
| KIF1B_HUMAN | KIF1B | physical | 27173435 | |
| REEP3_HUMAN | REEP3 | physical | 27173435 | |
| MFR1L_HUMAN | MTFR1L | physical | 27173435 | |
| CRTC2_HUMAN | CRTC2 | physical | 27173435 | |
| SH3B4_HUMAN | SH3BP4 | physical | 27173435 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
