REEP3_HUMAN - dbPTM
REEP3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID REEP3_HUMAN
UniProt AC Q6NUK4
Protein Name Receptor expression-enhancing protein 3
Gene Name REEP3
Organism Homo sapiens (Human).
Sequence Length 255
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein.
Protein Description Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes..
Protein Sequence MVSWMISRAVVLVFGMLYPAYYSYKAVKTKNVKEYVRWMMYWIVFALYTVIETVADQTVAWFPLYYELKIAFVIWLLSPYTKGASLIYRKFLHPLLSSKEREIDDYIVQAKERGYETMVNFGRQGLNLAATAAVTAAVKSQGAITERLRSFSMHDLTTIQGDEPVGQRPYQPLPEAKKKSKPAPSESAGYGIPLKDGDEKTDEEAEGPYSDNEMLTHKGLRRSQSMKSVKTTKGRKEVRYGSLKYKVKKRPQVYF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Phosphorylation-----MVSWMISRAV
-----CHHHHHHHHH		15.0424719451
7Phosphorylation-MVSWMISRAVVLVF
-CHHHHHHHHHHHHH		9.7024719451
22PhosphorylationGMLYPAYYSYKAVKT
HHHHHHHHCHHHCCC		13.9723663014
90 (in isoform 2)Ubiquitination-34.9921890473
90 (in isoform 1)Ubiquitination-34.9921890473
90UbiquitinationGASLIYRKFLHPLLS
CCHHHHHHHHHHHHC		34.9921890473
99 (in isoform 2)Ubiquitination-58.3721890473
99 (in isoform 1)Ubiquitination-58.3721890473
99UbiquitinationLHPLLSSKEREIDDY
HHHHHCCCCCCHHHH		58.3721890473
106PhosphorylationKEREIDDYIVQAKER
CCCCHHHHHHHHHHH		10.1527642862
111 (in isoform 2)Ubiquitination-30.7421890473
111 (in isoform 1)Ubiquitination-30.7421890473
111UbiquitinationDDYIVQAKERGYETM
HHHHHHHHHHCCHHH		30.7421890473
115PhosphorylationVQAKERGYETMVNFG
HHHHHHCCHHHEEHH		17.9127642862
131PhosphorylationQGLNLAATAAVTAAV
HHHHHHHHHHHHHHH		15.0021406692
135PhosphorylationLAATAAVTAAVKSQG
HHHHHHHHHHHHCCC		12.2721406692
150PhosphorylationAITERLRSFSMHDLT
HHHHHHHHCCCCCCC		26.6830266825
152PhosphorylationTERLRSFSMHDLTTI
HHHHHHCCCCCCCEE		19.2229255136
157PhosphorylationSFSMHDLTTIQGDEP
HCCCCCCCEECCCCC		28.1023927012
158PhosphorylationFSMHDLTTIQGDEPV
CCCCCCCEECCCCCC		20.7123927012
170PhosphorylationEPVGQRPYQPLPEAK
CCCCCCCCCCCHHHH		25.5928796482
180PhosphorylationLPEAKKKSKPAPSES
CHHHHHCCCCCCCCC		53.3923403867
185PhosphorylationKKSKPAPSESAGYGI
HCCCCCCCCCCCCCC		46.4123403867
187PhosphorylationSKPAPSESAGYGIPL
CCCCCCCCCCCCCCC		31.1923403867
190PhosphorylationAPSESAGYGIPLKDG
CCCCCCCCCCCCCCC		16.1723403867
201PhosphorylationLKDGDEKTDEEAEGP
CCCCCCCCCCCCCCC		46.7428355574
209PhosphorylationDEEAEGPYSDNEMLT
CCCCCCCCCCCHHHH		39.2423927012
210PhosphorylationEEAEGPYSDNEMLTH
CCCCCCCCCCHHHHH		36.7730278072
216PhosphorylationYSDNEMLTHKGLRRS
CCCCHHHHHHHHHHH		21.8923927012
218UbiquitinationDNEMLTHKGLRRSQS
CCHHHHHHHHHHHHC		55.17-
223PhosphorylationTHKGLRRSQSMKSVK
HHHHHHHHHCCCCCC		21.8530576142
225PhosphorylationKGLRRSQSMKSVKTT
HHHHHHHCCCCCCCC		29.4430576142
228PhosphorylationRRSQSMKSVKTTKGR
HHHHCCCCCCCCCCC		21.8730576142
240PhosphorylationKGRKEVRYGSLKYKV
CCCCEEEHHCEEEEE		19.0823186163
242PhosphorylationRKEVRYGSLKYKVKK
CCEEEHHCEEEEECC		16.8623401153
244MethylationEVRYGSLKYKVKKRP
EEEHHCEEEEECCCC		44.73115976501
245PhosphorylationVRYGSLKYKVKKRPQ
EEHHCEEEEECCCCC		26.72-
254PhosphorylationVKKRPQVYF------
ECCCCCCCC------		9.7925884760
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of REEP3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of REEP3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of REEP3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of REEP3_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of REEP3_HUMAN

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Related Literatures of Post-Translational Modification

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